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WO/2004/000783A1 |
The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to co...
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WO/2004/000771A1 |
The invention relates to 3,3,4,4-tetrafluorocyclopentane compounds of formula (I), in which R1, A1, A2, Z1, Z2 and m are defined as cited in claim 1. Said compounds are suitable for use as components of liquid crystal media.
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WO/2003/106443A1 |
Compounds of formula (I) (R and R1 are a wide range of substituents, Q is CO, CHOH or CHOR2, R2 is alkyl, alkenyl, alkynyl or cycloalkyl group, each of which is optionally substituted, or is alkanoyl, alkanoyoxy, aminocarbonyl, alkylamin...
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WO/2003/106447A1 |
Process for the preparation of an ester of formula (1), wherein R1represents a leaving group, CN, OH or a COOR5 group, R3 and R4each independently represent a 1-3 C alkyl group, and R2 and R5 each independently represent an ester residue...
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WO/2003/104178A1 |
Where Y, R¿1?-R¿8? and R¿101?-R¿108? are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting M...
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WO/2003/104203A1 |
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of t...
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WO/2003/103660A1 |
Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and fo...
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WO/2003/102536A2 |
Destructible surfactants and methods of using same are provided. The invention includes anionic surfactants having a dioxolane or dioxane functional group that enable degradation of the surfactant under acidic conditions. The invention a...
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WO/2003/099776A1 |
The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or i...
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WO/2003/097619A1 |
A novel class of compounds of the general formula (I), which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the...
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WO/2003/095439A1 |
This invention relates to dihydro-furan-2-one derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formula (V-1), wherein R2 and p are herein defined. Th...
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WO/2003/093223A1 |
Disclosed are novel biphenyl carboxamides of formula (I), in which R1, R2, m, n, R3, Y, and A have the meanings indicated in the description, several methods for producing said substances, the use thereof for controlling undesired microo...
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WO/2003/091238A1 |
A catalyst and depolymerization conditions for efficiently converting a lactic acid polymer into a lactide having a high optical purity. These are used for the purpose of, e.g., subjecting a waste high-molecular lactic acid polymer to ch...
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WO/2003/089424A1 |
Methods for preparation of cyclic alkylene carbonates which include a six-membered ring as part of their chemical structure are disclosed. According to the present invention, an oxide, alkoxide, or carboxylate salt of a metal selected fr...
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WO/2003/087034A1 |
The invention relates to 3-aminophenol derivatives of formula (I) or to their physiologically compatible, water-soluble salts, wherein R1 is identical to a radical of formula (II) or to a radical of formula (III), and to dyes that contai...
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WO/2003/086673A1 |
A method and a device for removing harmful substances capable of safely processing the harmful substances and improving a processing efficiency, the device comprising a harmful substance separating and extracting device (10) for storing ...
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WO/2003/086288A2 |
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...
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WO/2003/085002A1 |
Cyclodextrins cross-linked by reaction with organic carbonates and the use thereof as agents capable or removing pollutants from fluids of various origin, in particular from contaminated waters.
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WO/2003/082205A2 |
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and so...
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WO/2003/083063A2 |
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affi...
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WO/2003/082850A1 |
The present invention relates to the field of perfumery. More particularly, it concerns an aldoxane derivative of Formula (I) capable of protecting an active aldehyde R¿1?CHO, for example a perfumery or flavor aldehyde, from a chemicall...
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WO/2003/080564A1 |
This invention is directed to menthol-substituted compounds and their pharmaceutically acceptable salts which are useful as antithrombotic agents by inhibiting plasminogen activator inhibitor-1 (PAI-1). In addition, the present invention...
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WO/2003/078409A1 |
Carboxylic acid compounds represented by the following general formula (I) (wherein each symbol is as defined in the description) and drugs containing these compounds: (I) Because of binding to DP receptor and antagonizing the same, the ...
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WO/2003/078420A2 |
A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula (I) wherein R, Ar, and Q are defined as set forth herein, and inter...
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WO/2003/078417A1 |
A process for formation of N-aryl piperazines with chiral side-chains having the structure shown in formula below, and for making intermediate compounds therefor: (Formula I). In this process, chirality is introduced at the piperazine ri...
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WO/2003/076405A1 |
The present invention relates to monocyclic aroylpyridinones, processes for their preparation, and their use in medicaments, especially for the treatment of COPD: (formula I).
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WO/2003/076374A1 |
A process for producing a compound (I) which comprises the step of reacting a compound (II) with a base in an aprotic solvent as shown by the scheme: (II) (I) wherein R1 and R2 each independently represents lower alkyl.
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WO/2003/074467A2 |
The present invention provides HIV aspartyl protease inhibitors of the formula (I): and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, Y is O, S, NH or N...
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WO/2003/072537A2 |
Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the ...
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WO/2003/070713A1 |
The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not ad...
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WO/2003/070719A1 |
Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and&sol or improved recognition domains are disclosed, including methods of preparing and utilizing the same.
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WO/2003/070676A1 |
A process for easily producing from an inexpensive material an optically active 3-halo-1,2-propanediol derivative useful as an intermediate for medicines. The process comprises reacting 2-chloroallyl alcohol, which is easily available at...
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WO/2003/070714A1 |
The present invention relates to a method for the synthesis of highly fluorinated compounds and to novel highly fluorinated compounds. In particular, the present invention relates to the synthesis of highly fluorinated acetals and ketals...
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WO/2003/064408A1 |
The present invention relates to an improved process for the preparation of ethyl 2,3-dihydrobenzo[1,4]dioxin-2-carboxylate. More particularly the present invention provides a process for the preparation of ethyl 2,3-dihydrobenzo[1,4]dio...
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WO/2003/059874A2 |
The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula (I) and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeuticall...
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WO/2003/059901A1 |
The invention relates to a process for the conversion of group X in a 2−6(−substituted)−1,3−dioxane−4yl) acetic acid derivative according to formula 2 into a group OY in the presence of a phase transfer catalyst and an oxylatin...
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WO/2003/057254A1 |
Preventives/remedies for urinary disturbance containing a compound having both of an acetylcholine esterase inhibitory effect and an &agr 1 antagonistic effect which exhibits an excellent effect of improving the urinary function of the b...
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WO/2003/055873A1 |
The present invention relates to aminoindane derivatives having the formula I wherein X, Y, U, R?1-2¿, R?13-16¿ and R are as defined in the claims, or an acid addition salt thereof. The compounds of the invention posses the combined ef...
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WO/2003/053949A1 |
The invention relates to C1-C6 fragments of epothilones and to an efficient method for producing such fragments and the derivatives thereof.
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WO/2003/053951A1 |
A method of synthesizing trimethylene carbonate is disclosed involving (a) reacting 1,3-propanediol and a compound chosen from phosgene and bis-chloroformates to form a polycarbonate intermediate having a specified structural formula; an...
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WO/2003/053950A1 |
The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-β -hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in ...
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WO/2003/053952A1 |
A method of synthesizing trimethylene carbonate, which includes the steps of reacting 1,3-propanediol and phosgene in vapor form, providing a combination of temperature and pressure at which trimethylene carbonate is in its vapor phase, ...
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WO/2003/051824A1 |
&agr -Cyanoacrylates of the formula (I), where: R1 is ORa wherein Ra is hydrogen, substituted alkyl, branched alkyl, branched alkenyl, cycloloalkyl, heterocyclyl, aryl, phenylalkyl or alkylimino; is NRbRc wherein Rb is hydrogen, alkyl ...
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WO/2003/049702A2 |
Compounds having the general structure of the Formula (I) and compositions containing them, for treatment of various diseases.
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WO/2003/048117A2 |
The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a -S(O)z(C1-C4)Alk wherein z is 0, 1 or 2, a -NHSO2(C1-C4)Alk, -SO2NH(C1-C4)Alk, -NHSO2-(C1-C4...
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WO/2003/048109A1 |
Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.
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WO/2003/046086A1 |
Azo compounds of formula (I), wherein X stands for halogen, in particular for chlorine, or C1−C4alkoxy, in particular for methoxy, Y stands for −CH2− or −O−, R1 and R2, independently from each other, stand for hydrogen, C1−C8...
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WO/2003/044065A2 |
Disclosed is a method for the production of optionally coupled, non-blocking polymers based on conjugated dienes and optionally monovinyl aromatic compounds by anionic polmerization in an inert organic solvent in the presence of a lithiu...
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WO/2003/042164A1 |
The invention provides novel $g(b)¿2? adrenergic receptor agonist compounds of formula (I): wherein R?1¿-R?13¿ and w have any of the values described in the specification. The invention also provides pharmaceutical compositions compri...
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WO/2003/042168A1 |
The invention relates to &agr -oxygenated or &agr -thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitute...
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