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Document Title |
JPH06279398A |
PURPOSE: To obtain the subject compound for medical use, having vasodilator action and protecting action on heart muscle by reacting an o-(aminoalkylamino) thiophenol with a specific glycidic acid ester in the presence of an iron ion and...
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JPH0675176B2 |
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JPH06507616A |
The invention relates to therapeutically active azaheterocyclic compounds and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.
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JPH0667914B2 |
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JPH0660166B2 |
The present invention is directed to a fluorescence polarization assay for benzodiazepines and their metabolites, to the various components needed for preparing and carrying out such an assay and to methods of making these components. Sp...
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JPH06506930A |
PCT No. PCT/GB92/00805 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed May 1, 1992 PCT Pub. No. WO92/19277 PCT Pub. Date Nov. 12, 1992 (I) Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be th...
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JPH06506934A |
PCT No. PCT/GB92/00804 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed May 1, 1992 PCT Pub. No. WO92/19607 PCT Pub. Date Nov. 12, 1992 (I) Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be th...
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JPH0645611B2 |
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JPH0643390B2 |
An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an exter...
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JPH0643312B2 |
A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane ...
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JPH06157481A |
PURPOSE: To prepare a novel compound inhibiting the angiotensinogen-cleaving action of renin. CONSTITUTION: The compound has the formula I [wherein A is H, aryl or the like; B is -CH2-, the formula II (wherein R3 is H, 1-4C alkyl or the ...
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JPH0637458B2 |
Novel compounds of the formula wherein A is a group useful for the treatment of cardiac arrythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparation of such compounds as well as interm...
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JPH0637480B2 |
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JPH0623104B2 |
A pharmaceutical compound characterized by a delayed release of the therapeutically active component, comprising a sulfonic type ion exchange resin and cis(± )-3-ace- tytoxy-5- [2- (dimethylamino) ethyl] -2,3-dihydro-2- (4-methoxyphenyl...
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JPH0623105B2 |
Seizures are ameliorated with certain benzothiazepines.
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JPH0621071B2 |
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JPH0641104A |
PURPOSE: To produce a hydroxylamine derivative effective as a lipoxygenase inhibitor and useful for treating inflammatory and allergic diseases. CONSTITUTION: The compd. of the formula I (R is H, alkyl, aryl, biaryl, chcloalkyl or the li...
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JPH064606B2 |
The compound of formula:- and the pharmaceutically acceptable salts thereof possess neuroleptic activity with a much reduced incidence of side effects such as acute dystonia, acute dyskinesia and tardive dyskinesia.
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JPH062754B2 |
Process for the preparation of benzothiazepinone derivatives of the formula …… by alkaline hydrolysis of benzothiazoles of the formula …… to give o-aminothiophenols of the formula …… their isolation by acidification and react...
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JPH06768B2 |
The present invention relates to a process for the preparation of benzothiazepin derivatives of general formula Iwherein R stands for hydrogen and acetyl or of acid addition salts thereof in which a corresponding compound of general form...
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JPH0585549B2 |
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JPH0581597B2 |
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JPH0573748B2 |
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JPH0573747B2 |
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JPH0573729B2 |
Disclosed are a pharmaceutical composition for improving the constitution of lipids in blood, which comprises as an active ingredient 2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-8-c
hloro-2,3- dihydro-HY # 1,5-benzothiazepin...
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JPH0573728B2 |
There are disclosed a prophylactic and curing composition for arteriosclerosis, which comprises as an active ingredient a 8-chloro-1,5-benzothiazepine derivative represented by the formula: wherein R<1>, R<2>, R<3> and R<4> each represen...
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JPH0573746B2 |
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JPH0573749B2 |
PURPOSE:To economically obtain the titled compound useful as a hypotensor, a cerebral or coronary vasodilator and a platelet coagulation inhibitor, by alkylating 4-hydroxyphenyl group of a compound corresponding to the titled compound to...
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JPH05255290A |
PURPOSE: To obtain the subject agent used for treatment, etc., of allergosis, thrombotic disorder, etc., having an inhibiting activity for production of tumor necrosis factor and composed of a specific 11-oxo-7-thia-10-azaspiro[5.6]-dode...
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JPH05506654A |
This invention relates to diltiazem analogs having the formula: where the substituents are defined in the specification. These compounds are useful in treating cardiovascular problems. The invention also relates to a process for preparin...
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JPH0566389B2 |
Novel fused 7-membered ring compounds represented by formula (I) wherein R<1> and R<2> each represents hydrogen, halogen, tri-fluoromethyl, lower alkyl, alkoxy or, when taken together, they represent tri- or tetra-methylene, R<3> represe...
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JPH0564144B2 |
Novel fused 7-membered ring compounds represented by the following formula (I), wherein R<1> and R<2> each represents hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when taken together, they represent tri- or tetra-m...
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JPH0563468B2 |
Novel condensed seven-membered ring compounds of the formula: [wherein R<1> and R<2> are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R<3> and R<5> are indepe...
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JPH0559909B2 |
Compounds of formula (I): (wherein: R1 represents an optionally substituted alkyl, cycloalkyl, aryl, partially hydrogenated aryl or heterocyclic group; R2, R3, R4 and R5 represent hydrogen or an optionally substituted alkyl, cycloalkyl, ...
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JPH05222011A |
PURPOSE: To provide the subject composition containing, as active component, anti-coagulant nonionic contrast agents, wherein some of the agents are new compounds, and having the ability to reduce the risk of clot formation in diagnostic...
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JPH05222005A |
PURPOSE: To provide the subject compound which has the ability to inhibit angiotensinogen-cleaving action of the natural proteolytic enzyme, renin and is useful for preventing and treating renin-associated hypertension, hyperaldosteronis...
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JPH05202013A |
PURPOSE: To profitably and simply obtain the intermediate of diltiazem hydrochloride having a coronary vasodilating action and useful for treating ischemic cardiac diseases simply in one process and in a good yield without requiring any ...
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JPH05163245A |
PURPOSE: To obtain a new dibenzazepine derivative extremely useful as a therapeutic agent for various allergic diseases and bronchial asthma because of its having excellent antihistamine action and antiallergic action and yet no exhibiti...
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JPH0533705B2 |
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JPH0533951B2 |
Herbicidal compounds of the formula in which, for example, X is Br, Cl or F; Y is Cl or Br, R2 is CHF2, R3 is CH3 R is lower alkyl and R1 is H,Na, lower alkyl or -SO2R.
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JPH0527629B2 |
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JPH0586043A |
PURPOSE: To obtain a preventing and treating agent for after-trouble based on cerebral neurocyte disorder, containing a benzothiazepin derivative as an active ingredient, having improving/protecting action to injury of cerebral neurocyte...
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JPH0578250A |
PURPOSE: To provide the subject agent exhibiting excellent suppressive action on hepatitis and pancreatitis. CONSTITUTION: The objective agent containing, as active ingredient, a compound of formula I [R1 is lower aralkyl having substitu...
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JPH0565278A |
PURPOSE: To provide the subject new compound having cardiotonic action, free from pulse-rate accelerating side effect and, accordingly, useful as a cardiotonic agent. CONSTITUTION: The compound of formula I (R1 is lower alkyl or cycloalk...
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JPH0565257A |
PURPOSE: To obtain a new polycyclic compound useful as an antihistamine agent and an antiallergic agent having low side action and excellent selectivity. CONSTITUTION: A polycyclic compound shown by the formula A-COCH3 [A is group shown ...
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JPH0559028A |
PURPOSE: To provide a new benzothiazepine derivative useful as an anti-ulcer agent or stomachic agent having a protease-inhibiting action and a mucosa- protecting action as action mechanisms and its physiologically acceptable salt. CONST...
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JPH056544B2 |
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JPH0473427B2 |
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JPH04288064A |
PURPOSE: To provide a novel compd. which has antihyperalgesic and is useful for the treatment of the pains of an inflammation state, rheumatoid arrthritis, osteoarithritis, etc. CONSTITUTION: This compd. is expressed by formula I (X is o...
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JPH04273865A |
PURPOSE: To provide the subject compound which has excellent heat stability and is useful for a bleaching agent, an oxidizing agent or a disinfectant. CONSTITUTION: This is a compound of formula I, which is exampled by 2-[1,1,3- trioxo-3...
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