Heterocyclic Compounds

Matches 601 - 650 out of 2,239	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >

Document	Document Title
WO/1997/003977A1	THIOPYRANS MICROBICIDES Novel 2H-3,4-dihydrothiopyrans of general formula (I) and the salts thereof, wherein R = hydrogen, C1-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, n is 0, 1 or 2, are valuable microbicides. They can be used in plant protection in the form of s...
WO/1997/003064A1	TRIKETONE DERIVATIVES Triketone derivatives represented by general formula (I), wherein Y1 represents C1-4alkyl, halogeno or C1-4haloalkyl; Y2 and Y3 independently represent each C1-4alkyl; Y4 represents hydrogen, C1-4alkyl or halogeno; n is an integer of 0, ...
WO/1997/001550A1	HERBICIDAL KETALS AND SPIROCYCLES Compounds of Formula (I), and their agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein Q is (Q-1) or (Q-2); R1 and R2 are each independently C1-C6 alkoxy, C2-C6 haloalkoxy, C1-C6 al...
WO/1996/040110A1	NOVEL BENZOPYRAN COMPOUNDS AND METHODS FOR THEIR USE The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
WO/1996/041166A2	DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face ...
WO/1996/040647A1	'alpha'-(1,3-DICARBONYLENOL ETHER) METHYL KETONES AS CYSTEINE PROTEASE INHIBITORS Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accor...
WO/1996/041144A2	POLYOXYHYDROCARBYL RELATED PRODUCTS AND METHODS FOR FLUORESCENCE ASSAYS Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy. Fluorescence immunoassays methods are p...
WO/1996/040660A1	CERTAIN SUBSTITUTED BENZYLAMINE DERIVATIVES: A NEW CLASS OF NEUROPEPTIDE Y1 SPECIFIC LIGANDS This invention encompasses compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein Ar is an aryl group preferably selected from the group consisting of phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 2-, 4- or 5...
WO/1996/040101A1	CERTAIN ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS FOR THE TREATMENT OF CERTAIN TUMORS The invention relates to the use of compounds of formula (I) wherein Ar, R, R1 and R2 are as defined in the specification, (for the manufacture of a medicament) for the treatment of a tumor selected from human breast carcinoma, lung carc...
WO/1996/039374A1	2,4-PENTADIENOIC ACID DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY Compounds of Formula (1), wherein Z is selected from the group consisting of the radicals shown in Formula (2) and in Formula (3), Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 groups, or Y i...
WO/1996/036608A1	'alpha','beta'-UNSATURATED KETONE DERIVATIVES 'alpha','beta'-Unsaturated ketone derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, both being useful as a drug, wherein the ring moiety A represents (a), (b), (c) or (d) (wherein B represents ...
WO/1996/030333A1	BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS Compounds of formula (I), wherein X represents a single bond, O, S or CR9R10 where R9 and R10 each independently represent a hydrogen atom or a C1-4alkyl group; R1a, R1b and R1c each independently represent a substituent selected from: a...
WO/1996/030368A1	PYRAZOLE DERIVATIVES Novel pyrazole derivatives represented by general formula (I) and herbicides containing the same as the active ingredient. The derivatives have a remarkably excellent crop-weed selectivity in both foilage and soil treatments.
WO/1996/026933A1	NOVEL SELECTIVE INHIBITORS OF VIRAL OR BACTERIAL NEURAMINIDASES Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
WO/1996/026200A1	HERBICIDAL BENZOYL DERIVATIVES The invention concerns benzoyl derivatives of formula (I) in which the substituents have the following meanings: L and M represent hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkinyl, C1-C4 alkoxy (these groups being optionally substitut...
WO/1996/026201A1	BENZOPYRAN-CONTAINING COMPOUNDS AND METHOD FOR THEIR USE Certain benzopyran antiestrogens are disclosed for treating estrogen sensitive diseases such as breast cancer. Prodrug forms provide ease of manufacturing, good shelf life, and bioavailibility, and preferred stereoisomers are shown to be...
WO/1996/020186A1	CARBOXYLIC ACID DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME A carboxylic acid derivative represented by the following general formula (I): R-CH2COOH, salts thereof, a compound that can be converted into the above compound (I) in vivo, a process for producing these compounds, and a medicinal compo...
WO/1996/020196A1	3-ARYL-TETRONIC ACID DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS ANTI-PARASITIC AGENTS The invention concerns novel 3-aryl-4-hydroxy-'DELTA'3-dihydrofuranone derivatives of formula (I), wherein: A and B together with the carbon atom to which they are bound form a five to seven member ring which is interrupted by at least o...
WO/1996/020174A1	1,3,3-(TRISUBSTITUTED)CYCLOHEXANE MONOMERS AND RELATED COMPOUNDS This invention relates to certain 1,3,3-(trisubstituted)cyclohexane monomers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
WO/1996/019470A1	PROCESS FOR THE PREPARATION OF PYRAZOLE DERIVATIVE An industrially advantageous process for the preparation of a pyrazole derivative useful as a herbicide capable of dispensing with isomer separation suffering from low yield and preparation of carboxylic acid necessitating complicated st...
WO/1996/016962A1	PROCESS FOR PRODUCING PYRAZOLE DERIVATIVE A process for producing pyrazole derivatives according to the reaction formula (A) wherein R1 is H or C1-C4 alkyl; R2, X1, X2, X3 and X4 are each C1-C4 alkyl; X5 is halogen; and n is 0, 1 or 2; and a process for producing an aromatic coa...
WO/1996/014307A1	CERTAIN SUBSTITUTED BENZYLAMINE DERIVATIVES; A NEW CLASS OF NEUROPEPTIDE Y1 SPECIFIC LIGANDS This invention encompasses compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein W, X, Y, A, and T represent organic or inorganic substituents, n is 1, 2, or 3, m is 2, 3, or 4, R1-R4 are hydrogen or organic...
WO/1996/011686A1	DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY Retinoid-like activity is exhibited by compounds of formula (I) where X is S, O, or NR' where R' is hydrogen or lower alkyl; R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-4; and...
WO/1996/009629A1	NOVEL ELECTROCONDUCTIVE COMPOSITION A composition comprising a matrix of a thermoplastic, thermosetting or a structurally crosslinked polymer, in which is incorporated an electroconductive network of crystal needles of a charge transfer complex (abbreviated to CT complex) ...
WO/1996/008489A1	DERIVATIVES OF BENZOPYRAN AND OF BENZOTHIOPYRAN, THEIR PREPARATION AND THEIR USE AS AGONISTS OF DOPAMINERGIC RECEPTORS Compounds of formula (I), wherein R, R', R", Z, m, Y, n, R1, X, p and Ar have the meanings reported in the description; and pharmaceutically acceptable salts thereof are described. The compounds of formula (I) are useful in the treament ...
WO/1996/005191A1	NATRIURETIC CYCLIC COMPOUNDS Compounds, methods and compositions are provided for inducing natriuresis in a mammal. Methods for isolating and synthesizing the natriuretic compounds are also provided. Therapeutic methods using the natriuretic compounds are also provi...
WO/1996/005166A1	SUBSTITUTED AMINE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME A substituted amine derivative represented by general formula (I), having an agonistic activity on 5-HT4 receptors, and useful as a 5-HT4 receptor agonist for preventing and/or treating diseases accompanied with the insufficiency of such...
WO/1996/004265A1	2,6-DIDEOXY-2,3-DIDEHYDRO-6-THIO DERIVATIVES OF 'alpha'-D-NEURAMINIC ACID The invention provides 2,6-dideoxy-2,3-didehydro-6-thio derivatives of 'alpha'-D-neuraminic acid. Methods for preparation of the compounds of the invention, pharmaceutical formulations comprising the compounds, and use of the compounds a...
WO/1996/000738A1	ENDOTHELIN ANTAGONISTS II Novel antagonists of endothelin containing an N-terminal fragment (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute an...
WO/1996/000214A1	ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS Compounds of formula (I) wherein R, R1, R2 and Ar are as defined in the specification, have valuable pharmaceutical properties and are effective especially as matrix metalloproteinase inhibitors, for example for the treatment of arthriti...
WO/1995/035286A1	NEW HIV PROTEASE INHIBITORS Oligopeptide analogs containing sulfonamide, urea or carbamate linkages in the backbone are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AID...
WO/1995/035303A1	SYNTHESIS OF CONDURITOL EPOXIDES AND AZIRIDINES AND METHODS OF USING SUCH TO SYNTHESIZE HIGHER DISACCHARIDES There are described novel coupling reactions useful for the preparation of cyclitol and/or carbohydrate conjugates and carbocyclic analogs thereof. Such coupling reactions employ epoxides and/or aziridines described herein as electrophil...
WO/1995/030644A1	AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE Novel carbocyclic amides together with their salts, solvates and physiologically active derivatives which have a number of uses in medicine, in particular as central muscle relaxants, and in the treatment or prophylaxis of anxiety, infla...
WO/1995/024385A1	SULPHONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITORS This invention relates to a novel class of sulfonamides that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physicoche...
WO/1995/023780A2	SKIN LIGHTENING COMPOSITIONS This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure (I) or (II) wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substitu...
WO/1995/019973A2	PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES A process of preparing intermediates useful in making compounds with retinoic acid-like activity is disclosed. The intermediates are halogenated chromans and thiochromans of formula (I) shown above and are prepared by the alkylation of a...
WO/1995/018803A1	ACETYLENES DISUBSTITUTED WITH A PHENYL OR HETEROARYL GROUP AND A 2-OXOCHROMANYL, 2-OXOTHIOCHROMANYL OR 2-OXO-1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY Compounds of formula (1) where R1 and R2 are hydrogen, lower alkyl of 1-6 carbons, or halogen; R3 is hydrogen, lower alkyl of 1-6 carbons, halogen, OR11, SR11, OCOR11, SCOR11, NH2, NHR11, N(R11)2, NHCOR11 or NR11COR11; X is O, S or NR' w...
WO/1995/014669A1	NOVEL BENZENESULFONYLIMINE DERIVATIVES AS INHIBITORS OF IL-1 ACTION The present invention relates to novel benzenesulfonylimine derivatives and their use as inhibitors of Interleukin-1 (IL-1) action. Such inhibitors are useful in the treatment of various disease states as disclosed herein including rheum...
WO/1995/014670A1	HETEROCYCLIC BENZENESULFONYLIMINE DERIVATIVES AS INHIBITORS OF IL-1 ACTION The present invention relates to heterocyclic benzenesulfonylimine derivatives and their use as inhibitors of Interleukin-1 (IL-1) action. Such inhibitors are useful in the treatment of various disease states as disclosed herein includin...
WO/1995/014014A2	PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies ...
WO/1995/014013A1	PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies ...
WO/1995/014011A2	5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of the...
WO/1995/014012A1	5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of the...
WO/1995/012588A1	ANTINEOPLASTIC HETERONAPHTHOQUINONES Tricyclic heteronaphthoquinone derivatives, that have antineoplastic activity, are disclosed, together with processes for their synthesis. Some of these antineoplastic compounds have a saccharide moiety. Some members of this structurally...
WO/1995/011891A1	NOVEL (R)-5-CARBAMOYL-8-FLUORO-3-N,N-DISUBSTITUTED-AMINO-3,4-DIHYDRO-2H-1-BENZOPYRANES Compounds of general formula (I), wherein R1 is n-propyl or cyclobutyl; R2 is isopropyl, tertiary butyl, cyclobutyl, cyclopentyl or cyclohexyl; R3 is hydrogen; R4 is hydrogen or methyl; as (R)-enantiomer and in the form of free base or p...
WO/1995/007950A1	PROCESS FOR THE PRODUCTION OF CYANINE DYES The present invention relates to a process for the production of cyanine dyes with their methine chain showing group (M) and the charge compensation occurring by linked end groups through transformation of cationic cyanine dyes comprisin...
WO/1995/004526A1	LUPANE TRITERPENOID DERIVATIVES This invention relates generally to the field of medicinal chemistry, and more specifically to derivatives of a subclass of triterpenoid acids that have multi-medicament properties, that is derivatives of the lupane, betulinic acid, form...
WO/1995/004054A1	PYRAZOLE DERIVATIVE A pyrazole derivative represented by general formula (I) or a salt thereof, and a herbicide containing the same as the active ingredient, wherein R1, R2, X1, X2, X3, X4 and n are each as set forth in claim 1.
WO/1995/002587A1	SUBSTITUTED PIPERAZINYLCAMPHOR DERIVATIVES AS OXYTOCIN ANTAGONISTS Compounds of formula (I) are oxytocin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to ceasarean delivery.
WO/1995/001358A1	SUBSTITUTED SPIROHETEROCYCLIC 1H-3-ARYLPYRROLIDINE-2,4-DIONE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USE AS PEST-CONTROL AGENTS The invention concerns substituted spiroheterocyclic 1H-3-arylpyrrolidine-2,4-dione derivatives of formula (I) in which A and B, together with the carbon atom to which they are bound, are an unsubstituted or substituted 5- or 6-membered ...

Matches 601 - 650 out of 2,239	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >