Heterocyclic Compounds

Matches 701 - 750 out of 9,617	< 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 >

Document	Document Title
WO/2014/002106A1	NOVEL COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use ...
WO/2013/191188A1	FUSED HETEROCYCLIC COMPOUND This fused heterocyclic compound represented in formula (1) has excellent effectiveness in pest control. (In the formula, A1 represents -NR4-, etc., A2 represents a nitrogen atom, etc., R1 represents an ethyl group, a cyclopropyl group, ...
WO/2013/191986A1	ANTIMICROBIAL COMPOUNDS Provided are compounds which are useful for controlling microorganisms in aqueous or water-containing systems or in systems which are exposed to moisture, including at elevated temperature. The antimicrobial compounds are of the formula ...
WO/2013/185976A1	A NEW PROCESS FOR PREPARATION OF 4-METHYLOXAZOLE-5-CARBOXYLIC ESTER The present invention is related to a new process for the preparation of 4-methyloxazole-5-carboxylic ester, which is a valuable intermediate in the synthesis of pyridoxine (vitamin B6). The present invention is also related to a new int...
WO/2013/182993A1	METHOD FOR PREPARING NITROGEN COMPOUNDS The present invention relates to a method for preparing nitrogen compounds using carbon dioxide, and to the use of said method in the production of vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, pestici...
WO/2013/182070A1	DRUG FOR PREVENTING OR TREATING MYCOBACTERIAL DISEASES Disclosed in the present invention is a drug for preventing or treating mycobacterial diseases. In particular, disclosed is the use of a compound represented by the following general formula (I) or pharmaceutically acceptable salts, hydr...
WO/2013/183642A1	AXIALLY CHIRAL PYRIDINE DERIVATIVE OR SALT THEREOF, AND METHOD FOR PRODUCING SAME AND CHIRAL CATALYST COMPRISING SAME Provided is a pyridine derivative represented by general formula (1) or a salt thereof, by which an optically active form can be obtained with favorable enantioselectivity. (In the formula, R1 to R6 and R1' to R6' each independently are ...
WO/2013/178451A1	SYNTHESIS OF DIAMIDO GELLANTS BY USING AMINO ACID N-CARBOXYANHYDRIDES The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a N-carboxyanhydride according to formula II and a N-carboxy- anhydride according to formula III with a ...
WO/2013/178362A1	CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present inventi...
WO/2013/174508A1	NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS The present invention relates to a novel class of 1,3-benzoxazol-2(3H) -ones of formula (1) and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating a...
WO/2013/173218A1	1,3-DIARYL-SUBSTITUTED HETEROCYCLIC PESTICIDES Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Q is and Z1, Z2, J1, J2, M, R1a, R1b, R2a, R2b, R2c, R2d, R14 and R14a are as defined in the disclosure. Also disclosed are compositions containing the compounds ...
WO/2013/167737A1	PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY This invention relates to pharmaceutical compositions comprising 5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole (C1100), to processes for preparing the compositions, and to various therapeutic uses of the combinations. Also provide...
WO/2013/168014A1	COMPOSITIONS AND METHODS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amoun...
WO/2013/163889A1	NEW INTERMEDIATE COMPOUND FOR PREPARING VITAMIN B6 Provided is a new intermediate compound for preparing vitamin B6, which can be used to synthesize the known intermediate compound for preparing vitamin B6, 4-methyloxazole-5-carboxyLate. Further provided is a process for preparing the ne...
WO/2013/160322A1	PROCESS FOR SYNTHESIS OF 4-METHYLOXAZOLE-5-CARBOXAMIDE The present invention provides a novel process for synthesis of 4-methyl-oxazole-5- carboxamide (OXA) which comprises reacting a compound of formula (I) with a high concentration of aqueous ammonia: (I) Wherein R1 is H or C1-10 alkyl.
WO/2013/161851A1	BENZAMIDE DERIVATIVE The present invention pertains to a benzamide derivative represented by formula (I), or a pharmaceutically acceptable salt thereof.
WO/2013/153873A1	PHOTOSENSITIVE COMPOUND, PHOTOSENSITIVE RESIN, AND PHOTOSENSITIVE COMPOSITION A photosensitive compound represented by formula (1) or formula (2). (Chemical formula 1) (In formula (1) and formula (2), n is an integer of 1-3; R1 is a linear or branched alkyl group having 1-6 carbon atoms or an alkylene group having...
WO/2013/147629A1	THE NEW DERIVATIVES OF (Z)-1,2-DIPHENYLETHENE The present invention relates to the new chemical compounds containing (Z)-1,2- diphenylethene moiety in the structures, particularly the new derivatives of cis-stilbene, the new derivatives of 4,5-diphenyl-1,3-oxazole, the new derivativ...
WO/2013/144101A1	PROCESS FOR PREPARING CIS-ALKOXY-SUBSTITUTED SPIROCYCLIC PHENYLACETYLAMINO ACID ESTERS AND CIS-ALKOXY-SUBSTITUTED SPIROCYCLIC 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES The present invention relates to a novel process for preparing cis-alkoxy-substituted spirocyclic phenylacetylamino acid esters and cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and also novel intermediates and...
WO/2013/147118A1	N-PHENYL-N'-PHENYLSULFONYLPIPERAZINE DERIVATIVE AND METHOD FOR PRODUCING INTERMEDIATE FOR SAME The present invention provides: a salt of a 2-(oxazol-2-yl)phenol derivative which is an intermediate for use in a process for producing an N-phenyl-N'-phenylsulfonylpiperazine derivative; a crystal of the salt; a method for producing th...
WO/2013/142712A1	ANTIMICROBIAL AGENTS The invention provides compounds of formual (I): wherein R1-R7 and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
WO/2013/131409A1	PHENYL-OXAZOLYL DERIVATIVES, PREPARATION METHOD THEREOF, AND RELATED APPLICATION OF THE PHENYL-OXAZOLYL DERIVATIVES AS AN IMPDH INHIBITOR Disclosed are phenyl-oxazolyl derivatives having a general formula (I), a preparation method thereof, and an application of the phenyl-oxazolyl derivatives as an inosine monophosphate dehydrogenase (IMPDH) inhibitor.
WO/2013/133343A1	FLUORINE-CONTAINING Α,Β-UNSATURATED ALDEHYDE, METHOD FOR PRODUCING SAME, OPTICALLY ACTIVE FLUORINE-CONTAINING COMPOUND USING FLUORINE-CONTAINING Α,Β-UNSATURATED ALDEHYDE, AND METHOD FOR PRODUCING SAME The purpose of the present invention is to provide a fluorine-containing α,β-unsaturated aldehyde, a method for producing same, an optically active fluorine-containing compound using the fluorine-containing α,β-unsaturated aldehyde, ...
WO/2013/134079A1	OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.
WO/2013/128421A1	SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to m...
WO/2013/123634A1	PROCESS FOR PRODUCTION OF DFMB DERIVATIVES Disclosed is a process for the production of a compound of formula (ΙΠ). The process comprises a step of reacting a compound of formula (I) with an excess amount of a compound of formula (II) in absence of aromatic solvent:wherein - n ...
WO/2013/121449A1	COMPOSITIONS AND METHODS FOR THE MODULATION OF SPECIFIC AMIDASES FOR N-ACYLETHANOLAMINES FOR USE IN THE THERAPY OF INFLAMMATORY DISEASES The present invention regards compositions and methods for the modulation of amidases capable of hydrolysing N-acylethanolamines useable in the therapy of inflammatory diseases. In particular, the present invention regards a compound of ...
WO/2013/120448A1	METHOD FOR PREPARING LINEZOLID INTERMEDIATE Disclosed is a new method for preparing a methyl substitute of a linezolid intermediate, (S)-2-((3-(3-Fluoro-4-Morpholine phenyl)-2-oxy-5-oxazoline)) (I), wherein the intermediate (I) is obtained by the cyclisation of a 3-Fluoro-4-morpho...
WO/2013/120496A1	PROCESS FOR THE PREPARATION OF LINEZOLID IN CRYSTALLINE FORM AND SALTS THEREOF The present invention relates to a process for the preparation of Linezolid, in particular a process for large scale production of a stable Linezolid crystalline form and pharmaceutically acceptable salts thereof, without any contaminati...
WO/2013/111048A1	IMPROVED PROCESS FOR THE PREPARATION OF STABLE CRYSTALLINE FORM-I OF LINEZOLID, SUBSTANTIALLY FREE OF RESIDUAL SOLVENT The invention relates to a substantially pure linezolid hydroxide having R-isomer content more than about 99.9% relative to its S-isomer. Further aspect of invention provides the ambient moisture condition, which is critical for enantiom...
WO/2013/108800A1	SUBSTITUTED PHENYLAZOLE DERIVATIVE Provided are: a compound having an excellent hypoglycemic activity and an excellent protective activity for a β cell or the pancreas, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition having an excellent th...
WO/2013/107283A1	BENZOHETEROCYCLIC COMPOUNDS AND USE THEREOF Disclosed are compound of formula (I) and pharmaceutically accepted salts and prodrugs thereof, wherein each of R1, R2, R3, R4, R5, R6, X1 and X2 is as defined in the description. These compounds are protein kinases inhibitors, especiall...
WO/2013/103297A1	POLYOXAZOLINE POLYMERS AND METHODS FOR THEIR PREPARATION, CONJUGATES OF THESE POLYMERS AND MEDICAL USES THEREOF The present invention relates to functionalized ploy(2-oxazoline) polymers, which are very suitable as a carrier and/or delivery vehicle (conjugate) of drugs, such as small therapeutic molecules and bio-pharmaceuticals. These polymers ar...
WO/2013/097773A1	NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.
WO/2013/093751A1	PACKAGING FOR LINEZOLID Provided is a stable microcrystalline form of Linezolid and a processes for preparation thereof. Also provided is a multiple packing and vacuum sealed pack comprising Linezolid, or stable microcrystalline form of Linezolid and optionally...
WO/2013/091082A1	BIS-(ARYL/HETEROARYL)-METHYLENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR TREATING CANCER The present disclosure relates to novel bis-(aryl/heteroaryl)-methylene compounds of formula (I) having vitamin D receptor agonist and histone deacetylase (HDAC) inhibitory efficacy as well as to methods for reducing or inhibiting the pr...
WO/2013/096771A1	NON-SYSTEMIC TGR5 AGONISTS Compounds of structure (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagon...
WO/2013/092711A1	TRPM8 ANTAGONISTS The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). Said compounds are useful in the treatment of diseases associated wit...
WO/2013/091696A1	SYNTHESIS OF INTERMEDIATES FOR PREPARING ANACETRAPIB AND DERIVATIVES THEREOF The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
WO/2013/090454A2	NOVEL GLP-1 RECEPTOR MODULATORS The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of ...
WO/2013/084013A1	CYCLOALKANE CARBOXYLIC ACID DERIVATIVES AS CXCR3 RECEPTOR ANTAGONISTS The present invention relates to compounds of formula 1 that are useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention rela...
WO/2013/080999A1	AGENT FOR INHIBITING EXPRESSION OF NPC1L1 AND/OR LIPG MRNA AND AGENT FOR PREVENTING AND/OR TREATING OBESITY Provided is an agent for treating and/or preventing obesity. An agent for inhibiting expression of NPC1L1 (Niemann-Pick disease, type C1, gene-like 1) and/or LIPG (Lipase, endothelial) mRNA, comprising a compound having CETP inhibitory a...
WO/2013/081372A1	PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HYPERLIPIDEMIA The present invention provides a pharmaceutical composition for preventing or treating hyperlipidemia comprising (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2 -methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}me th...
WO/2013/081373A1	PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HYPERTRIGLYCERIDEMIA OR HYPERTRIGLYCERIDEMIA-ASSOCIATED DISEASES The present invention provides a pharmaceutical composition for preventing or treating hyperlipidemia comprising (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2 -methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}me th...
WO/2013/076227A1	NOVEL HETEROCYCLIC ALKANOL-DERIVATIVES The present invention relates to novel heterocyclic alkanol derivatives, to a method for producing said compounds, to agents comprising said compounds, and to the use thereof as biologically active compounds, in particular for controllin...
WO/2013/078441A1	HETEROCYCLIC COMPOUNDS AND USES THEREOF Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activ...
WO/2013/072923A1	PROCESS FOR THE PREPARATION OF CRYSTALLINE LINEZOLID The present invention discloses a stable crystalline Form-I of linesolid process for preparation thereof.
WO/2013/073596A1	OPTICALLY ACTIVE BISOXAZOLINE COMPOUND, ASYMMETRIC CATALYST, AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANE COMPOUND USING SAID CATALYST An optically active bisoxazoline compound represented by formula (1) (wherein R1, R2 and R3 independently represent an alkyl group having 1 to 8 carbon atoms, a phenyl group or a benzyl group; n represents an integer of 0 to 3; and * rep...
WO/2013/069545A1	COMPLEX COMPOUND AND OPTICAL RECORDING MEDIUM CONTAINING SAME Provided is a complex compound which is composed of a compound represented by formula (I), a metal and at least one kind of ion that is selected from the group consisting of ions obtained by adding one or more protons to amines, ammonium...
WO/2013/067578A1	MODULATORS OF C3A RECEPTORS Heterocyclic compounds that modulate C3a receptors and their use in the treatment or prevention of inflammatory diseases, infectious diseases, cancers, metabolic disorders, obesity, type 2 diabetes, metabolic syndrome and associated card...

Matches 701 - 750 out of 9,617	< 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 >