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WO/1995/004045A1 |
This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production of physiological ef...
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WO/1995/001979A1 |
The present invention relates to novel heterocyclic compounds having general formula (1) wherein: X is O, S, Se, or NR2; Y1, Y2, Y3, Y4 independently are N or CR2; Z is O, S, Se, NR2 or C = N; and A is (a) or (b) wherein W is O, S, NH or...
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WO/1995/000501A2 |
The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated dise...
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WO/1995/000465A1 |
A clathrate compound comprising a tetrakisphenol represented by general formula (I) as the host compound and 4,5-dichloro-2-alkyl-3(2H)-isothiazolone as the guest compound, wherein X represents -(CH2)n-; n represents 0, 1, 2 or 3; and R1...
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WO/1995/000510A1 |
A process for preparing the compound of formula (I) which comprises treating a compound of formula (II) wherein R2 is hydrogen, CN or CO2R1 and R1 is hydrogen or (C1-C6)alkyl with a reducing agent with the proviso that when R2 is CN or C...
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WO/1994/025455A1 |
The invention concerns 3-halo-3-heteroaryl carboxylic acid derivatives of formula (I) in which R is a formyl group, a CO2H group or a group which can be hydrolysed to give a COOH group and the other substituents are as follows: R2 and R3...
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WO/1994/022812A1 |
Described are compounds of the formula (I) in which Y is oxygen or an NR6 group; Z1 and Z2 are hydrogen, halogen, alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy, haloalkyl, haloalkoxy, haloalkenyloxy, cyano or nitro; R1 is hydrogen, alkyl, ...
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WO/1994/021618A1 |
Nitric esters of general formula (I), wherein Y is a substituted cycloalkyl group or a group (a) wherein R is a hydrogen atom, a methyl radical, a 2,4- dichlorophenyl radical or a nitrate residue, R' is a hydrogen atom or a methyl radica...
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WO/1994/021617A1 |
The present invention is related to a process for making isothiazoles, wherein a thioamide is converted directly to the isothiazole by reacting the thioamide with a halogen in a solvent. The reaction results in the precipitation of the h...
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WO/1994/020479A1 |
The invention relates to N-(beta-branched alkyl)-1,2-benzisothiazolin-3-ones having two or more carbon atoms in the alkyl side chain such as N-(2-ethylhexyl)-1,2-benzisothiazolin-3-one. The compounds are suitable as paint film fungicides.
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WO/1994/019332A1 |
A retroviral protease inhibiting compound of formula (I) is disclosed.
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WO/1994/019344A1 |
Compounds of formula X-NH-CO-Z and pharmaceutically acceptable salts thereof, and the use of a compound of said formula or a pharmaceutically salt thereof, wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), ...
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WO/1994/018196A1 |
The present invention relates to a group of piperazine and piperidine derivatives of formula (I), wherein Y is a heteroaryl group optionally substituted by one or more halogen, nitro, C1-6alkyl, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, h...
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WO/1994/016564A1 |
Stable composition of 1,2-benzisothiazolin-3-one (BIT) in dipropylene glycol having lower pH and lower viscosity than known compositions. The BIT is present as an alkali metal salt obtained by reacting 0.75 to 1.07 moles alkali metal hyd...
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WO/1994/014436A1 |
A retroviral protease inhibiting compound of formula (A) is disclosed.
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WO/1994/013645A1 |
New compounds of formula (I) wherein R1 is H, CH3, OCH3, NO2, NH2, CN, CF3, CHF2, CH2F or halogen, R2 is a heterocyclyl radical selected from 1-imidazolyl, triazolyl, tetrazolyl, pyrazolyl, pyrimidinyl, oxazolyl, thiazolyl, isoxazolyl an...
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WO/1994/012169A1 |
Novel carboxy-peptidyl compounds of formula (I) are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, peri...
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WO/1994/008943A1 |
A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substitut...
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WO/1994/004917A1 |
A process for determining the presence of an isothiazolone in a sample, comprises treating a first aliquot of the sample with base and then with a phosphomolybdotungstic acid reagent, and observing and, if desired, measuring, the colour ...
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WO/1994/002558A1 |
The invention relates to a method for denaturing road salt by adding an aversive agent, such as benzyldiethyl-(2,6-xylylcarbamoyl-methyl)ammonium benzoate, i.e. denatonium benzoate, or N,N,N,N-benzyldiethyl-(2,6-xylylcarbamoyl-methyl)amm...
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WO/1994/002465A1 |
This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation an...
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WO/1993/016986A1 |
Azo oxime ethers of general formula (I), in which X is CH or N, R1 is hydrogen, C1-C3alkyl, trifluoromethyl or cylclopropyl and R2 is aryl or heteroaryl, have an activity against phytopathogenic fungi. They can be used in the form of for...
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WO/1993/016982A1 |
Compounds of formula (I) wherein W is a carbonyl, sulphonyl or sulphinyl group, and X is a carbonyl, sulphonyl or sulphinyl group or -C(O)-CH2- (in which the carbonyl group is bonded to Y), provided that at least one of W and X contains ...
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WO/1993/016073A1 |
The present invention relates to a group of piperazine and piperidine derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in therapy, in particular in the treatment of psychoti...
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WO/1993/016054A1 |
Compounds of formula (I), wherein the radical (a) is in position 3 or 5; X is a hydrogen atom, a cyano radical or a saturated or unsaturated alkyl radical; Y in position 4 or 5 is a hydrogen atom, an NO2, NH2 or C=N radical, a straight o...
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WO/1993/012754A2 |
The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
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WO/1993/012069A1 |
A compound represented by general formula (I), a pharmaceutical composition containing the same, and a process for producing the same, wherein R?1¿: hydrogen, lower alkyl, lower alkanoyl or aralkyl; R?2¿: optionally hydroxylated lower ...
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WO/1993/010073A1 |
The present invention relates to novel acyclic ethylenediamine derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are defined as in the specification...
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WO/1993/009102A1 |
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one o...
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WO/1993/008799A1 |
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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WO/1993/007534A1 |
A photographic element comprising a support, at least one photosensitive silver halide layer and associated therewith a colour coupler of general formula (1) or (2), wherein A and B represent the same or different electron-withdrawing gr...
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WO/1993/004682A1 |
Compounds of general formula (I) are disclosed as novel antipsychotic agents.
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WO/1993/004684A1 |
Compounds of the general formula (I) are disclosed as novel antipsychotic agents.
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WO/1993/004057A2 |
Disclosed are herbicides containing at least one 3-aminobenzo[b]thiophene (I) with an antagonistic action (in which R?1¿ = -COX or -COOX; X = H, halogen, optionally substituted amino, optionally substituted C¿1?-C¿10? alkyl, optionall...
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WO/1993/003022A1 |
Treatment of Aids, inhibition of the replication of HIV and related viruses, and formulations using thiourea derivative compounds or salts thereof are disclosed. Also disclosed are novel thiourea compounds.
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WO/1992/020669A1 |
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
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WO/1992/020664A1 |
The present invention relates to an improved process for selectively preparing 4-isothiazolin-3-one having structural formula (I), consisted of preparing 3,3'-dithiodipropionyldichloride by reacting 3,3'-dithiodipropionic acid with thion...
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WO/1992/020696A1 |
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
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WO/1992/019624A1 |
Compounds having the formula R1-(CH2)n-Het wherein R1 is a residue having the formula (B), (C), (D); Het represents a radical phenyl-4 tetrahydro-1,2,3,6 pyridyl-1 whose phenyl cycle is optionally substituted by a halogen atom or an alky...
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WO/1992/019748A1 |
In addition to virions, herpesvirus-infected cells produce non-infectious particles, termed L-particles, which consist of tegument surrounded by envelope but lack the nucleocapsid. L-particles of a herpesvirus can be prepared substantial...
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WO/1992/019606A1 |
Compounds having the formula: R1-(CH2)n-Het wherein R1 is a residue of formula (A), (B), (C); Het represents a radical phenyl-4 tetrahydro-1,2,3,6 pyridyl-1 whose phenyl cycle is optionally substituted by a halogen atom or an alkyl, alko...
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WO/1992/016514A1 |
Isoxazol- and isothiazol-5-carboxylic acid amides have formula (I), in which X stands for oxygen or sulphur, R?1� stands for hydrogen, if necessary substituted alkyl, cycloalkyl, cycloalkenyl, alkenyl, (if necessary epoxydized at the d...
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WO/1992/012966A1 |
A novel 3-benzylidene-1-carbamoyl-2-pyrrolidone analog represented by general formula (I), which is excellent in an antiinflammatory action and more particularly is useful for treating chronic inflammation without causing adverse effects...
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WO/1992/011250A1 |
Method for preparing a "syn" derivative of propanamide of forumula (I) by the action of a derivative of camphosultam of general formula (II) or (III) on aldehyde of formula (IV) in the presence of a Lewis acid and an organic base. In for...
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WO/1992/007465A1 |
The present invention is directed to microbiocidal combinations and processes for inhibiting the growth of microorganisms. The novel combinations and processes of the present invention show unexpected activity against micoorganisms, incl...
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WO/1992/005164A1 |
Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.
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WO/1992/004315A1 |
Monocyclic aryl compounds having selective LTB4 antagonists properties and comprising an amido substituent, a substituent group having a terminal carboxylic acid or derivative thereof and a lipophilic substituent, therapeutic composition...
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WO/1992/003053A1 |
Isoxazolines or isothiazolines having the formula (I), or their salts, in which (Z)¿n?, X and R have the definition given in the first claim, are useful as safeners against the phytotoxic side effects of herbicides, preferably in cereal...
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WO/1992/003727A1 |
A process for determining the presence of an isothiazolone in a sample, comprises treating the sample with base and then with a phosphomolybdtungstic acid reagent, and observing and, if desired, measuring, the colour thus generated. The ...
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WO/1991/016316A1 |
Chiral oxazolines having general formula (I) wherein R is C1 to C10 alkyl or phenyl and the R1 groups are independently hydrogen or C1 to C4 alkyl are prepared in substantially optically pure form by a process comprising the steps of (1)...
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