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Matches 1 - 50 out of 443

Document Document Title
WO/2021/043260A1
A pyrimidine compound, relating more specifically to a pyrimidine compound and a preparation method therefor, and a use thereof in the preparation of a drug. Provided is a compound represented by formula (I), or a tautomer, stereoisomer,...  
WO/2021/019983A1
The purpose of the present invention is to react radioactive zirconium at a high reaction rate to synthesize a zirconium complex even using low-concentration DOTA or NOTA. A mixed solution, obtained by finally mixing zirconium dissolved ...  
WO/2020/210909A1
This application relates to compounds of Formula I. R1a, R1b and R1c is –CO2H, –SO2H, –SO3H, –SO4H, –PO2H, –PO3H or –PO4H. R2 is a linker, e.g. butylene. R3 is a linkage, e.g.–O–, –S–, -S(O)-, S(O)2-, –NHC(O)–, ...  
WO/2020/206503A1
The invention relates to compounds according to Formula (I) wherein A is –As(OH)2 or an arsenoxide equivalent group; each of R1, R2, R3 and R4 is independently selected from H, X, OH, NH2, CO, SCN, -CH2NH, -NHCOCH3, -NHCOCH2X or NO, an...  
WO/2020/150417A3
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes...  
WO/2020/156106A1
Heterocyclic aryl formamides or a salt thereof, a preparation method, a weeding composition, and an application. The structural formula of the heterocyclic aryl formamide compound or the salt thereof is as shown in formula I, and the com...  
WO/2020/150417A2
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes...  
WO/2020/102820A1
Macrocyclic complexes and macrocyclic compounds. The macrocyclic complexes or macrocyclic compounds have a TACN moiety with one or more amine group(s) or a O- or S- substituted TACN moiety. The macrocyclic complexes have a high-spin Fe(I...  
WO/2020/011228A1
Antibiotic compounds having both antibiotic and aggregation-induced emission (AIE) characteristics. The compounds comprise an azole antibiotic unit, for example naphthalimide triazole (NT), and an AIE unit, for example triphenylethylene ...  
WO/2020/008204A1
The present invention relates to an oxidatively curable coating formulation comprising an oxidatively curable alkyd-based resin and unsymmetrically substituted 1,4,7- triazacyclononane-based chelant, which chelant may optionally be compl...  
WO/2019/178510A1
Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, p...  
WO/2019/118313A1
Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof: wherein: "Z" and R1 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a re...  
WO/2018/213853A1
Provided are macrocyclic compounds and compounds with two or more macrocyclic groups, iron coordinated macrocyclic compounds, and iron coordinated compounds with two or more macrocyclic groups. The iron is high-spin iron(III). The iron c...  
WO/2018/202535A1
Substituted benzoyl amides and their use as herbicides. The invention relates to benzoyl amides of general formula (I) as herbicides. In formula (I) X, R and Ra represent radicals such as alkyl, cycloalkyl and halogen. Q is a five-member...  
WO/2018/175418A1
16-membered macrolide compounds inhibit growth of various microbial species and have utility in the treatment of systemic or topical microbial infections, including methicillin-resistant strains (Formula I).  
WO/2017/118174A1
The present invention discloses an organic functional compound for preparing an organic electronic device and an application thereof. The organic functional compound has a general formula (I). The organic functional compound comprises an...  
WO/2017/055885A1
The invention relates to processes for the production of compounds of the general formula (I): wherein R1 is hydrogen atom, a linear or branched alkyl group having 1 to 4 carbon atoms, or phenyl group; and R2 is, independently of R1, a l...  
WO/2016/153054A1
Provided are an efficient method for producing a nitrogen-containing compound or salt thereof to be used in the production of a treatment agent for diseases involving an integrin. Also provided is a production intermediate of the same. A...  
WO/2014/201073A9
The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.  
WO/2015/100609A1
Provided are new biphenyl derivatives of formula (Ia). These compounds act as aromatase and sulfatase inhibitors. They are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved...  
WO/2015/046916A1
The present invention relates to a specific combination of dopant compounds and host compounds. By using a combination of the dopant and host compounds according to the present invention, an organic electroluminescent device has improved...  
WO/2014/201073A1
The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.  
WO/2014/177689A1
The present invention relates to a method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorpora...  
WO/2014/157207A1
Provided is a room-temperature phosphorescent material which is responsive to external stimuli. A luminescent metal complex responsive to external stimuli according to the present invention is represented by general formula (I) (wherein ...  
WO/2014/111639A1
The invention relates to amphiphilic derivatives of a triazamacrocyclic compound, as well as to said derivatives as active molecule transporters. The invention also relates to a nanodrug including at least one amphiphilic derivative of a...  
WO/2014/111661A1
The invention relates to complexing agents of formula (I) where A, chrom1, chrom2 and chrom3 are such as defined in the description. The invention also relates to lanthanide complexes resulting from said complexing agents.  
WO/2014/079953A1
The present invention relates to a compound with formula (V'). The invention also relates to the synthesis method for compound (V') and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivati...  
WO/2014/040709A1
The present invention relates to a compound of formula (1) wherein X1 represents O or NR6, X2 represents O or NR6, X3 represents O or NR1, R1 represents H or C1 to C3 alkyl, R2 represents H, or a linear or branched C1 - C8 alkyl optional...  
WO/2013/090454A3
The invention relates to compounds that are characterized by possessing at least four cycles (A-C and phenylene ring). Such compounds modulate the glucagon-like peptide 1 (GLP-1) receptor and have a therapeutic use that includes diseases...  
WO/2013/116682A1
The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of ...  
WO/2013/090454A2
The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of ...  
WO/2013/086396A1
Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation me...  
WO/2013/065725A1
The present invention relates to a phthalamide derivative represented by general formula (I) or a salt thereof. [In the formula, X1 represents a halogen atom or the like; X2 represents a halogen atom or the like; m represents 0, 1, 2 or ...  
WO/2012/175666A1
Compounds of formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides and herbicides.  
WO/2012/158707A1
Presently disclosed are methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist.  
WO/2012/105814A3
The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the presen...  
WO/2011/100838A9
Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.  
WO/2011/100838A8
Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.  
WO/2012/082618A3
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a co...  
WO/2012/105814A2
The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the presen...  
WO/2012/020742A1
Disclosed is a novel compound that acts as an antagonist for P2X3 and/or P2X2/3 receptors. Also disclosed is a pharmaceutical composition that acts as an antagonist for P2X3 and/or P2X2/3 receptors, said composition containing: a compoun...  
WO/2011/111971A3
The present invention relates to a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2-4-triazin-4(1H)- yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyc...  
WO/2012/003598A1
The present invention provides intermediates for the synthesis of 1,2-bis(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane and preparation method thereof. The intermediates are protonated salts of 1,4-ditosylate-1,4,7-triazacyclononane or ...  
WO/2012/003599A1
The present invention provides an improved process to synthesize bis(triazacyclononane) ligands, in which 1,4-di(arylsulfonate)-1,4,7-triazacyclononane is reacted with dihaloethane to produce 1,2-bis(4,7-diarylsulfonate-1,4,7-triazacyclo...  
WO/2012/003712A1
The present invention provides improved processes for the synthesis of 1,4-ditosyl- 1,4,7-triazacyclonone and protected analogues thereof, and to synthesise bis(triazacyclononane) ligands.  
WO/2011/115802A1
Conjugates of 1,3-bis(1,4,7-triazacyclonon-1-yl)-2-hydroxypropanes with a variety of conjugating members are used in the formation of dinuclear metal complexes which bind to phosphate esters. By virtue of their conjugated forms, the comp...  
WO/2011/111971A2
The present invention relates to a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2-4-triazin-4(1H)- yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives, which are oxazolidinone antibiotic compounds having a cyc...  
WO/2011/100838A1
Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.  
WO/2010/114308A1
The present invention relates to novel amino acid derivatives containing heterocyclic chelating residues thereof; radioactive or nonradioactive metal complexes thereof; methods for preparation thereof; and apyrogenic and sterile preparat...  
WO/2010/103204A1
The invention relates to compounds that can be used as metal ion chelating agents or as pollution control agents, having general formula (I), to precursor compounds having formula (II) and to labeled compounds having formula (III). The p...  

Matches 1 - 50 out of 443