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JP6138251B2 |
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JP6129319B2 |
The present invention relates primarily to compounds of the formula (Ia) or (Ib) (as described herein), to mixtures comprising or consisting of compounds of the formula (Ia) or (Ib), and to perfumed products comprising a (preferably sens...
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JP2017039730A |
To provide novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, and pochoximes.The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt and/or solvate thereof ...
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JP2017036219A |
To provide a compound useful for the treatment of prostate cancer and having activity as androgen receptor (AR) antagonist, a pharmaceutical composition comprising the compound as an active ingredient, and method for producing the compou...
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JP2017019732A |
To provide a method for producing ε-caprolactone using a raw material derived from biomass.The method for producing ε-caprolactone comprises using adipic acid derived from biomass as a raw material. In the production method, a catalyst...
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JP6053425B2 |
A solid pharmaceutical preparation which contains either a dibenz[b,e]oxepine derivative represented by the following formula (I) [wherein A represents a single bond, -CH=CH-, or (CH2)n- (wherein n is an integer of 1-3); and R<1> and R<2...
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JP6052283B2 |
A photoresist composition containing (A) a polymer having a structural unit (I) that includes an acid-labile group, and (I) a compound represented by the following formula (1). In the following formula (1), R1, R2, R3 and R represent a h...
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JP2016533329A |
In some embodiments, the present invention is Δ12-PGJ3New derivatives and Δ12-PGJ3And a modular synthetic pathway for obtaining derivatives thereof. In some embodiments, Δ12-PGJ3Derivatives of are useful as chemotherapeutic agents. Th...
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JP6014656B2 |
A stable micronised monoclinic form of asenapine maleate is described, which comprises 5% by weight or less of orthorhombic form or any other crystalline form of asenapine maleate, wherein the asenapine maleate has a particle size distri...
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JP2016155873A |
To provide compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. The present ...
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JP5975581B2 |
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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JP2016138122A |
To provide a low molecular weight compound being an antagonist of chemokine receptor function.The method comprises administering to a subject an effective amount of a compound represented by formulas (I) and (II) or physiologically accep...
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JP5960991B2 |
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JP5958015B2 |
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JP5936669B2 |
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ...
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JP5935857B2 |
Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof or a solvate thereof has strong and sustaining intraocular pressure lowering activity and, fu...
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JP5931046B2 |
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JP5920889B2 |
The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr 4...
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JP2016507511A |
The present disclosure relates to macrocyclic picoline amides of formula (I) and the use of these compounds as fungicides. The disclosure also includes fungicidal compositions for controlling or preventing fungal attacks, including macro...
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JP5878494B2 |
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ...
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JP2016029063A |
To provide a solid preparation which contains a specific dibenz[b,e]oxepine derivative and is excellent in storage stability such as light stability.This invention relates to the solid preparation that contains a raw preparation containi...
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JP5869664B2 |
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JP5855106B2 |
The invention relates to methods for producing 1,6-hexanediol and very pure e-caprolactone from a dicarboxylic acid solution (DCL), comprising steps (a) esterification of the DCL with alcohols, (b) partial catalytic hydrogenation of the ...
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JP5851282B2 |
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JP5847088B2 |
The present invention relates to compounds of the formula I, wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endo...
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JP5835236B2 |
Provided is a compound which has strong and sustaining intraocular pressure lowering action and, further, has no fear of side effect on eyes. Since a compound represented by the formula (I): wherein definition of each group is as describ...
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JP5819284B2 |
The present invention relates to a novel process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
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JP5815702B2 |
The present invention is directed to novel compounds of formula (I) as well as to the process for their preparation. Novel compounds of formula (I) can be converted into asenapine through an efficient process. The invention also relates ...
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JP2015532268A |
The present invention relates to a method for producing a metathesis product comprising contacting a metathesis starting material with a metathesis catalyst under metathesis conditions, wherein the metathesis catalyst is reduced to half ...
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JP5768230B2 |
For the purpose of treating/preventing disorders or diseases associated with estrogen deficiency, an extract from a hypha of Agaricus blazei Murrill and a brefeldin A component are utilized.
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JP2015145401A |
To provide compounds for medicament to inhibit histone deacetylase.This invention provides a compound such as phenyl hydroxamic acid substituted with a group comprising, for example, oxazepine, diazepine, thiazepine skeletons, pyrimidine...
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JP5754811B2 |
The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof, a pharmaceutically acceptabl...
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JP2015124156A |
To provide a method for obtaining alcohol by hydrogenation of carboxylic acid compound efficiently by using a homogeneous system catalyst, especially a method for obtaining alcohol by hydrogenation of various carboxylic acid compound and...
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JP5741902B2 |
To provide a liquid crystal composition and a display element having negative dielectric anisotropy (Δε) of a large absolute value and being excellent in chemical stability, and a compound having negative dielectric anisotropy (Δε) o...
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JP5718674B2 |
The present invention provides a novel macrocyclic compound exhibiting superior odor qualities and having a musk-like aroma, a method for producing the same, and a novel flavor or fragrance composition, and food products or beverages, fr...
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JP5708994B2 |
To provide a liquid crystal composition and a display element having negative dielectric anisotropy (Δε) of a large absolute value and being excellent in chemical stability, and to provide a compound having negative Δε of a large abs...
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JP5696043B2 |
Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR 1 , wherein R 1 is C 1 -C 7 alkyl, C 3 -C 7 cycloalkyl, aryl, or heterocycle; or NR 2 R 3 , wherein R 2 and R ...
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JP5690653B2 |
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JP5662618B2 |
The purpose of the present invention is to provide a novel compound with Eg5 inhibiting activity that is useful as an antitumoral agent. The present invention pertains to a compound expressed by the general formula (I) (in formula (I), A...
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JP2015017126A |
To provide a production method of olopatadine, with which Z/E isomers are obtained with a high ratio of 4/1, the yield of the entire reaction can be increased, and the useful product can be simply isolated.Olopatadine is obtained by a me...
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JP5655258B2 |
Provided is a novel compound which is excellent in odor quality, has a natural feeling and a fruity feeling and has a musk aroma. The present invention relates to a compound represented by the following formula (1): wherein wavy lines re...
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JP5652397B2 |
Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof or a solvate thereof has strong and sustaining intraocular pressure lowering activity and, fu...
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JP5620847B2 |
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JP5611502B2 |
A solid pharmaceutical preparation which contains either a dibenz[b,e]oxepine derivative represented by the following formula (I) [wherein A represents a single bond, -CH=CH-, or (CH2)n- (wherein n is an integer of 1-3); and R<1> and R<2...
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JP5608854B2 |
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JP5602049B2 |
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JP2014520771A |
Macrocyclic lactone compounds (Q) are new. Macrocyclic lactone compounds (Q) of formulae (I) and/or (II) are new. line with dotted line : an additional double bond in the 11th- or 12th-position, which is in cis or trans configuration; an...
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JP5576854B2 |
Described is pentamycin in a purity exceeding 95%, certain polymorphs and solvates of pentamycin, processes for their manufacture, and a method for decreasing the rate of degradation of pentamycin.
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JP5569857B2 |
An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia, and the like, based on the serotonin 5-HT 5A receptor modulating action. It was confirmed that a bicyclic ac...
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JP2014141498A |
To provide intermediates and preparation methods for making zearalenone macrolide analogs.The present invention provides compounds of the formula (IV), and intermediates and preparation methods of the compounds. [Rand Rare H or the like;...
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