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Matches 601 - 650 out of 4,492

Document Document Title
WO/2010/056205A9
The present invention provides Gd-chelates modified so as to comprise an amino acid unit attached to the chelate via a linker group suitably selected from C2-4alkylene and C3-5alkynylene, and the use of such chelates as an intravascular ...  
WO/2010/114308A1
The present invention relates to novel amino acid derivatives containing heterocyclic chelating residues thereof; radioactive or nonradioactive metal complexes thereof; methods for preparation thereof; and apyrogenic and sterile preparat...  
WO2010109851A1
Disclosed is a novel lubricant composition which is useful as a material for a lubrication layer in a magnetic recording medium. The lubricant composition contains at least one compound represented by formula (1). In the formula, X repre...  
WO/2010/108125A2
Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.  
WO/2010/103783A1
A process for the preparation of 1-alkyl-5-benzoyl-1H-tetrazole derivatives, which comprises: step (1) of reacting a keto-amide derivative represented by formula (I) [wherein A is a halogen atom or the like; n is an integer of 0 to 5; an...  
WO/2010/076033A9
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspe...  
WO/2010/091169A2
Processes for preparing valsartan and essentially amorphous valsartan are described.  
WO/2010/086615A1
The invention provides a compound of formula (I): wherein: R1 is an optionally substituted 2-(1-azathiaxanthone); each -R2 is independently of the formula -CH2-C(=O)-R4, wherein R4 is an amino acid or a salt thereof, attached to the rema...  
WO/2010/085583A1
Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiment...  
WO/2010/075869A1
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)- mediated transcription and signaling under hypoxic conditions. In one asp...  
WO/2010/074089A1
Provided are novel low-molecular compounds which exhibit calcium receptor antagonist activity, and which are highly safe and orally administrable, namely, compounds having general formula (I) or pharmacologically acceptable salts thereof...  
WO/2010/071559A1
The present invention provides a process for the manufacture of the compound 3-{4-methyl-5-[(1R)-1-(2-(3-methylphenyl-2H-tetrazol-5-yl)-e thoxy]-4H-[1,2,4]triazol-3-yl}-pyridine of formula 14 wherein a) the compound 3-(5-methanesulfonyl-...  
WO/2010/067913A1
The present invention relates to a method of removing triphenylmethane protection group. The method for preparing biphenyl benzoic acid derivatives of the present invention is economically advantageous and very excellent in the aspect of...  
WO/2010/063724A1
Nitrate derivatives of cilostazol are described. They have superior properties and clinical advantages compared to cilostazol in the treatment of vascular and metabolic diseases.  
WO/2010/065432A1
A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of -O-C 1-6 alkyl, -O-aryl, -O-heteroaryl, -O-C 3-...  
WO/2010/056527A2
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the co...  
WO/2010/055207A1
This invention relates to a group of chelating agents, novel chelates, biomolecules labeled with these chelates or chelating agents as well as solid supports conjugated with these chelates, chelating agents and labeled biomolecules. The ...  
WO/2010/055005A1
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates...  
WO/2010/043000A1
The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions cau...  
WO/2010/041748A1
Disclosed is a prophylactic or therapeutic agent for diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, heart failure, cardiomyopathy, myocardial ischemia, cer...  
WO/2010/025197A1
This invention relates to a new synthesis, intermediates and precursors leading to a mixture of the compounds 11 and 12 as shown below. It also relates to the resolution of the stereoisomeric mixture to provide in substantial stereochemi...  
WO/2010/022565A1
Tetrazole derivatives, poly(dimethylsiloxane) (PDMS) surface-functionalized with the same and methods for making said PDMS. The surface-functionalized PDMS is applicable in the general fields of microfluidics, bioMEMS (bio-microelectrome...  
WO/2010/021351A1
Disclosed is a therapeutic agent for hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like, which has a CaSR activating (agonistic) activity. Specifically disclosed is a compound represented by general formula (1) [wherei...  
WO/2010/022249A2
The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatmen...  
WO/2010/016549A1
A tricyclic compound having a PPARγ-agonistic activity which is represented by general formula (I) [wherein Z represents a single bond or the like; Y represents a hydrogen atom, an optionally substituted lower alkyl or the like; X repre...  
WO/2010/012442A2
The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W1 to W9, and R1 to R3 are as defined herein.  
WO/2010/009879A2
The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates.  
WO/2010/009508A1
A compound of Formula (A) wherein Z is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the heteroaryl or substituted heteroaryl connected to a 2,4-dinito-6-(trifluoromethyl)phenyl ring via a carbon-carbon bond.  
WO/2010/006755A2
The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a r...  
WO/2010/003084A2
PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3, and R4 are as defined herein.  
WO/2009/158561A1
A composition including at least one peroxide-generating electrocatalyst, preferably a guinone, at least one peroxide-activation catalyst, preferably an iron complex of a tetraamido macrocyclic ligand, and carbon. The compositions may- b...  
WO/2009/150248A1
The present invention relates to a compound of general formula (I) : and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in particular to an enantiomer mixture, and esp...  
WO/2009/148291A2
There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I) or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed a...  
WO/2009/148290A2
Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I) or a pharmaceutically acceptable salt thereof are disclosed. Pharmaceutical compositions containing the subject ...  
WO/2009/145219A1
Disclosed is a means for treating Alzheimer's disease, which utilizes a secretase inhibitor and is highly safe. Specifically disclosed is a compound represented by general formula (I) [wherein A represents a phenyl group or the like; R1...  
WO/2009/127715A1
The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).  
WO/2009/125606A1
Provided is a compound represented by formula (I) having a PAI-1 inhibiting action. [In formula (I), R1 represents an optionally substituted C6-10 aryl group etc., T represents a single bond etc., m is 0 or 1, when m is 0 G represents -N...  
WO/2009/124962A2
The invention relates to compounds of formula (I) wherein R1, R2, R4, Ra, Rb, Rc, Re, A*, W1, W2 and W3 are as defined in claim 1, for the treatment of CXCR3 related diseases.  
WO/2009/124764A1
The invention relates to a compound composed of a metal ion, or metal, such as a radiopharmaceutical from a metal radio-nuclide, and a marker precursor, which is constructed of a bi-functional, macrocyclic chelator, a spacer, a linker, a...  
WO/2009/117888A1
Phosphodiesterase III inhibitors of formula (I) in medical chemistry field, wherein the definitions of R1, R2, n see also the description. The preparation methods and the uses for the treatment of cardiovascular diseases of compounds of ...  
WO/2009/115644A1
This invention relates to luminescent lanthanide(III) chelates based on β-diketones comprising an azacycloalkane backbone and biomolecule conjugates and solid supports comprising these chelates. In contrast to lanthanide chelates based ...  
WO/2009/112736A1
The invention relates to a material particularly adapted for the extraction of metal cations in an aqueous medium, that comprises a solid substrate on which are bonded polyazacycloalkane compounds having a cycle including at least 4 nitr...  
WO/2009/106470A2
The present invention relates to nitrooxyderivatives of angiotensin II receptor antagonist having the general formula (I): where in R is selected f rom the group consisting of (IIa) - (IIk): when R is selected from (Ilk), Y is selected f...  
WO/2009/106817A2
There is provided a compound of formula R1-CO-X-Y-Z-R2 wherein X and Z are each optional groups independently selected from saturated or unsaturated carbon chains having a length of 1 to 3 carbons; Y is SO, S, SO2, CH=CH, CH2CH2 or O; R1...  
WO/2009/103218A1
Ethylidene hydrazidecarboxamide derivatives of formula (I) or pharmaceutically acceptable salts, hydrate or solvation thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic ...  
WO/2009/065059A9  
WO/2009/094845A1
5-(3-heteroaromatic ring substituted phenyl) tetrazole compounds of formula (I), pharmaceutically acceptable salts thereof, wherein the substituents are defined as same as claims. Preparation methods thereof, pharmaceutical compositions ...  
WO/2009/094242A1
A compound having the structure (I) wherein R is an angiotensin receptor antagonist active group, Y is selected from the group consisting of (II), and 2) -C(R1H)OC(O)X((CR12R13)-(CHR10)m-(CH2)n-Zp-(CH2)q-(CHR11)r-( CR16R17))-R5; Z is O- ...  
WO/2009/090903A1
A novel platinum (II) binuclear complex compound capable of binding to DNA in a manner different from cisplatin preparations, a method of producing this compound, and an anticancer agent containing this compound as the active ingredient ...  
WO/2009/089022A1
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for det...  

Matches 601 - 650 out of 4,492