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Matches 401 - 450 out of 4,448

Document Document Title
WO/2017/140283A1
The invention relates to solvated crystalline forms of olaparib of formula I, with the systematic name 4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-flu orophenyl]methyl(2H)- phtalazin-1-one, a method of their preparation and ...  
WO/2017/131221A1
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a and R4b are as defined in the specification, processes for their preparation, pharmaceutical compositions cont...  
WO/2017/123156A1
In certain aspects, the invention provides crystalline forms of olaparib (4-[(3-[(4- cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl] methyl(2H)phthalazin- 1 -one). In related aspects, the invention provides processes for pre...  
WO/2017/106634A1
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...  
WO/2017/090655A1
The present invention provides a pest control composition which includes a compound represented by formula (1) (in the formula, each symbol is as defined in the description) or an N-oxide compound thereof, and at least one compound selec...  
WO/2017/074988A1
Disclosed is a process for preparing a compound of Formula 1, from a compound of Formula 2 wherein X, R1, R2, R3, R4, R5, n, R6, R7, G and W are as defined in the disclosure. Also disclosed are compounds of Formulae 2 and 4 wherein X, R1...  
WO/2017/069226A1
A compound represented by general formula [I] (in the formula, X represents N or the like, Y represents CH or the like, RA represents an optionally substituted cycloalkyl group or the like, R1 represents an alkyl group or the like, R2 re...  
WO/2017/061288A1
Provided is a method for measuring tyrosine phosphatase and tyrosine kinase activity, as a high-sensitivity measuring method, which is suitable for high throughput and which uses a compound represented by general formula (I) (in the form...  
WO/2017/059085A1
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's dis...  
WO/2017/054765A1
The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R1, Z and Q are as described in the description.  
WO/2017/049192A1
The disclosure relates to methods and compositions for reactivating a silenced FMR1 gene. In some aspects, methods described by the disclosure are useful for treating a FMR1- inactivation-associated disorder (e.g., fragile X syndrome).  
WO/2017/036404A1
Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine ...  
WO/2017/038873A1
The purpose of the present invention is to provide a compound having inhibitory activity with respect to the discoidin domain receptor 1. The present invention provides a urea derivative represented by the formula below or a pharmacologi...  
WO/2017/036266A1
Provided are 3-aryl pyridazinone as shown by formula I, and a preparation method, pesticide composition and use. The 3-aryl pyridazinone provided has a highly-efficient herbicidal activity, a relatively broad phytocidal range, good crop ...  
WO/2017/037146A1
The invention provides novel compounds having the general formula (I), wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.  
WO/2017/028798A1
Disclosed are a pyridazinone compound as shown in the following general formula I or a pharmaceutically acceptable salt, a preparation method, a pharmaceutical composition and a use thereof in the preparation of a hepatitis B virus inhib...  
WO/2017/023992A1
The present invention provides compounds of Formula (I): [INSERT CHEMICAL STRUCTURE HERE] (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are...  
WO/2017/012922A1
The invention relates to substituted cyclic aryl and heteroaryl carboxylic acid hydrazides of general formula (I) or salts thereof, wherein the groups of formula (I) have the definitions stated in the description, for increasing the stre...  
WO/2017/010399A1
Provided are compounds having RORγt inhibitory effects represented by formula (I). Compounds represented by formula (I) (wherein L represents -NR1ACO-, -SO2- or the like, A represents a substituted or unsubstituted aromatic carbocyclic ...  
WO/2016/198507A1
Compound of formula (I) wherein A is selected from (i), where RF1 is H or F; (ii); (iii) a N-containing C6 heteroaryl group; and B is (B), where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected fro...  
WO/2016/195077A1
This novel guanidine compound having excellent bactericidal activity is represented by formula [I]. (In the formula, Y represents a divalent group represented by formula [II] (wherein each of R7-R9 independently represents a hydrogen ato...  
WO/2016/187620A2
This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeuti...  
WO/2016/180833A1
The present invention relates to a process for preparing a pyridazine amine compound of formula V, and to processes for preparing dichloropyridazine amine compounds of formula IVa, IVb, or mixtures thereof. Furthermore, the present inven...  
WO/2016/177710A1
Compounds of formula I, or pharmaceutical salts thereof, wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.  
WO/2016/177760A1
Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases...  
WO/2016/168059A1
This disclosure relates to the field of moiecuies having pesticida i utility against pests in Phyla Arthropoda, Moliusca, and hJematoda, processes to produce such moiecuies, intermediates used In such processes, pesticidai compositions c...  
WO/2016/165650A1
Disclosed are a co-crystal of olaparib and urea and a preparation method therefor. Specifically disclosed is a co-crystal form A, and an X-ray powder diffraction pattern of this crystal form has characteristic peaks at points where 2thet...  
WO/2016/168058A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2016/159049A1
The present invention pertains to a compound that can be useful as an agent for the treatment and/or prevention of cancer, hepatitis, liver fibrosis, fatty liver, and the like.  
WO/2016/153874A1
The invention generally relates to compositions and methods for treating Parkinson's disease. Aspects of the invention provide composition including an alpha/beta unsaturated aldehyde scavenger compound in a therapeutically effective amo...  
WO/2016/150255A1
Disclosed are a condensed ring derivative, and a preparation method, an intermediate, a pharmaceutical composition and a use thereof. The condensed ring derivative of the present invention has a significant inhibitive effect on URAT1, wh...  
WO/2016/130460A9
Compounds, compositions, kits and methods for treating conditions related to Retinal degenerations, and related diseases, including retinitis pigmentosa and atrophic age-related macular degeneration, are disclosed.  
WO/2016/144973A1
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore- forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as ...  
WO/2016/139361A1
The present invention encompasses compounds of general formula (I) wherein the groups R1 to R9, X1 and X2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of di...  
WO/2016/138114A1
The present invention relates to compounds of formula (I): (I) and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM ...  
WO/2016/128465A1
Disclosed are compounds of formula (I) wherein A is CH or N, B is CR or N; and D is CR; R represents hydrogen, OH or NH2; R1 and R2, independently of each other, represent hydrogen, N(R3)2, halogen, cyano, nitro, R4-C1-C4alkyl, R4-C1-C4h...  
WO/2016/123796A1
Provided are compounds of formula (I), Wherein R 1, R 2, R 3, R 4, R 5 and R 6 are as defined in the specification, and pharmaceutically acceptable salts thereof, which are useful as agents in the treatment of diseases and conditions med...  
WO/2016/119052A1
Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of usi...  
WO/2016/119051A1
Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus...  
WO/2016/115013A1
The present invention is directed to cinnoline derivatives of formula (I) pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, use in the...  
WO/2016/112513A1
This invention provides compounds and compositions for inducing mesenchymal stem cells into chondrocytes ex vivo and in vivo. The compound could lead to a stem cell-based therapy for osteoarthritis and joint injuries. The present inventi...  
WO/2016/102672A2
The invention is directed to compounds of general formula (I), and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the tre...  
WO/2016/096143A1
The invention relates to the provision of a new crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, a use of this form for medical purposes, methods for the production of the crystalline form according to the invent...  
WO/2016/094729A1
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of G...  
WO/2016/066973A1
The present invention concerns a compounds belonging to the family of fluorinated pyridazin-3-ones, for the use thereof in the treatment of broncho-pulmonary conditions, said compound having formula (I), or a pharmaceutically acceptable ...  
WO/2016/050016A1
The present invention provides a substituted heterocyclic compound as a kinase inhibitor, and a preparation method therefor and uses thereof. The compound is a compound represented by the formula I or a medicinal salt, a hydrate, a solva...  
WO/2016/049774A1
Urea-based and bis-urea based compounds and analogues thereof are disclosed. These compounds are useful in the treatment of androgen-dependent diseases or disorders and androgen receptor-mediated diseases or disorders. Specifically, the ...  
WO/2016/052455A1
A pyridazine compound represented by formula (1) has excellent efficacy in controlling harmful arthropods. (In the formula: A represents a nitrogen atom or CR6; R1 represents e.g. a C2-C10 alkyl group including at least one halogen atom;...  
WO/2016/039458A1
The present invention provides a pharmaceutical composition containing, as an active ingredient, a dihydropyridazine-3,5-dione derivative or a salt thereof or a solvate of these.  
WO/2016/039441A1
The purpose of the present invention is to develop and provide an agricultural and horticultural insecticide that is novel in terms of factors such as the occurrence of pests resistant to existing chemicals and the like because significa...  

Matches 401 - 450 out of 4,448