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WO/1996/013260A1 |
A compound having formula (I) wherein Me represents a methyl group, having an antibacterial activity.
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WO/1996/006087A1 |
This invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation and bone resorption, pharmaceutical compositions for effecting such activity, and a...
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WO/1996/005185A1 |
The present invention relates to novel alkylamino derivatives of formula (I). These compounds exhibit a high selectivity and a high affinity for sigma 2 receptor and therefore are useful in the treatment of central nervous system disorde...
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WO/1996/003966A1 |
A hair styling and conditioning process comprising the steps of: contacting the hair with a compound having an electrophilic group and at least one hydrophobic group whereby the electrophilic group reacts with nucleophilic sites on and i...
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WO/1995/033733A1 |
The present invention provides substituted dibenzoxazepine and dibenzothiazepine compounds of Formula (I), which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective...
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WO/1995/033734A1 |
The present invention provides substituted dibenzoxazepine and dibenzthiazepine compounds of Formula (I) which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective a...
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WO/1995/021833A1 |
Substituted oxazacycloalkenes of formula (I) in which A is optionally substituted alkane diyl (alkylene), Ar is optionally substituted arylene or heteroarylene; E is a 1-alkene-1,1-diyl group containing a radical R1 in the 2nd position o...
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WO/1995/021834A1 |
Disclosed is an optically active 4,1-benzoxazepin-2-one derivative of formula (I), wherein R1 represents a lower alkyl group; X represents a hydrogen atom or a metal ion; ring A represents a phenyl group substituted with halogen; ring B ...
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WO/1995/018972A1 |
A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diver...
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WO/1995/018104A1 |
A novel benzamide derivative represented by general formula (I), or a salt, hydrate or solvate thereof. The compound is useful as a 5-HT4 receptor agonist for preventing and treating central nervous system diseases such as schizophrenia,...
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WO/1995/004534A1 |
Novel compounds are described which are endothelin receptor antagonists.
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WO/1995/003279A1 |
Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents...
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WO/1995/003289A1 |
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production...
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WO/1994/029286A1 |
The present invention provides substituted dibenzoxazepine and dibenzothiazepine compounds of formula (I) which are useful as analgesic agents for the treatment of pain, and for prostaglandin-E2 mediated diseases, pharmaceutical composit...
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WO/1994/028901A1 |
An amino acid derivative having an angiotensin I-converting enzyme inhibitor activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibitor activity, and represented by general formula (I) wherein R1 represents ...
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WO/1994/027981A1 |
The present invention provides substituted dibenzoxazepine compounds of formula (I) which are useful as analgesic agents for the treatment of pain, and as prostaglandin-E2 antagonists for the treatment of prostaglandin-E2 mediated diseas...
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WO/1994/026719A1 |
This invention relates to new mercapto-amide derivatives possessing inhibitory activities against the neutral endopeptidase and the angiotensin converting enzyme, and represented by general formula (I), wherein R1 is hydrogen or a mercap...
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WO/1994/022840A1 |
This invention relates to novel substituted caprolactams, including 4-azacaprolactams such as those of formula (Ic) in which R4, R7, R22, and R27 are as defined in the description, and derivatives thereof which inhibit HIV protease and a...
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WO/1994/019329A1 |
This invention relates to substituted cyclic carbonyls and derivatives thereof useful as Human Immnunodeficiency Virus (HIV) protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these com...
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WO/1994/014776A2 |
This invention relates to compounds of formulae (I), (II), (II), wherein A1 is O, S, N-R1 or CHR1; A4 is N-R4 or CHR4; R2 is a sidechain containing an acid or ester group; R1, R4 and R5 are substituents such as H, alkyl and aryl alkyl, a...
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WO/1994/013651A1 |
The invention concerns substituted 3-amino-1-arylalkylbenzazepin-2-ones of general formula (I), in which Ar is aryl; X is -O- or -S(O)n- and n is 0, 1 or 2; X1 is C1-C2 alkylene or a single bond; R1 is hydrogen, lower alkyl, aryl(lower a...
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WO/1994/008977A1 |
This invention relates to novel substituted caprolactams of formula (I), including 4-azacaprolactams, and derivatives thereof which inhibit HIV protease and are useful for treatment of HIV disease. Also included in this invention are pha...
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WO/1994/007483A1 |
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production...
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WO/1994/005634A1 |
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production...
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WO/1994/004518A1 |
Compounds characterized generally as morpholino/thiomorpholino-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of f...
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WO/1994/001421A1 |
The present invention relates to novel substituted benzothiazepines and benzoxazepines of formula (I), wherein R1, R2, R7, R8, R9 and X are as defined below, and to novel intermediates used in the synthesis of such compounds. Such compou...
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WO/1993/019045A1 |
Substituted amides, agricultural compositions containing them and a method to control arthropods in agronomic and nonagronomic environments, the amides having formula (I) wherein X is oxygen or sulfur and Q, G and Y are as defined in the...
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WO/1993/019046A1 |
A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
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WO/1993/013082A1 |
The present invention provides substituted dibenzoxazepine compounds of formula (I) which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound o...
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WO/1993/009105A1 |
The present invention provides substituted dibenzoxazepine compounds of formula (I) which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound o...
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WO/1993/009104A1 |
The present invention provides substituted dibenzoxazepine compounds of formula (I), which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound ...
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WO/1993/008174A1 |
A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII¿b?III¿a? receptor and is provided in therapeutic compositions for ...
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WO/1993/007128A1 |
This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral...
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WO/1993/007132A1 |
The present invention provides substituted dibenzoxazepine compounds of formula (I), which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound ...
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WO/1993/003372A1 |
Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an...
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WO/1993/000095A2 |
This invention relates to compounds of formula (I), wherein A1 to A5 form an accessible substituted seven-membered ring, which may be saturated or unsaturated, optionally containing up to two heteroatoms chosen from the group of O, S and...
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WO/1992/019605A1 |
The present invention provides substituted dibenzoxazepine compounds of formula (I) which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound o...
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WO/1992/019617A2 |
The present invention provides dibenzoxazepine compounds of formula (I) which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of formula (I...
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WO/1992/016524A1 |
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production...
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WO/1992/012133A2 |
Compounds of formula (I), wherein Q, X, R?1�, R?2�, R?9� and Z are as defined in the text, including compositions containing said compounds and a method for using them to control arthropods.
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WO/1991/010645A2 |
There are provided novel chelating agents useful in the preparation of contrast media for diagnostic imaging or of radiotherapeutic or detoxification compositions.
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WO/1991/007394A1 |
Novel, substitued benzoxazines of the structure compounds of formula (I) wherein: X and Y are independently selected from the group consisting of: hydrogen, C1-6 alkyl, C1-6 alkyoxy C1-6 alkyl, C1-6 aminoalkyl, C1-6 hydroxyalkyl, and C1-...
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WO/1991/005549A1 |
Novel benzoheterocyclic compounds of formula (I), wherein R?1¿ is H, halogen, alkyl, optionally substituted amino, alkoxy; R?2¿ is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy, optionally ...
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WO/1991/000273A1 |
Cyclic anthranilic acid derivatives of general formula (I) and acid addition salts and alkali salts thereof, useful for treating rheumatism, autoimmune diseases and metabolic bone diseases, wherein R1, R2 and R3 may be the same of differ...
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WO/1990/007111A2 |
A molecular model of the interaction of various non beta-lactam antibiotics with the active site of a penicillin receptor has been developed so that it is now possible to predict the ''fit'' and ''reactivity'' of potential antibacterial ...
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WO/1990/000407A1 |
Methods for treating animals comprising applying to the animal's dermis or membrane physiologically active compounds in intimate mixture with an effective amount of penetration enhancers having formula (I) are disclosed, where R=H, alkyl...
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WO/1989/008643A1 |
The invention relates to urethane-protected amino acid-N-carboxyanhydride and N-thiocarboxyanhydride compounds which are useful in peptide, polypeptide, and protein synthesis. Disclosed herein is the preparation and use of these novel co...
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WO/1989/007640A1 |
The present invention relates to a detergent composition in aqueous solution comprising, (i) a surfactant selected from anionic, nonionic, zwitterionic and cationic surfactants and mixtures thereof, (ii) a precursor compound capable of g...
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WO/1988/008424A1 |
The aromatic amines (I), alkyl amines (II), bicyclic amines (III), cycloalkyl amines (IV), aromatic bicyclic amines (V), hydroquinone amines (VI), quinone amines (VII), amino-ethers (VIII) and bicyclic amino ethers (IX) are useful as pha...
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WO/1987/006226A2 |
An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an exter...
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