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Patent Searching and Data


Matches 801 - 850 out of 5,296

Document Document Title
WO/2004/031154A1
Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ß protein production and neurological disorders such as Alzheimer's dis...  
WO/2004/031155A1
The invention relates to a novel process for the manufacture of substituted enantiopure 10hydroxy-­dihydrodibenz[b,f]azepines (la), (lb) wherein each of R1 and R2, independently, are hydrogen, halogen, amino or nitro; and each of R3 and...  
WO/2004/031248A1
The present invention relates to a novel nitrosation polymer of Formula (A) in which X, Y, R1, R2 and R3 are as defined in Claim 1. The invention also relates to a process for the preparation of the said polymer.  
WO/2004/028538A1
Small organic molecules capable of effecting a 'pharmacological trabeculocanalotomy' in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity ...  
WO2003068732A3
The invention provides compounds of formula (I) wherein A and B represent the groups -(CH2)m- and -(CH2)n- respectively; R<1> represents hydrogen or C1-6alkyl; R<2> represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, t...  
WO2003066597A3
A variety of small, guanidino group-containing molecules capable of acting as MC4-R agonists are provided. The compounds have various structures provided herein. The compounds are useful in treating MC4-R mediated diseases and may be for...  
WO2003082260A3
A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.  
WO/2004/024702A1
The invention relates to carboxamide compounds of general formula (I), in which the groups and radicals A, B, W, X, Y, Z, R1, R2, R3, and k have the meanings indicated in claim 1. The invention also relates to methods for producing said ...  
WO2003086306B1
The present invention relates to novel compounds of: (Formula I); which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.  
WO2003079975A3
The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) [Insert chemical formula here] process, comprising: contacting a compound of formula (II): [Insert ch...  
WO/2004/018432A1
The present invention discloses novel substituted azepine compounds of Formula (I) or pharmaceutically acceptable salts thereof which have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compound...  
WO/2004/017911A2
This invention relates 4-amino-azepan-3-ones of formula (1) which are useful as protease inhibitors, particularly of cathepsin S, and as such are useful for preventing a number of diseases amongst which are atherosclerotic lesions and pu...  
WO/2004/014391A1
The present invention relates to the use of carbamazepine derivatives in treating tinnitus.  
WO2003086306A3
The present invention relates to novel compounds of: (Formula I); which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.  
WO/2004/012726A2
Therapeutic methods for the prevention ad treatment of conditions and diseases of the gastrointestinal tract involving an overproduction of nitric oxide by inducible nitric oxide synthase are described, the methods including administerin...  
WO/2004/013105A1
The present invention is directed to the polymorphic Form B and the amorphous form of Benazepril hydrochloride. The present invention is also directed to processes for the preparation of Form B and the amorphous form of Benazepril hydroc...  
WO/2004/011431A1
Compounds of formula (I), wherein R1 and R1' are hydrogen or deuterium, R2, R3 and R4 are hydrogen or deuterium, R5 is the residue of an amino acid, X is S or N-ALK, formula (II), is piperidinyl or tetrahydropyridinyl, ALK is (C1-4)alkyl...  
WO/2004/005256A2
The present invention relates to cyclic amine derivatives of formula(I) (I)whereinR represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy;R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, ...  
WO2003076429A3
This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula ( I ) wherein the remaining symbols have the significance given in the specification, as well as processes f...  
WO/2004/002549A1
The present invention relates to drug delivery systems, comprising an ARB or a RI, or at least two representatives selected from the group consisting of an ARB, an ACEI and a RI, or, in each case, a pharmaceutically acceptable salt there...  
WO/2004/002491A1
The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.  
WO2003078358A3
This invention relates to the miniaturisation of radiosyntheses onto microfabricateddevices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tom...  
WO/2003/105857A1
The present invention is directed to pharmaceutical compositions containing active compounds, which inhibit the activity of the chemokines, MIP-l&agr and RANTES. It also is directed to methods of treating inflammatory and immunoregulator...  
WO/2003/106414A2
The present invention provides a method of preparing a 5H-dibenz[b,f]azepine-5-carboxamide of formula (1) wherein R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, halogen, nitro, cyano, carboxyl, A, -C...  
WO/2003/103662A2
The Invention provides use of an antibody against platelet glycoprotein VI (GPVI) for the preparation of a medicament for the prevention of intraarterial thrombosis in a Patient characterized by (i) having suffered from an acute coronary...  
WO2003074474A3
The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component phase compositions comprising one or more ...  
WO/2003/104282A2
The present invention provides a fusion protein comprising (a) the extracellular domain of glycoprotein VI or a variant thereof that is functional for binding to collagen and (b) the Fc domain of an immunoglobulin or a function-conservat...  
WO2003045909A3
Disclosed are methods and intermediates for the preparation of azepines of formula (1).  
WO2002094176A3
This invention relates to the use of a compound having combined, in particular concurrent, inhibitorz activity on neutral endopeptidase (NEP) and on a novel metalloprotease designated IGS5, or of a pharmaceutically acceptable salt or sol...  
WO/2003/099786A2
The invention provides compounds of formula (I): wherein A and B represent the groups -(CH2)m- and -(CH2)n- respectively;R1 represents hydrogen or C1-6alkyl;R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, triflu...  
WO/2003/099792A1
The invention provides compounds of formula (I): wherein A and B represent the groups -(CH2)m- and -(CH2)n- respectively;R1 represents hydrogen or C1-6alkyl;R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, triflu...  
WO/2003/097050A2
Therapeutic methods for the prevention and treatment of respiratory diseases or conditions are described, the methods including administering to a subject in need thereof a respiratory disease or condition effective amount of a selective...  
WO/2003/097163A2
Therapeutic methods for the prevention and treatment of respiratory diseases or conditions are described, the methods including administering to a subject in need thereof a respiratory disease or condition effective amount of a selective...  
WO/2003/096989A2
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided....  
WO2002074735A3
Novel compounds of formula (I), where X, Y, Z, R, R<1>, R<2> and R<3> have the meanings given in claim 1 are inhibitors of the coagulation factor Xa and may be used for prophylaxis and/or therapy of thromboembolitic diseases and for the ...  
WO/2003/095428A1
The invention provides compounds of formula (I):wherein A and B represent the groups -(CH2)m- and -(CH2)n-respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, triflu...  
WO/2003/094918A1
Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutical...  
WO2002002520A8
The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.  
WO/2003/093254A1
The invention relates to novel compounds of formula (I), wherein R, R1, R1', X and T have the meaning given in patent claim 1. Said novel compounds are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therap...  
WO/2003/092698A1
A process for the preparation of benazepril hydrochloride (2) starting from the Michael adduct (14), obtained reacting compounds of formula (11) and (13), as defined in the disclosure.  
WO/2003/091208A1
A method of continuously manufacturing lactam under high temperature and high pressure fluid, characterized by comprising the step of leading ketone and a hydroxylamine compound in a reaction field under high temperature and high pressur...  
WO2002076375A3
The present invention relates to an improved process for the preparation of trifluoromethanesulfonic ester of ethyl (R)-2-hydroxy-4-phenylbutyrate, referred to here as triflate in structural Formula I, and to the use of this compound as ...  
WO2002051983A3
The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making  
WO2002094799A3
Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptir activity, are provided. Such ligands may be used to modulate M...  
WO/2003/088908A2
Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating de...  
WO/2003/086306A2
The present invention relates to novel compounds of: (Formula I); which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.  
WO2002100849A3
Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases a...  
WO2003037271A3
The invention relates to compounds having the formula (I). Preferred compounds are antagonists of C-C chemokine receptor 8. The invention also relates to a method for treating a subjected having an inflammatory disorder or viral disorder...  
WO/2003/084932A1
A method for preparing 6−aminomethyl−6,11−dihydro−5H−dibenz[b,e]azepine, characterized in that it comprises reducing 2−(11H−dibenz[b,e]azepine−6−ylmethyl)−1H−isoindo le−1,3(2H)−dione with a metal hydride or a me...  
WO2002076939A3
Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present ...  

Matches 801 - 850 out of 5,296