Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 4,503

Document Document Title
WO/2022/166680A1
Provided are a novel crystal form of Odevixibat (referred to as "compound I"), a preparation method therefor, a pharmaceutical composition containing said crystal form, and a use of said crystal form in the preparation of a IBAT inhibito...  
WO/2022/092260A1
The present invention addresses the problem of providing a cross-coupling reaction method that can use a wide variety of compounds as starting materials, that can substantially not use organic solvent, and that can rapidly provide reacti...  
WO/2022/092896A1
The present invention relates to an ophthalmic therapeutic agent having a poorly soluble drug of chemical formula 1 as a pharmacologically active ingredient. Specifically, the ophthalmic solution formulation is administered to a patient ...  
WO/2022/069894A1
The invention relates to a compound of formula I, wherein: R1 is as defined in the specification, or a pharmaceutically acceptable salt or solvate thereof, which compounds are useful in the treatment treatment of a disorder or condition ...  
WO/2022/053659A2
The use of a heterocyclic compound of the general formula (I) with the following definitions: X S or NR4 with R4 being C1-4-alkyl, R1 C3-12-hydrocarbon residue which can contain 1 to 3 heteroatoms selected from the group consisting of ni...  
WO/2022/055467A1
The invention relates to a certain new 4-(2-((5-(substitutedamino)-1,3,4-thiadiazole-2-yl)thio)acet yl)benzenesulphonamide derivatives for use in pharmaceutics, chemical and pharmaceutical industry, and to a method for the synthesis of s...  
WO/2022/056281A1
Provided herein are compounds including compounds of formula (I), compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosph...  
WO/2022/040747A1
The present invention relates to compounds that have zinc and/or iron ionophore activity and their use in treating diseases that are modulated by reducing zinc and/or iron. In particular embodiments, the compounds are compounds of formul...  
WO/2022/046625A1
The disclosed technology relates to 2,5-dimercapto-1,3,4-thiadiazole metal salts and electrolytes therewith for use in redox flow batteries.  
WO/2022/046718A1
The disclosed technology relates to Zinc salts of 2,5-dimercapto-1,3,4-thiadiazole ("DMTD"), and electrodes therewith for use in zinc ion battery systems.  
WO/2022/037006A1
An analgesic and antipruritic pharmaceutical composition and an application method therefor, relating to the technical field of medicinal chemistry. It is found in the study that an analgesic effect generated by independently inhibiting ...  
WO/2022/015821A1
The present application relates to compounds of formulae (I)-(VII) as defined herein, compositions containing these compounds, methods of their use, and methods of making. The compounds have nematacide activity.  
WO/2021/257020A1
Within the scope of the invention, 15 novel 3-[2-(1,3-benzodioxole-5-yl)ethyl)]-6-aryl-7H-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazine derivatives were synthesized. The cytotoxic and apoptotic effects of some synthesized compounds in human l...  
WO/2021/249517A1
Provided is a new kind of molecular glues for triggering polyubiquitination and degradation of CCNK (cyclin K). Specifically, a new kind of molecular glues for creating a modified CDK12 protein so as to bind DDB1 of DDB1-CUL4-RBX1. The m...  
WO/2021/215958A1
The present group of inventions relates to the field of thiadiazole chemical technology, more particularly to 2,5-dimercapto-1,3,4-thiadiazole and to a method for producing same. The method for producing 2,5-dimercapto-1,3,4-thiadiazole ...  
WO/2021/209475A1
The invention relates to a compound of formula (I) wherein R1-R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.  
WO/2021/189112A1
A method for detection of a nerve agent in a sample, which method comprises (a) irradiating an optical sensing element, the optical sensing element comprising a fluorescent sensing compound provided on a substrate, and measuring the lumi...  
WO/2021/183830A1
A method of treating a patient suffering from disease that is caused by organ/tissue fibrosis includes the administration of a PKM2 activator. The PKM2 activator can reduce LOX protein expression and activate PKM2.  
WO/2021/175225A1
Disclosed in the present invention are a series of tricyclic compounds, and particularly disclosed are a compound shown in formula (I) or a pharmaceutically acceptable salt thereof.  
WO/2021/175223A1
Disclosed are a series of benzo 2-azaspiro[4.4]nonane compounds, and specifically disclosed are a compound as represented by formula (P) or a pharmaceutically acceptable salt thereof.  
WO/2021/171235A1
Provided herein is a process for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride: Formula (I). The said process comprises preparing 3,7-dibromophenothiazin-5-ium bromide wet Crude(III) from phenothiazine (II) along pro...  
WO/2021/155781A1
The present invention relates to a benzene sulfonamide compound containing a five-membered heterocycle represented by formula (I), and an enantiomer, a diastereomer, and a racemate thereof and a mixture thereof, and a pharmaceutically ac...  
WO/2021/153786A1
The present invention provides a compound having an excellent control effect against pests. A compound represented by formula (1) of the present invention (in the formula, Q represents a group indicated by Q1 or a group indicated by Q2 (...  
WO/2021/153794A1
The present invention provides a method of controlling soybean rust fungus that has an F129L amino acid substitution in the mitochondrial cytochrome b protein. The compound represented by formula (I) can be used to control soybean rust f...  
WO/2021/134143A1
Disclosed is a method for preparing diazoxide, comprising: reacting o-aminobenzenesulfonamide with N-chlorosuccinimide in a chlorine solvent to obtain 2-amino-5-chlorobenzenesulfonamide, mixing the 2-amino-5-chlorobenzenesulfonamide, an ...  
WO/2021/127499A1
Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g, protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), a...  
WO/2021/127301A1
4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarb...  
WO/2021/119503A1
The present invention provides cromakalim prodrugs, compositions, and their use for the modulation of ATP-sensitive potassium (KATP) channels for therapeutic purposes.  
WO/2021/115494A1
A novel crystalline modification II of flufenacet is provided, characterized by an X-ray powder diffractogram (XRD), an infrared (IR) spectrum, a melting point and/or a differential scanning calorimetry (DSC) profile. There is also provi...  
WO/2021/110885A1
The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activit...  
WO/2021/113802A1
The present invention relates to methods and compositions for the treatment of psychiatric disorders such as treatment-resistant depression (TRD) with KCNQ (also known as Kv7) channel openers. Also disclosed is a method of inducing or en...  
WO/2021/113621A1
Systems and methods for monitoring and/or controlling anti-scalant concentration. The systems may include components that form an automated control loop. The methods may be online methods that allow the concentration of an anti-scalant t...  
WO/2021/098840A1
Sulfonylurea ring substituted monocyclic β-lactam antibiotics, and specifically relating to a compound represented by formula (I), a pharmaceutically acceptable salt or a stereoisomer thereof, and an application thereof in the preparati...  
WO/2021/092264A1
The present disclosure is directed to use of MrgprX2 antagonists in the treatment of inflammatory disorders, e.g., inflammatory disorders of the skin. This invention is also directed to pharmaceutical compositions comprising a MrgprX2 an...  
WO/2021/074646A1
There is provided an alkali metal salt of 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo- 1,2,4-thiadiazol-5-yl]benzamide and formulations thereof. This salt finds particular utility in the treatment or prevention of a disorder or conditio...  
WO/2021/068816A1
Disclosed are an alkene-containing amide compound and the use of an agriculturally acceptable salt thereof as a herbicide. The compound is as represented by general formula (I): the substituents in general formula I are defined in the de...  
WO/2021/056105A1
Compositions and methods based on the use of mutated HIV-1 gp120 polypeptides having amino acid substitutions at positions 61, 105, 108, 375, 474, 475 and 476 are described. These mutated HIV-1 gp120 polypeptides, which make the HIV env ...  
WO/2021/055388A1
The disclosed technology relates to derivatives of 2,5-dimercapto-1,3,4-thiadiazole.  
WO/2021/055849A1
The application relates to lipids of Formula (A-1) and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include such a lipid as well as additional lipids such as phospholipids, structural lipids, and...  
WO/2021/043116A1
Disclosed are biphenyl compounds, a preparation method therefor, and the medical use thereof. The structure of the biphenyl compounds is as shown in formula (I) or formula (II). The biphenyl compounds of the present invention or a pharma...  
WO/2021/043114A1
The present invention relates to the technical field of pesticides, and particularly relates to a substituted thiadiazinone dioxide and a preparation method therefor, a herbicidal composition, and an application therefor. The substituted...  
WO/2021/041450A1
A comonomer comprising: wherein W is selected from the group consisting of: S, Se, O, and N-Q; and Q is selected from the group consisting of: a straight-chain or branched carbyl, silyl, or hydrocarbyl, a branched or cyclic alkyl with 1 ...  
WO/2021/040519A1
The invention relates to compounds and pharmaceutically acceptable salts thereof, and to their medical use. Exemplary medical uses are the prevention and treatment of a bacterial infection, for example, a mycobacterial infection, such as...  
WO/2021/031788A1
Disclosed are an immune checkpoint inhibitor capable of blocking a PD-1/PD-L1 signaling pathway, a phenyl-substituted five-membered heterocyclic compound or a pharmaceutically acceptable salt, racemate, optical isomer or solvent compound...  
WO/2021/022111A2
The present disclosure provides novel β-arrestin-modulating compounds and methods of making and using same.  
WO/2020/262134A1
The present invention addresses the problem of providing a purification method for an actinic ray-sensitive or radiation-sensitive resin composition which can be used to form a pattern in which defects are inhibited. The present inventio...  
WO/2020/254558A1
The present disclosure relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein can inhibit the ClC...  
WO/2020/254530A1
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts; stereoisomers, enantiomers, tautomers and N-oxides of those compounds.. Furthermore, the present invention relates to a...  
WO/2020/250223A1
The invention relates to a novel substituted amino acids, agricultural compositions comprising the novel substituted amino acids, and their use for controlling undesired plant growth alone or in combination with crop protection agents su...  
WO/2020/251872A1
Disclosed are compounds of Formula A, or a salt thereof: Wherein "A1", R1, R2, R3, R6, and R7 are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also desc...  

Matches 1 - 50 out of 4,503