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Matches 101 - 150 out of 5,290

Document Document Title
WO/2017/023679A1
Provided in some embodiments are compounds of Formula A, as defined herein, that modulate the activity of 5-HT2C receptor. Also provided in some embodiments are methods, such as, for weight management, inducing satiety, and decreasing fo...  
WO/2017/021466A1
The present invention relates to a process for the preparation of a solid form of ivabradine hydrochloride by reduction of Compound 2 or a salt thereof in an aqueous solvent followed by extraction of ivabradine wherein the extraction com...  
WO/2017/012890A1
The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.  
WO/2017/011371A1
The description relates to MDM2 binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins w...  
WO/2016/193386A3
A method for the preparation of purified ivabradine and salts thereof, a method for the purification of ivabradine and salts thereof, a new reactant used in said methods and the use of said reactant for the preparation of ivabradine.  
WO/2017/004522A1
Provided herein are compounds and methods for inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).  
WO/2016/207082A1
The invention relates to haloalkylsulphonamide derivatives of the formula (I) wherein A, W, X, m, n, p, R, R1, R2, R5, R6, R7and R8 are as defined in the specification. Furthermore, the present invention relates to processes for making c...  
WO/2016/197398A1
Disclosed are a sulfonic acid inner salt compound of amidine and a preparation method therefor. The product of a sulfonic acid inner salt of amidine is obtained and synthesized by adopting an o-aminobenzenesulfonyl chloride compound and ...  
WO/2016/193452A1
The present invention relates to compounds according to Formula I: or a pharmaceutically acceptable salt thereof. The compounds can be used as inhibitors of RORy and are useful for the treatment of RORy mediated diseases.  
WO/2016/193386A2
A method for the preparation of purified ivabradine and salts thereof, a method for the purification of ivabradine and salts thereof, a new reactant used in said methods and the use of said reactant for the preparation of ivabradine.  
WO/2016/187339A1
Galantamine and its pharmaceutically acceptable salts are of use in treating persons meeting criteria for having a risk of developing Alzheimer's type dementia, before dementia occurs by reducing the decline of Aβ amyloid in CSF or the ...  
WO/2016/182850A1
The present invention relates to methods and intermediates for the preparation of omacetaxine and cephalotaxine derivatives thereof. The resulting products are useful in the treatment of proliferative diseases and infectious diseases.  
WO/2016/105165A3
The present invention relates to a novel compound having excellent hole-injection, hole-transport and light-emitting capabilities and the like, and represented by chemical formula 1 (wherein at least one of R1 and R2, Re and R3, R3 and R...  
WO/2015/153683A8
This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses me...  
WO/2016/164565A1
A substituted trans-cycloheptene according to formula (I); wherein : a) Z and L are each selected from the group consisting of SiR1R2, CH2, CHOH, and CHR2; R1 is phenyl or CH3; R2 is phenyl, CH3, (CH2)nCN, or (CH2)nOH, wherein n is an in...  
WO/2016/160579A1
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I), ...  
WO/2016/151451A1
The present invention provides a process for the preparation of crystalline Lorcaserin hydrochloride hemihydrate of Formula (la), which comprises, Formula (la) (i) providing a solution of Lorcaserin base in a solvent; (ii) if water is pr...  
WO/2016/148200A1
A method for producing ε-caprolactam wherein the method includes a step (A) for producing cyclohexanone oxime by oxidizing cyclohexylamine and a step (B) for producing ε-caprolactam from the cyclohexanone oxime by a vapor-phase Beckman...  
WO/2016/142250A1
This invention relates to novel benzazepine dicarboxamide compounds of the formula (I), wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR a...  
WO/2016/142164A1
Object of the present invention is an improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts.  
WO/2016/138882A1
A seven-element-ring berberine analogue and pharmaceutically acceptable salt thereof. The seven-element-ring berberine analogue has the structure shown by formula A, and the definition of each substituted radical is as defined in the spe...  
WO/2016/140971A1
The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating canc...  
WO/2016/112814A1
A caprolactam preparation method provided in the present invention comprises the following steps: (1) in the presence of an oxime catalyst and absence of any organic solvent, conducting an ammoximation on cyclohexanone, ammonia, and hydr...  
WO/2016/105165A2
The present invention relates to a novel compound having excellent hole-injection, hole-transport and light-emitting capabilities and the like, and to an organic electroluminescent device which comprises the compound in at least one orga...  
WO/2016/102039A1
The present invention relates to heterocyclic compounds and electronic devices, in particular organic electroluminescent devices, containing these compounds.  
WO/2016/096778A1
This invention relates to novel benzazepine sulfonamide compounds of the formula (I), wherein R4 or R5 is -SO2-NR7R8 and R1 to R8 and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts the...  
WO/2016/094876A1
Methods and compositions for glial cell-derived neurotrophic factor (GDNF) induction in the eye, and for treatment and/or prevention of retinal disorders are described.  
WO/2016/087370A1
The present invention relates to derivatives of formula (I) wherein (R1)n, ring (A), Y1, Y2, X, R4, L1, L2, and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use...  
WO/2016/079684A1
Process for the synthesis of benzazepine derivatives The invention relates to a process for the synthesis of 7,8-dimethoxy-1,3-dihydro- benzazepin-2-one of formula (II), as well as to a process for the synthesis of compound of formula (I).  
WO/2016/004911A8
The present invention relates to a new solid form of ivabradine hydrochloride and (R)-mandelic acid of formula (II) hi the molar ratio of 1:1. The method of preparing the above mentioned cocrystal consists in mixing or grinding the indiv...  
WO/2016/068108A1
Disclosed is a method for selectively producing ε-caprolactam from a substance, as a raw material, which can be derived from biomass resources, through a short reaction step while inhibiting production of by-products, and without produc...  
WO/2016/059942A1
Provided is a three-phase AC/DC conversion device disposed between a three-phase AC power supply and a light-emitting diode group, the device comprising: a three-phase full-bridge circuit in which pairs of switching elements are connecte...  
WO/2016/055028A1
The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300....  
WO/2016/051799A1
Provided is a tau aggregation inhibitor which is capable of sufficiently suppressing tau aggregation in cells. The present invention is a compound represented by formula (I) or a salt thereof. This compound is used for at least one appli...  
WO/2016/046835A1
The invention relates to the compounds of formula I and formula laor its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of f...  
WO/2016/039660A1
The present invention relates to medicine, and more particularly to pharmacology and psychiatry, and can be used in the manufacture of drugs for treating treatment-resistant forms of schizophrenia. To this end, it is proposed to use the ...  
WO/2016/039141A1
 A method for separating co-crystals, wherein co-crystals are supplied from the top of a crystal separation column, a solvent, which exhibits an incongruent dissolution system with respect to the co-crystals, or a solvent, which forms ...  
WO/2016/040225A1
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulato...  
WO/2016/026172A1
Disclosed are an amorphous ivabradine hydrochloride, and a preparation method therefor and uses thereof. The method for preparing the ivabradine hydrochloride comprises the following steps: dissolving ivabradine hydrochloride in water to...  
WO/2015/159170A3
The present invention relates to an improved and efficient process for the preparation of highly useful and versatile chiral compound (S)-(-)-l-(4-methoxyphenyl) ethylamine of formula (1) and formula (1-R) from novel chiral compounds (S)...  
WO/2016/009314A1
Subject-matter of the present invention is a novel amorphous compound comprising ivabradine, in particular a solid amorphous compound consisting of ivabradine and chrysin. Subject-matter of the invention is also a process for the prepara...  
WO/2016/004911A1
The present invention relates to a new solid form of ivabradine hydrochloride and (R)-mandelic acid of formula (II) hi the molar ratio of 1:1. The method of preparing the above mentioned cocrystal consists in mixing or grinding the indiv...  
WO/2015/185990A1
This invention relates to medicine, and more particularly to methods for producing double salts of (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1Н-3-benzazepine (lorcaserin), the products of said methods and compositions for the treatment ...  
WO/2015/175528A1
Provided herein are methods of producing compounds, such as cyclohexanone, hexanediamine, hexanediol, hexamethylenediamine, caprolactam and nylon, from 5- (halomethyl)furfural.  
WO/2015/170346A1
The present invention discloses a process for synthesis of Lorcaserin and its analogues using epoxide/chiral epoxide.  
WO/2015/170053A1
The invention relates to a hemipamoate of ivabradine with formula (I): and to the hydrates thereof. The invention also relates to drugs.  
WO/2015/161730A1
The present invention relates to a new type of eutectic crystal of lorcaserin hydrochloride and benzoic acid. Compared with the prior art, the eutectic crystal has the improved properties of good stability, low solubility, and being suit...  
WO/2015/153683A1
This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses me...  
WO/2015/146053A1
Provided are: a non-ionic photoacid generator including an imide sulfonate compound and having high light sensitivity to an i-line, excellent thermal stability, and excellent solubility in a hydrophobic material; and a resin composition ...  
WO/2015/143692A1
Compounds of Formula I and their uses of effective AXL inhibitors and for the treatment of physical condition mediated by AXL.  

Matches 101 - 150 out of 5,290