Heterocyclic Compounds

Matches 851 - 900 out of 7,009	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >

Document	Document Title
WO/2008/120712A1	PHARMACEUTICAL COMPOSITION, FOOD OR BEVERAGE CAPABLE OF ENHANCING SYMPATHETIC NERVE ACTIVITY Disclosed is a safe prophylactic or therapeutic composition for obesity or a complication thereof, which has an activity of regulating the autonomic nerve activity, particularly an activity of enhancing the sympathetic nerve activity, an...
WO/2008/116301A1	FLUORINATED DERIVATIVES OF DEFERIPRONE The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprisin...
WO/2008/116029A1	MODULATION OF BACTERIAL QUORUM SENSING WITH SYNTHETIC LIGANDS The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sens...
WO/2008/110307A1	2-ARYL-5-HETEROCYCLYL-CYCLOHEXANE-1,3-DIONE COMPOUNDS AND THEIR USE AS HERBICIDES Cyclohexanedione compounds of Formula (I) wherein R1 is methyl, ethyl, n-propyl, iso-propyl, cyclopropyl, halomethyl, haloethyl, halogen, vinyl, ethynyl, methoxy, ethoxy, halomethoxy or haloethoxy, R2 and R3 are, independently hydrogen, ...
WO/2008/109591A1	PHLORIZIN ANALOGS AS INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
WO/2008/108323A1	DRUG FOR TREATMENT OF INFLUENZA Disclosed is a drug for treatment or prevention of H5N1 influenza. Specifically disclosed is a drug for treatment or prevention of H5N1 influenza, which contains a compound represented by the general formula (I) below as an active ingred...
WO/2008/106047A2	CARBAMATE COMPOUNDS Carbamate compounds having a structure represented by formula (I) (where R1,R2, R3, R4, R5 and R6 are as defined herein) are useful as anti-tumor agents.
WO/2008/106225A1	MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME The present invention provides cycloalkyl containing macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
WO/2008/106204A1	MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME The present invention provides amide containing macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
WO/2008/101914A2	N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration ...
WO/2008/101885A1	N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration ...
WO/2008/101886A1	N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration ...
WO/2008/101938A1	GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZONITRILE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE Glucopyranosyl-substituted benzyl-benzonitrilederivatives as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suita...
WO/2008/101939A1	TETRASUBSTITUTED GLUCOPYRANOSYLATED BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE Tetrasubstituted glucopyranosylated benzene derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to th...
WO/2008/090151A1	ANTIVIRAL COMPOUNDS The invention provides a new class of compounds exhibiting an inhibitory effect on neuraminidase (NA), hemagglutinin (HA) and structural M2 protein bearing viruses. These compounds are also useful as inhibitors of the replication factors...
WO/2008/075353A1	SULFONAMIDE DERIVATIVES WITH THERAPEUTIC INDICATIONS The present invention relates to sulfonamide derivatives of formula (I) (wherein R1, R2, R3, R3', R4and R5are as defined in the claims), to pharmaceutical compositions comprising the same, and to uses thereof. Compounds of the invention ...
WO/2008/071948A2	AMINOALCOHOL DERIVATIVES AND THEIR THERAPEUTIC USE A compound of formula (1 ) Including pharmaceutically acceptable salts thereof, wherein: R1 is aryl or heteroaryl optionally substituted with R8; R2 is H or alkyl or CH2 (when forming part of a ring with R3, R4 or R5); R3 is H, alkyl, CH...
WO/2008/071405A1	4-PHENYL-PYRANE-3,5-DIONES, 4-PHENYL-THIOPYRANE-3,5-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.
WO/2008/070496A2	N- ( (3-BENZYL) -2, 2- (BIS-PHENYL) -PROPAN-1-AMINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES This present invention provides for cholesteryl ester transfer protein (CETP) inhibitors, of formula Ia and Ib / pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels...
WO/2008/067911A1	BIPHENYL-SUBSTITUTED SPIROCYCLIC KETOENOLS The invention relates to new compounds of the formula (I) in which W, X, Y, Z and CKE have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, an...
WO/2008/065493A1	PYRAZOLE ANALOGS The invention relates to the compounds of formula (I), or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparation of, compositions contai...
WO/2008/065181A2	PYRAN DERIVATIVES, PROCESS OF PREPARATION AND USE THEREOF IN PERFUMERY AND FLAVOURING Pyran derivatives of general formula (I) wherein Y is a 5-, 6- or 7-membered ring, preferably a 5-membered ring, methyl or ethyl mono- or polysubstituted, and optionally unsaturated, and R1, R2, R3, R4 are, each independently, a hydrogen...
WO/2008/055870A1	GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZONITRILE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE Glucopyranosyl-substituted benzyl-benzonitrile derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to...
WO/2008/053360A2	ALBUMIN BINDING MOLECULES AND USES THEREOF The invention relates to portable albumin binders, which are useful for improving the pharmacokinetic properties of diagnostic or therapeutic agents, in particular increasing the blood circulation time and/or the tissue penetration capac...
WO/2008/052930A2	PREPARATION OF 4-ALK0XY-7- (TETRAHYDROPYRAN-4-YL) BENZOTHIAZOL-2-AMINE DERIVATIVES New process for the preparation of 4-(4-alkoxyphenyl)tetrahydropyrane derivatives used in the preparation of 4-alkoxy-7-(tetrahydropyran-4-yl)-benzothiazol-2-ylamine and derivatives.
WO/2008/053206A2	PROCESS FOR PREPARATION OF ALDONIC ACIDS AND DERIVATIVES THEREOF A process for the preparation of L-gluconic acid or a salt thereof, comprises treating an aqueous solution of 6-bromo-6-deoxy-2,3-anhydro-D-manno-1,4-lactone with a base at a pH of at least 12 and at a temperature of 45 to 6O0C to obtain...
WO/2008/044339A1	THERAPEUTIC/PREVENTIVE AGENT FOR INTRAOCULAR DISEASE CONTAINING STATIN COMPOUND It is intended to provide a DNA synthesis inhibitor in retinal vascular endothelial cells, and a therapeutic agent and a preventive agent for an intraocular disease associated with an intraocular disease. The invention is based on Exampl...
WO/2008/042688A2	PHLORIZIN ANALOGS AS INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.
WO/2008/037603A1	PROCESS FOR EXTRACTING PHLORIDZINE FROM APPLE SEEDS The invention relates to a process for extracting phloridzine from apple seeds, comprising the steps of: production of a first concentrated extract from said seeds; liquid-liquid extraction of said phloridzine from said concentrated extr...
WO/2008/039645A1	COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are ...
WO/2008/034859A1	GLUCOPYRANOSYL-SUBSTITUTED DIFLUOROBENZYL-BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE Glucopyranosyl-substituted difluorobenzyl-benzene derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according...
WO/2008/036216A1	PIPERIDINE DERIVATIVES AS RENIN INHIBITORS The present invention is directed to aspartic protease inhibitors represented by the following structural formula; or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions compr...
WO/2008/036247A1	RENIN INHIBITORS The present invention is directed to aspartic protease inhibitors represented by the following structural formula (I), or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions c...
WO/2008/034511A1	INDANE COMPOUNDS FOR USE AS COMPONENTS OF LIQUID CRYSTAL MEDIA The invention relates to claimed indane compounds of formula (I), in which R1, A1, A2, B, Z1, Z2, Z3, X1, X2, m and n are defined as per claim 1. Said compounds have at least one tetrahydropyran ring (B) and are suitable for use as compo...
WO/2008/032156A1	DIARYL ETHER DERIVATIVES AND USES THEREOF Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described her...
WO/2008/026140A2	MALODOR COUNTERACTING COMPOSITIONS AND METHOD FOR THEIR USE The invention relates to a malodor counteractancy or counteracting (MOC) method that resorts to the use of specific malodor counteracting (MOC) mixtures of fragrance ingredients. More particularly, the invention relates to new MOC compos...
WO/2008/024302A2	COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer inductio...
WO/2008/024963A1	BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES Disclosed are compounds and pharmaceutically acceptable salts of Formula (I) wherein A, Q1, Q2, Q3, R3, R4, R5, R0, m, and p are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related ...
WO/2008/024961A1	DIHYDROPYRIDAZINE, TETRAHYDROPYRIDINE, CHROMANONE, AND DIHYDRONAPHTHALENONE DERIVATIVES AS HEAT-SHOCK PROTEIN 90 INHIBITORS Disclosed are compounds and pharmaceutically acceptable salts of Formula (I), wherein A, Q1, Q2, Q3, R3, and R4 are as defined herein. Compounds of Formula (I) are heat-shock protein 90 (HSP-90) inhibitors, useful in the treatment of dis...
WO/2008/019746A1	TETRAHYDROPYRAN COMPOUNDS The invention relates to mesogenic tetrahydropyran compounds having at least four rings of the formula (I), in which R1, A1, A2, X1, L1, L2, m and n are each as defined in claim 1, and to a process for their preparation, to their use in ...
WO/2008/019477A1	VIRAL POLYMERASE INHIBITORS Compounds of formula (I) : wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
WO/2008/015240A1	N-PHENYL-PRENYLAMINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS The present invention is related to a family of N-phenyl-prenylamine derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinso...
WO/2008/012372A1	PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL FORM I The present invention provides an improved process for the manufacture of candesartan cilexetil form I. Further disclosed is a candesartan cilexetil preparation containing less than 0.15%, preferably less than 0.10%, of (+-)-1 -Hydroxyet...
WO/2008/012371A1	PROCESS FOR THE PREPARATION OF AMORPHOUS AND CRYSTALLINE FORMS OF CANDESARTAN CILEXETIL USING COLUMN CHROMATOGRAPHY The present invention provides processes for the preparation of amorphous and crystalline candesartan cilexetil with quality that complies to Ph.Eur./ICH Guidelines by an economical way using easy accessible substances and pure starting ...
WO/2008/009118A1	4-HYDROXYTHIOBENZAMIDE DERIVATIVES OF DRUGS Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enh...
WO/2008/009897A1	PROCESS FOR PREPARING PREGABALIN AND ITS OPPOSITE ENANTIOMER The invention relates to the preparation of pregabalin and its opposite enantiomer, or a pharmaceutically-acceptable salt of either thereof, and to the intermediates used for their preparation.
WO/2008/008442A1	PREPARATION AND UTILITY OF HMG-COA REDUCTASE INHIBITORS Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodr...
WO/2008/001752A1	TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY STATIN Disclosed is a pharmaceutical composition for treatment or prevention of chronic obstructive pulmonary diseases. The pharmaceutical composition contains an HMG-CoA reductase inhibitor as an active ingredient.
WO/2008/000407A1	INHIBITORS OF CXCR2 The invention relates to compounds of the formula (I), in which R1, R2, X, A, B and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as in...
WO/2007/148648A1	THERAPEUTIC OR PROPHYLACTIC AGENT FOR MULTIPLE SCLEROSIS Disclosed is a therapeutic or prophylactic agent for multiple sclerosis. The therapeutic or prophylactic agent comprises a glycine derivative having a specific structure (e.g., a compound [(E)-2-(2,6-dichlorobenzamide)-5-[4-(isopropyl-py...

Matches 851 - 900 out of 7,009	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >