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Matches 501 - 550 out of 5,290

Document Document Title
WO/2008/009671A1
The invention relates to an improved process for the preparation of a tetrahydro-1H- azepine of formula (I) wherein R1 and R2 have the meaning given in the claims; by a ring closure metathesis of the corresponding diene of formula (II) i...  
WO/2008/011539A2
In one embodiment the invention provides novel compounds of Formula (I) as well as prodrugs, salts, hydrates, solvates and N-oxides thereof. The invention also provides pharmaceutical compositions that include such compounds as well as m...  
WO/2007/050425A3
A compound of formula I,wherein A, X, q, R1, R2a, R2b, R2c, R3a, and R3b are defined herein, useful as liver X receptor modulator.  
WO/2008/000131A1
The present application discloses a type of α-amino-N-substituted amide compounds, compositions and uses thereof. The present compounds are represented by general formula I. It is easy to prepare these compounds. These compounds have st...  
WO/2007/120589A3
An efficient syntheses for the preparation of (3R,6S)-3-amino-6-(2,3- difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one. The process uses a crystallization driven asymmetric transformation to set the amine stereocenter followed by a c...  
WO/2007/149728A2
Aryl tetrahydrobenzazepine derivatives with minimal 5-HT2B activity relative to 5-HT2A and 5-HT2C activity that are useful for treating glaucoma are disclosed.  
WO/2007/026224A3
The present invention relates to pharmaceutical compositions comprising benzyl(idene)-lactam derivatives of formula (I) wherein R1 is a group of the formula (G1) or (G2) depicted below, and a pharmaceutically acceptable salt or optical i...  
WO/2007/146838A2
Substituted phenyl acetic acid compounds of formula (I), pharmaceutical compositions, methods for their preparation and methods are provided that are useful in the treatment and prevention of disorders or conditions responsive to DP-2 re...  
WO/2007/141798A1
Disclosed herein is an economically viable and cost effective process for preparation of oxcarbazepine of formula (I) via a novel intermediate of formula (XVIII).  
WO/2007/139215A1
A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity u...  
WO/2007/138998A1
Disclosed is a pharmaceutical composition which is effective for the treatment or prevention of a disease associated with uric acid, such as hyperuricemia, tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary cal...  
WO/2007/139002A1
It is intended to provide a method for producing an excellent compound effective in the treatment, prevention or the like of pathological conditions associated with uric acid such as hyperuricemia, tophus, acute gouty arthritis, chronic ...  
WO/2007/109615A3
β-lactamyl alkanoic acids and pharmaceutical compositions thereof are described. Methods for treating various diseases and disease states using one or more β-lactamyl alkanoic acids are also described. Substituted 2-(azetidin-2-on-l-yl...  
WO/2007/135293A2
The invention especially relates to 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation thereof, compositions containing the same, and the use thereof as medicaments, especially anticancer drugs. Formula (I).  
WO/2007/132841A1
Disclosed is a serotonin 5-HT2C receptor activator comprising a compound represented by the formula below or a salt or prodrug thereof: (I) wherein the ring A represents a 5- or 6-membered aromatic heterocyclic ring which may have a subs...  
WO/2005/122671A3
A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V b) hydrolyzing compound V to form crude Oxcarbazepine III c) purifyi...  
WO/2007/126020A1
[PROBLEMS] To provide a novel compound having an activity of blocking an NMDA receptor channel, and also provide a pharmaceutical agent comprising the compound. [MEANS FOR SOLVING PROBLEMS] A pharmaceutical agent for the treatment or pre...  
WO/2007/121523A1
Oxcarbazepine having a D[v,0.5] value of between about 15 microns to about 30 microns and a D[v,0.9] value of less than or equal to 90 microns.  
WO/2007/123516A1
The invention is directed to compounds of Formula II: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein t...  
WO/2007/118651A1
A process for preparing compounds of formula (I) or a solvate or hydrate thereof, where R, R1, R2, R3 and R5 have the meanings as indicated in the specification. Such compounds are useful in the treatment of a number of conditions associ...  
WO/2007/120517A2
The present invention provides processes, methods and intermediates for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, salts, hydrates and crystal forms thereof which are useful as serotonin (5-HT) receptor ago...  
WO/2007/120589A2
An efficient syntheses for the preparation of (3R,6S)-3-amino-6-(2,3- difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one. The process uses a crystallization driven asymmetric transformation to set the amine stereocenter followed by a c...  
WO/2007/115943A2
Process for the preparation of an N-alkyl lactam with improved colour quality, where 0.01 to 10% by weight of a C1-10-alcohol or a compound which releases 0.01 to 10% by weight of a C1-10-alcohol is added to the N-alkyl lactam. Mixture c...  
WO/2007/117166A1
A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, str...  
WO/2007/117180A1
The invention relates to novel azaheterocycles of interest as potential physiologically active substances (agonists, antagonists, receptor modulators, ferment inhibitors, oncolytics, antibacterial and antiparasitic agent etc.), to combin...  
WO/2000/072801A3
The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphaV integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors...  
WO/2007/110335A1
The invention relates to malonamide derivatives of Formula (I) wherein A1 is -CHR- or -C(O)-; A2 is -C(O)- and R2/R3 are independently from each other hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; or A2 is -O-C(O)- and R2/R3 a...  
WO/2007/105482A1
A process for the production of amides or lactams by conducting the rearrangement of an oxime in the presence of a cyclic compound having a structure represented by the general formula (1) as a ring constituent and a fluorinated alcohol ...  
WO/2007/104933A1
The invention provides a new method for treating disorders associated with activation of the Notch signal transduction pathway comprising administering an effective amount of a compound of Formula (I), in free form or in a pharmaceutical...  
WO/2007/101347A1
Disclosed herein are compounds as resented by Formula (I): wherein R1,R2, R3, R4, n, W, A, and Q are as defined herein. The compounds of formula (I) are useful as antagonists of the IAPs via binding to BIR domain. The compounds are usefu...  
WO/2007/102171A2
Novel water soluble amino acid salts of 1 H- 1-benzazepine- 1 -acetic acid, process of preparation of such novel salts and methods of using them are provided. Also provided are pharmaceutical compositions comprising such novel salts and ...  
WO/2007/088878A1
Disclosed is a commercial method which is practically suitable for producing a 2-iminocarboxylic acid derivative and a benzazepinone by a short process under mild conditions. Specifically disclosed is a method for producing a benzazepino...  
WO/2007/079957A1
The invention relates to the substituted propiolic acid amides of general formula (I), to methods for producing them, to drugs containing said compounds and to the use thereof for producing drugs.  
WO/2007/080131A2
Compounds of formula (I) wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredie...  
WO/2007/050380A3
The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET...  
WO/2007/026971A3
This invention provides a process for preparing benzazepine compounds of the formula (1): wherein X1is a halogen atom, R1and R2are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and hig...  
WO/2007/074553A1
According to the invention, a catalyst for a strecker reaction comprising a quaternary ammonium salt and a method for stereoselectively producing an α-aminonitrile derivative using the same are provided. By using the α-aminonitrile der...  
WO/2007/065292A1
A type of optically pure diamides, which have the general formula as follows. The configuration is L or D, wherein Het represents 4-8 membered heterocycles contaning nitrogen atom on the backbone; each of R1, R2, R3 is hydrogen, hydrocar...  
WO/2007/028132A3
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H- benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, de...  
WO/2007/060828A1
Disclosed is a commercially advantageous method for obtaining a monomer by performing a depolymerization reaction of a polyamide. Specifically disclosed is a method for obtaining a monomer through a depolymerization reaction of a polyami...  
WO2007037518A9
The invention is intended to provide a novel compound which is useful as an antibacterial agent and a manufacturing intermediate thereof and relates to a mutilin derivative represented by the formula (I) which is useful as an antibacteri...  
WO/2007/057658A1
The present invention relates to a process for preparing arylated or vinylated olefins.  
WO/2007/028083A3
The present invention provides 6-substituted 2,3,4,5-tetrahydro-lH- benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, ...  
WO/2007/027719A3
The present invention provides analogs of formula (I) of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and ora...  
WO/2007/024612A3
Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft reject...  
WO/2006/069363A3
The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same, preparations, and uses thereof.  
WO/2007/025709A3
The invention relates to novel diamines of the formula (I) in which all variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments ...  
WO/2007/050425A2
A compound of formula I,wherein A, X, q, R1, R2a, R2b, R2c, R3a, and R3b are defined herein, useful as liver X receptor modulator.  
WO/2007/048595A1
The present invention relates to compounds of formula (I) comprising a lactam or a lactam derivative moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as pharmaceuticals.  
WO/2007/045184A1
The invention provides peptides derivatives which 2-site contains proline or crico-amino acid having endothelium essence receptor antagonizing activity, its preparing process, medicinal compositions containing them, and their use in trea...  

Matches 501 - 550 out of 5,290