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Matches 701 - 750 out of 4,405

Document Document Title
WO/2008/071646A1
The present invention relates to compounds of general formula I wherein the groups and radicals B, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least ...  
WO/2008/062012A1
The present invention relates to novel pyridazin- 4 -ylmethyl- sulfonamide compounds (I) and to their N-oxides, their agriculturally acceptable salts and their veterinarily acceptable salts and also to agricultural compositions comprisin...  
WO/2008/062044A1
The invention relates to novel cyclic compounds of the formula (I), in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.  
WO/2008/062276A2
The present invention provides Stearoyl CoA Desaturase (SCD) inhibitors, hi particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase 1 (SCD 1)...  
WO/2008/061108A2
The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, composition...  
WO/2008/057871A2
Macrocyclic peptides are disclosed having the general formula: (I) wherein R3, R'3, R4, R6, R', X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.  
WO/2008/056897A1
The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.  
WO/2008/057282A1
The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The inve...  
WO/2008/057873A2
Macrocyclic peptides are disclosed having the general formula (I) wherein R3, R3', R4, R6, R', X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.  
WO/2008/052441A1
A hydrophobic binding pocket on ubiquitin-protein ligase E3 is described, and used in designing the inhibitors disrupting ubiquitin conjugating enzyme E2 and E3 interaction. Four types of inhibitors designed by using the binding pocket a...  
WO/2008/053043A1
The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-yl carboxylates of the formula (I) in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alky...  
WO/2008/049585A1
The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R1 is hydrogen, C1-C6alkyl, C1-C8haloalkyl or C3-C6cycloalky...  
WO/2008/049584A1
The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R1 is hydrogen, C1-C6alkyl, C1-C6haloalkyl or C3-C6cycloalky...  
WO/2008/047082A2
4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro -benzyl]-2H-phthalazin-1-one as crystalline Form A.  
WO/2008/044767A1
Disclosed is a novel SCD inhibitor. The SCD inhibitor comprises a compound represented by the formula [I], a salt thereof, or a prodrug of the compound or the salt. wherein the ring A represents an aromatic ring which may be substituted;...  
WO/2008/041088A2
The present invention relates to N-hydroxy benzamides of formula (I) wherein groups R1-R5, X and A are as defined in the description, their preparation and their use as antitumour agents.  
WO/2008/039999A1
Disclosed are sulfone compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, c...  
WO/2008/034516A1
The invention describes antibiotic maduraphthalazin salts that show a low solubility in water and a delayed release of the active substance and are characterized by the fact that they consist of an anionic component, which is formed by a...  
WO/2008/031550A2
The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of cognitive dysfunction.  
WO/2008/030466A1
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, ...  
WO/2008/024302A2
Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer inductio...  
WO/2008/023720A1
[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with fatty acid amide hydrolase (FAAH), particularly frequent urination, urinary incontinence and/or overactive bladder. [MEANS FOR SOLVING PROB...  
WO/2008/023357A1
The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using thes...  
WO/2008/018544A1
Disclosed is a sulfonamide compound having a chemical structure characterized in that the compound has an amide structure wherein a carbon atom in the amide binds to a nitrogen atom in a sulfonamide through a lower alkylene, or a salt of...  
WO/2008/014955A2
The present invention relates, inter alia, to a compound having the formula (I):-wherein (R)n is selected from the group consisting of 4-Br, 4-OCH2CH3, 4-OCH2CF3, 2-CH3-4-C1, 2-CH3-4-OCH3, 2-CH3-4-OCF3, 2-F-4-Br, 2-F-4-CF3, 3-CH3-4-Br, 3...  
WO/2008/016239A1
The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.  
WO/2008/013838A2
The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.  
WO/2008/012782A2
The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hy...  
WO2007122156A9
The present invention relates to compounds of formula (I), and salts thereof, processes for  
WO/2008/003611A1
Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.  
WO/2007/144200A1
The present invention relates to a process for the coupling of two molecules by means of a Diels-Alder reaction with an inverse electron requirement, which comprises the following steps: reaction of (a) a triazine or tetrazine having one...  
WO/2007/138242A1
Compounds of formula (I) are found to be active against HCV. wherein: R1 is a moiety -A1-L1-A1', -A1-L1-A1'-A1" or -A1-L1-A1'-Y1-A1"; A and B are the same or different and each represent a direct bond or a -CO- NR'-, -NR'-CO-, -NR'-CO-NR...  
WO/2007/138351A2
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory dis...  
WO/2007/136626A1
The invention provides solid dosage formulations, methods of making and using the formulations comprising at least one hydralazine compound or a pharmaceutically acceptable salt thereof, and at least one excipient or carrier, wherein the...  
WO/2007/125952A1
Disclosed is a compound represented by the formula (I) below, a pharmaceutically acceptable salt thereof, or a solvate of any of them. (I) In the formula, R1 represents an optionally substituted lower alkyl group; Y represents -S(O)n- (w...  
WO/2007/126957A2
The present invention provides organic compounds of the following structure; A-L1-B-C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.  
WO/2007/121668A1
A direct chemiluminescent reagent for magnetic separation and immunoassay method using thereof, comprises an isoluminol derivative as a luminescent label, immuno-magnetic nano-beads coated with goat anti-FITC polyclonal antibodies as sep...  
WO/2007/123939A2
The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed. is the...  
WO/2007/119434A1
A pyridazinone compound represented by the formula (I) have excellent effect on weed control and are useful as an active ingredient of herbicides.  
WO/2007/116314A1
N-Phenyl-1,1,1 -trifluoromethanesulfonamide compounds of formula 1 a, formula 1 b or formula 1c useful for controlling endo- and/or ectoparasites in the environment are provided, together with methods of making the same and methods of us...  
WO/2007/112347A1
Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: (I) wherein the substituents are as defined herein.  
WO/2007/110237A2
Compounds of Formula (I) wherein R1 is aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R2 is defined heterocyclyl, R3 is alkyl, aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substitute...  
WO/2007/104582A1
The invention relates to poly-substituted tetrahydronaphtalene derivatives of formula (Ia) and to methods for the production and the use thereof as anti-inflammatory agents.  
WO/2007/104144A1
There are provided compounds represented by formula (I): in which R1 is F, CI, -N(R5)2 or -CN and Q+ is selected among various organic cations that include an heterocyle. These compounds are useful as electrolytes, ionic liquids or molte...  
WO/2007/100880A1
The present invention is directed to cinnoline and quinazoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to metho...  
WO/2007/098169A1
The present invention is directed tojcjnnoline compounds of formula (I) that are PDE 1 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. This invention is also directed to methods...  
WO/2007/075783A2
This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing ca...  
WO2007058392A9
It is intended to provide a novel heterocyclic compound having an HCV entry inhibition activity and a medicinal application thereof. The invention relates to the use of the heterocyclic compound represented by the general formula [1]: [w...  
WO/2007/073283A1
This invention relates to novel Cinnoline -based compounds and their pharmaceutically acceptable salts, tautomers or in vivo- hydrolysable precursors, compositions and methods of use thereof . These novel compounds provide a treatment or...  
WO/2007/071358A1
The present invention relates to novel nicotinic acid derivatives, of formula (I), wherein the substituents are defined in the specification, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.  

Matches 701 - 750 out of 4,405