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Matches 601 - 650 out of 5,295

Document Document Title
WO/2006/090044A1
The invention relates to a lactam production method. More specifically, the invention relates to a method of producing lactams from alkyl cyanovalerate compounds obtained using, for example, unsaturated mononitrile compounds as raw mater...  
WO2006023187A3
The present disclosure relates to chemical compounds and their use in human therapy. A specific embodiment relates to compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof and pharmaceutically accep...  
WO2006056696A3
2-alcoxy-3,4,5-trihydroxy-alkylamides, the preparation thereof, compositions containing them and use thereof. The invention relates particularly to 2-alcoxy-3,4,5-trihydroxy-alkylamides, the preparation thereof, compositions containing t...  
WO2006075925A3
A process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (1) by ring opening of 11a,10b-dihydro-6H-dibenz/b,f/oxireno[d]azepine-6-carboxamid e (5), characterised in that the ring opening is carried o...  
WO/2006/085688A1
It is intended to provide a psychogenic pain therapeutic agent that exerts an excellent therapeutic effect on psychogenic pain which is an intractable disease. More specifically, it is intended to provide a psychogenic pain therapeutic a...  
WO2006021213A3
The present invention concerns compounds inter alia according to general formula: (1a). Compounds according to the invention are vasopressin V1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment o...  
WO/2006/078753A1
The invention provides N-substituted heterocyclic-sulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R1, R2, Z and n are a...  
WO/2006/079090A2
Methods and inte&pgr nediates for the preparation of Fenoldopam mesylate and ntermediates thereof are provided.  
WO/2006/075925A2
A process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (1) by ring opening of 11a,10b-dihydro-6H-dibenz/b,f/oxireno[d]azepine-6-carboxamid e (5), characterised in that the ring opening is carried o...  
WO/2006/073967A1
Compounds useful as prodrugs of potassium channel inhibitor compounds, in particular as prodrugs of Kv1.5 channel inhibitors.  
WO2006046039A3
The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, R14, R15, A, Ar, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and th...  
WO/2006/069363A2
The present invention is directed to crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, compositions containing the same, preparations, and uses thereof.  
WO/2006/064757A1
A compound represented by the general formula (I), a salt thereof, an N-oxide form thereof, a solvate thereof, or a prodrug of any of these; and a drug containing any of these. (I) (In the formula, all the symbols are as defined in the d...  
WO2006039383A3
Chiral synthesis from an achiral starting material by chiral diamine­mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid.  
WO/2006/060225A2
Processes for asymmetric synthesis of 1O(S)-amino-3-hydroxy-4-oxo-4,6,7,8,9,10­hexahydropyrimido[ 1,2-a]azepine-2-carboxamides and related compounds are disclosed. The enantiomerically enriched carboxamides are useful as HIV integrase i...  
WO/2006/056696A2
2-alcoxy-3,4,5-trihydroxy-alkylamides, the preparation thereof, compositions containing them and use thereof. The invention relates particularly to 2-alcoxy-3,4,5-trihydroxy-alkylamides, the preparation thereof, compositions containing t...  
WO/2006/056695A1
Substituted caprolactames, method for the preparation thereof, compositions containing them and use thereof. The invention relates to the preparation of substituted caprolactames, a method for the preparation thereof, compositions contai...  
WO/2006/057460A1
An URAT1 activity inhibitor which contains a nitrogen-containing fused ring compound represented by the following general formula [1]: [1] wherein each symbol is as defined in the description. This URAT1 activity inhibitor is useful in, ...  
WO/2006/056339A1
(S)-(+)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-car boxyamide is prepared starting from racemic 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine by phthaloylation, separation of the diastereomeric salts of the phthaloyl de...  
WO/2006/053683A2
The present invention generally relates to gene silencing using sense DNA (sDNA) - antisense RNA (aRNA) hybrids wherein the sense DNA strand is coupled to a peptide which facilitates the uptake of the hybrid into cells.  
WO/2006/053674A2
A process for the preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxyamide by hydrolysis of 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine with peroxy compounds in alkali medium and in the presence of solvent...  
WO2006032994A3
This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic r...  
WO/2006/047479A2
The invention is directed to compounds of Formula (I) wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyr...  
WO/2006/047503A2
The invention relates to compounds of Formula (I) wherein A, R1, R2, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kina...  
WO/2006/046039A2
The present invention relates to tetracyclic indole compounds of formula (I); wherein R1, R2, R14, R15, A, Ar, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and th...  
WO2005096709A3
A process for preparing 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5- carboxamide, compound of formula (I), said process comprising a. reacting compound of of formula (Ivb) with alkali metal methoxide to yield compound of formula (II); a...  
WO2005118549A3
Compounds of formula (I) and salts thereof are disclosed: wherein A, R
WO/2006/033003A1
The invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2&lcub 4-[(methylamino)methyl]phenyl&rcub -1,3,4,5-tetrahydro-6H-azepino [5,4,3-cd]indol-6-one, via a key S...  
WO/2006/031550A1
The invention relates to the field of separation by distillation of 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) from a mixture comprising ACN, HMD, tetrahydrozaepine (THA), adiponitrile (ADN) and low boilers (LB). A method f...  
WO/2006/021213A2
The present invention concerns compounds inter alia according to general formula: (1a). Compounds according to the invention are vasopressin V1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment o...  
WO/2006/020959A2
The present invention relates to the compounds of Formula (I), their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of ...  
WO/2006/018260A1
The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.  
WO/2006/016152A1
The invention provides compounds, compositions and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, which are 3-aminocaprolactam derivatives, for the preparation of a medicament intended to treat an ...  
WO/2006/014703A2
The present disclosure relates to chemical compounds and their use in human therapy. In a specific embodiment, compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable ...  
WO/2006/014135A1
Compounds of formula (I) wherein Ar1 and Q are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the ...  
WO/2006/014206A1
Compounds comprising formula (I) or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, and E are as described herein. These compounds are useful for treating diseases.  
WO/2006/005951A1
A method for chiral inversion of optically pure or optically enriched mixtures of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-car boxamide (I) and (R)-(-)-10,11­dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-ca rboxamide (II) w...  
WO/2006/005486A1
The invention relates to compounds of the general formula (I), wherein R1-R5 and R2’-R4’ are as described in the claims and to pharmaceutically suitable acid additon salts, optical pure enantiomers, racemates or diastereomeric mixtur...  
WO/2006/005195A1
This invention relates to the use of nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases. The invention further relates to pharmaceutical compositions comprising nicotine receptor ago...  
WO2004113297A3
This invention relates to novel aza-ring derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositio...  
WO/2006/002764A1
The invention relates to compounds of following formula (I), the respective sulfonic acid chloride, sulfonic acid, derivatives such as sulfonamides, and a method for the production and use thereof in medicaments.  
WO/2005/123659A1
The invention relates to a method of synthesising a compound having formula (I) and to the use thereof for the synthesis of ivabradine and the pharmaceutically-acceptable acid addition salts and hydrates of same.  
WO/2005/122671A2
A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V b) hydrolyzing compound V to form crude Oxcarbazepine III c) purifyi...  
WO2005097778A8
The present invention relates to novel benzazepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.  
WO/2005/118549A2
Compounds of formula (I) and salts thereof are disclosed: wherein A, R1, m, R2, n, R3, R4, q, W1, W2, R5 and R6 are as defined in the description. Methods of preparing the compounds and uses thereof in medicine, for example in the treatm...  
WO/2005/117865A1
The present invention relates to compounds of formula (I) wherein A, R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositi...  
WO/2005/118550A1
The reaction between 10-methoxy-iminostilbene (IV) and bis(trichloromethyl)carbonate affords 10-methoxy-N-chlorocarbonyl-iminostilbene (XVI) in high yields, then ammonolysis and subsequent hydrolysis of the enol ether provides particular...  
WO2004113297A9
This invention relates to novel aza-dng dedvatives useful as monoamine neurotransmifter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions...  
WO/2005/110993A1
Method of synthesising ivabradine of formula (I), the salts thereof for addition to a pharmaceutically acceptable acid and the hydrates thereof. The crystalline form a of ivabradine hydrochloride is also described, as are drugs comprisin...  
WO/2005/111027A1
A method of synthesising compounds of formula (I), wherein R1 and R2, which are the same or different, are each a branched or linear (C1-C8) alkoxy grouping or together form, with the carbon atom bearing them, a 1,3-dioxane, 1,3-dioxolan...  

Matches 601 - 650 out of 5,295