Heterocyclic Compounds

Matches 101 - 150 out of 30,869	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2024/036270A1	KRAS INHIBITORS The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.
WO/2024/035618A1	PROCESSES FOR PREPARING OXAZOLIDINONE COMPOUNDS The invention relates to crystalline forms and processes for preparing a compound of Formula I (I) and pharmaceutically acceptable salts thereof which are useful for the treatment of bacterial infections, particularly mycobacterial infec...
WO/2024/032529A1	PROTEIN DEGRADATION AGENT AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF Provided are a protein degradation agent and a preparation method therefor and a pharmaceutical use thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor, a ...
WO/2024/033388A1	BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES The present invention provides new bicyclic tetrahydrothiazepine derivatives having the general formula (I) wherein Y, R1, R2 and R4 are as defined herein, compositions including the compounds, processes of manufacturing the componds and...
WO/2024/033293A1	DIFLUORO- AND TRIFLUORO-ACETYL HYDRAZIDES AS SELECTIVE HDAC6 INHIBITORS The present invention relates to acylhydrazides obtained in situ by enzymatic hydrolysis of the parent prodrug 2-(difluoromethyl)- or 2-(trifluoromethyl)-1,3,4- oxadiazole, in histone deacetylase 6 (HDAC6).
WO/2024/032501A1	COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF Provided are a compound of formula 0, a stereoisomer thereof, a tautomer thereof, a geometric isomer thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a polymorph thereof, a solvate thereof, a hydrate thereof, a...
WO/2024/033479A1	(AZA)SPIROHEPTANE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS The application relates to compounds of formula (B1A), (B1B), (B1C) or a salt, a solvate, a hydrate, a polymorph, a tautomer, a racemate or a stereoisomer thereof, to pharmaceutical compositions comprising such a compound, and to the com...
WO/2024/032530A1	AROMATIC HETEROCYCLIC CYCLOHEXYL AMINOALKYL PIPERIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF Provided are an aromatic heterocyclic cyclohexyl aminoalkyl piperidine derivative, a preparation method and a use thereof. Specifically, provided are a compound of formula (I), a stereoisomer thereof, a tautomer thereof or a pharmaceutic...
WO/2024/032584A1	PROTEIN TYROSINE KINASE INHIBITOR AND MEDICAL USE THEREOF The present invention relates to a protein tyrosine kinase inhibitor for treating protein tyrosine kinase-mediated proliferative diseases or symptoms, such as ocular diseases and malignant tumors accompanied by pathological neoangiogenes...
WO/2024/033389A1	BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES The present invention provides new bicyclic tetrahydrothiazepine derivatives having the general formula (I) wherein R1, R2 and R4 are as defined herein, compositions including the compounds, processes of manufacturing the compounds and m...
WO/2024/034565A1	IMIDAZOLYLAZOLE COMPOUND AND PEST CONTROL AGENT Provided is a compound represented by formula (I-1a) or the like, or a salt thereof. [In formula (I-1a), R1 represents a substituted or unsubstituted C1-6 alkyl group, a substituted or unsubstituted C2-6 alkenyl group, or the like; R2 re...
WO/2024/033457A1	BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES The present invention provides new bicyclic tetrahydrothiazepine derivatives having the general formula (I) wherein R1, R2 and R4 are as defined herein, compositions including the compounds, processes of manufacturing the componds and me...
WO/2024/029489A1	KIT INHIBITORS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF Provided herein are compounds and compositions useful in inhibiting a receptor tyrosine kinase, KIT.　The compounds and compositions provided herein are useful for the prevention or treatment of one or more KIT mediated diseases or cond...
WO/2024/031089A1	SARS-COV2 MAIN PROTEASE INHIBITORS The present disclosure relates to compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.
WO/2024/028533A1	2-(PYRROLIDIN-1-YL)THIAZOLE COMPOUNDS AND THEIR USE AS ANTIBIOTIC AGENTS The present invention relates to compounds containing a 2-(pyrrolidin-1-yl)thiazole carbon backbone with a structure described in general formula (5). (5) Wherein R1 = H, methyl, ethyl; R2 = benzyl, (3-indolyl)methyl; R3 = 3-indolyl, ary...
WO/2024/028243A1	PYRAZOLO PESTICIDAL COMPOUNDS The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description, Formula...
WO/2024/028169A1	NOVEL SPECIFICALLY SUBSTITUTED THIOPHENOLIC COMPOUNDS The present invention relates to novel thiophenolic compounds (I) which are useful in the treatment of proliferative and/or hyper-proliferative diseases. Preferably, the compounds of the present invention are endowed with inhibitory acti...
WO/2024/030633A1	COMPOSITIONS AND METHODS FOR INHIBITION OF KRAS Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulat...
WO/2023/129564A9	DEGRADERS OF GRK2 AND USES THEREOF Provided herein are compounds (e.g., compounds of Formulae (I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, isotopically labeled derivatives, solvates, hydrates, polymorphs, co-crystals, and prodrugs thereof, pharma...
WO/2024/028711A1	PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM MONOSULFATE The present invention concerns a process for the preparation of isavuconazonium monosulfate, the process allowing to obtain isavuconazonium monosulfate as a isolated powder in good yield, with high HPLC purity (> 95%) and the proper amou...
WO/2024/029613A1	HETEROCYCLIC COMPOUND FOR INDUCING DEGRADATION OF MUTANT KRAS PROTEIN Provided is a compound useful as an active ingredient in a pharmaceutical composition for treating pancreatic cancer.　The present inventors carried out investigations with regard to compounds useful as an active ingredient in a pharmac...
WO/2024/030651A1	GPX4 INHIBITORS AND USE THEREOF The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, sp...
WO/2024/026262A1	SUBSTITUTED PYRAZOLYL-PYRIDINYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK3 Provided herein are compounds and compositions thereof for modulating IRAK3. In some embodiments, the compounds and compositions are provided for treatment of cancer.
WO/2024/022519A1	HETEROCYCLE FUSED PYRIMIDINE COMPOUND AND USE THEREOF Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof as a USP1 inhibitor and a pharmaceutical composition comprising the compound or the pharmaceutically acceptable salt thereof. The compound and the pharm...
WO/2024/023330A1	SUBSTITUTED BICYCLIC HETEROARYL SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF CANCER The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof; wherein X1 is CR7 or N, X2 is CR8 or N, X3 is CR9 or N and wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claims, as well...
WO/2024/020517A1	3-(6-PYRIDIN-3-YL)-2-[4-(4-METHYL-4H-1,2,4-TRIAZOL-3-YL)PIPERIDIN-1-YL]BENZONITR ILE DERIVATIVES AND SIMILAR COMPOUNDS AS QPCTL AND QPCT INHIBITORS FOR THE TREATMENT OF CANCER Provided herein are compounds of formula (II) and formula (I) that are inhibitors of QPCTL and QPCT: (II) & (I) Also provided are pharmaceutical compositions comprising the compounds, as well as the compounds for use in methods for the t...
WO/2024/017306A1	SULFUR-CONTAINING HETEROAROMATIC RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF Disclosed are a sulfur-containing heteroaromatic ring compound, a pharmaceutical composition thereof, and a use thereof. Specifically disclosed are a compound as represented by formula (I), a pharmaceutically acceptable salt thereof, a s...
WO/2024/020084A1	HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 Provided herein are compounds and compositions thereof for modulating IRAK4. In some embodiments, the compounds and compositions are provided for treatment of inflammatory or autoimmune diseases.
WO/2024/017247A1	CYANINE DYE AND PREPARATION METHOD THEREFOR AND USE THEREOF, SAMPLE ANALYSIS METHOD, AND ANALYZER The present application relates to a fluorescent dye, and in particular, to a cyanine dye, and a preparation method therefor and a use thereof. Specifically, provided is a compound having a structure as represented by general formula I, ...
WO/2024/017897A1	1,3,4-OXADIAZOLE DERIVATIVES AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS The present invention relates to selective oxadiazole-based inhibitors of histone deacetylase 6 (HDAC6) and uses thereof in treating various diseases and disorders.
WO/2024/019916A2	CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS The present invention relates to monobactam compounds of Formula (I):(Formula (I)) and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formu...
WO/2024/018290A1	STABLE SYNERGISTIC PESTICIDAL COMPOSITION The present invention relates to a stable synergistic pesticidal composition capable of protecting plant propagation materials such seeds, seedlings; and plants/crops from harmful effects of seed-borne, soil borne pathogenic fungi and/or...
WO/2024/017855A1	NOVEL ISOTHIAZOL-3-YL AND ISOXAZOL-3-YL SULFONAMIDE COMPOUNDS The invention relates to novel compounds having the general formula (I) wherein R1, R2, R3, X and Y are as described herein, composition including the compounds and methods of using the compounds.
WO/2024/015569A2	SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with abnormal levels of amino acids by modulation of SLC6A19 transport.
WO/2024/015497A1	TYROSINE KINASE 2 INHIBITORS AND USES THEREOF This disclosure relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, in which all of the variables in Formula (I) are as defined in the application. The compounds of this disclosure are capable of inhibiting ...
WO/2024/015425A1	HERBICIDAL BENZOXAZINES Disclosed are compounds of Formula (I), including all stereoisomers, N-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides A is a 5- or 6-membered heterocyclic ring, containing ring members se...
WO/2024/013209A1	PCSK9 INHIBITORS AND METHODS OF USE THEREOF Disclosed herein are PCSK9 inhibitors. Also disclosed herein are methods of using PCSK9 inhibitors to treat certain diseases and disorders.
WO/2024/015637A1	GLUTATHIONE PEROXIDASE 4 (GPX4) INHIBITORS FOR THE TREATMENT OF CANCER The application relates to relates to glutathione peroxidase 4 (GPX4) inhibitors of the general Formulae I and II which induce ferroptosis in a cell and are useful for the treatment of cancer.
WO/2024/009215A1	NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein c...
WO/2024/008941A1	NEW SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS Compounds of Formula (I): wherein R1, R2, R3, R4 and are as defined in the description. Medicaments.
WO/2024/010050A1	AMINE COMPOUND, AND ORGANIC ELECTROLUMINESCENCE ELEMENT, ELECTRONIC EQUIPMENT, AND ELECTRONIC ELEMENT CONTAINING SAME [Problem] The purpose of the present invention is to provide a compound that prevents internal elemental deterioration of an organic EL element, that, in order to significantly improve light-extraction efficiency, does not affect materia...
WO/2024/009283A1	AT2 ANTAGONISTS FOR NON-ADDICTIVE PAIN RELIEF Angiotensin AT2 receptor antagonists have been clinically validated for the treatment of chronic neuropathic pain. We discovered a series of lead compounds comprising a trisubstituted heterocyclic core that show high in vitro (sub-nanomo...
WO/2024/009120A1	TRIAZINE DERIVATIVES AND METHODS OF USE THEREOF Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.
WO/2024/008805A1	HETEROAROMATIC KETONES AND THEIR USE IN RADICAL AND CATIONIC POLYMERIZATION The invention relates to heteroaromatic ketones of formula (I) for radical and cationic polymerization (I), wherein the substituents A, B, C and D can be the same or different and are nitrogen or carbon, while R1 and R2, independently of...
WO/2024/007511A1	ARYLAMINE COMPOUND, ORGANIC ELECTROLUMINESCENT DEVICE, AND ELECTRONIC APPARATUS The present application provides an arylamine compound, an organic electroluminescent device comprising same, and an electronic apparatus. The arylamine compound of the present application contains benzocarbazole and benzoxazole groups a...
WO/2024/008166A1	α,β-UNSATURATED AMIDE COMPOUND, AND PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF Provided in the present invention are an α,β-unsaturated amide compound, and a preparation method therefor, and a pharmaceutical composition and the use thereof. Specifically, provided in the present invention is a compound as represen...
WO/2024/006916A1	AZETIDINYL PYRIMIDINES AND USES THEREOF AS JAK INHIBITORS Provided herein are compounds useful as inhibitors of Janus kinase (JAK) proteins and in treating JAK-related diseases.
WO/2024/003408A1	SMALL-MOLECULE INHIBITORS OF THE FRS2-FGFR INTERACTION The invention relates to a compound of the general formula (100) wherein Y is O or S, X is N or CH, L is a linker selected from formula (I), a C1-C4 alkyl, a C1-C3 amine, a C1-C3 amide, and a C1-C3 amide-ether, wherein Q is N or CH, and ...
WO/2024/002328A1	NITROGEN-CONTAINING COMPOUND AND USE THEREOF Provided are a nitrogen-containing compound and use thereof. Specifically, provided is a nitrogen-containing compound represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, a met...
WO/2024/002377A1	CLASS OF PRMT5 INHIBITORS AND USE THEREOF Provided is a class of compounds with methyltransferase inhibitory activity. Specifically, provided is a class of compounds with PRMT5 inhibitory activity. The compounds can be used for preparing a pharmaceutical composition for treating...

Matches 101 - 150 out of 30,869	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >