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WO/2003/051274A2 |
Compounds of Formula (I) wherein R?1¿, R?3¿, R?4¿, R?5¿ and X are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy...
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WO/2003/050092A2 |
The invention relates to a new process for the preparation of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2
,3-benzodizepine of Formula (I) which comprises reacting a compound of general Formula (II) (wherein R1 and R2 ind...
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WO2002009683A9 |
Aldosterone blockers used for the treatment and prevention of inflammation are disclosed.
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WO/2003/041715A1 |
The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have formula (I) or a solvate, hydrate or pharmaceutically accepta...
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WO/2003/041658A2 |
Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.
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WO/2003/040096A2 |
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
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WO/2003/037871A1 |
Provided herein is a compound having the formula (I) (R2 is typically a tertiary nitrogen atom, being either alkyl−substituted or member of q heterocyclic ring&semi R7 is typically a monocyclic or bicyclic aromatic ring or a heterocycl...
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WO/2003/037271A2 |
The invention relates to compounds having the formula (I). Preferred compounds are antagonists of C-C chemokine receptor 8. The invention also relates to a method for treating a subjected having an inflammatory disorder or viral disorder...
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WO/2003/037852A1 |
Compounds of the formula (I) are useful in treating disease conditions mediated by TNF-&agr , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenerative cartilage los...
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WO/2003/037872A1 |
Provided herein is a compound having the formula (I), (R2 is typically a tertiary nitrogen atom, being either alkyl-substituted or member of a heterocyclic ring; R7 is typically a monocyclic or bicyclic aromatic ring or a heterocyclic ri...
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WO/2003/035602A1 |
Compounds represented by the following general formula (I) and which have a PPAR&gammad modulator activity: (I) wherein A represents optionally substituted aryl&semi B represents optionally substituted aryl, optionally substituted cycloa...
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WO/2003/031416A2 |
This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R?1¿ is H, alkyl or phenylalkyl; R?...
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WO/2003/031376A1 |
A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library g...
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WO/2003/029232A1 |
The invention provides compounds represented by the general formula I Iwherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders i...
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WO/2003/022277A1 |
The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic ac...
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WO/2003/015703A2 |
The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives a...
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WO/2003/014093A1 |
The invention concerns a composition for oxidation dyeing of keratinous fibres, in particular human hair, comprising an oxidation base of the type paraphenylenediamine substituted by a diazacycloheptane radical as formula (I). The invent...
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WO/2003/013545A1 |
The invention relates to novel benzo-fused heterocycles of structure (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the prepa...
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WO/2003/008390A1 |
Compounds of general formula (I):in which: R¿1? is hydrogen, C¿1?-C¿2O? alkyl, C¿3?-C¿10? cycloalkyl, C¿4?-C¿2O? cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C¿2?-C¿10? alkylene group or...
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WO/2003/004472A1 |
The present invention relates to new compounds of formula (I) wherein Z, Y, X, P, Q, R, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?11¿, R?12¿, A, m and n are defined as in any one of claims 1 to 3, a proce...
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WO/2003/004480A2 |
A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are us...
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WO/2003/002532A1 |
Cyclic diamine compounds represented by the general formula (1), acid−addition salts thereof, or hydrates of both, and medicines containing the compounds, salts or hydrates: (1) [wherein R1 and R2 are each hydrogen or methoxy, with the...
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WO/2003/000788A1 |
A thermoplastic resin composition which comprises (A) a styrene resin and&sol or polyphenylene ether resin, (B) an olefin resin, and (C) a partially hydrogenated block copolymer, the ingredient (C) being contained in an amount of 2 to 30...
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WO/2002/102380A1 |
The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
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WO/2002/100860A2 |
The invention concerns novel heterocyclic compounds of general formula (I), and their addition salts with a base or an acid. The invention also concerns a method for preparing said compounds, and their use as medicines, in particular as ...
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WO/2002/100822A1 |
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medic...
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WO/2002/099388A2 |
Compounds disclosed here or a pharmaceutically acceptable salt thereof, are bradykinin B1 antagonist compounds useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
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WO/2002/098865A2 |
The invention concerns novel benzodiazepinone derivatives and their uses in therapy particularly for treating pathologies involving the activity of a phosphodiesterase of cyclic nucleotides. The invention also concerns methods for prepar...
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WO/2002/094799A2 |
Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptir activity, are provided. Such ligands may be used to modulate M...
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WO/2002/094189A2 |
The present invention relates to compositions comprising S-tofisopam substantially free of R-tofisopam, and methods for treating or preventing convulsions and/or seizures comprising administration of the composition to subjects in need o...
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WO/2002/092585A1 |
The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions...
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WO/2002/092096A1 |
It has been confirmed that antitumor agents containing as the active ingredient (3R)-N-(1-(1-tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(
2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phe
nyl)urea favorably inhibit the prol...
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WO/2002/088101A2 |
The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheime...
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WO/2002/088096A1 |
The invention concerns novel 2,3-benzodiazepine derivatives and their uses in the therapeutic field. The invention also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds correspond more partic...
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WO/2002/088115A1 |
The present invention relates to a novel sulfonamide derivatives and novel intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly, to novel sulfonamide derivatives and inte...
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WO2001056563A9 |
The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advance...
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WO/2002/083685A1 |
The present invention provides compounds of the general formulas (I) and (II) wherein Y is NR or -(CH¿2?)¿n?; R is H or alkyl; 'Z' represents optionally substituted phenyl or a 6-membered aromatic ring having one nitrogen atom; 'W' rep...
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WO/2002/083145A1 |
A compound of the formulae (I) or (II): wherein Y is a moiety selected from NR or -(CH¿2?)¿n?; wherein R is hydrogen or (C¿1?-C¿6?) lower alkyl, and n is 1; (Z), represents; (1) a phenyl ring optionally substituted with one or two su...
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WO/2002/083652A1 |
This invention is concerned with dihydro-benzo [b] [1, 4] diazepin-2-one derivatives of the general formula wherein R1, R2, R3 , X and Y are as defined in the specification. The invention further relates to medicaments containing these c...
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WO/2002/083665A1 |
This invention is concerned with dihydro-benzo[b][1,4]diazepin-2-one derivatives of general formula (I) wherein R?1¿, R?2¿, R?3¿ and Y are as defined in the specification. The invention further relates to medicaments containing these ...
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WO/2002/081457A1 |
The present invention relates to diazepine derivatives of formula (I) wherein R represents hydrogen or C¿1-4? alkyl; R¿1? represents hydrogen or C¿1-4? alkyl; R¿2? represents trifluoromethyl, C¿1-4? alkyl, C¿1-4? alkoxy, trifluorom...
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WO/2002/078680A1 |
The invention relates to the use of pharmaceutical compositions comprising GABA-receptor modulators in ophthalmology, for the prevention and/or treatment of neurodegenerative diseases of the eye, whereby the GABA-receptor modulators are ...
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WO/2002/079172A1 |
This invention relates to a method for preparing monocyclic $i(N)-acyl-aminolactam compounds of the formula (I) and combinatorial libraries thereof.
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WO/2002/078628A2 |
The present invention relates to 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HI...
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WO/2002/076402A2 |
The invention provides conjugates of fatty amines and pharmaceutical agents useful in treating cancers, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparations of the fatty amine-pharmaceuti...
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WO/2002/076925A2 |
The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereofwhich have selective histamine-H3 receptor antagonist activity as well as methods for preparing such c...
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WO/2002/076404A2 |
The invention provides conjugates of fatty alcohols and pharmaceutical agents useful in treating cancer, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparation of the fatty alcohols-pharmace...
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WO/2002/072570A2 |
Disclosed are novel compounds of the formula (I). Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I). Also disclosed are methods of treating various diseases or conditions, such as, for example, allerg...
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WO/2002/070493A1 |
The invention relates to a bisaryl derivative of the formula I, wherein (R, R) is selected from (H, H), O, (H, CH¿3?), (H, OH) and (H, CN); Ar is substituted phenyl; and A is a group of following formula II, III, IV or V: The compounds ...
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WO2001012600A9 |
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) are useful in vitro or in vivo for preventing or treating coagulation disorders.
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