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Matches 1 - 50 out of 1,674

Document Document Title
WO/2021/057791A1
Provided are a chemical compound as a thyroid hormone Beta receptor agonist and a use thereof, further comprising a pharmaceutical composition containing the chemical compound. The chemical compound or pharmaceutical composition can be u...  
WO/2020/252383A3
The present disclosure relates to novel compounds capable of binding to PCSK9, thereby modulating PCSK9 biological activity. Also provided are compositions comprising these compounds, methods of preparing the compounds, and methods for u...  
WO/2021/043185A1
Provided herein is a compound as a thyroid hormone β receptor agonist and use thereof. It further relates to a pharmaceutical composition comprising the compound. The compound or the pharmaceutical composition can be used in the manufac...  
WO/2021/032648A1
Bile acid derivatives, methods of manufacture thereof, and uses thereof are disclosed herein. The bile acid derivatives have demonstrated potential as therapeutics for treating liver disease.  
WO/2020/251972A1
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamil...  
WO/2020/249428A1
A process for the manufacture of ethyleneamines and ethanolamines, comprising the steps of (i) converting a glycolaldehyde derivative of formula (II), in which R2, R3 are - the same or different -hydrogen, alkyl, such as C1-6-alkyl, or c...  
WO/2020/251974A1
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamil...  
WO/2020/239105A1
The present invention provides a novel method for synthesizing metribuzin, comprising the following steps: 1) adding 6-tert-butyl-4-amino-3-mercapto-1,2,4-triazine-5(4H)-ketone to a certain amount of sulfuric acid in batches, and heating...  
WO/2020/225569A1
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or hydrate thereof, wherein: the group X-Y is -NHSO2- or -SO2NH-; Z is a monocyclic aryl or heteroaryl group, each of which is optionally s...  
WO/2020/221276A1
The present invention relates to a salt of 5-((2-ethynyl-5-isopropylpyridin-4-yl)oxy)pyrimidine-2,4-dia mine and a solid form thereof, a method for preparing the solid form and a pharmaceutical composition comprising the solid form, as w...  
WO/2020/206583A1
This invention described herein relates to compounds of general formula (I) : (I), in which variable groups are as defined herein, and to their preparation and use. Uses for the compounds and for compositions containing them include trea...  
WO/2020/201460A1
A multicomponent crystal (or co-crystal) comprising a first active pharmaceutical ingredient and a second active pharmaceutical ingredient. The multicomponent crystal is formed / sustained by non- covalent interactions between the nitrog...  
WO/2020/169069A1
A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds ...  
WO/2020/051207A3
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presenc...  
WO/2020/157189A1
The present invention includes name compounds of general formula (I) in which R1, Y, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical composi...  
WO/2020/157194A1
The present invention includes name compounds of general formula (I) : (I) in which R1, R2, R3 and R4 are as defined herein, methods for their preparation, pharmaceutical compositions and combinations comprising said compounds, and their...  
WO/2020/144093A1
The presently claimed invention relates to a novel, highly efficient and general process for the preparation of the triazine intermediates and their use in the preparation of UV absorbers.  
WO/2020/077123A1
Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by TH...  
WO/2020/051207A2
The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presenc...  
WO/2020/011220A1
A heteroaryl derivative represented by general formula (I), a preparation method therefor, and a pharmaceutical composition comprising the derivative and a use thereof as a therapeutic agent, in particular as an A2a receptor and/or an A2...  
WO/2020/009971A1
The present application provides, inter alia, a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein Y, Ar, X1, X2, X3, R1, R2, R3, R4, R5, and R6 are as described herein. Methods of making these compounds and m...  
WO/2020/005935A1
This invention provides compounds that modulate glucose uptake activity and cellular transport/uptake of glucose, and particularly GLUTS3, but also including but not limited to GLUT1-14 (SLC2A1-SLC2A14). Compounds of the invention are us...  
WO/2019/243823A1
The present invention relates to compounds of formula (I). The compounds may be used to modulate the Stimulator of Interferon Genes (STING) protein and thereby treat diseases such as cancer and microbial infections.  
WO/2019/218797A1
Provided is a compound, characterized in being a compound as shown in the following structure: The novel small molecule compound synthesized by the present invention, when applied for external use, can be used for promoting hair regrowth...  
WO/2019/167982A1
The present invention pertains to: a saturated ring-condensed dihydropyrimidinone or dihydrotriazinone compound having RORγ antagonist activity or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing same;...  
WO/2019/158070A1
A heterocyclic compound as an A2A and/or A2B receptor antagonist. Specifically, provided is a compound as represented by the following formula I, wherein each group is as defined in the description. The compound has A2A and/or A2B inhibi...  
WO/2019/141552A1
The present invention relates to the triazine compounds of formula (I), or their agriculturally acceptable salts or derivatives as herbicides, wherein the variables are defined according to the description, use of triazine compounds of f...  
WO/2019/122932A1
Compounds of general formula (I): (Formula (I)) wherein R1, R2, X1 and X2 are as defined herein are useful for the treatment of cancer, particularly solid tumours.  
WO/2019/056247A1
The present invention belongs to the technical field of pesticides, and in particular relates to a triazinone derivative containing an acylhydrazone structure and a preparation method therefor, and insecticidal and bactericidal uses ther...  
WO/2019/040394A1
The present disclosure is directed to non-corrosive cleaning compositions that are useful, e.g., for removing residues (e.g., plasma etch and/or plasma ashing residues) and/or metal oxides from a semiconductor substrate as an intermediat...  
WO/2019/028272A1
Disclosed herein are compositions and methods for stabilizing a benzothiazole luciferin analog such as D-luciferin and 6-amino-D-luciferin. The compositions may include the benzothiazole luciferin analog, a thionucleobase compound of for...  
WO/2018/226923A1
An antimicrobial compound comprising 1, 3, 5-triazine core substituted with quinoline or imidazolidine-2, 4-dione.  
WO/2018/208123A1
The present invention relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1...  
WO/2018/148745A1
The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, ab...  
WO/2018/130184A1
The present invention relates to a 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine. Specifically, the present invention relates to a 1,2,4-triazine-3-amine derivative as represented by general formu...  
WO/2018/120978A1
The present invention relates to an organic electroluminescence device containing a 1,2,4-triazine based bipolar main material, comprising: a cathode, an anode, and an organic layer; the original layer is one or more of a hole transport ...  
WO/2018/120979A1
The present application relates to a 1,2,4-triazine based bipolar main material and an application thereof. The 1,2,4-triazine based bipolar main material has a compound having the structure of formula (I), wherein R1-R6 represent substi...  
WO/2018/101312A1
The present invention provides an industrially advantageous method for producing a 3,5-disubstituted triazine compound that is useful as an active ingredient for medicines. More specifically, the present invention provides a production m...  
WO/2018/095391A1
An organic mixture, an organic composition, an organic electronic component, and a preparation method therefor. The organic mixture comprises two organic compounds H1 and H2, the organic compound H1 being a spiro compound, the organic co...  
WO/2018/087019A1
The invention relates to a method for producing amide bonds, particularly peptide bonds, with the aid of new amide coupling reagents containing an anion of formula (I); the invention also relates to these new reagents and to the producti...  
WO/2018/074565A1
Provided is a novel compound having a P2X7 receptor inhibitory action, and a pharmaceutical composition having a P2X7 receptor inhibitory action. a compound represented by Formula (I), or a pharmaceutically acceptable salt or the like th...  
WO/2018/071547A1
This document discloses a powder formulation of lamotrigine for oral administration. Also disclosed is a suspension of lamotrigine and a method of treating diseases.  
WO/2018/060076A1
The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmf...  
WO/2018/060071A1
The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmf...  
WO/2018/049092A1
Small molecule inhibitors (SMIs) of the Prolactin receptor, pharmaceutical compositions of the SMIs, and methods for treating patients suffering from disorders characterized increased expression or excitation of the Prolactin receptor, i...  
WO/2018/030466A1
The purpose of the present invention is to provide a heterocyclic compound that can have GCN2-inhibiting activity and is expected to be useful in the prevention and treatment of GCN 2-related diseases and the like, including cancer. Prov...  
WO/2018/015328A1
The present invention relates to compounds of formula (I) a compound of formula (1') as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions co...  
WO/2017/204318A1
Provided is a novel compound having an antagonism to P2X3 and/or P2X2/3 receptors. A compound represented by formula (I) [wherein: R1 represents an optionally substituted alkyl group, etc.; R2 represents an optionally substituted aromati...  
WO/2017/204316A1
The present invention provides a novel compound having P2X3 and/or P2X2/3 receptor antagonism. A compound represented by formula (I): (wherein, R1 represents a substituted or unsubstituted alkyl or the like, R2 represents a substituted o...  
WO/2017/144708A3
An antiviral compound for use in the treatment of negative-sense, single-stranded RNA [herein after ssRNA] virus infections different from the Influenza A and Influenza B virus infections wherein said antiviral compound is of general for...  

Matches 1 - 50 out of 1,674