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Patent Searching and Data


Matches 301 - 350 out of 2,414

Document Document Title
WO/2005/070405A1
Methods of using certain &agr -aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.  
WO/2005/068451A2
A method for the synthesis of dictyostatin or a derivative thereof having Formula (I) is provided.  
WO/2005/067919A1
The present invention discloses compounds of formulae I, II, III or IV or pharmaceutically acceptable salts, esters, or prodrugs thereof: (I), (II), (III), (IV), which exhibit antibacterial properties. The present invention further relat...  
WO/2005/061481A1
The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) (I) wherein R,,-R4, Z, X, A-B, D-E, G-J, and K-L are as defined herein, the synthesis thereof and the use of these comp...  
WO2005023792A3
The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorder...  
WO/2005/053676A1
The use of a pentadienoic acid derivative of formula (I) for the preparation of a medicament for the prevention or treatment of hyperuricemia and/or one or several associated disorders or diseases, and/or for reducing the serum uric acid...  
WO/2005/051895A1
Disclosed are &dgr -amino-&gammad -hydroxy-&ohgr -aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and ...  
WO2005014517A3
The present invention pertains to compounds of formula (I) wherein X is O, NH, N(C1-4)alkyl, CO or CHOH, Y is CH or N, A and B are each hydrogen or together form a second bond between the carbon atoms to which they are attached, R1 is hy...  
WO/2005/030749A1
Novel calcilytic compounds and methods of using them are provided.  
WO2004041161A3
The present invention is directed to compounds of the formula (I) (wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11>, R<27>, R<28>, R<29>, R<30>, R<31>, X, m, n and the dashed line are defined herein) which are u...  
WO/2005/023772A1
The invention relates to malonamide derivatives of formula (I), wherein: R1 is one of the following groups (Formulae a), b), c), d)); R2 is lower alkyl, lower alkinyl, -(CH2)n-O-lower alkyl, -(CH2)n-S-lower alkyl, -(CH2)n-CN, -(CR'R')n-C...  
WO/2005/023792A2
The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorder...  
WO/2005/023831A1
The invention relates to detection of cholesterol ozonation products that are generated by atherosclerotic plaque material, and to methods of detecting vascular conditions that relate to the accumulation and oxidation of cholesterol.  
WO/2005/023830A2
As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cytotoxic cholesterol oxidation or ozonation products. The present application is directed to the products of cholester...  
WO2004087673B1
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metas...  
WO/2005/018674A1
A drug containing, as the active ingredient, a compound having an Hsp90 inhibitory effect or a pharmacologically acceptable salt thereof is used as a remedy for diseases associated with the translocation of immunoglobulin gene. In the di...  
WO/2005/019181A1
The invention relates to compositions and methods useful for inhibiting cell migration. These compositions and methods can be used to inhibit metastasis of tumor cells in mammals. The compositions are characterized by comprising a coumpo...  
WO2004058976A3
The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials...  
WO/2005/014517A2
The present invention pertains to compounds of formula (I) wherein X is O, NH, N(C1-4)alkyl, CO or CHOH, Y is CH or N, A and B are each hydrogen or together form a second bond between the carbon atoms to which they are attached, R1 is hy...  
WO2003032912A9
The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder. Furthermore, the invention provides methods of tre...  
WO2004062629A3
The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof; selectively functionalized apoptolidin derivat...  
WO2004087673A3
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metas...  
WO/2004/087672A1
In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-RC, Q, Y1, Y2 and n are as defined herein, whereby the compos...  
WO/2004/087673A2
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metas...  
WO2004052847A3
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...  
WO2004052837A3
Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1,-C20alkyl; C2-C20alkenyl; C3-C10,cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with ...  
WO/2004/076395A1
The invention relates to a method for producing cyclopentanone and optionally caprolactone, by reacting a dicarboxylic acid solution in the presence of at least one catalyst. The invention also relates to the use of a dicarboxylic acid s...  
WO2002092589A3
The invention relates to the isolation, structural determination, synthesis and utilization of decalactones and their derivatives as medicaments. Said novel natural substances were isolated from the culture broth of a fungus, which is pr...  
WO2004039773A8  
WO2003032912A8
The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder. Furthermore, the invention provides methods of tre...  
WO/2004/062629A2
The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof; selectively functionalized apoptolidin derivat...  
WO2004019879A8
Motilide compounds having the formula (I), wherein R<1>, R<2>, R<3>, and R<4> are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.  
WO/2004/058976A2
The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials...  
WO/2004/052847A2
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...  
WO/2004/052837A2
Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1,-C20alkyl; C2-C20alkenyl; C3-C10,cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with ...  
WO2004030440A3
Various processes are disclosed for preparing procyanidin oligomers having (4,8)interflavan linkages. In an improved process, a tetra-O-protected-epicatechin or -catechin monomer or oligomer is coupled with a protected, C-4 alkoxy-activa...  
WO2004019879A3
Motilide compounds having the formula (I), wherein R<1>, R<2>, R<3>, and R<4> are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.  
WO/2004/041161A2
The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine...  
WO/2004/039773A2
Novel compounds and their use for modulationof L-Isoaspartyl (D-Aspartyl) 0-Metyltransferase and/or glyceraldehyde-3-phosphate dehydrogenase activity enable the prevention treatment or alleviation of diabetes, autoimmune diseases and neu...  
WO2003084482A3
Methods and compositions of antidepressants and analogs thereof for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful fo...  
WO2003097649A3
The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especia...  
WO/2004/033702A1
Microorganisms belonging to the genus Streptomyces and being capable of producing K99−5278A, K99−5278B and K99−5278C, which are drugs efficacious against infection with so−called fungi such as molds and yeasts, are cultured in a ...  
WO/2004/030440A2
Various processes are disclosed for preparing procyanidin oligomers having (4,8)interflavan linkages. In an improved process, a tetra-O-protected-epicatechin or -catechin monomer or oligomer is coupled with a protected, C-4 alkoxy-activa...  
WO/2004/031166A1
The present invention relates to novel metastable derivatives of benzoxepines of the formula (I) in which n represents 0,1 or 2 ; and the radicals R, which may be identical or different, are alkyl or alkoxy groups, or halogen atoms, whic...  
WO2003088927A3
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agent...  
WO/2004/024142A1
It is intended to provide an Hsp90 family protein inhibitor, etc. comprising as the active ingredient a cyclic benzoic acid derivative represented by the following general formula (I), which is useful as drugs such as an antitumor agent,...  
WO2003060852A3
An osmium-assisted process for the oxidative cleavage of oxidizable organic compounds such as unsaturated organic coumpounds, including alkenes and olefins into aldehydes, carboxylic acids, esters, or ketones. The process uses a metal ca...  
WO/2004/024141A1
It is intended to provide an Hsp90 family protein inhibitor, etc. comprising as the active ingredient a cyclic phenylacetic acid derivative represented by the following general formula (I), which is useful as drugs such as an antitumor a...  
WO/2004/022552A1
A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, -SiRaRbRc, CH2ORd, or C...  
WO2004009578A3
The present invention provides a compound of the formula (I) wherein R<1> is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R<0>, R<2> and R<3> are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OC...  

Matches 301 - 350 out of 2,414