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Matches 101 - 150 out of 342

Document Document Title
WO/2001/096318A1
The invention concerns a method for preparing cyclic urea compounds from at least an activated carbamic acid derivative containing an unprotected primary or secondary amine function, comprising a cyclization step which consists in a reac...  
WO/2001/064697A1
The invention relates to ligands or complexes useful as catalysts for catalytically bleaching substrates with atmospheric oxygen, and as catalysts in the of treatment of textiles such as laundry fabrics whereby bleaching by atmospheric o...  
WO/2001/064826A2
The invention relates to catalytically bleaching substrates, especially laundry fabrics, with a bleaching composition and a peroxyl source.  
WO/2001/016270A1
The invention relates to a method of bleaching a substrate that comprises applying to the substrate, in an aqueous medium, a specified ligand which forms a complex with a transition metal, the complex catalysing bleaching of the substrat...  
WO/2001/014346A1
The present invention is directed to a macrocyclic compounds of formula (I), wherein Q, X, R¿1? and R¿5? are as defined herein. Compounds of the invention are useful for therapeutic and prophylactic treatment of bacterial infection in ...  
WO/2000/056743A1
A compound of the formula [M¿a?(X¿b?L)¿c?Y¿d?Z¿e?]?nt±¿ wherein: M is a metal ion or a mixture of metal ions; X is a cation or a mixture of cations; L is a ligand, or mixture of ligands each containing at least two different donor...  
WO/2000/001676A1
This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation...  
WO1999051565A9
Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to ...  
WO/1999/036396A1
The invention relates to compounds of general formula (I) which find an application in the treatment of diabetes.  
WO/1999/005145A1
The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles.  
WO/1998/051665A2
This invention relates to macrocyclic molecules of formula (I) which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). The present invention also relates to pharmaceutical compositions ...  
WO/1997/047622A1
Cytokine production inhibitors containing compounds represented by general formula (I), novel triazepine compounds, and intermediates for producing these triazepine compounds. The compounds (I) inhibit the production of cytokines such as...  
WO/1997/044324A1
The present invention provides novel compounds of formulae (I-VIII) for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) and a new use of known compounds IX to X for this purpose.  
WO/1997/030080A1
Compounds of Formula (I) and Formula (III) which are useful in the treatment of thrombin and trypsin related disorders.  
WO/1997/030072A1
The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis ...  
WO/1997/018207A2
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...  
WO/1997/010822A1
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective 'beta'3 receptor agonists useful in the treatment of Type II ...  
WO/1997/001350A1
The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4+ T cell immune responses by identifying compounds that block the interaction of CD4 and MHC, class II, gene products and a method ...  
WO/1997/001360A2
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conj...  
WO/1996/040274A2
The invention provides polymeric polychelants containing polymer repeat units of the formula [L-Ch-L-B] (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at le...  
WO/1996/030348A1
The present invention provides an efficient process of reacting a bis-indolyl acid of Formula (II), wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of Formula (III)...  
WO/1996/030377A1
Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring sytem. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridg...  
WO/1996/028420A2
Aziridines may be subjected to a cyclooligomerization reaction to produce polyazacycloalkane compounds useful for example in the preparation of chelating agents for use in diagnostic imaging contrast agents. N-benzyl-aziridine in particu...  
WO/1996/025167A1
A method of inhibiting viruses in which a virus is contacted with an antiviral amount of a compound of formula (I). Activity is shown against HIV and other viruses. In formula (I), W is a bridge carbon which has a polar or non-polar side...  
WO/1996/016062A1
An osteoporosis remedy containing a triazepine compound represented by general formula (I) or a salt thereof as the active ingredient; novel triazepine compounds; and intermediate compounds for producing the same, wherein: R1 represents ...  
WO/1996/005180A1
A retriviral protease inhibiting compound of formula (A) is disclosed.  
WO/1995/028392A1
The invention provides amphiphilic compounds of the formula (I) Ch-(-L-Ar-(-AH)n)m (where Ch is a hydrophilic chelant moiety or a salt or a chelate thereof); each L is an optionally oxo substituted C2-25-alkylene linker wherein at least ...  
WO/1995/019347A1
The present invention provides new and structurally diverse compositions comprising compounds of general formula (I), wherein U is -(CH2)nX or -(CH2)nNR1(CH2)X; R1 is hydrogen, C1-C8 alkyl, C1-C8 hydroxyalkyl or C1-C8 alkoxyalkyl; V is -...  
WO/1995/012586A1
A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux, cooled and then filtered. Product purities...  
WO/1995/009848A2
This invention relates to dichelants, in particular compounds having two macrocyclic chelant groups linked by a bridge containing an ester or amide bond, especially compounds of formula (V) (wherein each X which may be the same or differ...  
WO/1995/007269A1
The invention relates to retroviral protease inhibitors of the general formula (I): W-(A)n-B-(A*)m-V where W, A, B, A*, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilising group w...  
WO/1995/002582A1
The invention relates to compounds of formula (I) wherein R1 is hydrogen or acyl, R2, R3, R4 and R5 are each independently of the others unsubstituted or substituted alkyl or alkenyl, and X together with the two bonds shown in the formul...  
WO/1995/001966A1
Contrast agents particularly useful for X-ray diagnostic examinations of vascular system of the human and animal body are disclosed.  
WO/1994/022840A1
This invention relates to novel substituted caprolactams, including 4-azacaprolactams such as those of formula (Ic) in which R4, R7, R22, and R27 are as defined in the description, and derivatives thereof which inhibit HIV protease and a...  
WO/1994/011340A1
A compound representd by general formula (I), a salt thereof, and a pest control agent, wherein: X represents halogen, alkyl, alkoxy, cycloalkyloxy, alkylsulfonyloxy, alkylthio or alkylsulfonyl; R1 represents hydrogen or alkyl; R2 repres...  
WO/1994/008981A1
An improved process for preparing triazacyclo compounds and, in particular, 1,4,7-tritosyl-1,4,7-triazyacyclononane. The process involves reacting a diethylenetriamine triarylsulphonate with a cyclising agent selected from the group cons...  
WO/1994/008977A1
This invention relates to novel substituted caprolactams of formula (I), including 4-azacaprolactams, and derivatives thereof which inhibit HIV protease and are useful for treatment of HIV disease. Also included in this invention are pha...  
WO/1994/004485A1
Ligands and compositions for gallium-68 PET heart imaging are disclosed. The ligands form stable complexes with Ga-68. Variation of pendant substituents permits organ targeting with perfusion characteristics akin to a potassium mimic. Ma...  
WO/1994/003464A1
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chelator. The compound has formula (I), where x is 2, 3 or a combination of p 2(s) and q 3(s) where p + q = y; y is 3 ...  
WO/1994/000439A1
An improved process is described for obtaining triazacyclononanes (I), especially 1,4,7-trimethyl-1,4,7-triazacyclononane. The first step involves reacting diethylenetriamine (DET) with a sulfonylation agent to form a sulfonamidated DET,...  
WO/1993/012096A1
Linked cyclic polyamines of formula: Z - R - A - R' - Y, where Z and Y are each cyclic polyamine moieties, A is an aromatic or heteroaromatic moiety, and R and R' are each an alkylene chain or heteroatom-containing chain, show high activ...  
WO/1993/012097A1
The pH controlled selectivity of the sulfomethylation reaction is used to prepare a series of di-, tri-, tetra- and hexaazacyclomacrocycles with specified patterns of pendent side-chain chelating groups. The prepared mono and diacetic ac...  
WO/1992/019665A1
This invention concerns cyclic aromatic amide oligomer compositions and a process for preparing such cyclic oligomers.  
WO/1992/016548A1
Compositions which are immunologically crossreactive with antibodies are provided, together with preparative and therapeutic methods therefor. The compositions preferably comprise a plurality of covalently bound synthetic compounds, at l...  
WO/1992/008725A1
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses. The compound has formula (I), where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y; y is 3 or 4; R is (CH2)zP(=0)(R1)(OR2); R...  
WO/1992/004919A1
A diagnostic composition suitable for administration to a warm-blooded animal, which comprises a MRI-effective amount of a zwitterionic complex of a paramagnetic ion having a cyclic or open chain structure and a pharmaceutically acceptab...  
WO/1992/000958A1
Cholecystokinin antagonists are provided having formula (I) wherein Ar is (a), (b), (c), (d), (e), (f) or (g) (wherein the aromatic moiety may be substituted or unsubstituted), or (h); R1 is H, C1 to C6 alkyl, C1 to C6 alkenyl, cycloalky...  
WO/1991/000285A1
Tri-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, which may be th...  
WO/1990/009379A1
Aza macrocycles of formula (1) wherein A is a group -(CH¿2?)¿p?- or -(CH¿2?)¿p?N(R)(CH¿2?)¿q?- where R is a group -CH(R?4¿)X?4¿; m, n, p, and q, which may be the same or different, is each an integer 2 or 3; R?1¿, R?2¿, R?3¿ a...  
WO/1989/001934A1
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel ...  

Matches 101 - 150 out of 342