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WO/2003/028729A2 |
The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic co...
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WO/2003/029216A1 |
The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inh...
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WO/2003/029224A1 |
The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhi...
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WO/2003/024448A2 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds e.g. (1) and methods for inhibiting deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell p...
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WO/2003/011841A1 |
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. Also disclosed are compositions containing a compound of this invention in combination with...
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WO/2003/008393A1 |
The invention relates to a method for producing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) by ring closure reaction from $g(a)-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone.
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WO/2003/008392A1 |
The invention relates to triazine derivatives of formula (I), and the physiologically compatible salts and solvates thereof, wherein R?1¿, R?2¿, A and R?5¿ have the designations cited in claim 1. Said derivatives exhibit a phosphodies...
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WO/2002/098864A1 |
The present invention relates to pyrimidine, triazine and pyrazine derivatives of the general formula (I), wherein R?1¿, R?2¿, R?3¿, R?4¿, X, Y and Z have the significances given in the specification ,as well as their pharmaceuticall...
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WO/2002/098879A1 |
The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
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WO/2002/098880A1 |
The invention relates to novel 5-Ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
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WO2002068398A9 |
The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine containing molecules of the solvent in stoichiometric ratios are disclosed. The present invention also provides processes f...
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WO/2002/088084A1 |
The invention provides compounds useful as PGI2 receptor agonist and pharmaceutical compositions, particularly pharmaceutical compositions containing as the active ingredient compounds represented by the general formula (1) or pharmaceut...
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WO/2002/070494A1 |
Aryl- and heteroaryl substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, f...
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WO/2002/067675A2 |
This invention relates to dihydrotriazinones, triazinones and related compounds, compositions comprising such compounds and an agronomically acceptable carrier, and the use thereof as broad spectrum fungicides and insecticides. This inve...
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WO/2002/068423A1 |
The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memo...
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WO/2002/062423A1 |
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds po...
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WO/2002/056682A2 |
This invention relates to dihydrotriazinones, triazinones and related compounds, compositions comprising such compounds and an agronomically acceptable carrier, and the use thereof as broad spectrum fungicides and insecticides. This inve...
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WO/2002/050078A1 |
The invention relates to novel substituted imidazotriazinones (I), methods for the production thereof, and the use thereof for producing medicaments particularly for improving perception, concentration capacity, learning capacity and/or ...
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WO/2002/040486A2 |
Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): or a pharmaceutically acceptable salt, prodr...
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WO/2002/016329A1 |
Phenylalanine derivatives (A) and (B) and analogues thereof exhibit an a4 integrin inhibiting activity and are useful as remedies for various a4 integrin-related diseases. (A) (B)
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WO/2002/009716A2 |
This invention is a method of treating cancer, including carcinomas and sarcomas through the administration of a pharmaceutical composition containing an aldehyde 5-oxo-1,2,4-triazine hydrazide derivative. The aldehyde 5-oxo-1,2,4-triazi...
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WO/2002/009715A2 |
This invention is a method of treating cancer, including carcinomas and sarcomas through the administration of a pharmaceutical composition containing a arylaldehyde 5-oxo-1,2,4-triazine hydrazide derivative. The arylaldehyde 5-oxo-1,2,4...
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WO/2002/006252A1 |
There is described a compound of formula (I), wherein X¿1? is R¿8?; X¿2? and X¿3? are each independently of the other H or R¿8?; R¿1? is unsubstituted or substituted aryl or heteroaryl, the substituents being selected, for example,...
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WO/2001/098388A1 |
Polymeric networks can be obtained by condensing an aldehyde or a mixture of aldehydes or precursors thereof with a component A containing amines, optionally in the presence of a solvent S. Component A contains at least one polyetheramin...
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WO/2001/095856A2 |
The present invention relates to a novel urea derivative which is useful as an anti-cancer agent, its pharmaceutically acceptable acid addition salt or stereoisomer, and to a process for preparing the urea derivative and an anti-cancer c...
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WO/2001/090071A2 |
The invention relates to novel substituted iminoazines of general formula (I), in which R?1¿, R?2¿, R?3¿, R?4¿, Z?1¿, Z?2¿ and Z?3¿ are defined as cited in the description. The invention also relates to several methods and interme...
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WO/2001/087851A1 |
The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the trea...
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WO/2001/087852A1 |
The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds of formula (I) useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for...
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WO/2001/072696A1 |
Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as arthropodicides wherein A is H; E is H or C¿1?-C¿3? alkyl; or A and E can be taken together to form -CH¿2?-, -CH¿2?CH¿...
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WO/2001/072715A2 |
The present invention provides heterocyclic vinylic compounds that can be used to form biocidal polymers. The polymers thus generated can used alone or can be grafted onto textiles, fabrics and polymers. The polymers are readily converte...
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WO/2001/070675A2 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...
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WO/2001/068612A2 |
This invention relates aryl substituted pyridines, pyrimides, pyrazines and triazines of Formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A¿1?, A¿2?, A¿3?, R¿1?-R¿4?, X and Y are set in the spe...
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WO/2001/068585A1 |
A compound represented by the general formula (I) and a salt thereof: R?1¿-A-X-NHCO-Y-R?2¿ wherein R?1¿ is an optionally substituted heterocyclic group or optionally substituted phenyl; R?2¿ is optionally substituted fused phenyl, op...
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WO/2001/049669A1 |
A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3-5-diamine (lamotrigine) of formula (I). 2,3-Dichloronitrobenzene in C¿1?-C¿6? aliphatic alkanol is hydrogenated at 55-90 psi gas pressure using metal catalyst at ...
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WO/2001/046162A2 |
The invention relates to novel 3-substituted 1,2,4-benzotriazines of the general formula I. In said formula, R?1¿ represents a straight-chain or branched, saturated, or mono or polyunsaturated, unsubstituted hydrocarbon group with 1 to ...
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WO/2001/045684A2 |
The present invention provides a method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, an adenosine A1 agonist or a physiologically ...
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WO/2001/039778A2 |
The invention relates to the use of triazinones such as triazine-diones and triazine-triones for producing agents for treating animals for parasitic protozoans, especially preventatively. The invention also relates to said agents.
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WO/2001/022951A2 |
Use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives for the Prevention and Treatment of Multiple Sclerosis, pharmaceutical compositions containing them, and a process for using them. The compounds of the invention h...
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WO/2001/017978A1 |
Compounds represented by general formula (I) which have a TNF-$g(a) production inducing effect, a herbicidal effect and an insecticidal effect and drugs and pesticides containing these compounds as the active ingredient: wherein R?1¿ an...
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WO/2001/014339A2 |
Heterocyclic aromatic amides (HAA) according to Formula (I) wherein X¿1?-X¿4?, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are useful as antifungal agents.
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WO/2001/005769A2 |
Heterocyclic aromatic amides having a hydroxy group adjacent to the amide functionality of Formula (I) wherein (a) represents a 5- or 6- membered heterocyclic aromatic ring in which (i) each of X¿1?-X¿4? is O, S, NR', N, CR' or a bond;...
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WO/2001/000595A1 |
The invention relates to a novel method for the production of 2-heterocyclyl methyl benzoic acid derivatives of general formula (I), wherein n, X and Z have the meaning cited in the description, providing good yields and high purity. The...
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WO/2001/000598A1 |
The invention relates to the area of erythropoiesis, in particular to the use of N-[4-(6-oxotetrahydrotriazinyl)phenyl]amides of general formula (I) for producing medicaments for preventing and/or treating anaemia. The invention also rel...
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WO2000010977A9 |
Amino-substituted heterocycles are disclosed to be suitable nitrogen sources for the osmium catalyzed asymmetric aminohydroxylation of olefins, achieving suprafacial, vicinal addition of a heterocycle moiety and a hydroxyl group. The ena...
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WO/2000/075113A1 |
Nitrogenous six-membered heterocycle compounds bearing as the substituents -X-A-R?3¿, -N-(R?1¿)-(R?2¿-substituted Ph) and -CONH¿2?; salts or prodrugs thereof; and Syk inhibitors containing the compounds, the salts or the prodrugs as ...
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WO/2000/075119A2 |
The invention relates to novel, substituted 2-Aryl-1,2,4-triazine-3,5-di(thi)ones of the general formula (I), wherein Q?1¿, Q?2¿, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ have the meanings given in the description. The invention als...
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WO/2000/073276A2 |
The invention relates to carboxylic acid derivatives of formula (I), whereby the substituents have the meanings as explained in the description. The invention also relates to the production and use of said novel carboxylic acid derivativ...
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WO/2000/069832A1 |
The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the trea...
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WO/2000/069833A1 |
The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment ...
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WO/2000/068204A1 |
The invention relates to novel substituted benzoyl ketones of formula (I), wherein n represents 0, 1, 2 or 3; A represents a simple bond or alkanediyl (alkylene); R?1¿ represents hydrogen or optionally substituted alkyl or cycloalkyl; R...
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