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WO/2010/121963A1 |
The present invention relates to substituted resorcinol derivatives which inhibit the activity of Heat Shock Protein HSP90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurode...
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WO/2010/120741A1 |
The present invention relates to compositions and methods for modulating retinol binding to retinol binding protein 4 (RBP4). In particular, the present invention provides compounds having Formula (1) or (2) (Formulae (1), (2)); wherein ...
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WO/2010/116121A1 |
The present invention relates to a process for making isoxazoline herbicides (or isoxazoline herbicide precursors), to the intermediate used in this process, and to two processes for making the intermediate.
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WO/2010/108733A1 |
A compound of formula (I): wherein A1, A2, A3, A4, G1, R1, R2, R3, R4, R5a, R5b and R6 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compo...
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WO/2010/101247A1 |
Disclosed is a novel cyclohexane derivative having NPY Y5 receptor antagonism. Specifically disclosed is a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), A repres...
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WO/2010/097372A1 |
The invention relates to the compounds of the general formula (I) wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are defined as described below, to enantiomers thereof, to diastereomers thereof, to mixtures and salts there...
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WO/2010/094669A1 |
The present invention is concerned with isoxazole-isoxazole and isoxazole-isothiazole derivatives of Formula (I), having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and...
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WO/2010/076033A9 |
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspe...
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WO/2010/092180A1 |
The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of s...
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WO/2010/090344A1 |
There is provided a hydrazide compound having a controlling effect on pests represented by the formula (1): wherein, G is a 5-membered heterocyclic group, M is an oxygen atom or a sulfur atom, Q1, Q2, Q3 and Q4 is independently a nitroge...
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WO/2010/089297A1 |
The present invention relates to isoxazole-5-carboxamide derivative having the general Formula (I), or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazol...
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WO/2010/091009A1 |
The present invention relates to isoxazole-3-carboxamide derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3...
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WO/2010/089510A2 |
The invention relates to a compound of the general formula (I) in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, NR8R9 group; m, n, o and p are independently an integer equal to 0,...
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WO/2010/087313A1 |
Disclosed is a novel neurite elongation stimulator. The neurite elongation stimulator comprises a compound represented by general formula (1) as an active ingredient. In general formula (1), R1 to R3 independently represent a hydrogen a...
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WO/2010/087315A1 |
Disclosed is a novel anti-Alzheimer’s disease agent. The anti-Alzheimer’s disease agent comprises a compound represented by general formula (1) as an active ingredient. In general formula (1), R1 to R3 independently represent a hydr...
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WO/2010/087306A1 |
Disclosed is a novel anti-neurodegenerative disease agent. The anti-neurodegenerative disease agent comprises a compound represented by general formula (1) as an active ingredient. In general formula (1), R1 to R3 independently represen...
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WO/2010/083442A1 |
Disclosed are compounds of Formula (1), in which A1, Z1, Z1A, Z2, Z2A, L1 and Z3 are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating d...
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WO/2010/078408A1 |
The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.
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WO/2010/075869A1 |
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)- mediated transcription and signaling under hypoxic conditions. In one asp...
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WO/2010/077882A2 |
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists...
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WO/2010/077883A2 |
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists...
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WO/2010/072602A1 |
The invention relates to substituted amidine compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to the use of the substituted amidine co...
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WO/2010/072147A1 |
The invention provides benzisoxazole piperidinyl derivatives, their salts and their hydrates: Wherein R, X, Y, R’ and T have the same definition as that described in the description. The kind of compounds has antagonistic effect on 5-H...
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WO/2010/072781A2 |
The present invention relates to imine compounds which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by ...
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WO/2010/071558A1 |
The present invention provides a process for the preparation of the compound 1- [5- (3-chloro-phenyl) -isooxazol-3-yl] - ethanone: Wherein the compound 5- (3-chlorophenyl) -isooxazol-3- carboxylate is reacted with CH3MgX. The present inv...
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WO/2010/066450A1 |
The invention provides a method for preparing sulfur-containing compounds, the method comprising reacting a donor compound comprising at least one sulfur having at least one lone pair of electrons, with an acceptor compound; wherein the ...
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WO/2010/057880A1 |
Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
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WO/2010/058314A1 |
This invention relates to known and novel hydroxyquinolin-2(1H)-ones and derivatives thereof which are useful for the treatment of cognitive-related disorders and neuropathic pain disorders in a mammal, e.g., a human. The invention also ...
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WO/2010/050445A1 |
A compound having an ACC inhibitory effect and useful for prevention/treatment of adiposis, diabetes, hypertension, hyperlipemia, heart failure, diabetic complication, metabolic syndrome, sarcopenia, cancer and the like. The compound ha...
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WO/2010/048207A2 |
Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
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WO/2010/036630A2 |
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are ...
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WO/2010/036631A2 |
Compounds of formula I are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are ad...
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WO/2010/031735A1 |
The present invention relates to compounds of the general formula (I) (I) wherein X, n and R1 are as described herein, as well as pharmaceutically acceptable salts and esters thereof, as well as their manufacture, pharmaceutical composit...
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WO/2010/032437A1 |
Disclosed is a compound represented by formula (I) or a salt thereof. (In the formula, X represents an alkyl group or the like; Y represents an alkyl group; each Z independently represents a nitro group or the like; n represents an inte...
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WO/2010/027051A1 |
Disclosed is a novel intermediate for producing a substituted isoxazoline compound that is useful as a harmful organism control agent. Specifically disclosed are: a substituted acetophenone compound represented by general formula (1) or ...
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WO/2010/026918A1 |
An α-trifluoromethyl-β-substituted-β-amino acid can be produced by: reacting an α-trifluoromethyl-β-substituted-α,β- unsaturated ester with hydroxylamine to convert the α-trifluoromethyl-β-substituted-α,β-unsaturated ester int...
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WO/2010/023609A1 |
The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in th...
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WO/2010/025035A1 |
A process for preparing isoxazole compounds of formula (I) in which a nitroaryl of the formula (II) is contacted with an alkyl acetoacetate of the formula (III) or a salt thereof in the presence of an activating agent and a base to provi...
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WO/2010/020521A1 |
A compound of formula (I): wherein A1, A2, A3, A4, A1', A2', A3', A4', A5', A6', G1, R1, R2,R3,R4,R5a and R5b are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermedia...
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WO/2010/021882A2 |
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4, and R5 are defined ...
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WO/2010/019097A1 |
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist, and a second active ingredient which is selected from a phosphodiesterase inhibi...
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WO/2010/019101A1 |
Thepresent invention relates to a novel crystalline form of 4- (5-{ (IR) -1- [5- (3-chlorophenyl) isoxazol-3-yl] ethoxy }-4- methyl-4H-l, 2, 4-triazol-3-yl) pyridine. Further, the present invention also relates to the use of the novel cr...
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WO/2010/019098A1 |
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist selected, and a second active ingredient which is a β2-adrenoceptor agonist, of ...
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WO/2010/019547A1 |
Disclosed herein are cannabinoid receptor ligands of formula (I), wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such...
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WO/2010/019100A1 |
The present invention relates to a novel crystalline form of 4- (5-{ (IR) -1- [5- (3-chlorophenyl) isoxazol-3-yl] ethoxy } -4- methyl-4H-l, 2, 4-triazol-3-yl) pyridine. Further, the present invention also relates to the use of the novel ...
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WO/2010/015613A1 |
The present invention relates to compounds of Formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain ...
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WO/2010/012442A2 |
The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W1 to W9, and R1 to R3 are as defined herein.
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WO/2010/012795A1 |
The present invention relates to fungicide N-(2-phenoxyethyl)carboxamide derivatives of formula (I), their aza, thia and sila analogues, their process of preparation, their use as fungicides, particularly in the form of fungicidal compos...
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WO/2010/009847A1 |
The invention relates to heterocyclically substituted amides, a method for the production thereof, and the use thereof as herbicides, compounds of the general formula (I) and the Λ/-oxide and salts thereof. The invention describes compo...
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WO/2010/008734A2 |
Methods of preparing compounds of formula I are disclosed: (Formula should be inserted here)
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