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Document Title |
JP4549443B2 |
Method of treating or inhibiting proliferation of a peroxisome proliferator-activated receptor (PPAR) gamma -responsive cell, comprising contacting the cell with a PPARgamma agonist. Also claimed is a composition comprising: (a) a PPARga...
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JP4550133B2 |
Method of treating or inhibiting proliferation of a peroxisome proliferator-activated receptor (PPAR) gamma -responsive cell, comprising contacting the cell with a PPARgamma agonist. Also claimed is a composition comprising: (a) a PPARga...
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JP4503833B2 |
A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate products of this method ...
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JPWO2008102908A1 |
Providing new herbicides. General formula (1):[In the formula, Q is -N (R)5) SO2R6Represents R5And R6Represents an alkylene or the like that may be bonded to each other to form a ring. ] Is a haloalkyl sulfone anilide derivative or a sal...
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JP4445136B2 |
Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyl...
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JP4401297B2 |
Compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is -SO2- or -(CRaRb)r-, n is 1 or 2, R2 is aryl or heteroaryl, and R1, R3, R4, R5, R6, R7, R8, R9, Ra, Rb, m, p, q ...
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JP4364944B2 |
The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as anti-neoplastic agents, and for the treatment of cancer. The invention further provides a formulation for administering th...
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JP4327911B2 |
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JP4306805B2 |
Benzoyl derivatives of the formula I where the variables have the following meanings: R1, R2 are hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulf...
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JP2009149678A |
To provide novel amino acid compounds for use in detecting and evaluating brain and body tumors.The amino acid compounds have a high specificity on the target site, when being in vivo administered, and for example, 2-amino-3-fluoro-2-met...
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JP4259620B2 |
4-(3-Heterocyclyl-benzoyl)-pyrazole derivatives (I) and their salts are new: R1, R3 = H; NO2; halo; CN; 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, 1-6C alkylsulphinyl or 1-6C alkylsulphonyl optionally substituted by halo; H2NSO2; (1-6C alk...
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JP2009513510A |
The present invention relates to macro-cyclic compounds of formula (I), wherein R1, is (C1-8)alkyl, (C1-4)alkoxy(C1-4)alkyl, hydroxy(C1-6)alkyl, (C1-4)alkylthio(C1-4)alkyl, (C1-6)alkenyl, (C3-7)cycloalkyl, (C3-7)cycloalkyl(C1-4)alkyl, pi...
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JP2009062355A |
To provide a new nitrogen-containing heterocyclic compound or its salt, and to provide a pest control agent containing the compound as an active ingredient.Provided are a nitrogen-containing heterocyclic compound represented by formula (...
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JP2009507849A |
A compound of formula I wherein R1, R2, R3, R4 and R5 are described herein.
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JP2009007311A |
To obtain a new diphenhydramine derivative that has a pharmacological activity as an antihistaminic agent and a sleep-introducing agent and alleviated bitterness; to provide a method for producing the same; and to obtain an oral preparat...
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JP4167731B2 |
derivs. of formula (I) are new: R = H, halogen, 1-4C alkyl, 1-4C haloalkyl, 1-4C alkoxy or 1-4C haloalkoxy; R1 = halogen, X1R2 or R2; X = S; X1 = O or S; R2 = H; 1-4C alky, 3-7C cycloalkyl, 2-6C alkenyl, 4-7C cycloalkenyl or 2-6C alkynyl...
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JP4164028B2 |
A compound of Formula Ior a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseases medi...
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JP2008533088A |
New N-hydroxyamides of n-alkyl carboxylic acids omega substituted with suitable tricyclic systems characterised by a central 7-membered ring, having activity as inhibitors of histone deacetylase (HDAC).
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JP2008526912A |
Macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in a...
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JP2008037777A |
To easily and efficiently produce a high quality potassium salt of 3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide compound.A compound represented by formula (1) (wherein R1 and R2 are same or different and each H or an organic group inac...
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JP2008037778A |
To easily and efficiently produce a high quality 3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide compound or a salt thereof.When a mixture liquid of -ketoamide-N-sulfonic acid represented by formula (1) (wherein R1, R2 and R3 are each H o...
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JP2008504225A |
This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired...
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JP2008019214A |
To provide a method for producing a perindopril with the need of neither use of any protecting group nor the step of separating the stereoisomer.The method for producing a perindopril of the formula(I)(wherein, Ra is H or a 1-4C alkyl; R...
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JP2007520492A |
One aspect of the present invention relates to ionic liquids comprising an anionic sweetener. Another aspect of the present invention relates to the use of an ionic liquid of the present invention comprising a pendant Bronsted-acidic gro...
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JP2006348042A |
To provide a pharmaceutical composition for preventing or treating cartilage damage in a mammal.The pharmaceutical composition for preventing or treating the cartilage damage in the mammal contains a GABA analog having characteristics as...
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JP2006523196A |
This invention relates to novel compounds useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.
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JP3815691B2 |
PURPOSE: To obtain a new propenoic acid derivative, having antagonistic actions on adenosine A1 and useful as a preventing and a therapeutic agent for renal failure, a diuretic agent, etc. CONSTITUTION: This propenoic acid derivative is ...
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JP3787809B2 |
To provide a method for forming a 7 membered oxathiazepine ring in high yield by controlling a three-dimensional structure. This method for synthesizing an oxathiazepine ring is to synthesize a compound having an oxathiazepine ring expre...
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JPWO2004080943A1 |
General formula (I)The compound or salt thereof as indicated by (all symbols in the formula are as described herein). The compound represented by the general formula (I) or a salt thereof has an activity of controlling a peroxysome proli...
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JP2006514983A |
Methods for the preparation of N-arylated oxazolidinone compounds via a copper catalyzed cross coupling reaction are disclosed.
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JPWO2004026292A1 |
Equation (I)(A indicates an alkoxycarbonylalkyl group, etc., R indicates a hydroxyl group which may be protected, or A and R together form a 6- or 7-membered ring containing an oxygen atom, and B indicates a carbonyl. Indicates a group o...
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JP2002508362A5 |
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JP2005534678A |
This invention relates to a method of treating ADHD by administering an alpha2delta ligand such as, for example, gabapentin or pregabalin, or a pharmaceutically acceptable salt thereof.
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JP3704055B2 |
To obtain a new intermediate useful for a method for diastereoselective synthesis for preparing optically active cis-nucleosides, nucleoside analogs and derivatives. This intermediate is represented by the formula (I), wherein, W and X a...
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JP2005263779A |
To provide a method for industrially and efficiently producing 3,4-dihydro-1,2,3-oxathiazine-4-one-2,2-dioxide compound or its salt, which is excellent in operation stability, without using an expensive apparatus.When producing 3,4-dihyd...
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JP2005522525A |
This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
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JP3665335B2 |
PCT No. PCT/EP94/02784 Sec. 371 Date Jan. 25, 1996 Sec. 102(e) Date Jan. 25, 1996 PCT Filed Aug. 24, 1994 PCT Pub. No. WO95/05739 PCT Pub. Date Mar. 2, 1995Use of 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides having the formula ...
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JP2005518338A |
The present invention is directed to the separation of enantiomers of racemates of formula (I). The separation proceeds by applying deemed racemates to continuos enantioselective chromatography like SMB. The methods predominantly is perf...
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JP2005517026A |
Chemically amplified photoresist compositions comprising, (a) a compound which cures upon the action of an acid or a compound whose solubility is increased upon the action of an acid; and (b) a compound of the formula Ia, Ib, IIa, IIb, I...
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JP2005505506A |
The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other dise...
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JP2005504777A |
Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group consisting of O, NR, and CH2, where R-H or C...
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JP2004536049A |
This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides ca...
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JP2004155772A |
To provide a naphthalene compound having an excellent effect against plant blights and use of the same as the plant blight control.The naphthalene compounds expressed by formula (1) [wherein, R1 is a 1-3C alkyl; Q is any of Q1 to Q4 grou...
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JP3507124B2 |
PURPOSE: To obtain a benzyidene derivative useful as a nonsteroidal antiinflammatory agent, etc., in a high purity and yield by condensing a specific quinonemethide derivative with a specified nitrogen-containing heterocyclic compound in...
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JP2004505916A |
The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in me...
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JP2003532619A |
Novel sulfonylinide and sulfonylmethide compounds are described which are useful as conductive salts. Also described is the use of the above compounds in salt form in battery electrolytes, particular salts having mixed perfluorocaron and...
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JP2003532619A5 |
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JP3396065B2 |
PURPOSE: To obtain a heterocyclic compound useful as an intermediate for medicines in high yield under a mild condition without any side reaction by reacting a specific nitrogen-containing heterocyclic hydroxyiminoacetic ester with a dic...
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JP2003511351A |
A controlled-release oral dosage formulation of a salt-forming active ingredient, wherein the active ingredient is present as at least two different salts in a solid aggregation state, wherein the two different salts have different water...
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JP2003508430A |
A controlled-release oral dosage formulation of a salt-forming active ingredient, wherein the active ingredient is present as at least two different salts in a solid aggregation state, wherein the two different salts have different water...
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