Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1,001 - 1,050 out of 5,295

Document Document Title
WO/2002/036555A1
Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.  
WO/2002/034760A2
The invention relates to substituted urea compounds which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, b...  
WO/2002/028830A1
Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof which have an effect of inhibiting $g(a)4 integrin and, therefore, are useful as remedies or preventives for inflammatory diseases wherein the $g(a)4 integri...  
WO2001019797A3
This invention relates to novel lactams having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the pr...  
WO/2002/026705A2
The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one s...  
WO/2002/026750A2
Disclosed are substantially enantiomerically pure bis-phosphine compounds comprising a substantially enantiomerically pure chiral backbone linking two phosphine residues wherein one of the phosphine residues has three phosphorus-carbon b...  
WO/2002/026856A1
An optical device comprises a substrate and at least one semiconductive polymer supported by said substrate, wherein said semiconductive polymer is a copolymer in which one of the repeat units is a group of formula (I) below or a homopol...  
WO2001089451A3
The present invention provides methods which use 4-amino-azepan-3-one protease inhibitors of cathepsin S in the treatment of diseases in which cathepsin S is implicated, especially treatment or prevention of autoimmune disease; treatment...  
WO/2002/024649A1
The invention relates to novel compounds which are substituted amino-aza-cycloalkane derivatives of the general formula I. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutic...  
WO/2002/024653A1
Compounds have the structure: including srereoisomers and pharmaceutically acceptable salts thereof; wherein a is 0, 1 or 2; A, B and C are independently CH, CR or N, wherein R is C¿1-6? alkyl; D is-(CH¿2?)¿n?C(=O)(CH¿2?)¿m?-; R¿1?...  
WO/2002/022572A2
One aspect of the present invention relates to heterocyclic compounds formula A; whereof the substituents are defined in the description. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligand...  
WO2001070673A3
The present application describes novel cyclic beta -amino acid derivatives of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O,...  
WO/2002/020526A2
Disclosed are cyclic and acyclic amidines, pharmaceutical compositions containing such amidines, and their use in treating or preventing progesterone receptor mediated diseases or conditions, such as osteopenia and osteoporosis.  
WO/2002/020475A2
The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmceutical composi...  
WO/2002/017924A1
The present invention relates to methods of treating parasitic diseases which are mediated by cysteine proteases by administration of 4-amino-azepan-3-one protease inhibitors. In particular, the present invention relates to a method of t...  
WO/2002/017712A2
Compounds of formula (I): wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amount of a compou...  
WO/2002/016339A1
The invention concerns novel benzofuran or benzothiophene derivatives of general formula (I). Said compounds are useful as medicines in particular for treating pathological syndromes of the cardiovascular system.  
WO/2002/014513A1
Use of a polypeptide having a ligand activity to sensory epithelium neuropeptide-like receptor (SENR) which is a G protein-coupled receptor protein and DNA encoding the same. Drugs against attention deficit disorder or narcolepsy contain...  
WO/2002/012169A1
The invention relates to novel amino diphenyl ethers and amido diphenyl ethers, to methods for the production thereof, and to their use in medicaments, especially for the indications of arteriosclerosis and hypercholesterolemia.  
WO2001051479A3
The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X = O, (CH2)m, S, SO, SO2, NH, NR8 or a chemical b...  
WO/2002/012196A2
Lactam inhibitors are provided which have the structure (I), x is (a) or (b) wherein Y is O or S and R?4¿ is (i), (ii) or R?8¿ at least one of R?1¿ and R?2¿ is hydrogen, and R?1¿, R?2¿, R?3¿, R?5¿, R?6¿, R?7¿, and R?8¿, are as...  
WO/2002/010146A1
Compounds of formula (I) in which: each A is independently hydrogen, C¿1-6?alkyl optionally substituted by hydroxyl, C¿1-6?alkoxy, C¿1-6?alkenyl or C¿1-6?acyl group or a halogen atom or hydroxyl, CN or CF¿3? group; R3 is hydrogen, m...  
WO/2002/010139A1
Iminoazepinyl Hexanoic Acid derivatives of formula (I) as well as pharmaceutically acceptable salts and derivatives thereof useful in the inhibition of the inducible isoform of nitric oxide synthase for the treatment of arthritis, osteoa...  
WO2001014328A3
Compounds of Formula (I) are antagonists of VLA-4 and/or alpha 4 beta 7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutica...  
WO2001023357A3
The invention comprises novel compounds of formula E-B-(Alk)p-Q-(Alk)q-A-G wherein G is a radical of formula (I), (II) or (III) that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases...  
WO/2002/006220A1
Free-flowing flakes of vinyl caprolactam monomer usable below its melting point of 34°C without developing coloration.  
WO/2002/006232A1
This invention provides compounds of Formula (I) wherein: R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, T, T?1¿, T?2¿, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting me...  
WO2001056992A3
The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine as well as novel intermediates (I), (V), (VI), (VII), (IX) prepared by or used for said processes, and the preparation of said intermediates. ...  
WO/2002/006241A1
There is disclosed a compound having the formula or a pharmaceutically acceptable salt thereof, wherein: R¿1a?, R¿1b? and R¿1c? are independently fluorine or hydrogen; R¿2? is C¿1? to C¿12? alkyl being straight or branched chain, s...  
WO/2002/002520A2
The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.  
WO2001025212A3
The invention relates to compounds of general formula (I), wherein the radicals R independently represent a hydroxy group, a hydrogen atom, a halogen atom, a pseudohalogen, a substituent, an optionally substituted alkyl radical, alkenyl ...  
WO/2002/002512A2
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.  
WO/2002/002530A1
A novel GPR14 antagonist. The GPR14 antagonist comprises a compound represented by the formula (I) or a salt thereof wherein Ar represents optionally substituted aryl; X represents a spacer; n is an integer of 1 to 10; R represents an op...  
WO/2002/002531A1
The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for...  
WO/2002/000626A1
Compounds according to general formulae (1 and 2), wherein G?1¿ is an azepine derivative and G?2¿ is a group according to general formulae (9 - 11) are new. Compounds according to the invention are vasopressin V¿2? receptor agonists. ...  
WO/2001/098273A1
The invention provides compounds of general formula (I) wherein m, n, Q, Z?1¿, Z?2¿, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ and R?8¿ are as defined in the specification, processes for their preparation, pharmaceutical composi...  
WO/2001/096294A1
The invention relates to a method for the production of caprolactam from a compound of formula (I): NC-(CH¿2?)¿5?-CO-R where R = a carboxamido, carboxlic acid or carboxylate ester group, characterised in that a) a compound (I), or mixt...  
WO/2001/095911A1
The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, n...  
WO/2001/095856A2
The present invention relates to a novel urea derivative which is useful as an anti-cancer agent, its pharmaceutically acceptable acid addition salt or stereoisomer, and to a process for preparing the urea derivative and an anti-cancer c...  
WO/2001/096331A1
Lactam inhibitors are provided which have the structure (I) including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is l to 5; and R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?,...  
WO/2001/094294A1
Fungicidal compounds of formula (I), wherein R¿1? represents (CH¿2?)¿n?R¿3?, where n represents an integer from 5 to 10 inclusive and R¿3? represents H, optionally substituted phenyl, optionally substituted phenoxy or optionally sub...  
WO/2001/093840A2
The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the $g(a)¿v?ß¿3? integrin receptor. The invention also relates to the novel compounds, to the use thereof and to pharma...  
WO/2001/094304A1
A process for the production of sulfonic ester derivatives of the general formula (4) or (5) by reacting an amino alcohol of the general formula (1) or (2) with an organic sulfonyl halide of the general formula (3) in a mixed solvent of ...  
WO/2001/094308A1
The invention relates to a method for separating ammonia from solutions (I) containing lactam and ammonia by distillation. The method is characterized in that the separation takes place in a distillation device (a) at an absolute pressur...  
WO/2001/092226A1
One aspect of the present invention relates to novel heterocyclic compounds, such as Formula (1). A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, ...  
WO/2001/092235A1
This invention relates to novel lactams having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the pr...  
WO2001051474A3
One aspect of the present invention relates to polypharmacophoric compounds. In certain embodiments, the polypharmacophore compounds comprise individual pharmacophore units selected from the group consisting of D-1 agonists, D-2 agonists...  
WO2001010847A8
The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hyd...  
WO/2001/090082A1
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula (1) wherein one of X, Y, or Z is independently -S-, -O-, or > N-R?4¿, the others are-CH¿2-;? (p) is an i...  
WO/2001/090065A1
The invention concerns a method for purifying lactams, more particularly lactams obtained by cyclizing hydrolysis of aminonitrile. More particularly, the invention concerns the purification of $g(e)-caprolactam obtained by cyclizing hydr...  

Matches 1,001 - 1,050 out of 5,295