Heterocyclic Compounds

Matches 301 - 350 out of 1,777	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2004/031166A1	METASTABLE BENZOXEPNE DERIVATIVES WHICH CAN BE USED IN THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PROCESSES FOR THE PREPARATION THEREOF The present invention relates to novel metastable derivatives of benzoxepines of the formula (I) in which n represents 0,1 or 2 ; and the radicals R, which may be identical or different, are alkyl or alkoxy groups, or halogen atoms, whic...
WO/2004/024142A1	Hsp90 FAMILY PROTEIN INHIBITORS It is intended to provide an Hsp90 family protein inhibitor, etc. comprising as the active ingredient a cyclic benzoic acid derivative represented by the following general formula (I), which is useful as drugs such as an antitumor agent,...
WO/2004/024141A1	Hsp90 FAMILY PROTEIN INHIBITORS It is intended to provide an Hsp90 family protein inhibitor, etc. comprising as the active ingredient a cyclic phenylacetic acid derivative represented by the following general formula (I), which is useful as drugs such as an antitumor a...
WO/2004/022552A1	ANALOGS OF DISCODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, -SiRaRbRc, CH2ORd, or C...
WO/2004/019879A2	MOTILIDE COMPOUNDS Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.
WO/2004/011661A1	NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCES Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents (1) , (2) or (3) ; and R3, R7, R16, R17, R20, R21 and R21’ are the same or differe...
WO/2004/009577A1	HETERODIAMONDOIDS This invention is related to heteroatom containing diamondoids (i.e., 'heterodiamondoids' ) which are compounds having a diamondoid nucleus in which one or more of the diamondoid nucleus carbons has been substitutionally replaced with a ...
WO/2004/009578A2	PENTACYCLIC OXEPINES AND DERIVATIVES THEREOF, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention provides a compound of the formula (I) wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 ...
WO/2004/009603A1	DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS The present invention provides a compound of the formula (I) wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 ...
WO/2004/007476A1	GESELLSCHAFT FÜ R BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) The invention relates to 5-thiapethilones and 15-disubstituted epothilones according to formula I (I) with the following meanings: X= >C = O or >S = O R1 = C1-6 alkyl or C2-6 alkenyl R2 = H or C1-6 alkyl Y - Z = >C=C< or >C-O-C< (epoxide...
WO/2004/007483A1	NOVEL MACROCYCLES FOR THE TREATMENT OF CANCER DISEASES The invention relates to novel macrocycles of general formula (1) and to the use thereof in the treatment of cancer diseases.
WO/2004/005311A1	BAFILOMYCIN-LIKE METABOLITE FROM A NOVEL MICROMONOSPORA SPECIES The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this m...
WO/2003/099719A1	MICROPOROUS CRYSTALLINE ZEOLITE MATERIAL (ZEOLITE ITQ-22), SYNTHESIS METHOD THEREOF AND USE OF SAME AS A CATALYST The invention relates to a microporous crystalline zeolite material (ITQ-22) having, in the calcined state, empirical formula x (M1/nXO2): y YO2: z GeO2: (1-z) SiO2, wherein M is H+ or at least one inorganic cation of charge +n; X is at ...
WO/2003/097649A2	1-OXA-DIBENZOAZULENES AS INHIBITORS OF TUMOR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especia...
WO2003014105A9	BICYCLIC COMPOUND, PRODUCTION AND USE AS HIV INHIBITORS The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula (I) wherein: R?1¿ is ...
WO/2003/088927A2	NOVEL CURCUMIN ANALOGUES AND USES THEREOF The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agent...
WO/2003/086334A1	HAIR GROWTH TONIC A hair papilla cell growth promoter, a hair growth stimulant and a hair growth tonic containing a compound having an activity of inhibiting the function of WNT-5A.
WO/2003/084482A2	ANTIDEPRESSANTS AND THEIR ANALOGUES AS LONG-ACTING LOCAL ANESTHETICS AND ANALGESICS Methods and compositions of antidepressants and analogs thereof for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful fo...
WO/2003/080588A1	CYCLIC 1-(ACYLOXY)-ALKYL PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present inve...
WO/2003/076424A1	MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders...
WO2001083800A9	HETEROLOGOUS PRODUCTION OF POLYKETIDES Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
WO/2003/059340A1	METHOD FOR THE PREPARATION OF LARICIRESINOL, CYCLOLARICIRESINOL AND SECOISOLARICIRESINOL This invention relates to a method for the preparation of lariciresinol, cyclolariciresinol or secoisolariciresinol. The method is characterized by the steps of a) reducing hydroxymatairesinol to give 7-hydroxy-secoisolariciresinol, and ...
WO/2003/060852A2	CATALYTIC OSMIUM−ASSISTED OXIDATIVE CLEAVAGE OF OLEFINS An osmium−assisted process for the oxidative cleavage of oxidizable organic compounds such as unsaturated organic coumpounds, including alkenes and olefins into aldehydes, carboxylic acids, esters, or ketones. The process uses a metal ...
WO/2003/057204A2	MODULATION OF IAMT (PIMT OR PCMT) IN IMMUNE SYSTEM Modulation of L-Isoaspartyl (D-Aspartyl) O-Methyltransferase activity in immune system associated cells enables the prevention or alleviation of an autoimmune response by decreasing self-antigen presentation or T-cell proliferation.
WO/2003/053977A1	TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and / or prevention of disorders mediated by one or more estrogen receptors...
WO/2003/053927A1	PIPERAZINE DERIVATIVE A piperazine derivative represented by the formula (1) [wherein n is an integer of 1 to 8&semi R1 represents hydrogen or C1−10 alkyl&semi A represents CH or nitrogen&semi Ar1 represents phenyl or substituted phenyl&semi and Y represent...
WO/2003/051511A1	LEWIS ACID CATALYST COMPOSITION The invention discloses a Lewis acid catalyst composition comprising a specific mixed medium and a Lewis acid catalyst, characterized in that the Lewis acid catalyst is at least one member selected from the group consisting of compounds ...
WO/2003/045942A2	CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ...
WO/2003/044005A1	CRUENTAREN A AND B AS PHARMACEUTICALS AND AGROCHEMICALS Compounds of the general formula (la) or (Ib) and pharmaceutically and agrochemically acceptable salts thereof and all geometric isomers and stereoisomers, and mixtures thereof in enriched form, are suitable for use as cytotoxic active i...
WO/2003/041643A2	HSP90-INHIBITING ZEARALANOL COMPOUNDS AND METHODS OF PRODUCING AND USING SAME Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are ...
WO/2003/039255A1	USE OF SUBSTITUTED DIBENZOTHIEPINE DERIVATIVES AS INSECTICIDAL, ACARICIDAL AND NEMATICIDAL AGENTS A composition comprising a) compounds of formula (I):, wherein A−B denotes C−C or C=C&semi x is S, O, SO, SO2, NRa, or CRbRc&semi R1, R2 are H, halogen, OH, SH, NH2, CN, NO2, alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alke...
WO/2003/022790A2	BIPHENYLENE COMPOUNDS There are described biphenylene compounds of formula (I) wherein R¿1? is a C¿1?-C¿18?alkyl, C¿2?-C¿18?alkenyl, C¿6?-C¿10?aryl or C¿6?-C¿10?aryl or C¿6?-C¿10?heteroaryl radical each unsubstituted or mono- or poly-substituted by...
WO/2003/018002A2	CYCLOPROPYL AND CYCLOBUTYL EPOTHILONE ANALOGS The invention relates to cis- and trans-12, 13-cyclopropyl and 12, 13-cyclobutyl epothilones of formula (I) to (IV), wherein Ar is a radical represented by the following structure:, and the other radicals and symbols have the meanings as...
WO/2003/014104A1	FUNGICIDAL 1-BENZOXEPIN DERIVATIVES The invention concerns novel 1-benzoxepin derivatives, methods for preparing them, their use as fungicides, in particular in the form of fungicidal compositions, as well as methods for controlling phytopathogenic fungi of crops using sai...
WO/2003/010155A1	METHOD FOR PRODUCING NOVEL SPINOSYN DERIVATIVES The invention relates to a method for producing novel spinosyn derivatives, which are substituted in the C-21 position by a 1-hydroxy-ethyl radical, to novel spinosyn derivatives of this type per se and to their use for producing novel s...
WO/2003/002255A1	HYDROXYLATION OF BETA-DICARBONYLS WITH ZIRCONIUM CATALYSTS The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by comprising contacting a compound of Formula II with an oxida...
WO/2003/002549A1	EUROTINONE AND DERIVATIVES THEREOF, METHOD FOR THE PRODUCTION AND USE OF THE SAME The invention relates to novel compounds of general formula (I), wherein R(1), R(2), R(3), R(4) independently represent hydrogen or an alkyl radical. The compounds of formula (I) are inhibitors of KDR-kinase, having an anti-angiogenetic ...
WO/2002/098558A1	CATALYST FOR CARBOXYLIC ESTER PRODUCTION AND PROCESS FOR PRODUCING CARBOXYLIC ESTER A carboxylic ester production catalyst which has higher catalytic activity. The catalyst, which is used for producing a carboxylic ester by reacting oxygen, an aldehyde, and an alcohol or (b) by reacting oxygen with one or more alcohols,...
WO/2002/099113A1	MACROLIDE COMPOUNDS, ANTIFUNGAL AGENTS USING THE SAME, MACROLIDE COMPOUND−PRODUCING BACTERIUM BELONGING TO THE GENUS SORANGIUM AND PROCESS FOR PRODUCING MACROLIDE COMPOUNDS USING THE SAME Macrolide compounds having the following chemical structure, which are obtained by culturing Sorangium cellulosum, have an antifungal activity over various fungi such as those belonging to the genera Phytophthera, Absidia, Rhizopus and A...
WO/2002/094196A2	METHOD OF TREATMENT FOR CANCERS ASSOCIATED WITH ELEVATED Novel methods of treating proliferative disorders characterized by elevated Her-2, and the patient is then administered an effective amount of an HSP90 inhibitor.
WO/2002/092589A2	NOVEL DECALACTONES FROM ASSOCIATED FUNGI OF MARINE SPONGES AND THEIR SYNTHETIC DERIVATIVES AS MEDICAMENTS The invention relates to the isolation, structural determination, synthesis and utilization of decalactones and their derivatives as medicaments. Said novel natural substances were isolated from the culture broth of a fungus, which is pr...
WO/2002/090343A1	NEORUSTMICIN C DERIVATIVES AS FUNGICIDES The invention relates to novel neorustmicin C derivatives of formula I, wherein the substituents are defined as follows: R?1¿ represents hydrogen or C(=0)R?4¿; R?2¿ =NOR?5¿ or =0; R?3¿ represents hydrogen or C(=0)R?6¿; R?4¿ repres...
WO/2002/085883A1	TRICYCLIC ALKYLHYDROXAMATES, THEIR PREPARATION AND THEIR USE AS CELL PROLIFERATION INHIBITORS Compounds of formula (I), wherein R¿1?, R¿2?, A, X, Y and Z have the meanings defined in the specification, process of manufacturing these compounds and pharmaceuticals with HDAC inhibitor activity containing such a compound.
WO/2002/080846A2	EPOTHILONE DERIVATIVES AND METHODS FOR MAKING AND USING THE SAME This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R?1�, R?2�, R?3�, R?4�, R?5�, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful ...
WO2001057015A9	INTERNAL 1,15-LACTONES OF FLUPROSTENOL AND RELATED PROSTAGLANDIN F>2 alpha < ANALOGS AND THEIR USE IN THE TREATMENT OF GLAUCOMA AND INTRAOCULAR HYPERTENSION Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into op...
WO/2002/079184A1	INTERMEDIATES FOR PRODUCING SPINOSYNS The invention relates to intermediates for producing spinosyns, to various methods of producing them, and to the use of said intermediates for producing spinosyn derivatives.
WO/2002/074084A1	NEORUSTMICIN D DERIVATIVES AS FUNGICIDES The invention relates to novel neorustmicin D derivatives of formula (I) wherein the substituents have the following designations: R?1¿ represents hydrogen or -C(=O)R?4¿; R?2¿ represents =NOR?5¿ or =O; R?3¿ represents hydrogen or -C...
WO/2002/074085A1	NEORUSTMICIN A-DERIVATIVES The invention relates to the neorustmicin derivatives of formula (I), wherein R?1¿ represents hydrogen or -C(=O)R?4¿; R?2¿ represents -CH¿2?-OR?5¿ or =CH¿2?; R?3¿ represents -OH, =O or =NOR?6¿; R?4¿ represents hydrogen, C¿1?-C�...
WO2000024907A9	LIBRARY OF NOVEL "UNNATURAL" NATURAL PRODUCTS Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical ...
WO/2002/064643A1	POLYMER-SUPPORTED ALLYLSILANE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF A polymer-supported allylsilane compound with high stereoselectivity which comprises a polymer support and an allylsilyl compound fixed thereto and which is represented by the general formula (I) (I) (wherein the part located on the left...

Matches 301 - 350 out of 1,777	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >