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Matches 301 - 350 out of 6,849

Document Document Title
WO/2017/007756A1
This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or ...  
WO/2016/205202A1
The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertensi...  
WO/2016/198374A1
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2016/179645A1
The present disclosure relates to 4H-pyran compounds of formula (I) and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicam...  
WO/2016/181567A1
The present invention provides a modified milk powder containing a biological active ingredient 1,5-anhydro-D-glucitol (1,5-AG). The present invention is a modified milk powder containing 1,5-AG at a concentration of 7.7 to 3850 μg/g.  
WO/2016/182036A1
The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemot...  
WO/2016/178148A1
The present invention relates to a process for the preparation of amorphous dapagliflozin. The present invention relates to 2,3-butanediol solvate of dapagliflozin and process for its preparation.  
WO/2016/176560A1
The present invention provides unified synthesis of the CI -CI 9 building blocks of halichondrins and analogs theoreof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present inventi...  
WO/2016/172496A1
Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions ...  
WO/2016/172114A1
New methods of preparing bridged bi-aromatic ligands are disclosed. The methods employ direct di-ortho-lithiation of aromatic rings of bridged protected bi-aromatic diphenols. The ligands may be used to prepare transition metal compounds...  
WO/2016/171165A1
A medicine for preventing and/or treating diseases caused by the activation of caspase-1, for example, chronic inflammations or autoinflammatory diseases, said medicine comprising as an active ingredient a compound represented by formula...  
WO/2016/168058A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2016/167361A1
The purpose of the present invention is to provide a novel method for producing an organic compound substantially free of Pd in an inexpensive and simple manner. The present invention pertains to a method for producing an organic compoun...  
WO/2016/168056A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...  
WO/2016/162644A1
The present invention relates to the use of sodium dithionite to reduce at least one aldehyde or ketone function of a carbohydrate, C-glycoside, oligosaccharide, or water-soluble polysaccharide in the absence of a water-immiscible organi...  
WO/2016/162405A1
The present invention relates to compounds and compositions for use in methods of treating and/or preventing conditions, disorders or diseases that are mediated or caused by a virus.  
WO/2016/161286A1
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, suc...  
WO/2016/161279A1
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, suc...  
WO/2016/155578A1
The present invention relates to a crystal form I of Dapagliflozin which is a medicine for treating type II diabetes, and a preparation method therefor. The crystal form I is characterized in that an x-ray powder diffraction pattern has ...  
WO/2016/161269A1
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...  
WO/2016/151066A1
The present invention relates to compounds derived from deoxy fucose. These compounds are useful as lectin inhibitors, especially as inhibitors of LecB. The invention also relates to pharmaceutical compositions comprising these compounds...  
WO/2016/151989A1
The present invention can provide novel C-glycoside derivatives which are biologically important under high stereoselective, mild, atom economical condition.  
WO/2016/147197A1
The present invention discloses the process for preparation of (2S,3R,4R,5S,6R)-2-[4- chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro -2H-pyran-3,4,5-triol and its amorphous form.  
WO/2016/138821A1
The present invention provides compounds of the Formula (1), wherein R, R1-R3 are as described herein; methods of treating patients for diabetes using the compounds, and processes for preparing the compounds.  
WO/2016/139351A1
The invention relates to compounds of Formula (I) and their use as selective dipeptidyl peptidase I inhibitors, as well as pharmaceutical compositions comprising said compounds, and methods of treatment involving said compounds.  
WO/2016/138631A1
Compounds of formula I and the pharmaceutically acceptable salt thereof are disclosed, wherein R is selected from the group consisting of O and NH, R 1 is selected from the group consisting of CF 3, OCF 3 and Cl.  
WO/2016/139338A1
The present invention relates to a method for producing tetrahydropyranyl esters from the corresponding 4-hydroxy-tetrahydropyran compounds by reaction with a ketene compound.  
WO/2016/131098A1
ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in ...  
WO/2016/128422A1
The present invention relates to an improved process of producing cyclo-dehydrolinalool by the cyclization of the compound of formula (II).  
WO/2016/129490A1
Provided is a polar compound having high chemical stability, high ability to align liquid crystal molecules, and high solubility in a liquid crystal composition, and which has a large voltage holding ratio when used in a liquid crystal d...  
WO/2016/130527A1
Disclosed herein are substituted cyclic ether monomers, polymers, and drug conjugates thereof, which are useful for the treatment of diseases and conditions of the oral cavity. In particular, disclosed herein are monomers of Formula (I),...  
WO/2016/128995A1
The present invention DISCLOSES a novel process for preparing sodium glucose transporters 2 (SGLT2) inhibitor compounds of Formula IX. Wherein, R is halogen, alkyl or alkoxy group; and Ar is aryl group, substituted or unsustituted monocy...  
WO/2016/128423A1
The present invention relates to an improved process of producing cyclo-dehydrolinalool.  
WO/2016/120879A1
The present invention provides compounds comprising fused tricyclic backbone structure and processes for their preparation. The invention further provides compounds and compositions useful in the treatment of pain and any type of disorde...  
WO/2016/109470A1
Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.  
WO/2016/098016A1
The present application relates to the process for the preparation of SGLT2 inhibitors, further covers a process for the preparation of Canagliflozin, preparation of amorphous form of Canagliflozin and solid dispersion of Canagliflozin.  
WO/2016/097389A1
The invention relates to benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan rece...  
WO/2016/082510A1
The present invention relates to a liquid crystal compound of a structure as represented by formula I, where R is selected from H and alkyls or alkoxies that are either unsubstituted or have one or multiple H being substituted by halogen...  
WO/2016/082511A1
The present invention relates to a liquid crystal compound of a structure as represented by formula I, where R is selected from H and alkyls or alkoxies that are either unsubstituted or have one or multiple H being substituted by halogen...  
WO/2016/083517A1
The invention relates to a compound of formula (I), in which R' represents a hydrogen atom or an acyl group having between 2 and 18 carbon atoms, and R" represents a hydrogen atom or an alkyl group having between 1 and 18 carbon atoms, a...  
WO/2016/085392A1
The present invention relates to bis(sulfonamide) compounds and pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions comprising these compounds and to their use as a medicament for ...  
WO/2016/082583A1
The present invention relates to kinetic resolution of asymmetric catalytic hydrogenation of racemic δ-hydroxy ester and an application thereof. An iridium catalyst of a chiral spiropyridine amidocyanogen phosphin ligand is used; in a c...  
WO/2016/085987A1
The invention relates to a process comprising reacting mevalonic acid, or a solution comprising mevalonic acid, to yield a first product or first product mixture, optionally in the presence of a solid catalyst and/or at elevated temperat...  
WO/2016/080626A2
Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.  
WO/2016/066555A1
There is provided polymorphs of ferric maltol. Such forms may be useful in the treatment of iron deficiency with or without anaemia, such as iron deficiency anaemia.  
WO/2016/063990A1
The present invention relates to a compound represented by general formula (1). (The definition of each group in the formula is as described in the specification.) The compound is useful as a prophylactic and/or therapeutic agent for KCN...  
WO/2016/059648A1
The present invention discloses a process for synthesis of chiral 2,4-disubstituted- tetrahydropyran-4-ol and its derivatives having a general formal (I) comprising of asymmetric reaction of an aliphatic aldehyde and a homoallylic alcoho...  
WO/2016/061393A1
Monomethyl and monoethyl fumarate prodrugs, pharmaceutical compositions comprising the monomethyl and monoethyl fumarate prodrugs, and methods of using monomethyl and monoethyl fumarate prodrugs and pharmaceutical compositions for treati...  
WO/2016/057322A1
Provided herein are deuterated compounds and compositions useful in increasing PPAR5 activity. The compounds and compositions provided herein are useful for the treatment of PPAR5 related diseases (e.g., muscular diseases, vascular disea...  
WO/2016/055404A1
The present invention relates to a process for preparation of intermediates (Z,2E)-5-hydroxy-2-methoxyimino-N-methyl-pent-3-enamides from 4-substituted 5-meth-oxyimino-2H-pyran-6-ones and their processing for example to (Z)-5-cyclyloxy-2...  

Matches 301 - 350 out of 6,849