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Matches 401 - 450 out of 5,295

Document Document Title
WO/2010/011967A1
The present invention relates to methods of making a cyclic amide. The methods include the step of heating a fermentation broth in a manner effective to produce a cyclic amide (e.g., α-amino-ε-caprolactam), wherein the fermentation bro...  
WO/2010/011924A2
The invention relates to monomers that are derived from α- and β-amino-ε-caprolactam and to polymers (e.g., homopolymers and copolymers) prepared from these monomers. In many embodiments, the α-amino-ε-caprolactam or β-amino-ε-cap...  
WO/2010/007027A1
The present invention provides a compound of formula (I) said compound is inhibitor of MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-12 and/or MMP- 13....  
WO/2010/007253A2
A method for preparing the compounds of formula (IV): in which R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a linear or branched (C1-C6) alkyl group, a linear or branched (C1-C6) alkoxy group, a fluor...  
WO/2010/007382A1
A compound having the formula (1) wherein: R1 is a group selected from C3-8 cycloalkyl, C1-6 alkyl, C1-6 alkylene-C3-8 cycloalkyl, each of which groups may optionally be substituted with C1-6 alkyl, halogen, haloC1-6 alkyl or OR15, or R1...  
WO/2010/000196A1
Method for chemical synthesis of oxcarbazepine comprises adding 5-cyano-11-nitro-5H dibenzoaza of formula III, Raney nickel catalyst, and organic solvent into a reactor, adding hydrogen at 2-20A, controlling the temperature to 40-120℃ ...  
WO/2010/000197A1
A method for preparing 5H-cyano-imido stilbene, comprises: reacting carbamazepine of formula (II) used as dehydrating agent with bis(trichloromethyl)carbonate of formula (III) in organic solvent for 1-30 hours at 20-150oC, and obtaining ...  
WO/2009/157196A1
Disclosed is a compound having GPR52 agonist activity and serving as an agent for preventing or treating schizophrenia or the like. Specifically disclosed is a compound represented by formula (I) or a salt thereof. In the formula, A repr...  
WO/2009/158005A1
This invention relates to novel deuterium enriched benzazepinone compounds and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel benzazepinone compounds that are derivatives of ivabradine. The i...  
WO/2009/153461A2
Method for the synthesis of the compound of formula (I). Use in the synthesis of ivabradine, of addition salts thereof with a pharmaceutically acceptable acid, and of hydrates thereof.  
WO/2009/066041A3
The invention relates to compounds having formula (I), wherein R1 to R9 are as defined in claim 1, in racemic form or in the form of optical isomers, as well as the addition salts thereof with a pharmaceutically acceptable acid, which ca...  
WO/2009/150838A1
A process for amide or lactam production which comprises subjecting an oxime compound to rearrangement to yield the corresponding amide or lactam in a solvent in the presence of: at least one catalyst selected from a group consisting of ...  
WO/2009/143630A1
Compounds produced by combining imino sugars and creatine and salts thereof are herein disclosed. The compounds being in the form of creatine imino sugar amides and the salts being combinations of various creatine imino sugar amides with...  
WO/2009/139001A2
The present invention relates to an improved process for the preparation of 10-oxo- 10,l l-dihydiO-5H-dibenz[b,fjazepine-5-carboxamide (Oxcarbazepine) by reacting 10-methoxy-5H-dibenz[b,f]azepine (10-methoxyiminostilbene) and alkali meta...  
WO/2009/071631A3
The present invention is related to novel tricyclic compounds of formula (I) having TRPA1 receptor agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their u...  
WO/2009/124940A1
The present invention relates to new salt of ivabradine, to methods for its preparation andto pharmaceutical compositions comprising it.  
WO/2009/111004A1
The present invention provides processes and intermediates useful in the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a serotonin (5-HT) receptor agonist that is useful in the treatment or prophylaxis of, for exa...  
WO/2009/110468A1
Disclosed is a compound represented by formula (in the formula, R1, R2, R3, R4, R5, R6, R7 and X are as defined in the description), a salt thereof that is permissible as a medical drug, or a solvate of the compound.  
WO/2009/107389A1
Disclosed are a novel compound functioning as an LXR antagonist and a pharmaceutical product containing the compound. Specifically disclosed is a tricyclic compound represented by general formula (1), a pharmacologically acceptable salt ...  
WO/2007/003934A3
There is provided a compound having Formula (I). In particular the present invention provides compounds capable of inhibiting 17β-hydroxysteroid dehydrogenase Type 3 (17β-HSD3).  
WO/2009/092071A2
Prodrugs of meptazinol and other phenolic analgesics exhibiting low oral bioavailability with amino acids or lower peptides, pharmaceutical compositions containing such prodrugs and a method for providing pain relief with such prodrugs a...  
WO/2009/023664A3
In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11BETA-hydroxysteroid dehydrogenase type-1, pharmaceutical compositions containing the ...  
WO/2009/092073A2
The present invention relates to methods for reducing gastrointestinal side effects in a subject, the gastrointestinal side effects being associated with the administration of an opioid analgesic. The methods comprise orally administerin...  
WO/2009/080725A1
The present application discloses oxadiazole based compounds of Formula (I) active on sphingosine-1-phosphate (S1P) in particular useful to treat lupus erythematosus. A is phenyl or a 5 or 6-membered heteroaryl ring; R1 is up to two subs...  
WO/2009/061744A3
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (K...  
WO/2009/071631A2
The present invention is related to novel tricyclic compounds of formula (I) having TRPA1 receptor agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their u...  
WO/2008/135524A3
The present invention relates to substituted anthranilamides of general formula (I), wherein D, M, A4, A5, R2, R3, R4and R6 are defined as in the specification. The compounds have an antithrombotic and a factor Xa inhibiting activity.  
WO/2009/069610A1
[PROBLEMS] To provide a compound useful as an NMDA receptor antagonist. [MEANS FOR SOLVING PROBLEMS] A study was made on a compound having an antagonistic activity on an NMDA receptor, and it was confirmed that a fused indane compound ac...  
WO/2009/066041A2
The invention relates to compounds having formula (I), wherein R1 to R9 are as defined in claim 1, in racemic form or in the form of optical isomers, as well as the addition salts thereof with a pharmaceutically acceptable acid, which ca...  
WO/2007/102171A3
Novel water soluble amino acid salts of 1 H- 1-benzazepine- 1 -acetic acid, process of preparation of such novel salts and methods of using them are provided. Also provided are pharmaceutical compositions comprising such novel salts and ...  
WO/2009/062377A1
A method of resolution of an important chemical intermediate, 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane, comprises the following steps: reacted its two enantiomers of 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane with d...  
WO/2009/061744A2
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (K...  
WO/2009/058810A1
The present invention is directed to processes for the preparation of substituted 2, 4, 5, 6, 7, 8 - hexahydro -1, 2, 6 - triaza-azulene derivatives of formula (I) and (II), useful for the treatment of disease states mediated by serotoni...  
WO/2009/054983A1
The present invention is directed to heterocycle amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involve...  
WO/2009/051747A1
This invention relates to novel compounds that are 3-benzazepine derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel 3-benzazepine derivatives that are derivatives of lorcaserin. ...  
WO/2009/047796A1
The present invention relates to novel polymorphs of imipramine salts and the processes for their preparation.  
WO/2006/014703A3
The present disclosure relates to chemical compounds and their use in human therapy. In a specific embodiment, compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable ...  
WO/2007/011820A3
The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II) where the carbon atom designated * ...  
WO/2009/013299A3
The present invention relates to compounds of the general formula (I), in which A, Y, R1, R2, R3, R4 and R5 are as defined in claim 1, the enantiomers thereof, the diastereomers thereof, mixtures thereof and salts thereof, especially phy...  
WO/2008/055068A3
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein (B), Q, J, L and Z are as defined in the specification.  
WO/2009/023664A2
In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11BETA-hydroxysteroid dehydrogenase type-1, pharmaceutical compositions containing the ...  
WO/2009/023453A1
Compounds of formula (I), pharmaceutical compositions comprising them, and methods for their use are described.  
WO/2009/021758A1
The present invention relates to compounds of the general formula (I) in which A, B, D, Y, R1, R2, R3, R4 and R5 are as defined in claim 1, the enantiomers thereof, the diastereomers thereof, the mixtures thereof and the salts thereof, e...  
WO/2008/153945A3
Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutica...  
WO/2009/016390A1
The invention relates to 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one, and its pharmaceutical compositions and its use for preparing a medicament intended to prevent or treat inflammatory disorders.  
WO/2009/013299A2
The present invention relates to compounds of the general formula (I), in which A, Y, R1, R2, R3, R4 and R5 are as defined in claim 1, the enantiomers thereof, the diastereomers thereof, mixtures thereof and salts thereof, especially phy...  
WO/2009/015004A1
The present invention provides crystal forms of (2-amino-4, 5,6,7- tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone of the formula: Formula (I); processes for the production of such crystal forms; pharmaceutical compositions com...  
WO/2008/146308A9
The present invention encompasses a process for the preparation of highly pure ivabradine hydrochloride by treating ivabradine with alcoholic hydrogen chloride. The invention further encompasses amorphous ivabradine hydrochloride and pro...  
WO/2008/097546A3
Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a...  
WO/2008/065681A3
The present invention provides a process for preparing Ivabradine of formula (I) or its pharmaceutically acceptable salts, solvates, hydrate thereof, by reacting 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trie n-7-yl]methyl}...  

Matches 401 - 450 out of 5,295