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Matches 651 - 700 out of 5,949

Document Document Title
WO/2008/120992A1
The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, variants of bis(l-aryl-5-tetrazolyl)methanes, which are especially useful for com...  
WO/2007/069271A3
The present invention relates to process for purification of (S)-N-(1-Carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-t etrazol-5-yl)biphenyl-4-ylmethyl]-amine.  
WO/2008/119028A1
Alkenydiarylmethane compounds are described. Such compounds are a class of non-nucleoside inhibitors of HIV-I reverse transcriptase, which may also be used as part of a combination therapy to treat HIV infection. Compounds described here...  
WO/2008/087656A3
A process for the preparation of unsymmetrical biaryl compounds of Formula (I) wherein, R is alkyl, R' is cyano, protected or unprotected tetrazole, or Formula (a) wherein, R" is alkyl, aryl, aralkyl or alkoxy, said process comprising, r...  
WO/2008/104994A2
Compounds of the present disclosure are 2,2,2-tri-substituted acetamide derivatives of formula (I), its polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts and formulations thereof, useful as Glucokinase acti...  
WO/2008/105473A1
[PROBLEMS] To provide an anti-tumor agent which is excellent in the tumor accumulation property and the ability of reducing a tumor size. [MEANS FOR SOLVING PROBLEMS] Disclosed is an anti-tumor agent comprising a compound represented by ...  
WO/2008/105505A1
Disclosed are a high-quality bis-(1(2)H-tetrazol-5-yl)amine compound and a method for safely producing the compound at low cost.Also disclosed are a reaction intermediate necessary for the production of the compound and a method for prod...  
WO/2008/101665A1
The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection.  
WO/2008/097459A2
The invention is directed to compounds of formula (I): wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula (I) have AT1 receptor antagonist activity ...  
WO/2008/063287A3
The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and ...  
WO/2008/092120A1
The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quant...  
WO/2008/087656A2
A process for the preparation of unsymmetrical biaryl compounds of Formula (I) wherein, R is alkyl, R' is cyano, protected or unprotected tetrazole, or Formula (a) wherein, R" is alkyl, aryl, aralkyl or alkoxy, said process comprising, r...  
WO/2008/087177A1
This invention relates to novel semicarbazide and carbonylhydrazide derivatives that are found to be potent modulators of potassium channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse...  
WO/2008/086733A1
The invention provides a new pharmaceutical composition for treating cardiovascular disease, which contains the active component 2-butyl-4-chlorine-1-[2'-(1H-tetrazol-5-yl)1.1'-biphenyl-met hyl]imidazole-5-carboxylic acid,1-[(isopropoxy)...  
WO/2008/083543A1
A nitrogen-containing heterocyclic modified compounds and their uses in preparing the medicaments of preventing and treating the Alzheimer's disease, Parkinson's disease and other degenerative nervous system disease or type two diabetes....  
WO/2008/074756A1
The invention relates to novel biphenyl thio-urea derivatives of Formula (I), wherein A represents hydroxy or tetrazolyl; R1 represents halo, hydroxy or phenyl, which phenyl may optionally be substituted with halo; and R2 and R3, indepen...  
WO/2008/072758A1
Disclosed is a metal complex represented by the formula (A-1) or (B-1) below. This metal complex is excellent in heat resistance and acid resistance, and useful for redox reaction catalysts and the like.  
WO/2008/071400A1
The present invention relates to a new method for the production of valsartan, a valine derivative having the chemical name is (S)-N-(1 -carboxy-2-methylprop-1 -yl)-N-pentanoyl-N- [2'-(1 H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amine, and ph...  
WO/2008/072032A1
The novel positively charged pro-drugs of beta-lactam antibiotics in the general 'Structure 4' were designed. The positively charged amino group of the pro-drug not only makes the drugs soluble in water, but also bonds to the negative ch...  
WO/2008/068516A1
A compound of the formula: wherein R1 is selected from H, methyl, ethyl, carboxyl protecting groups and hydrophilic moieties, R2 and R3 are independently selected from H, methyl, ethyl and carboxyl protecting groups, R4 is selected from ...  
WO/2008/060399A2
In certain aspects, the present invention relates to metal coordinating complexes for use as imaging contrast agents. For instance, in some embodiments, the present invention is directed to an imaging contrast agent including a metal che...  
WO/2008/056776A1
Disclosed are a tetrazolium mesoionic compound having low melting point, an ionic liquid using such a tetrazolium mesoionic compound, and a method for producing such a tetrazolium mesoionic compound. Specifically disclosed is a tetrazoli...  
WO/2008/051017A1
The present invention relates to a cleavage agent and a cleavage method selectively acting on soluble assembly of amyloidogenic peptide or protein.  
WO/2007/132005A3
The invention relates to novel hybrid compounds comprising at least one polyol entity (Po) - for example oligomer or polymer - in which at least one of the hydroxyl functions of Po is substituted by at least one entity A that can be of a...  
WO/2008/046463A1
The invention relates to the subject matters characterized in the claims, namely metal chelates having a perfluorinated PEG group, a method for the production thereof, and the use thereof, a method for the production thereof, and the use...  
WO/2008/027385A3
Provided are processes for the synthesis of 5 -phenyl- 1-trityl-lH-tetrazole, an intermediate useful in the synthesis of irbesartan. The tritylation of 5-phenyl-lH-tetrazole is carried out using phase transfer catalysis in a biphasic sol...  
WO/2008/004110A3
The present invention provides a method for the preparation of N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-y l]methyl]-L-valine (Valsartan) which comprises; treating N-[[2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]me...  
WO/2008/021804A3
Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.  
WO/2007/144512A3
The invention relates to compounds of formula (I): in which: R1 is an alkanoyl group, R2 is an alkyl group substituted with a group G, or R1 and R2 form, together with the nitrogen atom which bears them, an imidazolyl or benzimidazolyl g...  
WO/2008/030618A1
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, ℗, L2, M, X, L3, and A are provided h...  
WO/2007/106546A3
Improved methods for synthesizing bifunctional chelates of tetraazamacrocycle derivatives and intermediates thereof are disclosed as well as novel tetraazamacrocycle derivatives and intermediates thereof.  
WO/2007/130890A3
Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein.  
WO/2008/028937A1
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: Formula (I) wherein the groups R1-R5, R10 and X1-X7 are as defined in the specification.  
WO/2008/027385A2
Provided are processes for the synthesis of 5 -phenyl- 1-trityl-lH-tetrazole, an intermediate useful in the synthesis of irbesartan. The tritylation of 5-phenyl-lH-tetrazole is carried out using phase transfer catalysis in a biphasic sol...  
WO/2008/026937A1
The invention relates to an improved method of dynamic nuclear polarisation (DNP) of carboxylic acids and to compounds and compositions for use in the method.  
WO/2008/021804A2
Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.  
WO/2007/103456A3
This invention relates to piperazine and piperidine biaryl compounds of Formula (I) or a pharmaceutically acceptable prodrug, salt, polymorph, solvate, enantiomer, diastereomer, racemate, mixture of stereoisomers thereof, or derivative t...  
WO/2008/018843A1
The invention relates to processes for producing pharmaceutically useful salt form of biphenyl-tetrazole compounds of the following formula by replacement of the acidic tetrazole proton with alkali metal or replacement of the alkali meta...  
WO/2008/012852A1
The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof t...  
WO/2008/006875A1
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I) wherein T represent a tetrazolyl substituents, A represents a carbo- or heterocycle, L1 and L2 represent various linking groups and Q represents a carbocyc...  
WO/2008/007391A2
The present invention relates to an improved process for the preparation of valsartan compound of formula-1 through novel intermediate compounds. It also relates to a novel process for the preparation of amorphous form of valsartan.  
WO/2008/006874A1
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I) wherein T 5 represent a tetrazolyl substituent, A represents a carbo- or heterocycle, L1 and L2 represent various linking groups and Q represents a 6-membe...  
WO/2008/004110A2
The present invention provides a method for the preparation of N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-y l]methyl]-L-valine (Valsartan) which comprises; treating N-[[2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]me...  
WO/2008/000645A1
Compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3...  
WO/2007/056219A3
The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor in...  
WO/2007/144512A2
The invention relates to compounds of formula (I): in which: R1 is an alkanoyl group, R2 is an alkyl group substituted with a group G, or R1 and R2 form, together with the nitrogen atom which bears them, an imidazolyl or benzimidazolyl g...  
WO/2007/068894A3
The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory- disorders, pharmaceutical compositions containing them, and processes for their preparation.  
WO/2007/134709A1
5-Iodotetrazoles of the formula (I) in which R1 has the meaning given in the description are exceptionally suitable for use as medicaments, in particular for the combating/prophylaxis of mycoses in humans and mammals.  
WO/2007/132005A2
The invention relates to novel hybrid compounds comprising at least one polyol entity (Po) - for example oligomer or polymer - in which at least one of the hydroxyl functions of Po is substituted by at least one entity A that can be of a...  
WO/2007/128874A1
This invention concerns novel labeling reactants based on azacycloalkanes, wherein a suitable group is linked to the molecule allowing introduction of the said molecules to bioactive molecules in solution or on solid phase.  

Matches 651 - 700 out of 5,949