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Matches 801 - 850 out of 15,226

Document Document Title
WO/2014/181215A3
The present invention relates to a new method for the determination of 'free' copper concentration in serum, i.e. the portion of serum copper not structurally bound to ceruloplasmin. The present invention also refers to a method with a h...  
WO/2015/197156A1
The invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.  
WO/2015/196335A1
Pyrazole compounds useful as positive allosteric modulators of follicle stimulating hormone receptor and pharmaceutically acceptable compositions thereof are provided.  
WO/2015/197981A1
The invention relates to the probes of formula (I); in which: X1 = NH, O or S; X2 = O or S; SE is a labile group, which may be removed under the action of a stimulus which may in particular be the presence of an enzyme, of a chemical com...  
WO/2015/194928A1
The invention relates to the compounds 3-(1´,1´ -dimethylallyl)-herniarin (1) y 3- (1,1´-dimethyl-3´ nitro allyl-herniarin] (3) (NHR) derived from coumarin, which have excellent antidepressant activity. The compound 3- (1,1´-dimethy...  
WO/2015/195478A1
Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII), respectively wherein, R1 and R2 are individually selected from hydrogen, alkyl, substit...  
WO/2015/192198A1
A method is described for treating a peroxisome biogenesis disorder by administering to an individual in need thereof an effective amount of an autophagy inhibitor. Uses, compositions, and commercial packages are also described. The pero...  
WO/2015/097231A9
The invention provides compounds of formula (I) or salts thereof, wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR1; each R1 being independently H or C(=O)R2, and...  
WO/2015/187940A1
A method of selectively depleting pathogenic T lymphocytes from a blood cell composition is carried out by (a) combining the cell composition ex vivo with an active compound in an effective amount, and then (b) irradiating the cells with...  
WO/2015/181182A1
A process for the stereoselective preparation of a chiral alcohol or a chiral amine, the process comprising reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an inline, with a second rea...  
WO/2015/180424A1
The present invention relates to a water-soluble α-naphthoflavone alcohol derivative, a preparation method therefor, and a use thereof. The structure of the water-soluble α-naphthoflavone alcohol derivative is represented by formula (I...  
WO/2015/109017A3
The present invention provides deuterated NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical co...  
WO/2015/174460A1
Provided is an enzyme-specific fluorescent compound capable of being retained in cells, which can emit fluorescence specifically in a target cell, particularly a cell capable of expressing a reporter enzyme such as β-galactosidase, and ...  
WO/2015/169854A1
The invention provides a method for the preparation of regioisomerically pure intermediates which are useful for the preparation of carboxy-fluorescein-type compounds. Such compounds have broad applications within bio-conjugation and/or ...  
WO/2015/169769A1
A method of enhancing the sweetness of sweetener in a food or beverage product comprising adding Naringenin to the product in an amount of 50 ppm to 200 ppm by weight of the total weight of the product wherein the Naringenin does not blo...  
WO/2015/166041A1
The present application relates to a compound of formula (I) for use in the prevention and/or treatment of cancer, wherein R1 to R9 are independently selected from hydrogen, aliphatic, alkoxy, thioalkyi, alkylamino, halogen, hydroxy, cya...  
WO/2015/162538A1
The invention relates to heterocyclic compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their pharmaceutical compositions for use in medicine for the treatment of ...  
WO/2015/160307A1
There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.  
WO/2015/160321A1
The present invention is about 8 different molecules, created from Chromene-2-one, their derivatives and pharmaceutical compositions containing these compounds. In generated 8 different molecule Rl and R2 positions were chosen as site of...  
WO/2015/161309A1
Certain embodiments are directed to apigenin analogues or derivatives. In certain aspects, the derivatives are developed as cystathionine-beta-synthase (CBS) inhibitors. In certain aspects, the derivatives are used as anticancer or anti-...  
WO/2015/153813A1
The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the sa...  
WO/2015/153648A1
This invention relates to a flavonoid composition that includes eriocitrin. The flavonoid may be included in a complex with other bioflavonoids. The composition may also include neoeriocitrin. This invention also relates to methods of us...  
WO/2015/144911A1
This invention relates to 3-phenyl-7-hydroxy-isocoumarin compounds which are MIF inhibitors, compositions comprising said inhibitors and methods for treating or preventing diseases associated with MIF.  
WO/2015/145371A1
The present invention relates to a compound of formula I, or an isotopic form, stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, a polymorph, a prodrug, N-oxide or S-oxide thereof; and processes for their preparati...  
WO/2015/141775A1
 The purpose of the present invention is to provide an agent for the prevention or treatment of inflammatory disease or degenerative disc disease. A coumarin derivative or a pharmaceutically acceptable salt or hydrate thereof that is t...  
WO/2015/100213A3
Disclosed is a method of preparing a urolithin, or an intermediate or analog thereof, having a dibenzo[b,d]pyran-6-one core. The method is especially advantageous for the large-scale preparation of urolithins or intermediates or analogs ...  
WO/2015/135061A1
Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA ...  
WO/2015/134610A1
The present invention provides methods for treating or preventing diabetic nephropathy and its related pathologies by inhibiting podocyte Semaphorin3a (Sema3a). The invention also provides a method for identifying or characterizing a com...  
WO/2015/134357A1
This disclosure relates to methods and pharmaceutical compositions for the treatment and prevention of diabetes. In certain embodiments, compounds disclosed herein are 2Η,2Ή- [9,9'-bibenzo[g]chromene]-4,4'(3H,3'H)-dione and its derivat...  
WO/2015/129813A1
The present invention provides: a deuteration method that is both cost effective and has an excellent deuteration rate; a method for selectively replacing a leaving group of an aromatic compound with deuterium; and a deuteration catalyst...  
WO/2015/127118A1
This invention describes a simple, rapid and cost-effective method to isolate bulk quantities of relatively pure and enriched anthocyanidins and other plant bioactives. The method is based on the principle of solubility. Some bioactives ...  
WO/2015/124114A1
Disclosed are a phenolic hydroxyl flavone compound semisynthesis method and iodine recovery method, relating to approaches A and B and iodine recovery. In approach A, flavone is dissolved in a pyridine solvent of ethylene glycol or glyce...  
WO/2015/123783A1
Compounds that are cathepsin B substrates and that are useful as imaging probes, for example in positron emission tomography (PET) or fluorescence imaging are described.  
WO/2015/124113A1
Provided is a semi-synthesis method for luteolin, galuteolin and luteolin rutinoside. In the method, two steps of dehydrogenation and demethylation are combined into one step, and reaction conditions of dehydrogenation and demethylation ...  
WO/2013/170155A3
The invention provides methods of purifying and quantifying procyanidin oligomers from cocoa-containing sources. The methods advantageously provide ways to isolate commercially useful quantities of a range of procyanidin oligomers.  
WO/2015/125892A1
The present invention provides a compound that is represented by general formula (I) (In the formula, Z represents AA. Y­ 1 represents N or CR1, Y2 represents N or CR2, Y3 represents N or CR3, and Y4 represents N or CR4. One of R1-R4 in...  
WO/2015/121452A1
The invention relates to a process for producing Nebivolol hydrochloride, (formula I) comprising the steps of: provision of a protected Nebivolol hydrochloride of the general formula (II), with P being an amine protecting group, and hydr...  
WO/2015/117202A1
The present invention relates broadly to anti-cancer agents. In particular, the present invention relates to selected benzopyran compounds, the preparation thereof, and their use in methods for treating cancer and reducing the incidence ...  
WO/2015/119436A1
The present specification relates to a fullerene derivative, an organic solar cell using the same, and a preparation method therefor.  
WO/2015/116460A1
A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to na...  
WO/2015/112898A1
Disclosed are derivatives of icariin. Disclosed are compounds having Formula I-VIII as defined herein. Methods of using these compounds for the treatment of cancer and inflammation are also disclosed.  
WO/2015/051045A3
The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositi...  
WO/2015/109013A1
The present invention provides deuterated NO-releasing nitrooxy-alkylenyl-linked-chromene conjugates, having the structure of Formula (1) wherein Z, R1, R2, R3, R4, X, and L are as defined in the detailed description; pharmaceutical comp...  
WO/2015/109014A1
The present invention provides NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions ...  
WO/2015/109011A1
The present invention provides NO-releasing nitrooxy-alkylenyl-linked-chromene conjugates, having the structure of Formula (1 ) wherein R1, R2, R3, R4, X, and L are as defined in the detailed description; pharmaceutical compositions comp...  
WO/2014/047328A3
The invention directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevent of cancers and other disorders. Compositions comprising compounds of the invention are used to trea...  
WO/2013/184755A3
Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.  
WO/2015/101339A1
Provided is a compound represented by formula I, wherein R9 is a C1-C22 hydrocarbyl group or a C2-C3 ester-substituted C1-C3 alkyl group, R5, R6, R7 and R8 are alkyl groups or H, and R1, R2, R3 and R4 are H or lower hydrocarbyl groups. O...  
WO/2015/100506A1
The invention relates to a method for producing a concentrated extract comprising phenolic compounds and having a high antioxidant activity from fruit obtained from apple thinning, said method comprising: freezing the fruit resulting fro...  
WO/2015/096347A1
The present disclosure relates to a leveling composition for electrodepositing metals. The composition comprises a compound of formula (I).  

Matches 801 - 850 out of 15,226