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Matches 1 - 50 out of 2,180

Document Document Title
WO/2022/133551A1
The present application is directed towards compounds, pharmaceutically acceptable salts or prodrugs thereof, which are inhibitors of Histone Deacetylase (HDAC) binding or function. The compounds especially may have some selectivity for ...  
WO/2022/129047A2
The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorder...  
WO/2022/129041A1
The present invention is directed to novel prodrugs of modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurologi...  
WO/2022/122773A1
The present invention relates to 4-(2-Fluoro-4-methoxy-5-3-(((l- methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl) carbamoyl)phenoxy)-l-methylcyclohexane-l-carboxylic acid derivatives and similar compounds of formula (I) as R...  
WO/2022/116714A1
Provided in the present application are a compound and the medical use thereof for novel coronavirus pneumonia, which belongs to the technical field of pharmaceuticals. The compound is a compound represented by formula I or formula II, o...  
WO/2022/103960A1
Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such...  
WO/2022/091014A1
The present invention relates to an industrial method for the preparation of Benzisothiazolinone formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemi...  
WO/2022/070451A1
Provided is a composition for treating water that has excellent storage stability as a liquid and high sterilization performance, a water treatment method in which the composition for treating water is used, a method for manufacturing th...  
WO/2022/058965A1
Provided herein, inter alia, are compounds of fatty acid glycerol derivatives and compositions including the same.  
WO/2022/051955A1
Disclosed is a method for preparing a saccharin compound. Provided is a method for preparing a saccharin compound as shown in formula (1). The method is characterized by comprising the following step: carrying out, in water in the presen...  
WO/2022/008283A1
The present invention to a group of compounds of formula (I) useful for the transfer of polyfluoroalkylthiol groups of at least two carbons atoms into a great variety of organic compounds as well as to the process for their preparation. ...  
WO/2020/102100A9
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2021/257849A1
Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are...  
WO/2021/219089A1
Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.  
WO/2021/200178A1
The present invention provides: an actinic ray-sensitive or radiation-sensitive resin composition containing (A) a resin in which polarity is increased due to acid activity, and (B) a compound which is represented by a specific general f...  
WO/2021/148934A1
The present invention relates to the process of reduction of compound of formula (II) by using a transition metal complex (Z) as a catalyst for hydrogenation reactions to get compound of formula (I). More particularly, the present invent...  
WO/2021/115495A1
The present invention relates to a sulfur-containing heterocyclic compound, characterized by: a compound represented by the following structural formula (I) or stereoisomer thereof, a geometric isomer, a tautomer, a racemate, a deuterate...  
WO/2021/083209A1
Provided are a compound of formula (I') or (I), a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of...  
WO/2021/082997A1
An amide compound containing a substituted acetophenone structure fragment, having a structure shown as general formula I. Please see the description for the definitions of substituents in the formula. The compound has a broad-spectrum b...  
WO/2021/055502A9
This invention provides a method of ameliorating the symptoms of, or treating a neurodegenerative disorder, Welander distal myopathy, psychiatric illness, or cancer in a mammal, the method comprising administering to the mammal an effect...  
WO/2021/063177A1
Use of an insecticide in preventing or killing pests. An active ingredient of the insecticide is an isothiazolinone heterocyclic compound, having the structure formula as represented by formula I or formula II, R1 is hydrogen or alkyl, R...  
WO/2021/059287A1
A method of oxygenating a benzylic C-H bond is provided. The method comprises light induced activation of an initiator and subsequent reaction with oxygen, resulting in the formation of free radicals. Subsequently, free radicals catalyze...  
WO/2021/032057A1
The invention relates to an agricultural fungicide, the use thereof and a preparation method therefor. The agricultural fungicide has the chemical structure as shown in formula I or formula II. The agricultural fungicide is used for prev...  
WO/2021/000867A1
Disclosed are an isoxazoline compound and an application thereof. The structure of the compound is as shown in general formula (I). The definitions of substituents in the formula are described in the description. The description also dis...  
WO/2021/000865A1
An isoxazoline compound, a preparation method therefor and an application thereof. The compound has a structured as represented by general formula I. Also provided is use of the compound represented by general formula I as an insecticide...  
WO/2020/255585A1
The present invention provides a method for purifying a compound that generates an acid when irradiated with active light or radiation, said method being capable of reducing the content of metal impurities, while having excellent recover...  
WO/2020/254697A1
The present invention relates to novel compounds (I) that can be employed in the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities responsive to modulation or inhibition of the activation of a compo...  
WO/2020/247701A2
The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration. In some embodiments, the present disclosure provides certain compounds and/or compositions that are ...  
WO/2020/201519A1
The present invention is directed to a novel process for purifying a recombinant polypeptide from a solution comprising one or more impurities, wherein the process is a chromatography process which uses saccharin. The present invention a...  
WO/2020/198368A1
The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disor...  
WO/2020/187440A1
The invention relates to aqueous benzisothiazoline-3-one-dispersions of sodium-1,2-benzisothiazoline-3-one-particles dispersed in water. The dispersions contain: (a) 15 wt.-% - 35 wt.-% sodium-1,2-benzisothiazoline-3-one and (b) ad. 100 ...  
WO/2020/167893A1
The present invention is directed to the administration of a cannabinoid aerosol formulation using a soft mist inhaler (SMI) with reduced cannabinoid-related irritation and/or coughing. Described is an aerosol formulation comprising a ca...  
WO/2020/147739A1
The present invention belongs to the technical field of pharmaceutical chemistry, and specifically relates to lysophosphatidic acid receptor antagonists and a preparation method therefor. The compounds of the present invention have high ...  
WO/2020/150417A2
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes...  
WO/2020/121667A1
An ammonium salt having a saccharin anion, which is represented by formula (1), exhibits excellent thermal stability even though no halogen atom is contained therein. (In the formula, each of R1-R4 independently represents an alkyl group...  
WO/2020/108538A1
An RORĪ³ inhibitor having sulfonyl structure, a preparation method thereof, and a pharmaceutical composition containing a plurality of compounds. The inhibitor has a structure represented by formula (I) or formula (V), wherein the compou...  
WO/2020/092906A1
Provided herein are co-crystals comprising Compound 1 and a coformer. Pharmaceutical compositions comprising the co-crystals and methods for treating, preventing and managing disease are also disclosed.  
WO/2020/086728A1
In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.  
WO/2020/084059A1
The present invention relates to N-nitrosaccharin of the general formula (I), wherein R is either a hydrogen (H) or a nitro group (NO2), its preparation and its use as nitrating agent.  
WO/2020/070181A1
The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and formula (A) are as defined in the description.  
WO/2020/064564A1
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, and their uses as insecticides.  
WO/2020/056090A1
Disclosed are compounds of Formulae 1 and 10 including all geometric and stereoisomers, tautomers, N oxides, and salts thereof, wherein E, L, J, A, T, R1, R2a, R2b, X, Y, R6a, R6b and R29 are as defined in the disclosure. Also disclosed ...  
WO/2020/040831A1
The present disclosure relates generally to compounds and pharmaceutical compositions for increasing glycosylation and treating congenital disorders of glycosylation.  
WO/2020/034945A1
The present invention provides a method for preparing a cyclohexane derivative, comprising the following steps: (1) subjecting a compound SM01 and a compound SM02 or a salt thereof to a nucleophilic substitution reaction to obtain a comp...  
WO/2020/034946A1
Provided is a method for preparing a cyclohexane derivative, the method comprising the following steps: subjecting a compound, 2-(4-(3,3-dimethylureido)cyclohexyl)acetaldehyde, represented by formula SM01 and a compound represented by fo...  
WO/2020/032813A1
New 5-substituted 5-hydrazine-3-methylisothiazole-4-carboxylic acid derivatives with antitumor activity and a method for their preparation have been disclosed. The disclosed compounds inhibit the proliferation of MV 4-11 human bifenotypi...  
WO/2020/002234A1
The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD)  
WO/2020/006294A1
Disclosed herein are methods of treating liver fibrosis by administering calpain inhibitors to subjects in need thereof.  
WO/2019/236890A1
The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SA...  
WO/2019/226490A1
Provided is a compound of Formula (I), wherein the variable groups are defined herein.  

Matches 1 - 50 out of 2,180