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Matches 701 - 750 out of 1,014

Document Document Title
JPH06279398A
PURPOSE: To obtain the subject compound for medical use, having vasodilator action and protecting action on heart muscle by reacting an o-(aminoalkylamino) thiophenol with a specific glycidic acid ester in the presence of an iron ion and...  
JPH0675176B2  
JPH06507616A
The invention relates to therapeutically active azaheterocyclic compounds and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.  
JPH0667914B2  
JPH0660166B2
The present invention is directed to a fluorescence polarization assay for benzodiazepines and their metabolites, to the various components needed for preparing and carrying out such an assay and to methods of making these components. Sp...  
JPH06506930A
PCT No. PCT/GB92/00805 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed May 1, 1992 PCT Pub. No. WO92/19277 PCT Pub. Date Nov. 12, 1992 (I) Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be th...  
JPH06506934A
PCT No. PCT/GB92/00804 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed May 1, 1992 PCT Pub. No. WO92/19607 PCT Pub. Date Nov. 12, 1992 (I) Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be th...  
JPH0645611B2  
JPH0643390B2
An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an exter...  
JPH0643312B2
A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane ...  
JPH06157481A
PURPOSE: To prepare a novel compound inhibiting the angiotensinogen-cleaving action of renin. CONSTITUTION: The compound has the formula I [wherein A is H, aryl or the like; B is -CH2-, the formula II (wherein R3 is H, 1-4C alkyl or the ...  
JPH0637458B2
Novel compounds of the formula wherein A is a group useful for the treatment of cardiac arrythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparation of such compounds as well as interm...  
JPH0637480B2  
JPH0623104B2
A pharmaceutical compound characterized by a delayed release of the therapeutically active component, comprising a sulfonic type ion exchange resin and cis(± )-3-ace- tytoxy-5- [2- (dimethylamino) ethyl] -2,3-dihydro-2- (4-methoxyphenyl...  
JPH0623105B2
Seizures are ameliorated with certain benzothiazepines.  
JPH0621071B2  
JPH0641104A
PURPOSE: To produce a hydroxylamine derivative effective as a lipoxygenase inhibitor and useful for treating inflammatory and allergic diseases. CONSTITUTION: The compd. of the formula I (R is H, alkyl, aryl, biaryl, chcloalkyl or the li...  
JPH064606B2
The compound of formula:- and the pharmaceutically acceptable salts thereof possess neuroleptic activity with a much reduced incidence of side effects such as acute dystonia, acute dyskinesia and tardive dyskinesia.  
JPH062754B2
Process for the preparation of benzothiazepinone derivatives of the formula …… by alkaline hydrolysis of benzothiazoles of the formula …… to give o-aminothiophenols of the formula …… their isolation by acidification and react...  
JPH06768B2
The present invention relates to a process for the preparation of benzothiazepin derivatives of general formula Iwherein R stands for hydrogen and acetyl or of acid addition salts thereof in which a corresponding compound of general form...  
JPH0585549B2  
JPH0581597B2  
JPH0573748B2  
JPH0573747B2  
JPH0573729B2
Disclosed are a pharmaceutical composition for improving the constitution of lipids in blood, which comprises as an active ingredient 2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-8-c hloro-2,3- dihydro-HY # 1,5-benzothiazepin...  
JPH0573728B2
There are disclosed a prophylactic and curing composition for arteriosclerosis, which comprises as an active ingredient a 8-chloro-1,5-benzothiazepine derivative represented by the formula: wherein R<1>, R<2>, R<3> and R<4> each represen...  
JPH0573746B2  
JPH0573749B2
PURPOSE:To economically obtain the titled compound useful as a hypotensor, a cerebral or coronary vasodilator and a platelet coagulation inhibitor, by alkylating 4-hydroxyphenyl group of a compound corresponding to the titled compound to...  
JPH05255290A
PURPOSE: To obtain the subject agent used for treatment, etc., of allergosis, thrombotic disorder, etc., having an inhibiting activity for production of tumor necrosis factor and composed of a specific 11-oxo-7-thia-10-azaspiro[5.6]-dode...  
JPH05506654A
This invention relates to diltiazem analogs having the formula: where the substituents are defined in the specification. These compounds are useful in treating cardiovascular problems. The invention also relates to a process for preparin...  
JPH0566389B2
Novel fused 7-membered ring compounds represented by formula (I) wherein R<1> and R<2> each represents hydrogen, halogen, tri-fluoromethyl, lower alkyl, alkoxy or, when taken together, they represent tri- or tetra-methylene, R<3> represe...  
JPH0564144B2
Novel fused 7-membered ring compounds represented by the following formula (I), wherein R<1> and R<2> each represents hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when taken together, they represent tri- or tetra-m...  
JPH0563468B2
Novel condensed seven-membered ring compounds of the formula: [wherein R<1> and R<2> are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R<3> and R<5> are indepe...  
JPH0559909B2
Compounds of formula (I): (wherein: R1 represents an optionally substituted alkyl, cycloalkyl, aryl, partially hydrogenated aryl or heterocyclic group; R2, R3, R4 and R5 represent hydrogen or an optionally substituted alkyl, cycloalkyl, ...  
JPH05222011A
PURPOSE: To provide the subject composition containing, as active component, anti-coagulant nonionic contrast agents, wherein some of the agents are new compounds, and having the ability to reduce the risk of clot formation in diagnostic...  
JPH05222005A
PURPOSE: To provide the subject compound which has the ability to inhibit angiotensinogen-cleaving action of the natural proteolytic enzyme, renin and is useful for preventing and treating renin-associated hypertension, hyperaldosteronis...  
JPH05202013A
PURPOSE: To profitably and simply obtain the intermediate of diltiazem hydrochloride having a coronary vasodilating action and useful for treating ischemic cardiac diseases simply in one process and in a good yield without requiring any ...  
JPH05163245A
PURPOSE: To obtain a new dibenzazepine derivative extremely useful as a therapeutic agent for various allergic diseases and bronchial asthma because of its having excellent antihistamine action and antiallergic action and yet no exhibiti...  
JPH0533705B2  
JPH0533951B2
Herbicidal compounds of the formula in which, for example, X is Br, Cl or F; Y is Cl or Br, R2 is CHF2, R3 is CH3 R is lower alkyl and R1 is H,Na, lower alkyl or -SO2R.  
JPH0527629B2  
JPH0586043A
PURPOSE: To obtain a preventing and treating agent for after-trouble based on cerebral neurocyte disorder, containing a benzothiazepin derivative as an active ingredient, having improving/protecting action to injury of cerebral neurocyte...  
JPH0578250A
PURPOSE: To provide the subject agent exhibiting excellent suppressive action on hepatitis and pancreatitis. CONSTITUTION: The objective agent containing, as active ingredient, a compound of formula I [R1 is lower aralkyl having substitu...  
JPH0565278A
PURPOSE: To provide the subject new compound having cardiotonic action, free from pulse-rate accelerating side effect and, accordingly, useful as a cardiotonic agent. CONSTITUTION: The compound of formula I (R1 is lower alkyl or cycloalk...  
JPH0565257A
PURPOSE: To obtain a new polycyclic compound useful as an antihistamine agent and an antiallergic agent having low side action and excellent selectivity. CONSTITUTION: A polycyclic compound shown by the formula A-COCH3 [A is group shown ...  
JPH0559028A
PURPOSE: To provide a new benzothiazepine derivative useful as an anti-ulcer agent or stomachic agent having a protease-inhibiting action and a mucosa- protecting action as action mechanisms and its physiologically acceptable salt. CONST...  
JPH056544B2  
JPH0473427B2  
JPH04288064A
PURPOSE: To provide a novel compd. which has antihyperalgesic and is useful for the treatment of the pains of an inflammation state, rheumatoid arrthritis, osteoarithritis, etc. CONSTITUTION: This compd. is expressed by formula I (X is o...  
JPH04273865A
PURPOSE: To provide the subject compound which has excellent heat stability and is useful for a bleaching agent, an oxidizing agent or a disinfectant. CONSTITUTION: This is a compound of formula I, which is exampled by 2-[1,1,3- trioxo-3...  

Matches 701 - 750 out of 1,014