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WO/2001/000608A1 |
Racemic or optically pure N-(4-cyano-3-trifluoromethylphenyl)-3-(4 -fluorophenylsulphonyl)-2-hydroxy-2-methylpropionamide of formula (I) is prepared by the following process: 2,3-dihydroxy-2-methylpropionic acid of formula (VII) is react...
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WO/2000/073289A1 |
The invention relates to novel aryl-substituted S(O)¿m? cycles of formula (I), in which F?1¿, F?2¿, G, V, W, X, Y, Z and m have the meanings defined in the description. The invention further relates to methods for producing said cycle...
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WO/2000/058294A1 |
Compounds of formula (I) are antibacterial agents wherein: R¿3? and R¿4?, taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated carbocyclic or heterocyclic ring of 5 to 1...
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WO/2000/054756A2 |
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effect...
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WO/2000/046218A2 |
The invention relates to a method of producing dimethyl sulfite by reacting a cyclic alkylene sulfite having at least 2 carbon atoms with methanol, optionally in the presence of a catalyst. The inventive method is carried out in a contin...
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WO/2000/046188A1 |
The invention relates to a method for producing alkanesulfonic acids from dialkyl sulfites, which comprises the following steps: transformation of dialkyl sulfite in the presence of a suitable catalyst in to the corresponding alkanesulfo...
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WO/2000/039078A1 |
The present invention relates to methods for production of sulfurized diphenyloxides wherein a diphenyloxide is reacted with elemental sulfur in the presence of solid acid catalyst. The solid acid catalyst can be a zeolite or a catalytic...
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WO/2000/035903A2 |
The invention relates to thiochromanoyl cyclohexenone derivatives of formula (I), wherein the variables have the following meanings: A is an optionally substituted, saturated or unsaturated alkyl chain; R?1¿ is cyano, rhodano, nitro, OR...
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WO/2000/025770A1 |
The present invention relates to a class of carbocyclic compounds of Formula (I) that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.
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WO/2000/023415A1 |
The present invention relates to compounds of general formula (I). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PP...
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WO/2000/023420A1 |
Compounds represented by formula (I), or salts thereof; a process for the preparation thereof; and somatostatin receptor regulators containing the compounds or salts: wherein A is an optionally substituted aromatic ring; B is an optional...
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WO/2000/023421A1 |
This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in t...
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WO/2000/015610A1 |
The present invention relates to the preparation of $i(N)-substituted-hydroxycycloalkylamine derivatives and more particularly, to the method for synthesis of $i(N)-substituted-hydroxycycloalkylamine derivatives represented in formula (1...
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WO/2000/012084A1 |
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
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WO/2000/009494A1 |
Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base....
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WO/1999/058125A1 |
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as 'ETM' followed by a numeric value which represents th...
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WO/1999/040047A1 |
The invention relates to methods for preparing macrocyclic products with 9 or more ring atoms by ring-closing diine metathesis of suitable diine substrates. The diine substrates can be converted into cycloakynes or into cycloalkadiines b...
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WO/1999/037608A1 |
The invention relates to novel naphthyl substituted and heterocyclic substituted sulfonamides of general formula (I) in which A, D, E, R?1¿ and R?2¿ have the meanings given in the description. The invention also relates to a method for...
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WO/1999/036391A1 |
The invention provides compounds, compositions and methods relating to novel aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of diseas...
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WO/1999/025687A1 |
A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-...
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WO1998038182A9 |
The invention concerns compounds of formula (I) wherein: I is an integer of from 1 to 4; m is an integer of from 0 to 2; R is independently selected from hydrogen, halogen, nitro, hydroxy, phenylalkoxy, C1-4 alkoxy, C1-6 alkyl, -SO3R'', ...
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WO/1999/010308A1 |
The invention concerns compounds of formula (I) in which: Ar represents an aromatic radical or a heteroaromatic radical optionally substituted in particular by an alkyl or a carboxylic group; R¿2? and R¿3?, represent in particular H, a...
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WO/1999/009020A1 |
Process for the manufacture of epoxy compounds of formula (D) wherein Rb represents a group selected from those of the formulae (1, 2 and 3) by reaction of a compound (A) or (B) with an alkylene oxide, in the presence of a catalyst, sele...
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WO/1998/052935A1 |
The invention concerns compounds of formula (I) in which: R�1?, R�2? and R�3? are as define in the description; X is as defined in the description; Y represents an oxygen atom, a sulphur atom, a CH�q?, SO or SO�2? group; n is b...
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WO/1998/051666A2 |
A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I) wherein X is oxygen, NR?4� or CHR?5??; R?1� is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R?2� is hydrogen, alkyl, aryl, ...
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WO/1998/045373A1 |
A composition comprising a polymer or compound containing at least one five-membered dithiocarbonate group of general formula (I) (wherein R?1�, R?2� and R?3� are the same or different and each represents hydrogen or lower alkyl), ...
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WO/1998/035953A1 |
A process allows the preparation of a fluorinated beta-sultone by reacting a fluorinated olefin with oleum.
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WO/1998/032751A1 |
A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, from another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate c...
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WO/1998/026005A1 |
An aqueous dispersion composition which comprises an amino compound and an aqueous dispersion of a compound having in the molecule both at least one 5-membered cyclic dithiocarbonate group of general formula (I) and an ether linkage and ...
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WO/1998/026006A1 |
An aqueous dispersion comprising the following copolymers (A) and (B) and water, and an aqueous dispersion composition comprising the dispersion and an amine compound. Copolymer (A): a copolymer prepared by copolymerizing (a) a vinyl mon...
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WO/1998/024849A1 |
A composition useful in the fields of coating materials, adhesives, inks, sealants, encapsulating agents, and so on, which comprises both a polymer or compound having at least one 5-membered dithiocarbonate group represented by general f...
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WO/1998/021186A1 |
The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.
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WO/1998/016522A2 |
The present invention pertains to new aminophenol derivates, their preparation and their use as fungicides.
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WO/1998/012190A2 |
Compounds of formula (I) wherein n is 0, 1 or 2; R?1� is a branched or straight chain C1-5 alkyl or C3-6 cycloalkyl optionally substituted with hydroxyl, or one or more halogens, especially fluorine; and X?1�, X?2�, X?3�, X?4�,...
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WO/1998/009952A1 |
HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the n...
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WO/1998/003500A1 |
The invention concerns novel carbanilides of formula (I), in which A, Q, R, X, Z and m have the meanings given in the description. The invention further concerns a plurality of processes for preparing these substances, and their use as h...
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WO/1997/047589A1 |
The present application concerns the use of aminophthalic acid derivatives as fungicides, and novel aminophthalic acid derivatives and several processes for their production.
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WO/1997/046521A1 |
Aliphatic nitrate esters having a sulfur or phosphorus atom 'beta' or 'gamma' to a nitrate group and their congeners having efficacy as neuroprotective agents are described. Preferred nitrate esters may be synthesized by nitration of a 3...
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WO/1997/045273A1 |
This invention includes novel sultine compounds and the reaction of these compounds to form colored compounds. The invention also includes the use of these color-forming compounds in the manufacture and imaging of thermal imaging papers ...
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WO/1997/042185A1 |
Compounds of formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation. In said formula (I) Q is (Q-1), (Q-2) or (Q-3); and A, R1-R7, and q are as defined in th...
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WO/1997/036893A1 |
The invention relates to a group of new piperazine and piperidine compounds having interesting pharmacological properties. It has been found that compounds of formula (a) wherein A represents a heterocyclic group of 5-7 ring atoms wherei...
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WO/1997/030986A1 |
The invention concerns hetaroyl derivatives of formula (I) in which the substituents have the following meanings: L, M are hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, C1-C4 alkoxy, wherein these groups can optionally be substitu...
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WO/1997/026240A1 |
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable sa...
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WO/1997/023476A1 |
Cyclic sulphones of formula (I) are disclosed, in which: R1 and R2 each independently of one another stand for H, A, CF3, CH2F, CHF2, C2F5, Hal, OH, OA, NH2, NHA, NA2, NO2 or CN; X stands for CR4R5, C=Z, O, S, NH, NA or NR3; Y stands for...
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WO/1997/021690A1 |
The present invention is directed to novel (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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WO/1997/014693A1 |
Compounds of general formula (I), in which R1 is C(CO2CH3)=CHOCH3, C(CO2CH3)=NOCH3, N(OCH3)CO2CH3 and C(CONHCH3)=NOCH3; R2 is cyano, halogen, C1-C4 alkyl and C1-C4 alkoxy; m is 0 or 1; R3 is cyano, halogen, C1-C4 alkyl, C1-C4 alkyl halid...
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WO/1997/009324A1 |
Benzoyl derivatives according to formula (I), where substituents L, M, X, Y and n have the meaning given in claim 1 and Q stands for a 2-position cross-linked cyclohexane-1,3-dione ring according to formula (II), where R15, R16, R18, and...
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WO/1996/033172A1 |
A compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal ...
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WO/1996/028418A1 |
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors...
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WO/1996/026200A1 |
The invention concerns benzoyl derivatives of formula (I) in which the substituents have the following meanings: L and M represent hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, C1-C4 alkoxy (these groups being optionally substitut...
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