Heterocyclic Compounds

Matches 401 - 450 out of 9,617	< 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >

Document	Document Title
WO/2018/109496A2	UNNATURAL AMINO ACIDS The present invention relates to a process for the preparation compounds of Formula (I): Formula (I) wherein X, Z, Q, Ar, R1, R2, R3 and R4 are each as defined herein. The present invention also relates to processes for the preparation o...
WO/2018/106643A1	HETEROCYCLIC AZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES The invention relates to heterocyclic compounds of formula (I) and (IV) or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases. The invention also provides pharmaceutically acceptable compositions co...
WO/2018/102419A1	COMPOUNDS CONTAINING A SULFONIC GROUP AS KAT INHIBITORS The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
WO/2018/089402A1	TRICYCLIC SULFONES AS ROR GAMMA MODULATORS There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...
WO/2018/081047A1	CYCLOHEXYL GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: (Formula (I)) wherein R1, R2, R3, A, W, L, R...
WO/2018/077898A1	N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE A compound according to formula (I) wherein L is CH2−O, CH2−S, CH2−CH2, or CH=CH; R1 and R2 are independently selected out of H, halogen, C1 to C3 alkyl, halogenated C1 to C3 alkyl, C1 to C3 alkyloxy, or halogenated C1 to C3 alkylo...
WO/2018/071535A1	PESTICIDAL AND PARASITICIDAL VINYL ISOXAZOLINE COMPOUNDS The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: Formula (I) wherein variables B1, B2, B3, R1, P1, P2, Y and Q are described herein are as defined in the description. The inventi...
WO/2018/064119A1	CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.
WO/2018/053587A1	COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
WO/2018/051360A1	A NOVEL PROCESS FOR THE PREPARATION OF CRYSTALLINE LINEZOLID FORM-III The invention relates to a novel process for preparation of crystalline Linezolid Form-III. The crystalline Linezolid Form-III obtained by the process is highly pure with HPLC purity equal to or greater than 99.9% with single un-known im...
WO/2018/050489A1	METHOD FOR PRODUCING A POLYBENZAZOL POLYMER (P) The invention relates to a method for producing a polybenzazol polymer (P) by reacting a reaction mixture (RG) which contains at least one aromatic dicarboxylic compound of general formula (I), at least one aromatic diamino compound of g...
WO/2018/047983A1	INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, X, Y, Z, D, R1, R2, R3, R4, R12, R15nd R16 are as defined in the specification, a process for their preparation, pharmaceut...
WO/2018/044783A1	HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders...
WO/2018/043913A1	ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME The present invention relates to a novel compound and an organic electroluminescent device comprising the same. The compound according to the present invention is used for organic material layers of the organic electroluminescent device,...
WO/2018/039232A1	METHODS FOR CROSS COUPLING Methods of preparing substituted bicyclo[1.1.1]pentane compounds of Formula (I) comprise reacting a compound of Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium cat...
WO/2018/039242A1	4-OXAZOLIDINONE ANTIMICROBIAL AGENTS Provided herein are oxazolidinone derivatives that can exhibit anti-microbial activity and/or activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exh...
WO/2018/039244A1	5-BENZYLIDENE-4-OXAZOLIDINONES Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biof...
WO/2018/036470A1	CYCLIC COMPOUND ACTING AS PDE4 INHIBITOR Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically accept...
WO/2018/033525A1	AGONISTS OR PARTIAL AGONISTS OF THE HISTAMINE SITE OF THE NMDA RECEPTOR FOR USE IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES This invention relates to compounds that are agonists or partial agonists of the histamine site of the NMDA receptor, the method of preparation thereof and applications thereof.
WO/2018/032356A1	PROCESS FOR PREPARATION OF LACTONE DERIVATIVES AND INTERMEDIATES THEREOF A novel process for the preparation of lactone derivatives, and intermediates thereof is described. The lactone derivatives are important precursors for the synthesis of anti-hepatitis C virus agents, including sofosbuvir.
WO/2018/029150A1	SULFONAMIDES AS GPR40- AND GPR120-AGONISTS The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GP...
WO/2018/028557A1	TRICYCLIC COMPOUND AND USE THEREOF The present invention relates to a series of tricyclic compounds and the use thereof as receptor agonists of 1-phosphate sphingosine 1 subtype (S1P1), and in particular to the compounds shown in formula (I), and tautomers or pharmaceutic...
WO/2018/029137A1	HETEROCYCLIC NAPHTHOQUINONES DERIVATIVES FOR USE IN THE TREATMENT OF CANCERS INCLUDING CUSHING DISEASE The present invention concerns heterocyclic naphthoquinones derivatives for use in the treatment of Cushing disease and other cancers, in particular via the inhibition of Ubiquitin Specific Proteases (USP) 8 and/or 2.
WO/2018/031886A1	OPTICAL COMPENSATION FILMS BASED ON STYRENIC FLUOROPOLYMER Disclosed are optical compensation films with exceptionally high positive out-of-plane birefringence. The optical compensation films are based on substituted styrenic fluoropolymers and have positive out-of-plane birefringence greater th...
WO/2018/018863A1	MILD AND EFFICIENT PREPARATION METHOD FOR Α-ACYLOXY ALKENYL AMIDE COMPOUND AND USE THEREOF IN SYNTHESIS OF AMIDE AND POLYPEPTIDE Disclosed are a mild and efficient preparation method for an α-acyloxy alkenyl amide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxy alkenyl amide compound is obtained by an addition reaction of...
WO/2018/019527A1	POLYFUNCTIONAL COMPOUNDS, METHODS FOR PREPARING SAME AND USES THEREOF The present invention relates to polyfunctional compounds of formula (I), (I) the methods for preparing same and the uses thereof, in particular in orthogonal or bioorthogonal processes.
WO/2018/018091A1	COMPOSITIONS FOR THE TREATMENT OF PULMONARY FIBROSIS The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
WO/2018/016376A1	METHOD FOR PRODUCING ORGANIC COMPOUND The present disclosure provides a reaction of a chlorine-containing compound with use of a flow reactor that has few limits on a solvent to be used therein. According to the present disclosure, a chlorine-containing compound and a reacti...
WO/2018/016743A1	OXAZOLIDINONE DERIVATIVE COMPOUND AS CETP INHIBITOR The present invention provides an oxazolidinone derivative compound represented by chemical formula I, an optical isomer thereof, or pharmaceutically acceptable salts thereof. The compound represented by chemical formula I according to t...
WO/2018/011746A1	CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...
WO/2018/011747A1	POLYCYCLIC COMPOUNDS AS ROR-GAMMA MODULATORS The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...
WO/2018/012769A1	AUTOPHAGY IMPROVING MATERIAL AND USE THEREOF Disclosed herein are a compound of chemical formula 1 or 2 and a use thereof. The compound according to the present application can be advantageously used in the prevention or treatment of metabolic diseases including type 2 diabetes, in...
WO/2018/008718A1	COMPOUND HAVING BENZAZOLE RING STRUCTURE AND ORGANIC ELECTROLUMINESCENT ELEMENT [Problem] To provide an organic compound having excellent characteristics, which exhibits, as a material for organic electroluminescent elements having high efficiency and high durability, excellent electron injection/transport performan...
WO/2018/009602A2	NOVEL PROCESSES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyra...
WO/2017/219083A1	ACTIVATORS OF HIV LATENCY The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating H...
WO/2017/223178A1	TREATING VIRAL INFECTIONS WITH IMPDH INHIBITORS Methods for treating or reducing the risk or severity of a hemorrhagic virus infection or certain other viral infections in a mammal that include administering a therapeutically effective amount of an IMPDH inhibitor selected from (S)-N-...
WO/2017/219769A1	POLYMORPH OF FAMOXADONE AND PREPARATION METHOD THEREFOR Provided are a polymorph of famoxadone, a use thereof and a preparation method therefor. In particular, the present invention relates to a polymorph of 5-methyl-5-(4-phenoxyphenyl)-3-phenylamino-2,4-oxazolidinedi one, and the preparation...
WO/2017/222361A1	USE OF THE COMPOUND 4-(2,3-DIHYDRO-2-THIOXO-3-BENZOXAZOLE METHYLAMINO)-SALICYLIC ACID AS AN ANTIBIOTIC The invention relates to the use of the compound (2,3-dihydro-2-thioxo-3-benzoxazole methylamino)-salicylic acid (4-DTS) derived from 2-mercaptobenzoxazole as an antibiotic agent that specifically inhibits, in the low micromolar range, b...
WO/2017/215552A1	ANTIMICROBIAL COMPOUNDS AND METHODS FOR USE THEREOF Compounds, pharmaceutical compositions, and methods for treatment of microbial infections are provided. The compounds can potentiate the therapeutic effects of one or more antimicrobial agents when co-administered. The compounds have ant...
WO/2017/209294A1	METHOD FOR PRODUCING SULFONIMIDIZED AROMATIC COMPOUNDS According to the present invention, it is possible to safely and easily obtain sulfonimidized aromatic compounds using various substrates and a novel sulfonimidization agent by irradiating, with light in the presence of an oxidizer, a co...
WO/2017/208905A1	METHOD FOR PRODUCING POLYMETHINE COMPOUND The present invention addresses the problem of providing a method for producing a polymethine compound with higher yield and higher efficiency compared with the conventional methods by preventing the production of by-products effectively...
WO/2017/192858A1	OXAZOLINE PSEUDODIMERS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF The present disclosure is directed to oxazoline mono- and hetero-pseudodimer compounds, such as compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: These compounds are useful for treating pain. The present ...
WO/2017/193041A1	MODULATORS OF THE INTEGRATED STRESS PATHWAY Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
WO/2017/190682A1	CRYSTALLINE FORM E OF TAFAMIDIS METHYLGLUCAMINE SALT, AND PREPARATION METHOD AND APPLICATION THEREOF The present invention discloses a novel crystalline form E of a tafamidis methylglucamine salt, and a preparation method and application thereof. When compared to other known crystalline forms, the new crystalline form provided in the in...
WO/2017/192931A1	SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS The invention provides substituted imidazo[1,2-α]pyridine compounds, substituted imidazo[1,2-α]pyrazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compos...
WO/2017/186624A1	PROCESS FOR THE PREPARATION OF HERBICIDAL PYRIDINYLIMIDAZOLONE COMPOUNDS The present invention relates to a process for the preparation of a compound of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification.
WO/2017/188485A1	COMPOUND Provided is a compound represented by formula (A-V), wherein Y represents a p-valent anion; R1A to R8A each independently represent a hydrogen atom or an alkyl group having 1-10 carbon atoms; R9A and R10A each independently represent a h...
WO/2017/184624A1	COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY In one aspect, compounds of Formulae (I) and (II), or pharmaceutically acceptable salts thereof, are featured; Formula (I), Formula (II) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formulae (I) and (II) ...
WO/2017/183625A1	ORGANIC ELECTROLUMINESCENCE ELEMENT [Problem] To provide an organic electroluminescence element comprising, in order to improve the element characteristics of the organic EL element, in particular, so as to absorb 400-410 nm wavelength sunlight and not have effects on an i...
WO/2017/182853A1	AN IMPROVED PROCESS FOR THE PREPARATION OF LINEZOLID The present invention relates to an improved process for the preparation of Linezolid. More specifically, the present invention relates to an improved process for preparing(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo- 5-oxazolidiny...

Matches 401 - 450 out of 9,617	< 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >