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WO/2023/164250A1 |
Provided herein are secretion inhibitors, such as inhibitors of Sec61 having a structure of formula (I): methods for their preparation, related pharmaceutical compositions, and methods for using the same.
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WO/2023/155710A1 |
The present invention belongs to the field of medicinal chemistry, and relates to an IKZF2 degradation agent, a pharmaceutical composition comprising same and use thereof. Specifically, the IKZF2 degradation agent has a structure represe...
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WO/2023/159155A1 |
Disclosed herein are compounds of Formulae 1A, 1B, 1C and 1D, (1A), (1B), (1C) and (1D) and methods of making and methods of using the same.
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WO/2023/156863A1 |
Provided is an inhibitor of AXL, Mer, and/or c-Met of Formula (I) or a pharmaceutically acceptable salt thereof: Formula (I), in which R1, R2, R3, G, and Q are described herein. Further provided is a method of treating or preventing an A...
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WO/2023/155927A1 |
The present disclosure provides an inhibitor, represented by formula I, of interaction between YAP/TAZ and TEAD, preparation thereof, a pharmaceutical composition thereof and use thereof. The compound provided in the present disclosure c...
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WO/2023/155454A1 |
The present invention relates to a carbonic anhydrase IX-targeting radioactive diagnostic and therapeutic medicament and a method for preparing same, and in particular, relates to a compound represented by formula (I), or a pharmaceutica...
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WO/2023/158795A1 |
Provided are compounds of the Formula (I): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.
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WO/2023/151640A1 |
Provided herein are compounds having the structure (I), wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of an immune cell.
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WO/2023/152666A1 |
The present invention provides 3-substituted pyridazine compound of formula (I), which are therapeutically useful as SMARCA2 and/or SMARCA4 degraders. These compounds are useful in the treatment and/or prevention of diseases or disorders...
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WO/2023/151697A1 |
The present invention relates to a compound represented by general formula (I) or a stereoisomer, a tautomer, a deuterated substance, a solvate, a prodrug, a metabolite and a pharmaceutically acceptable salt or eutectic crystal thereof, ...
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WO/2023/154913A1 |
The present invention relates to sulfonamides and related compounds which are inhibitors of PARG and are useful in the treatment of cancer.
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WO/2022/178428A9 |
The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of an extracellular or cell surface protein. In certain embodiments, the extracellular protein mediates a disease a...
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WO/2023/152773A1 |
The present invention relates to the Amorphous Solid Dispersions (ASDs) of Momelotinib di-hydrochloride and processes for preparation thereof. Compared to a crystalline form, a stable amorphous form of Momelotinib di-hydrochloride enhanc...
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WO/2023/153748A1 |
The present invention relates to an SOS1 inhibitor and a derivative thereof. A compound, or a pharmaceutically acceptable salt, hydrate, solvate, tautomer, enantiomer, or pharmaceutically acceptable diastereomer thereof of the present in...
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WO/2023/154519A1 |
Provided are compounds of the Formula (I); or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.
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WO/2023/150523A1 |
Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), ...
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WO/2023/150535A1 |
Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), ...
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WO/2023/150526A1 |
Arylsulfonamides of 5-substituted octahydrocyclopenta[c]pyrroles, and their derivatives, are competitive and non-competitive inhibitors of the muscarinic acetylcholine receptor M5 (mAChR M5) and have utility in the treatment of psychiatr...
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WO/2023/148501A1 |
The present invention relates to compounds of formula (I) that are MALT1 inhibitors. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to p...
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WO/2023/150525A1 |
Arylsulfonamides of 4-substituted-piperidines, and their derivatives, are competitive and non-competitive inhibitors of the muscarinic acetylcholine receptor M5 (mAChR M5) and have utility in the treatment of psychiatric disorders such a...
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WO/2023/150150A1 |
Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), ...
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WO/2023/148544A1 |
The present invention relates to a crystalline form of isavuconazonium sulfate. The present invention also relates to a process for preparation of isavuconazonium sulfate and a pharmaceutical composition containing the crystalline isavuc...
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WO/2023/143249A1 |
Disclosed in the present invention are a compound that inhibits MALT1 and promotes the degradation of MALT1 by means of recruiting E3 ubiquitin ligase, and the use of the compound in the preparation of a drug for treating related disease...
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WO/2023/144764A1 |
The present invention relates to substituted heterocyclic compounds represented by the general formula (I), or their isotopic forms, stereoisomers, or pharmaceutically acceptable salts thereof. The present invention also describes the me...
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WO/2023/069514A9 |
This disclosure relates to compounds of formulae I, II and III useful for degrading ITK via a ubiquitin proteolytic pathway. This disclosure also provides pharmaceutically acceptable compositions comprising said compounds, and methods of...
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WO/2023/142214A1 |
A series of 3-hydroxy-5-(isoxazol-5-yl) pyridine formylglycine compounds, a preparation method, a pharmaceutical composition, and the use. A structure of the compounds is shown as formula (I), and the compound derivatives comprise pharma...
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WO/2023/143605A1 |
The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors.The present invention provides a direct enantioselective ch...
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WO/2023/146785A1 |
The present disclosure provides compounds of the formula (III) and their pharmaceutically acceptable salts, and compounds of the formula (IV) and their pharmaceutically acceptable salts, and pharmaceutical compositions comprising these c...
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WO/2023/146989A1 |
Provided are compounds of Formula (I): (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions, processes of preparing and methods of treating thereof; wherein R1, R2, R3, R4, R6, R7, R8 and n are as defined h...
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WO/2023/144450A1 |
According to an aspect of the present invention, there is provided a [1,2,4]triazolo[3,4-b]benzothiazole scaffold, which can be used to inhibit efficiently human PARP enzymes. The compounds disclosed bind to the nicotinamide pocket of th...
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WO/2023/144793A1 |
The present invention relates to compounds of formula (I), that possess DNA polymerase theta (POLQ) enzyme inhibitory activity, methods for their preparation, pharmaceutical compositions containing them, and their use in the treatment or...
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WO/2023/146897A1 |
Described herein are selective HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular dis...
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WO/2023/144559A1 |
The present invention relates to compounds of formula I shown below: wherein R1, R4, R5 and R6 are each as defined in the application. The present invention also relates to processes for the preparation of these compounds, to pharmaceuti...
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WO/2023/146511A1 |
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating diseases. Specific diseases include those that are mediated by YAP/TAZ or those that are modulated by the interaction be...
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WO/2023/141852A1 |
Disclosed are compounds represented by formula 1a or formula 1b, and respective optical isomers, prodrugs, or pharmaceutically acceptable salts, and pharmaceutical compositions thereof, and the use thereof in the preparation of CDK2 inhi...
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WO/2023/146991A1 |
Provided are compounds of Formula (I): (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions, processes of preparing and methods of treating thereof; wherein Ring A, Ring B, X, R1, R2 and n are as defined he...
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WO/2023/147531A1 |
Disclosed are compounds of Formula (I) pharmaceutically acceptable salts thereof are defined herein, and pharmaceutical compositions thereof and combinations thereof, and methods of using the same as inhibitors of protein tyrosine phosph...
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WO/2023/143603A1 |
Use of a compound of Formula I for treating atherosclerosis and related diseases, disorders and conditions in a subject in need of such treatment, wherein the subject in need of such treatment is a subject carrying one or more genetic mu...
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WO/2023/139085A1 |
The invention relates to a compound of formula (I) wherein A1, A2, A3, R1, R2, R2', R3, R4 and R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
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WO/2023/141300A1 |
The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, ...
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WO/2023/139402A1 |
Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed. Formula (C)
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WO/2023/139132A1 |
The present invention relates to novel antagonists of the A2B adenosine receptor and pharmaceutical compositions comprising said antagonists as well as their uses for the treatment and prevention of disorders known to be susceptible to i...
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WO/2023/141225A1 |
The disclosure provides compounds, e.g., compounds of Formula I, and their use in treating medical diseases or disorders, such as neurological disorders. Pharmaceutical compositions and methods of making various azaindole and benzisoxazo...
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WO/2023/138412A1 |
The present disclosure relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvate, stereoisomer, or isotopic variant thereof useful as CDK20 inhibitors, pharmaceutical compositions comprising the same, and use ther...
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WO/2023/140649A1 |
The present specification relates to a compound represented by chemical formula 1 and to an organic light-emitting device comprising: a first electrode; a second electrode; and one or more organic material layers provided between the fir...
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WO/2023/134739A1 |
Provided in the present disclosure are a six-membered cyclothiazole compound as represented by formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, and the use thereof in the prevention...
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WO/2023/136295A1 |
One purpose of the present invention is to provide a compound which is suitable for use as a material for a capping layer in an organic EL element, has a high refractive index in a wavelength range from 450 nm to 750 nm, and has a low ex...
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WO/2023/136457A1 |
The present invention relates to a novel compound and an organic light-emitting device comprising same.
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WO/2023/137030A1 |
Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.
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WO/2023/134765A1 |
The present invention relates to five-membered-ring-containing derivatives, a preparation method therefor, and the uses thereof. In particular, the present invention relates to compounds represented by a general formula, a preparation me...
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