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Patent Searching and Data


Matches 351 - 400 out of 2,414

Document Document Title
WO/2004/019879A2
Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.  
WO2002030356A3
The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound wit...  
WO2002094196A3
Novel methods of treating proliferative disorders characterized by elevated Her-2, and the patient is then administered an effective amount of an HSP90 inhibitor.  
WO/2004/011661A1
Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents (1) , (2) or (3) ; and R3, R7, R16, R17, R20, R21 and R21’ are the same or differe...  
WO2003057204A3
Modulation of L-Isoaspartyl (D-Aspartyl) O-Methyltransferase activity in immune system associated cells enables the prevention or alleviation of an autoimmune response by decreasing self-antigen presentation or T-cell proliferation.  
WO/2004/009577A1
This invention is related to heteroatom containing diamondoids (i.e., 'heterodiamondoids' ) which are compounds having a diamondoid nucleus in which one or more of the diamondoid nucleus carbons has been substitutionally replaced with a ...  
WO/2004/009578A2
The present invention provides a compound of the formula (I) wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 ...  
WO/2004/009603A1
The present invention provides a compound of the formula (I) wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 ...  
WO/2004/007476A1
The invention relates to 5-thiapethilones and 15-disubstituted epothilones according to formula I (I) with the following meanings: X= >C = O or >S = O R1 = C1-6 alkyl or C2-6 alkenyl R2 = H or C1-6 alkyl Y - Z = >C=C< or >C-O-C< (epoxide...  
WO/2004/007483A1
The invention relates to novel macrocycles of general formula (1) and to the use thereof in the treatment of cancer diseases.  
WO/2004/005311A1
The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this m...  
WO2003032912A3
The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder. Furthermore, the invention provides methods of tre...  
WO/2003/099719A1
The invention relates to a microporous crystalline zeolite material (ITQ-22) having, in the calcined state, empirical formula x (M1/nXO2): y YO2: z GeO2: (1-z) SiO2, wherein M is H+ or at least one inorganic cation of charge +n; X is at ...  
WO2002080846A3
This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the tre...  
WO/2003/097649A2
The present invention relates to 1-oxa-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especia...  
WO2003014105A9
The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula (I) wherein: R?1¿ is ...  
WO/2003/088927A2
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agent...  
WO/2003/086334A1
A hair papilla cell growth promoter, a hair growth stimulant and a hair growth tonic containing a compound having an activity of inhibiting the function of WNT-5A.  
WO/2003/084482A2
Methods and compositions of antidepressants and analogs thereof for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful fo...  
WO2003041643A3
Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are ...  
WO/2003/080588A1
The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present inve...  
WO/2003/076424A1
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders...  
WO2001083800A9
Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.  
WO2003045942A3
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ...  
WO2003018002A3
The invention relates to cis- and trans-12, 13-cyclopropyl and 12, 13-cyclobutyl epothilones of formula (I) to (IV), wherein Ar is a radical represented by the following structure:, and the other radicals and symbols have the meanings as...  
WO2003022790A3
There are described biphenylene compounds of formula (I) wherein R1 is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10aryl or C6-C10heteroaryl radical each unsubstituted or mono- or poly-substituted by hydroxy, halogen, C1-C18alkyl, C...  
WO/2003/059340A1
This invention relates to a method for the preparation of lariciresinol, cyclolariciresinol or secoisolariciresinol. The method is characterized by the steps of a) reducing hydroxymatairesinol to give 7-hydroxy-secoisolariciresinol, and ...  
WO/2003/060852A2
An osmium−assisted process for the oxidative cleavage of oxidizable organic compounds such as unsaturated organic coumpounds, including alkenes and olefins into aldehydes, carboxylic acids, esters, or ketones. The process uses a metal ...  
WO/2003/057204A2
Modulation of L-Isoaspartyl (D-Aspartyl) O-Methyltransferase activity in immune system associated cells enables the prevention or alleviation of an autoimmune response by decreasing self-antigen presentation or T-cell proliferation.  
WO/2003/053977A1
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and / or prevention of disorders mediated by one or more estrogen receptors...  
WO/2003/053927A1
A piperazine derivative represented by the formula (1) [wherein n is an integer of 1 to 8&semi R1 represents hydrogen or C1−10 alkyl&semi A represents CH or nitrogen&semi Ar1 represents phenyl or substituted phenyl&semi and Y represent...  
WO/2003/051511A1
The invention discloses a Lewis acid catalyst composition comprising a specific mixed medium and a Lewis acid catalyst, characterized in that the Lewis acid catalyst is at least one member selected from the group consisting of compounds ...  
WO/2003/045942A2
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ...  
WO/2003/044005A1
Compounds of the general formula (la) or (Ib) and pharmaceutically and agrochemically acceptable salts thereof and all geometric isomers and stereoisomers, and mixtures thereof in enriched form, are suitable for use as cytotoxic active i...  
WO/2003/041643A2
Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are ...  
WO/2003/039255A1
A composition comprising a) compounds of formula (I):, wherein A−B denotes C−C or C=C&semi x is S, O, SO, SO2, NRa, or CRbRc&semi R1, R2 are H, halogen, OH, SH, NH2, CN, NO2, alkyl, alkoxy, alky­lamino, dialkylamino, alkylthio, alke...  
WO/2003/032912A2
The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder. Furthermore, the invention provides methods of tre...  
WO2001083800A3
Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.  
WO/2003/022790A2
There are described biphenylene compounds of formula (I) wherein R¿1? is a C¿1?-C¿18?alkyl, C¿2?-C¿18?alkenyl, C¿6?-C¿10?aryl or C¿6?-C¿10?aryl or C¿6?-C¿10?heteroaryl radical each unsubstituted or mono- or poly-substituted by...  
WO/2003/018002A2
The invention relates to cis- and trans-12, 13-cyclopropyl and 12, 13-cyclobutyl epothilones of formula (I) to (IV), wherein Ar is a radical represented by the following structure:, and the other radicals and symbols have the meanings as...  
WO/2003/014104A1
The invention concerns novel 1-benzoxepin derivatives, methods for preparing them, their use as fungicides, in particular in the form of fungicidal compositions, as well as methods for controlling phytopathogenic fungi of crops using sai...  
WO/2003/014105A1
The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula (I) wherein: R&quest 1...  
WO/2003/010155A1
The invention relates to a method for producing novel spinosyn derivatives, which are substituted in the C-21 position by a 1-hydroxy-ethyl radical, to novel spinosyn derivatives of this type per se and to their use for producing novel s...  
WO2002032916A3
The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and metho...  
WO/2003/002255A1
The present invention pertains to a process for preparing a compound of Formula I that is achiral, racemic or enantiomerically enriched at the hydroxylation center indicated by comprising contacting a compound of Formula II with an oxida...  
WO/2003/002549A1
The invention relates to novel compounds of general formula (I), wherein R(1), R(2), R(3), R(4) independently represent hydrogen or an alkyl radical. The compounds of formula (I) are inhibitors of KDR-kinase, having an anti-angiogenetic ...  
WO2001083800A8
Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.  
WO/2002/098558A1
A carboxylic ester production catalyst which has higher catalytic activity. The catalyst, which is used for producing a carboxylic ester by reacting oxygen, an aldehyde, and an alcohol or (b) by reacting oxygen with one or more alcohols,...  
WO/2002/099113A1
Macrolide compounds having the following chemical structure, which are obtained by culturing Sorangium cellulosum, have an antifungal activity over various fungi such as those belonging to the genera Phytophthera, Absidia, Rhizopus and A...  
WO/2002/094196A2
Novel methods of treating proliferative disorders characterized by elevated Her-2, and the patient is then administered an effective amount of an HSP90 inhibitor.  

Matches 351 - 400 out of 2,414