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Matches 651 - 700 out of 5,269

Document Document Title
WO/2010/121963A1
The present invention relates to substituted resorcinol derivatives which inhibit the activity of Heat Shock Protein HSP90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurode...  
WO/2010/120741A1
The present invention relates to compositions and methods for modulating retinol binding to retinol binding protein 4 (RBP4). In particular, the present invention provides compounds having Formula (1) or (2) (Formulae (1), (2)); wherein ...  
WO/2010/116121A1
The present invention relates to a process for making isoxazoline herbicides (or isoxazoline herbicide precursors), to the intermediate used in this process, and to two processes for making the intermediate.  
WO/2010/108733A1
A compound of formula (I): wherein A1, A2, A3, A4, G1, R1, R2, R3, R4, R5a, R5b and R6 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compo...  
WO/2010/101247A1
Disclosed is a novel cyclohexane derivative having NPY Y5 receptor antagonism. Specifically disclosed is a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), A repres...  
WO/2010/097372A1
The invention relates to the compounds of the general formula (I) wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are defined as described below, to enantiomers thereof, to diastereomers thereof, to mixtures and salts there...  
WO/2010/094669A1
The present invention is concerned with isoxazole-isoxazole and isoxazole-isothiazole derivatives of Formula (I), having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and...  
WO/2010/076033A9
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspe...  
WO/2010/092180A1
The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of s...  
WO/2010/090344A1
There is provided a hydrazide compound having a controlling effect on pests represented by the formula (1): wherein, G is a 5-membered heterocyclic group, M is an oxygen atom or a sulfur atom, Q1, Q2, Q3 and Q4 is independently a nitroge...  
WO/2010/089297A1
The present invention relates to isoxazole-5-carboxamide derivative having the general Formula (I), or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazol...  
WO/2010/091009A1
The present invention relates to isoxazole-3-carboxamide derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3...  
WO/2010/089510A2
The invention relates to a compound of the general formula (I) in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, NR8R9 group; m, n, o and p are independently an integer equal to 0,...  
WO/2010/087313A1
Disclosed is a novel neurite elongation stimulator. The neurite elongation stimulator comprises a compound represented by general formula (1) as an active ingredient. In general formula (1), R1 to R3 independently represent a hydrogen a...  
WO/2010/087315A1
Disclosed is a novel anti-Alzheimer’s disease agent. The anti-Alzheimer’s disease agent comprises a compound represented by general formula (1) as an active ingredient. In general formula (1), R1 to R3 independently represent a hydr...  
WO/2010/087306A1
Disclosed is a novel anti-neurodegenerative disease agent. The anti-neurodegenerative disease agent comprises a compound represented by general formula (1) as an active ingredient. In general formula (1), R1 to R3 independently represen...  
WO/2010/083442A1
Disclosed are compounds of Formula (1), in which A1, Z1, Z1A, Z2, Z2A, L1 and Z3 are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating d...  
WO/2010/078408A1
The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.  
WO/2010/075869A1
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)- mediated transcription and signaling under hypoxic conditions. In one asp...  
WO/2010/077882A2
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists...  
WO/2010/077883A2
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists...  
WO/2010/072602A1
The invention relates to substituted amidine compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to the use of the substituted amidine co...  
WO/2010/072147A1
The invention provides benzisoxazole piperidinyl derivatives, their salts and their hydrates: Wherein R, X, Y, R’ and T have the same definition as that described in the description. The kind of compounds has antagonistic effect on 5-H...  
WO/2010/072781A2
The present invention relates to imine compounds which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by ...  
WO/2010/071558A1
The present invention provides a process for the preparation of the compound 1- [5- (3-chloro-phenyl) -isooxazol-3-yl] - ethanone: Wherein the compound 5- (3-chlorophenyl) -isooxazol-3- carboxylate is reacted with CH3MgX. The present inv...  
WO/2010/066450A1
The invention provides a method for preparing sulfur-containing compounds, the method comprising reacting a donor compound comprising at least one sulfur having at least one lone pair of electrons, with an acceptor compound; wherein the ...  
WO/2010/057880A1
Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.  
WO/2010/058314A1
This invention relates to known and novel hydroxyquinolin-2(1H)-ones and derivatives thereof which are useful for the treatment of cognitive-related disorders and neuropathic pain disorders in a mammal, e.g., a human. The invention also ...  
WO/2010/050445A1
A compound having an ACC inhibitory effect and useful for prevention/treatment of adiposis, diabetes, hypertension, hyperlipemia, heart failure, diabetic complication, metabolic syndrome, sarcopenia, cancer and the like. The compound ha...  
WO/2010/048207A2
Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.  
WO/2010/036630A2
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are ...  
WO/2010/036631A2
Compounds of formula I are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are ad...  
WO/2010/031735A1
The present invention relates to compounds of the general formula (I) (I) wherein X, n and R1 are as described herein, as well as pharmaceutically acceptable salts and esters thereof, as well as their manufacture, pharmaceutical composit...  
WO/2010/032437A1
Disclosed is a compound represented by formula (I) or a salt thereof. (In the formula, X represents an alkyl group or the like; Y represents an alkyl group; each Z independently represents a nitro group or the like; n represents an inte...  
WO/2010/027051A1
Disclosed is a novel intermediate for producing a substituted isoxazoline compound that is useful as a harmful organism control agent. Specifically disclosed are: a substituted acetophenone compound represented by general formula (1) or ...  
WO/2010/026918A1
An α-trifluoromethyl-β-substituted-β-amino acid can be produced by: reacting an α-trifluoromethyl-β-substituted-α,β- unsaturated ester with hydroxylamine to convert the α-trifluoromethyl-β-substituted-α,β-unsaturated ester int...  
WO/2010/023609A1
The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in th...  
WO/2010/025035A1
A process for preparing isoxazole compounds of formula (I) in which a nitroaryl of the formula (II) is contacted with an alkyl acetoacetate of the formula (III) or a salt thereof in the presence of an activating agent and a base to provi...  
WO/2010/020521A1
A compound of formula (I): wherein A1, A2, A3, A4, A1', A2', A3', A4', A5', A6', G1, R1, R2,R3,R4,R5a and R5b are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermedia...  
WO/2010/021882A2
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4, and R5 are defined ...  
WO/2010/019097A1
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist, and a second active ingredient which is selected from a phosphodiesterase inhibi...  
WO/2010/019101A1
Thepresent invention relates to a novel crystalline form of 4- (5-{ (IR) -1- [5- (3-chlorophenyl) isoxazol-3-yl] ethoxy }-4- methyl-4H-l, 2, 4-triazol-3-yl) pyridine. Further, the present invention also relates to the use of the novel cr...  
WO/2010/019098A1
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist selected, and a second active ingredient which is a β2-adrenoceptor agonist, of ...  
WO/2010/019547A1
Disclosed herein are cannabinoid receptor ligands of formula (I), wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such...  
WO/2010/019100A1
The present invention relates to a novel crystalline form of 4- (5-{ (IR) -1- [5- (3-chlorophenyl) isoxazol-3-yl] ethoxy } -4- methyl-4H-l, 2, 4-triazol-3-yl) pyridine. Further, the present invention also relates to the use of the novel ...  
WO/2010/015613A1
The present invention relates to compounds of Formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain ...  
WO/2010/012442A2
The present invention relates to a novel benzenedicarboxamide derivative and the use thereof as an insecticide having the formula (I) wherein the chemical groups W1 to W9, and R1 to R3 are as defined herein.  
WO/2010/012795A1
The present invention relates to fungicide N-(2-phenoxyethyl)carboxamide derivatives of formula (I), their aza, thia and sila analogues, their process of preparation, their use as fungicides, particularly in the form of fungicidal compos...  
WO/2010/009847A1
The invention relates to heterocyclically substituted amides, a method for the production thereof, and the use thereof as herbicides, compounds of the general formula (I) and the Λ/-oxide and salts thereof. The invention describes compo...  
WO/2010/008734A2
Methods of preparing compounds of formula I are disclosed: (Formula should be inserted here)  

Matches 651 - 700 out of 5,269