| Document |
Document Title |
|
WO/2011/062070A1 |
Provided is a novel oxetane-ring-containing (meth)acrylic acid ester compound that, via polymerization, can harden into a material that is highly flexible or heat-resistant. The provided oxetane-ring-containing (meth)acrylic acid ester c...
|
|
WO/2011/061590A1 |
The present invention relates to carboxamide derivatives of Formula (I), where B1, B2, X, L, n, R, R1, R2, Z1, Z2, Rx and Ry are as defined in the claims, as compounds and compositions for inhibiting Human Immunodeficiency Virus (HIV) an...
|
|
WO/2011/053948A1 |
The present invention relates to compounds of the formula (I) wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the end...
|
|
WO/2011/051165A1 |
The present invention relates to novel 3-phenylpropionic acid derivatives, to a method for the production thereof, to the use thereof for treating and/or preventing diseases, and to the use thereof for producing medications for treating ...
|
|
WO/2010/151644A2 |
Disclosed is a general methodology to create nano fibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reacti...
|
|
WO/2010/138010A2 |
The present invention provides solvates of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1,7β,10β- trihydroxy-9-oxo-tax-11 -en-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3- phenylpropionate and C2-3-alkyl esters of formic acid, proce...
|
|
WO/2010/123186A1 |
Provided is a method for preparing a taxane derivative, comprising: carrying out condensation of a phenylisoserine derivatives having a protective group introduced thereto or a mixture of isomers thereof, as a side chain, with a baccatin...
|
|
WO/2010/123016A1 |
Disclosed is a compound having a GPR40 agonistic activity and useful for use in a pharmaceutical composition or useful as an insulin secretion promoter or a prophylactic or therapeutic agent for diabetes. Extensive studies have been made...
|
|
WO/2010/098288A1 |
Disclosed is a method whereby optically active fluorinated oxetane that can be an important pharmaceutical or agrochemical intermediate can be produced by reacting a fluorinated α-keto ester with an acyl alkenyl ether in the presence of...
|
|
WO/2010/094659A1 |
The invention relates to the use of compounds of formula (I), wherein the substituents are described in the description and claims, for the preparation of medicaments for the treatment of psychoses, dysfunction in memory and learning, sc...
|
|
WO/2010/092180A1 |
The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of s...
|
|
WO/2010/092153A1 |
The invention relates to substituted tetrahydronapthalenes, to derivatives thereof, to physiologically acceptable salts thereof, to physiologically functional derivatives, to the production thereof, to drugs containing at least one subst...
|
|
WO/2010/084502A1 |
The present disclosure provides a crystalline form of orlistat, particularly form A of orlistat. The characterization of said form is performed using X-ray diffraction studies, IR and Differential Scanning Calorimetry melting endotherm s...
|
|
WO/2010/079499A2 |
The present invention relates to compounds of formula I or salts thereof, wherein, R1 is selected from the group consisting of hydrogen and R4; R2 is selected from the group consisting of hydrogen, acetyl and R4; R3 is selected from the ...
|
|
WO/2010/069754A1 |
A UV radiation curable composition comprising a cationic photoinitiator according to Formula (I) or (II): wherein : R1, R2 and R3 independently represent a group selected from the group consisting of an aryl group and a heteroaryl group,...
|
|
WO/2010/057378A1 |
A method for the preparation of docetaxel of formula 1, comprising: (1) acylating the hydroxyl of compound 2 with compound 3 to obtain compound 4; (2) removing the hydroxyl-protecting group R1 of the obtained compound 4 to obtain compoun...
|
|
WO/2010/059916A2 |
The present invention relates to docetaxel and processes for preparing docetaxel, including process-related intermediates. The present invention also relates to processes for preparing substantially pure docetaxel and intermediates.
|
|
WO/2010/058280A1 |
To magnetize a desired drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to a target diseased site, provided is a drug using the magnetic properties of a metal salen complex represented by the...
|
|
WO/2010/035985A2 |
The present invention relates to a method for producing taxane derivatives with anticancer activity. The method of the present invention produces taxane derivatives in a short time under mild conditions by employing phenyl oxazinan dione...
|
|
WO/2010/020548A1 |
The present invention relates to a compound of the general formula (I) wherein R1/R2 are independently from each other lower alkyl, or form together with the N-atom to which they are attached a heterocyclic group, selected from pyrrolidi...
|
|
WO/2009/156889A1 |
The invention relates to derivatives of a compound of formula I: wherein R1 to R7 and X1 to X7 are as defined herein The invention relates to the uses thereof for treating diseases, conditions and/or disorders mediated by kappa opioid re...
|
|
WO/2009/146152A2 |
The present invention provides microtubule targeting compounds that are myelo-sparing. Particularly, the MTCs of the invention are structurally designed to exhibit specificity for inhibiting β-tubulin isotypes that are not related to th...
|
|
WO/2009/143664A1 |
The preparation method of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and the product of that method. Said method includes the following steps: a) reducing the substance represented by formula (II) to obtain the substance repr...
|
|
WO/2009/145981A1 |
Taxanes having an ethyl ester or cyclopropyl ester substituent at C(10), a keto substituent at C(9), a hydroxy substituent at C(7), a thienyl substituent at C(3') and a cyclobutyloxycarbamate or cyclopentyloxycarbamate substituent at C(3...
|
|
WO/2009/137084A2 |
A paclitaxel intermediate of formula 1 : wherein R1 is acetyl, R2 is tert-butyloxycarbonyl (BOC), R3 and R4 are phenyl and R5 is 1- ethoxyethyl, is provided. Also provided are processes for preparing taxane intermediates of formula 1 com...
|
|
WO/2009/118743A1 |
The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, pref...
|
|
WO/2009/115655A2 |
The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propio
nate of 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-l-hydroxy-7β,10Î...
|
|
WO/2009/095522A1 |
The invention relates to the preparation of novel taxane analogues and intermediates prepared from cyclohexenones in which ring C is incorporated into the polycyclic system, as well as to a novel method for accessing these compounds. Sai...
|
|
WO/2009/074321A1 |
The present invention relates to a method for rapid activation of a surfactant precursor, having the general formula (I) wherein at least one of R1 and R2 is a hydrophobic moiety, resulting in the formation of a surfactant, characterized...
|
|
WO/2009/068682A2 |
Novel organic compounds are described and claimed which may in particular be useful in the treatment of diseases being triggered by the (human) autoimmune system.
|
|
WO/2009/069668A1 |
Disclosed is a means which is effective for the treatment of melanoma. Specifically disclosed is an agent for increasing the expression of a malignant melanoma antigen, which comprises a compound selected from the group consisting of met...
|
|
WO/2009/062342A1 |
Cephalomannine derivatives of formula(I),their preparation, the composition including them, and their use of manufacturing of anti-tumor medicaments, especially of the medicaments against multidrug resistant tumor.
|
|
WO/2009/059046A1 |
The present invention provides compounds having the general structure A3 or a pharmaceutically acceptable derivatives thereof: wherein R is an alkyl group, and Ri comprises at least one moiety selected from a group consisting of an alkyl...
|
|
WO/2009/006590A9 |
Processes for preparing substantially pure docetaxel, new crystalline forms of docetaxel and processes for preparation thereof, processes for preparing docetaxel trihydrate, and pharmaceutical compositions comprising docetaxel.
|
|
WO/2009/053482A2 |
This invention relates to novel compounds with ester linkage (s) capped with either electron deficient olefinic linkage (s) or group (s) or reactive functional groups (termed herein as 'active methylene reagents'), and curable compositio...
|
|
WO/2009/052456A1 |
The present invention includes a pharmaceutical-based film system which includes various small-scale forms of pharmaceutically active agents, including tetrahydrolipstatin, in a film base. Such forms include nanoparticles, microparticles...
|
|
WO/2009/040827A1 |
The present invention provides a process of preparing tetrahydrolipstatin, comprising catalytical hydrogenation of lipstatin in polyethylene glycol. Optionally polyethylene glycol is mixed with an organic solvent selected from a group of...
|
|
WO/2009/040829A1 |
A novel process is outlined for the synthesis or preparation of docetaxel with the help of novel alloy for the deprotection of the protected docetaxel and its conversion into docetaxel.
|
|
WO/2009/030098A1 |
A cellulosimicrobium cellulans and its hydrolase, which effectively transforms taxane xylosides into paclitaxel or its analogs. A method of high effectively preparing paclitaxel and its analogs by biotransformation reactions using the hy...
|
|
WO/2009/023967A1 |
Processes for the preparation of docetaxel and paclitaxel or analogs from 9-dihydro-13-acetylbaccatin III via key intermediates (4), (5), (6), (6'), (8) and (8') or via intermediate (12) as well as processes for the preparation of said i...
|
|
WO/2009/004188A2 |
The invention relates to the solubilisation of docetaxel in an organic solvent, to the mixture thereof with polysorbate 80 and to the evaporation of the solvent.
|
|
WO/2008/149321A2 |
The present invention provides a process for preparing orlistat from amino orlistat using Pivaloyl Formic Anhydride (PFA) as an alkanoylating agent.
|
|
WO/2008/142265A1 |
Process for preparing 3'-N-substituted taxanes from paclitaxel, in which the following steps are carried out: a) deacetylation of the paclitaxel through the action of a peroxide, without the addition of a base; then b) protection of the ...
|
|
WO/2008/123751A1 |
The present invention provides a stable anhydrous crystalline docetaxel which has anti-tumor and anti-leukemia activity, and method for the preparation thereof.
|
|
WO/2008/123490A1 |
Disclosed is a cured product of an adamantane derivative having a specific structure, which is excellent in transparency, optical characteristics such as (long-term) light resistance, long-term heat resistance, dielectric constant and me...
|
|
WO/2008/123737A1 |
The present invention relates to a docetaxel / mono propylene glycol clathrate of formula (I) and a method for preparing same. The inventive docetaxel / mono propylene glycol clathrate having a low 7-epimer content and high stability can...
|
|
WO/2008/119252A1 |
A noble metal-containing Ti-Si material, characterized in that its composition in oxide form is xTiO2 100SiO2 yEOm zE, wherein x is 0.001~50.0, (y+z) is 0.0001~20.0 and y/z is <5, E is one or more noble metal(s) selected from Ru, Rh, Rd,...
|
|
WO/2008/116388A1 |
A process for preparing taxol, baccatin and derivatives thereof. In the process, C(10) hydroxy group of 10-deacetyl baccatin is selectively acylated with anhydride in the presence of metal nitrate catalyst. When a side chain is presented...
|
|
WO/2008/116387A1 |
A one-pot process for preparing taxol and derivatives thereof suitable for industry. In the process, C(10) and C(2') hydroxy groups of 10-deacetyltaxane are selectively acylated with acetic anhydride in the presence of metal salts. Subse...
|
|
WO/2008/115281A2 |
The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.
|
