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Matches 351 - 400 out of 15,199

Document Document Title
WO/2018/125880A8
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use and production.  
WO/2019/105216A1
Disclosed is an epigallocatechin gallate crystal form I, wherein the X-ray powder diffractogram thereof has diffraction peaks at the following 2-Theta° positions: 8.5±1, 12.2±1, 15.6±1, 17.1±1, 20.8±1, 21.6±1, 24.6±1, and 25.9±1...  
WO/2019/106238A1
The present disclosure relates to an improved process for the preparation of isochroman structured alpha2A adrenoceptor agonist, namely 2-(5-methoxyisochroman-1-yl)-4,5- dihydro-1H-imidazole of formula (I) and a pharmaceutically acceptab...  
WO/2019/104442A1
Cannabis and cannabis derived formulations, methods of making and methods of using the formulation in oral dosage forms, preferably in beverage forms, are disclosed herein.  
WO/2019/108877A1
Isoorientin analogues and related compounds that inhibit glycogen synthase kinase-3β activity are provided as are methods of using these compounds in the treatment of cognitive, neurodegenerative or neurological diseases or conditions, ...  
WO/2019/101353A1
The invention relates to a method for directly producing morin derivatives and high-purity morin of formula (1). The invention also relates to morin derivatives and high-purity morin that can be obtained using the claimed method.  
WO/2019/101826A1
The invention relates to amide-derivatives of 2-hydroxy-2-methyl-4-(3,5,6-trimethyl-1,4- benzoquinon-2-yl)-butanoic acid for use in a treatment for preventing or suppressing symptoms mediated by enhanced mPGES-1 expression or activity. I...  
WO/2019/099750A1
Provided herein are compositions, methods, systems and/or kits for preventing and/or treating neoplasms using at least one modulator selected from quercetin, sodium phenyl butyrate and epigallocatechin-3-gallate in combination with one o...  
WO/2019/090421A1
Described are methods for determining a recommended dosage and/or variety of cannabis for a subject based on genetic testing. The presence or absence of genetic variants in a sample from the subject is determined and used to determine a ...  
WO/2019/093623A1
The present invention provides a novel heterocyclic compound and an organic light-emitting diode using the same.  
WO/2019/094788A1
The present technology relates to compounds that inhibit human Ly6K and homologs thereof. Also disclosed are methods of using such compounds to: inhibit activity of a Ly6K protein in a cell; decrease migration, colony formation, and/or p...  
WO/2019/090428A1
Refrigerated solvent is fed through a cooling jacket around an essential element extraction vessel. After circulating through the cooling jacket, the solvent is re-chilled and at least some of the solvent is passed into the extraction ve...  
WO/2019/090920A1
A photochromic nano-composite microsphere and a coating material and a photochromic optical material prepared therefrom, and a coating using the coating material. The photochromic nano-composite microsphere has a three-layer composite co...  
WO/2019/085758A1
Disclosed in the present invention are a ketone-containing compound and applications thereof in organic electroluminescent devices. The compound consists of ketone and spiroanthracenefluorene groups, has a very deep HOMO energy level and...  
WO/2019/090085A1
Provided herein are compounds of formula (I), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions. (Formula I).  
WO/2019/079297A1
The present application provides, in some aspects, methods of treating cancers, such as homologous recombination (HR)-deficient cancers. In some embodiments, the disclosure provides a method for treating cancer by administering to a subj...  
WO/2019/076343A1
Disclosed are a PD-1/PD-L1 small-molecule inhibitor and a preparation method therefor and use thereof. In particular, disclosed are a compound which has a structure as shown in formula L, a stereoisomer or a tautomer thereof, or a pharma...  
WO/2019/078701A1
The present specification provides a compound represented by chemical formula 1 and an organic light-emitting device comprising same.  
WO/2019/078452A1
The present invention relates to: a 4-benzopyranone derivative and a pharmaceutically acceptable salt, solvate, racemate or stereoisomer thereof; a composition for preventing, alleviating or treating TNF-related diseases, containing the ...  
WO/2019/073064A1
The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 23 or higher and 83 or lower (in particular Ag1+, Ba2+,Pb2 +, Gd3+ and Bi3+) and one or more hematein ligand(s). In particular, th...  
WO/2019/071353A1
A method of reducing glutamate efflux from skeletal muscle by inhibiting system Xc- activity is provided. The method is useful for the treatment of statin-induced myalgia. Pharmaceutical compositions useful to treat statin-induced myalgi...  
WO/2019/073065A1
The present invention relates to specific complexes comprising heavy metal ions having an atomic number of 29 or higher and 83 or lower (preferably 29 or higher and 81 or lower) and one or more ligand(s) selected from the group consistin...  
WO/2019/070807A1
Methods of treating a viral infection in a subject are provided. The methods include administering a therapeutically effective amount of a pharmaceutical composition comprising ginkgolic acid (GA) to the subject in need thereof, where th...  
WO/2019/069297A2
Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes de...  
WO/2019/065532A1
Developed is a novel analgesic, the therapeutic targets of which are T-type calcium channels. The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable...  
WO/2019/063955A1
The present invention concerns the compounds of the following formula (I): (I) in which: - X represents an oxygen atom, a sulfur atom, a nitrogen atom or a CH radical, - The X--Y bond and Y are absent if X represents an oxygen or sulfur ...  
WO/2019/060986A1
Raw cannabis plant material is mixed with ethanol and spun-dry to extract cannabinoids. The ethanol may be chilled before adding it to the raw cannabis plant material, and a non-polar solvent stage may be used to increase the yield of th...  
WO/2019/062876A1
Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe responds to viscosity sensitively and specifically, can be used for the specific fluorescence label of proteins, and can also be use...  
WO/2019/063848A1
The present invention relates to a method for producing, obtaining and enriching dronabinol (Δ9-THC) as well as natural substances from plant extracts.  
WO/2019/062804A1
The present invention relates to a method for preparing an oxaspirocycle derivative, and an intermediate thereof. The method reduces reaction steps, improves reaction yield, is simple and easy to operate, and is favorable for industrial ...  
WO/2019/067636A1
Methods are provided for identifying whether a cancer patient, and especially a breast cancer patient, will be responsive to treatment. Specified TOPO2A, IDO1 and/or p16 fragment peptides are precisely detected and quantitated by SRM-mas...  
WO/2019/057969A1
The present invention relates to small molecule compounds and their use as agonists of farnesoid X receptor (FXR) and/or peroxisome proliferator activated receptor delta (PPARδ). The present invention also relates to the use of said com...  
WO/2019/059344A1
The present invention addresses the problem of providing a novel chemically activated water-soluble prodrug. The present invention provides a compound represented by formula (1), or a pharmacologically acceptable salt thereof (in the for...  
WO/2019/057821A1
The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.  
WO/2019/056123A1
Pharmaceutical compositions comprising one or more cannabinoids and a pharmaceutically acceptable carrier are disclosed. The compositions are in a form suitable for topical administration, and are useful in the treatment of pain. The can...  
WO/2019/056128A1
Compositions comprising two or more cannabinoids, a terpene, and a flavonoid suitable for use in treating insomnia are disclosed. In preferred embodiments, the cannabinoids are cannabidiol and tetrahydrocannabinol, while the terpenes and...  
WO/2019/056129A2  
WO/2019/054386A1
Provided is a heterocyclic compound represented by general formula (I), or a pharmacologically acceptable salt of the heterocyclic compound. In general formula (I): X represents O or NH; R1 represents a substituted or unsubstituted aryl ...  
WO/2019/030762A3
The present invention discloses a cannabinoid-based composition useful for treating or preventing dental pulp associated diseases. The composition comprises an effective amount of cannabis extract or a derivative thereof or at least one ...  
WO/2019/054633A1
The present invention provides a novel heterocyclic compound and an organic light-emitting device using same.  
WO/2019/053605A1
The present invention provides an environmentally benign, facile process for preparation of Tocotrienols from commercially available derivatives of o-Cresol.  
WO/2018/045217A8
Described herein are methods of treating neuron inflammation conditions, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effectiv...  
WO/2019/044672A1
[PROBLEM] To provide a novel method for synthesising a polyphenol. [SOLUTION] A polyphenol production method including the reaction of catechin in the presence of a catalyst and an oxidising agent, said catalyst comprising a metal oxide ...  
WO/2019/043259A1
The invention relates to cannabinoids and their isolation and purification and to obtaining them by means of centrifugal partition chromatography and pH-zone refining.  
WO/2019/043251A1
The present invention relates to novel compounds which are particularly useful for the synthesis of novel chromanol derivatives. These compounds have interesting properties. Particularly, the novel chromanol derivatives have interesting ...  
WO/2019/044872A1
The present invention addresses the problem of providing a rhodamine-based dye which is capable of suppressing fluorescent yield and forming an aggregate even under low concentration conditions. The present invention pertains to a compou...  
WO/2019/044736A1
The present invention provides a detection method and detection probe for colibactin and colibactin-producing bacteria. The present invention provides, for example, the detection of myristoyl-asparagine using a tissue sample or stool sam...  
WO/2019/038361A1
The present invention relates to medicaments for use in the prophylaxis or treatment of vasoconstriction related disorders or conditions. Specifically, the present invention relates to (2R) enantiomeric form of a 6-chromanol derivative f...  
WO/2019/038360A1
The present invention relates to the (S) enantiomeric form of certain 6-chromanol derivatives for use as a medicament. Especially, the present invention relates to the (S) enantiomeric form of a 6-chromanol derivative for use as a medica...  
WO/2019/038739A1
Pharmaceutical and nutraceutical compositions suitable for transdermal administration of plant-derived medicinal compounds are disclosed. The compositions comprise ground plant material (plant flour) and a dermally acceptable adhesive. I...  

Matches 351 - 400 out of 15,199