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Matches 1 - 50 out of 16,858

Document Document Title
WO/2021/070150A1
The present invention relates to an inhalable composition comprising a therapeutically effective dosage amount of compound (I), 2-{4-[(2S)-1,1-difluoro-2-hydroxypropyl]phenyl}-N-{4-[3-(2-e thylphenyl) pyrazine-2-yl]phenyl}acetamide or a ...  
WO/2021/068943A1
Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided are a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable...  
WO/2021/068820A1
Disclosed in the present invention are an alkene-containing carboxylate compound and use of an agriculturally acceptable salt thereof as a herbicide. Said compound is as represented by general formula (I). The definition of the substitue...  
WO/2021/068815A1
Disclosed in the present invention are a carboxylic acid ester compound and an application thereof, the structure of the compound being shown in general formula I, and the definition of each substituent in general formula I being provide...  
WO/2021/071919A1
The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided ...  
WO/2021/070132A1
Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3,...  
WO/2021/067460A1
The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.  
WO/2021/067374A1
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 enzyme and are useful in the treatment of F GFR3-associated diseases such as cancer.  
WO/2021/058754A1
The invention provides a composition of matter which: • (i) consists of at least 90 % by weight of an atropisomer (2A) and 0-10 % by weight of an atropisomer of formula (2B); or • (ii) consists of at least 90 % by weight of an atropi...  
WO/2021/060888A2
The present invention relates to a composition for preventing or treating cancer, containing a novel trifluoromethyl phenyl pyrazole derivative as an active ingredient, and, more specifically, to a composition for preventing, alleviating...  
WO/2021/055849A1
The application relates to lipids of Formula (A-1) and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include such a lipid as well as additional lipids such as phospholipids, structural lipids, and...  
WO/2021/047581A1
Disclosed is a hexahydrobenzopyrazole compound shown in formula (I), and a stereoisomer, a pharmaceutically acceptable salt, a solvate, a hydrate, an N-oxide, a prodrug, and a pharmaceutical composition thereof, a preparation method ther...  
WO/2021/047407A1
A biaryl compound, a pharmaceutical composition thereof, a preparation method therefor, and a use thereof. The compound has the structure shown in formula I, has a significant regulatory effect on RORγ, can be used as a highly effective...  
WO/2021/047583A1
Disclosed is a tricyclic pyrazole compound shown in formula (I), and a stereoisomer, a pharmaceutically acceptable salt, a solvate, a hydrate, an N-oxide, a prodrug, and a pharmaceutical composition thereof, a preparation method therefor...  
WO/2021/047677A1
Provided are an IRAK4 kinase inhibitor, and preparation thereof and use thereof, specifically provided are a compound represented by formula (I), a stereoisomer thereof, a geometric isomer thereof, a tautomer thereof, a pharmaceutically ...  
WO/2021/038419A1
Compounds that function as kinase inhibitors are provided. The kinase inhibitors can have any structure of the formulae provided herein, such as shown for Compounds 1-4. A pharmaceutical composition can include: the compound of one of th...  
WO/2021/038490A1
Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3 ...  
WO/2021/036845A1
Provided is a substituted benzoyl compound and an application thereof; specifically, provided is a compound represented by formula (I), a preparation method therefor and a use thereof as an herbicide. Q is optionally substituted oxocyclo...  
WO/2021/035788A1
A PDGFR kinase inhibitor represented by structural formula (I) as well as use thereof and a method using same for preventing or treating PDGFR kinase activity related diseases.  
WO/2021/037219A1
The present invention provides an amide pyrazole compound used as an FGFR irreversible inhibitor, a preparation method therefor, and use thereof. Specifically, the present invention provides a compound of formula I, or a pharmaceutically...  
WO/2021/039824A1
An RNA methyltransferase inhibitor containing at least one type of compound selected from the group consisting of sulfonamide-based compounds represented by general formula (1) and pyrazoline-based compounds represented by general formul...  
WO/2021/031984A1
Disclosed are a carboxylic acid oxime ester compound and the use thereof as a herbicide and for preparing a microbicide. The carboxylic acid oxime ester compound is as represented by general formula I:  
WO/2021/033165A1
The present disclosure relates to a process for the synthesis of pyrazolidinone, particularly alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate (pyrazolidinone) compound. The process of the present disclosure is simple, eco...  
WO/2020/247819A3
Described herein is a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein Ring A R1, R2, a, b, and n are as defined herein. Also described is a method of treating a subject having a disorder in need of treatment,...  
WO/2021/033166A1
The present disclosure relates to a process for the synthesis of pyrazolidinone, particularly alkyl 2-(3-chloropyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylate (pyrazolidinone) compound. The process of the present disclosure is simple, eco...  
WO/2021/030554A1
The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.  
WO/2021/028512A1
The present invention provides new arylsulfonamide compounds having the general formula (I), wherein L, R1, R2, R3 and R4are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods ...  
WO/2021/026182A1
Disclosed are methods of preparing Compound (I), and salts thereof. The methods of preparing Compound (I) are suitable for use on process scale.  
WO/2021/023213A1
The present invention relates to a steroid derivative regulator, in particular to a compound of formula (I), a salt and crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effect...  
WO/2021/023993A1
The present invention relates to a crystalline molecular complex comprising metazachlor and a carboxylic acid. The invention also relates to a process for the preparation of the crystalline molecular complex, a herbicidal composition com...  
WO/2021/026179A1
The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositio...  
WO/2021/025969A1
The present disclosure relates to solid state forms of Berotralstat, pharmaceutically acceptable salts thereof, particularly Berotralstat dihydrochloride, processes for preparation thereof and pharmaceutical compositions thereof.  
WO/2021/022761A1
The present invention relates to a preparation method for a halogen substituted compound. A piperazine derivative represented as formula I reacts with a halogenated acetyl halide derivative represented as formula VI to generate the halog...  
WO/2021/019537A1
The invention provides a process which comprises the step of thiomethylating a pyrazole, to create R2-C(O)-S-CH2- functionality at position 4 of the pyrazole ring. The process is useful in preparing Pyroxasulfone. The invention also prov...  
WO/2021/021634A1
Compositions for delivering nucleic acids to cells or tissue microenvironments are provided. In one embodiment, the compositions are lipid nanoparticle compositions formulated to have reduced splenic and hepatic clearance. It has been di...  
WO/2021/020429A1
The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.  
WO/2021/018849A1
The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.  
WO/2021/021706A1
The present application provides a compound of Formula (I): [Formula 1] or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, W, L, R8, and R9 are as described herein. Pharmaceutical compositions including these ...  
WO/2020/263967A8
This invention relates to 2H-indazole Derivatives of formula (I'), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The inventio...  
WO/2021/014437A1
The invention relates to a method for the preparation of 2-aminobiphenyls, key intermediates in the preparation of compounds of interest in the agrochemical industry. The process comprises reacting an ortho-substituted aniline and a phen...  
WO/2021/016388A1
The present disclosure provides compounds of Formula (I), (II- 1), (II-2), (II-3), or (II- 4). The compounds of the present disclosure may be inhibitors of kinases (e.g., a cyclin- dependent kinase (CDK) (e.g., CDK7)). In some embodiment...  
WO/2021/012949A1
Disclosed are a chiral phosphine ligand, 1,2-bis(diphenylphosphinoalkylamido)-1,2-disubstituted ethane, a synthesis method therefor and the use thereof in an asymmetric catalytic reaction, for example, in the asymmetric catalytic synthes...  
WO/2021/013712A1
The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition asso...  
WO/2021/009384A1
The present invention relates to novel pyrazolone derivatives of the following formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof and to a pharmaceutical composition comprising thereof. The present invention al...  
WO/2021/010492A1
The present invention provides KDM5 inhibitor. The compound disclosed herein represented by the general formula (Z): wherein all symbols have the same meanings as the definitions described in the specification; or a salt thereof is usefu...  
WO/2021/007189A1
Pure crystalline forms of 1-benzyl-N-(4-carbamimidoylbenzyl)-1H-pyrazole-4-carboxamide acetate, and an amorphous form, pharmaceutical compositions thereof, and methods for making the same, are disclosed.  
WO/2021/007190A1
A process for preparing and purifying a compound of Formula (I) is provided; or a salt thereof, wherein the subscript m is an integer of from 0 to 3; each Ra is independently selected from the group consisting of (C3-C8)cycloalkyl, (C1-C...  
WO/2020/210174A4
The present disclosure provides methods for producing N-(fluorosulfonyl)azoles, sulfonyldiazoles, or related derivatives thereof; and the related products including N- (fluorosulfonyl)azoles, sulfonyldiazoles, and related derivatives the...  
WO/2021/001825A1
The present invention provides novel inhibitors of cystathionin gamma synthase (CGS), their use as selective and non-selective herbicides, agricultural and non-agricultural herbicides, herbicides in integrated pest management, herbicides...  
WO/2021/000736A1
A substituted benzoyl-pyrazole compound, and an application thereof in agriculture; specifically, compounds represented by formula (I) and a preparation method therefor; a composition and preparation containing the compounds, and use the...  

Matches 1 - 50 out of 16,858