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Matches 1 - 50 out of 4,870

Document Document Title
WO/2022/167866A1
The present disclosure relates in part to chemical modulators of protein phosphatase 2A (PP2A), comprising formula (I). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, aut...  
WO/2022/166990A1
Provided in the present invention are a 2-(substituted phenoxy)aromatic formic acid FTO inhibitor, a preparation method therefor and the use thereof, and specifically disclosed are a compound represented by formula (I), and the use of a ...  
WO/2022/163555A1
The present invention addresses the problem of providing a production method having higher safety and efficiency in a method for producing a target benzoxazine compound that does not create a sudden temperature rise or smoke when introdu...  
WO/2022/163551A1
The present invention addresses the problem of providing a method for producing a benzoxazine compound having a hydroxy group or a thiol group with high purity and high efficiency. As a solution, a method for producing a benzoxazine comp...  
WO/2022/163553A1
The present invention addresses the problem of providing: a novel benzoxazine compound which can be cured under lower temperature conditions; a resin raw material composition which contains the benzoxazine compound; a curable resin compo...  
WO/2022/163552A1
The present invention addresses the problem of providing: a novel benzoxazine compound that has excellent heat resistance, and can be cured under a low-temperature condition; a resin raw material composition containing the same; a curabl...  
WO/2022/161462A1
A substituted morpholine derivative with a structure as shown in a formula (I). In addition, further disclosed are a pharmaceutically acceptable salt, a stereoisomer, a pharmaceutical composition and the use of the derivative.  
WO/2022/158993A1
The present invention relates to a method for the production of d-erythro-sphingosine and analogs thereof, wherein the method comprises a step of condensing a compound of formula (2): Formula (2), or a salt thereof, wherein R1 is hydroge...  
WO/2022/156784A1
A preparation method for an imidazopyridine compound as shown in formula IV, and an intermediate thereof as shown in formula I or formula II. The imidazopyridine compound as shown in formula IV can antagonize a P2X3 receptor, and has the...  
WO/2022/156783A1
The present invention provides a preparation method for an imidazopyridine compound as represented by formula IV and an intermediate as represented by formula I, formula II, or formula III. The imidazopyridine compound as represented by ...  
WO/2022/153962A1
The problem to be solved by the present invention is to provide: a compound useful as a hole transport material for photoelectric conversion elements whereby electric current can be efficiently taken out; and a photoelectric conversion e...  
WO/2022/147872A1
The present invention relates to a series of amide derivative neutral mitochondrial fluorescent markers, a preparation method therefor, and an application thereof; the present invention discloses for the first time that, after being link...  
WO/2022/144918A1
The presently claimed invention relates to the field of three-dimensional (3D) printing, specifically to photopolymerization-based 3D printing. In particular, the present invention provides a curable resin composition for use in 3D print...  
WO/2022/127704A1
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. A method for preparing a compound of formula (II), comprising the steps of reacting a compound of formula (I) with a cyclization reagen...  
WO/2022/129047A2
The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorder...  
WO/2022/126819A1
Disclosed are a photoactivated novel organic small-molecular matrix, a preparation method therefor and the use thereof in MALDI mass spectrometry detection. Compounds with structures as shown in formula I, formula II and formula III are ...  
WO/2022/122882A1
The invention relates to a process for producing a benzoxazine containing free aliphatic hydroxyl groups and monoester comprising the steps of: a) a reaction of a phenolic acid derivative with a monofunctional oligomer or molecule at a t...  
WO/2022/120945A1
A hole transport material, a preparation method therefor and an electroluminescent device. The main chain of the molecular structure of the hole transport material has a spiroanthracene fluorene structure, and the branched structure of t...  
WO/2022/117553A1
The present invention is directed to spiro-cyclic amine derivatives which are modulators of S1P receptors and are useful in the treatment of CNS disorders.  
WO/2022/109361A1
This disclosure relates to aryl amidines of Formula I and their use as fungicides.  
WO/2022/103331A1
Disclosed herein is a polymeric product formed from a cured polymeric material that comprises a repeating unit derived from a monomer according to formula I or formula II: where Ra, Rb and R1 to R6 are defined herein. Also disclosed here...  
WO/2022/091123A1
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula (I) to (IV) for the treatment of cancer.  
WO/2022/093789A1
Disclosed are compounds and their pharmaceutically acceptable salts that possess inhibitory activity against APEX, and methods of using the compounds and salts to treat cancer and precancerous conditions.  
WO/2022/093817A1
The present disclosure provides inhibitors of MIF tautomerase activity. In certain embodiments, the compounds inhibitors are useful in treating or preventing inflammatory and/or auto-immune diseases. In other embodiments, the compounds a...  
WO/2022/087433A1
The present disclosure relates to compounds of formula I that are capable of inhibiting creatine kinase. The present disclosure also relates to methods of treating cancer, such as hematological malignancies.  
WO/2022/068933A1
Provided are heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, methods of use the heterobifunctional compounds for the treatment of certa...  
WO/2022/058916A1
The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, wherein, R, R1, R2, R3 and R10 are as defined in the detailed description. The process further comprises the synthesis of an anthra...  
WO/2022/059684A1
Provided is a vitamin D derivative demonstrating excellent central nervous system migration, or a pharmaceutically acceptable salt or a solvate thereof. Specifically provided is a vitamin D derivative represented by formula (1), or a p...  
WO/2022/056439A1
The present disclosure relates to synthetic triterpenoids, methods for preparing such synthetic triterpenoids, and methods of using such synthetic triterpenoids to treat and/or prevent diseases or disorders such as cancers, particularly ...  
WO/2022/047014A1
The present disclosure relates to copper complexes, pharmaceutical compositions comprising these complexes, chemical processes for preparing these complexes, and their use in the treatment of neurodegenerative disease, e.g., amyotrophic ...  
WO/2022/022612A1
The invention relates to novel glutamine analogs shown as the formula I, a composition containing the glutamine analogs and the use thereof.  
WO/2022/026500A1
Disclosed are compounds of Formula 1, all stereoisomers, N-oxides and salts thereof, wherein G is CONR5R6 or selected from and R1 through R18 Rf and G are as defined in the Disclosure. Also disclosed are compositions containing the compo...  
WO/2022/004593A1
[Problem] To provide a method for producing a mixture containing a benzoxazine compound. The mixture has compatibility with other resins (and preferably epoxy compounds) and, when incorporated in a curable composition, can give a cured p...  
WO/2022/002245A1
The present disclosure relates to novel compounds useful as inhibitors of ATR kinase, as well as pharmaceutical compositions comprising these compounds and methods of treatment by administration of these compounds or the pharmaceutical c...  
WO/2022/004596A1
[Problem] To provide: a mixture which contains a benzoxazine compound and has compatibility with other resins (preferably with epoxy compounds), and which enables a curable composition that contains this mixture to form a cured product h...  
WO/2021/261925A1
Disclosed are a compound, a composition comprising same, and a fluorescent sensor for detecting acetylcholinesterase activity.  
WO/2021/254981A1
The present application relates to a novel and efficient process with high yield for preparing methyl {4,6- diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyr idin-3-yl]pyrimidin-5-yl}carbamate of the formula (I) in the crystal...  
WO/2021/250024A1
The invention concerns an ester containing benzoxazine monomer and to a process for synthesizing said monomer and to vitrimers obtained through the polymerization of the ester containing benzoxazine monomer. The invention also relates to...  
WO/2021/244391A1
Provided in the present invention is a small-molecule GLP-1R agonist, which is a compound of general formula (I), or a pharmaceutically acceptable salt, stereoisomer, ester, prodrug, solvate and deuterated compound thereof. The compound ...  
WO/2021/236449A1
Disclosed herein are p38a mitogen-activated protein kinase inhibitors, pharmaceutical compositions thereof, and therapeutic methods of using the p38a mitogen-activated protein kinase inhibitors.  
WO/2021/226629A1
The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). This disclosure also provides pharmaceutical compositions comprising the compounds, uses o...  
WO/2021/226276A2
Provided are compounds of Formula (II): or a pharmaceutically acceptable salt thereof, wherein R1, n, and Y1 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a ph...  
WO/2021/201449A1
The present invention relates to a compound for an organic electronic element, an organic electronic element using same, and an electronic device comprising the organic electronic element. According to the present invention, an organic e...  
WO/2021/202977A1
Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the comp...  
WO/2021/188769A1
Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse arr...  
WO/2021/179049A1
The present invention relates to the treatment of disorders associated with oxidative stress including neuropathic pain and small synthetically derived compounds for treating such disorders.  
WO/2021/180562A1
The invention relates to disulfide-containing benzoxazine monomers of formula I wherein R is -X-S-S-X'-. The invention is also directed to a process for synthesizing a disulfide-containing benzoxazine monomer of formula I, to a process f...  
WO/2021/170913A1
Chemical modulators of PP2A, comprising tricyclic sulfonimidamides are disclosed. The compounds are useful in preventing or treating cancer, diabetes, autoimmune disease, solid organ transplant rejection, graft vs host disease, chronic o...  
WO/2021/165339A1
The invention relates to a new process for preparing 2H-1,3-benzoxazine-2,4(3H)- dione.  
WO/2021/161230A1
The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis...  

Matches 1 - 50 out of 4,870