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Matches 1 - 50 out of 15,039

Document Document Title
WO/2022/168755A1
The present invention provides a nonaqueous electrolyte solution comprising: (I) at least one compound selected from the group consisting of compounds represented by general formula (1) in the description (for example, compounds represen...  
WO/2022/169239A1
In the present invention, a NLRP3-inhibitory compound 7 (NIC7) and a potent derivative NIC7w which are a novel small-molecule inhibitor for inhibiting NLRP3 inflammasomes are identified. Specifically, the compound and the derivative inhi...  
WO/2022/164822A1
The present disclosure provides compounds according to Formula (I), wherein X, R2, R3, R4, and R5 are defined herein. Further disclosed herein are pharmaceutical compositions, orally administrable dosage forms, and methods for using such...  
WO/2022/163843A1
Provided are a compound having high PIM2 inhibitory activity, and a PIM2 inhibitor and a pharmaceutical composition that contain the compound. This PIM2 inhibitor contains a compound represented by formula (1) (in the formula, A is a ben...  
WO/2022/161433A1
The present invention relates to a mercaptobenzothiazolyl substituted compound, a vegetable oil composition containing same, a preparation method for the compound or composition, and an application thereof in a drilling fluid composition...  
WO/2022/164135A1
The present invention relates to a benzothiazole or benzimidazole derivative, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of SIRTUIN 7 p...  
WO/2022/155936A1
Disclosed in the present invention is a method for synthesizing an aryl benzyl ether compound, i.e., synthesizing a corresponding aryl benzyl ether compound by means of an oxidative coupling reaction of a phenolic compound and a toluene ...  
WO/2022/159436A1
Provided is a compound, including a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein W is a direct bond or an optionally substituted C, and if W is a direct bond, then X1, X2, X3, and X4 are each independentl...  
WO/2022/155932A1
Disclosed is an application of an iron (III) complex containing 1,3-di-tert-butyl imidazolium cation in synthesizing arylbenzyl ether compounds. Specifically, di-tert-butyl peroxide is used as an oxidant, and a corresponding arylbenzyl e...  
WO/2022/158758A1
Provided is an organic compound which contributes to substantial improvements in the luminous efficiency and viewing angle of an organic electroluminescent device. An organic electroluminescent device according to the present invention c...  
WO/2022/159649A1
The present invention is related to the development of novel compounds and methods for the treatment and/or prevention of malaria. The compounds prevent the formation by the malaria parasite of the piasmodium surface anion channel (PSAC)...  
WO/2022/147694A1
Provided herein are novel compounds (e.g., Formula I, II, III, or IV), pharmaceutical compositions, and methods of using the same. The compounds herein can typically induce UCP-1 expression and/or browning of white adipose tissues. The c...  
WO/2022/148331A1
Provided herein are novel compounds (e.g., Formula I, II, III, or IV), pharmaceutical compositions, and methods of using the same. The compounds herein can typically induce UCP-1 expression and/or browning of white adipose tissues. The c...  
WO/2022/142731A1
Disclosed are an antiviral compound and a preparation method therefor. The structural formula of the compound is as represented by formula I. In formula (I), R1 is selected from: monosubstituted or polysubstituted H, F, methyl, and trifl...  
WO/2022/142727A1
Disclosed are an antiviral compound and method for preparation thereof. The structural formula of the compound is as shown in formula I; in formula (I), R 1 is selected from monosubstituted or polysubstituted H, F, methyl, and trifluorom...  
WO/2022/146086A1
The present invention relates to: a compound that is sensitive to γ-hydroxybutyric acid (GHB)-based compounds, and thus changes color; and an application thereof, and since the GHB-based compound-sensitive chromogenic compound of the pr...  
WO/2022/140520A1
Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compo...  
WO/2022/138944A1
The present disclosure provides a pharmaceutical composition for treating and/or preventing SWI/SNF complex-dysfunction cancer. More specifically, according to the present disclosure, a compound represented by formulae (1) to (23) (the f...  
WO/2022/135355A1
Provided is a method for catalytically activating carbon dioxide as a carbonylation reagent with inorganic sulfur. In the method, carbon dioxide can be used to replace a toxic and harmful carbonylation reagent in the presence of H2S and ...  
WO/2022/135613A1
Disclosed in the present invention are a guanidinothiazole compound, and a preparation method therefor and the use thereof. The structural formula of the guanidinothiazole compound is as shown in formula (IV). According to the present in...  
WO/2022/127654A1
An anti-fibrosis pharmaceutical composition and an application thereof. The anti-fibrosis pharmaceutical composition specifically comprises: (a) an NRP1 inhibitor and/or a HIF2α inhibitor; and (b) an EPCR pathway activator that promotes...  
WO/2022/127923A1
The present invention relates to a benzene ring compound and a use thereof. In particular, provided is a compound as shown in formula I, or an optical isomer thereof or a racemate thereof, or a solvate thereof, or a pharmaceutically acce...  
WO/2022/129925A1
The present disclosure relates to a novel class of bifunctional molecules that are useful in a targeted or selective degradation of a protein.  
WO/2022/129047A2
The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorder...  
WO/2022/122975A1
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as a drug, especially as an antibiotic. The present invention also relates to a pharmaceutical composition c...  
WO/2022/125636A1
Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compo...  
WO/2022/124148A1
Provided is a compound which is suited to nucleic acid detection or viscosity measurement. The disclosed compound is equipped with a donor and three acceptors which are bonded to said donor so as to be capable of rotating around said don...  
WO/2022/112188A1
The present invention provides novel compounds having the general formula: (I) wherein R1 to R3 are as described herein, compositions including the compounds and methods of using the compounds.  
WO/2022/111605A1
The present disclosure relates to an aryl or heteroaryl substituted 5-membered aromatic heterocyclic compound and the use thereof. In particular, provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof,...  
WO/2022/110916A1
A method for preparing a nitrogen-containing heterocyclic compound and a derivative thereof by means of an enzymatic-chemical cascade method, comprising: reacting an alcohol, an amine, an alcohol dehydrogenase, a flavin molecule and a co...  
WO/2022/105644A1
Provided in the present invention are a salt of a benzothiazole compound as represented by formula I, and a crystal form and the use thereof. The salt is selected from pamoate and palmitate. Further provided is the use of the salt of the...  
WO/2022/108377A1
The present invention relates to a novel compound having inhibitory activity against O-GlcNAcase and a use thereof.  
WO/2022/109148A1
The present disclosure relates generally to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-...  
WO/2022/100634A1
Provided are an organic electroluminescent device and a display apparatus comprising same. The organic electroluminescent device comprises a substrate, an anode electrode, a hole injection layer, a hole transport layer, a light-emitting ...  
WO/2022/103960A1
Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such...  
WO/2022/095569A1
Disclosed are a heterocyclic compound for an immune checkpoint inhibitor capable of blocking a VISTA signaling pathway, and a preparation method therefor and a use thereof. The compound is as represented by formula I. The compound has a ...  
WO/2022/090409A1
The invention relates to novel deuterated compounds of Formula (I) to a process for their preparation and to their use as medicament, in particular as antiviral medicament.  
WO/2022/083703A1
This disclosure relates to LPA antagonists of Formula (I) : including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.  
WO/2022/079290A2
The present invention relates to compounds with the ability to stimulate/induce ubiquitination of a target protein/target proteins. The compounds of the present invention may stimulate/induce ubiquitination of a target protein/target pro...  
WO/2022/076628A1
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis usin...  
WO/2022/076403A1
This disclosure provides compounds for the treatment of medical disorders such as cancer, and more particularly compounds which find use as inhibitors of CMG helicase.  
WO/2022/076629A1
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions, containing at least one such modulator, methods of treatment of cystic fibrosis usi...  
WO/2022/069462A1
The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.  
WO/2022/063153A1
Provided are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).  
WO/2022/063152A1
Provided are compounds of Formula I, compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).  
WO/2022/058733A1
The present invention relates to compounds for stabilising the native tetrameric form of transthyretin and protecting it from proteolytic cleavage; compounds for use in the prevention and treatment of transthyretin amyloidosis; and agent...  
WO/2022/057387A1
A 3-(3-Aryl/heteroaryl-4-thiazolinone)-N-aryl/heterocyclic benzamide compound, or a pharmaceutically-acceptable salt thereof, and a preparation method therefor. The compound type or a pharmaceutical composition thereof can be used to tre...  
WO/2022/057223A1
A benzothiazole meroterpenoid compound derived from deep sea fungi and a derivative thereof, and a preparation method therefor and the use thereof in the preparation of an anti-tumor drug. The benzothiazole meroterpenoid compound is a co...  
WO/2022/059028A1
The present invention relates to a novel crystalline polymorph of Sodium (2R,5S,13aR)-7,9-dioxo-10-[(2,4,6-trifluorobenzyl)carbamoyl] -2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]py razino[2,1-b][1,3]oxazepin-8-olate (Bicteg...  
WO/2022/053660A2
The use of an N-heterocyclic compound of the general formula (a) or (b) with the following definitions: X1 being S or O, X2 being S or O and at least one of X1 and X2 being S R2 H or C1-4-alkyl, R3 H or C1-4-alkyl R6 and R7 are hydrogen ...  

Matches 1 - 50 out of 15,039