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Matches 201 - 250 out of 428

Document Document Title
WO/1998/012193A1
Substituted carbamoyl triazoles have the formula (I), in which the variables have the following meanings: R?1� is hydrogen, C�1?-C�6? alkyl, C�1?-C�6? alkyl halide, C�3?-C�8? cycloalkyl, C�3?-C�6? alkenyl or C�3?-C�...  
WO/1998/011128A1
The invention concerns modified aminoacids of general formula (I) in which A, Z, X, n, m, R, R?2�, R?3�, R?4� and R?11� are defined in claims 1 through 5, their tautomers, their diastereomers, their enantiomers, their mixtures an...  
WO/1998/004528A2
Substituted pyridines of formula (IA) are produced by reaction of suitably substituted pyridylaldehydes with Grignard or Witting reagents, and the resulting products are appropriately reduced. The pyridines of formula (IA) are suitable a...  
WO/1997/042185A1
Compounds of formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation. In said formula (I) Q is (Q-1), (Q-2) or (Q-3); and A, R1-R7, and q are as defined in th...  
WO/1997/030045A1
A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.  
WO/1997/030046A1
A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.  
WO/1997/018207A2
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...  
WO/1997/001543A1
The invention concerns 1-amino-3-benzyluracils of formula (I) and their salts. In said formula (I), R1 = halogen; R2, R3 = H, CN, SCN, halogen, C1-C4-alkyl halide, C1-C4-alkoxy halide, C1-C4-alkylthio halide; R4 = R3 + C1-C4-alkyl, C1-C4...  
WO/1996/026205A1
Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure (a, b, c or d) wherein R1 to ...  
WO/1996/025406A1
Compounds of formula (I) in which A is possibly substituted alkylene, Ar is possibly substituted arylene or heteroarylene, E is preferably one of the grouping (a), (b), (c), (d), (e), Y1 is oxygen, sulphur or a possibly alkyl-substituted...  
WO/1996/017835A1
The invention pertains to novel oxathiazolinones of formula (I), a method for preparing them and their use as fungicides.  
WO/1996/014302A1
Pyrazole derivatives represented by formula (I) and physiologically acceptable salts thereof can suppress the production of both of prostaglandins and leukotrienes simultaneously, and, therefore, exhibit anti-inflammatory and analgesic e...  
WO/1996/013264A1
Antihyperglycemic compounds selected from the group consisting of C-substituted pentacycloazoles and N-alkyl-substituted pentacycloazoles.  
WO/1996/006095A1
A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.  
WO/1996/003388A1
A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by formula (II), wherein R3 is a radical selected from hydrido, alkyl, haloalkyl, aralkyl, heterocycloalkyl, acyl...  
WO/1995/033725A1
Compounds having the formula R5O-A-NR4-R2 (V), where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydrogen atoms or together represent -SO- or -SO2- an...  
WO/1995/026953A1
A benzoic acid compound represented by general formula (I) (wherein each symbol is as defined in the specification); an optical isomer or pharmaceutically acceptable salt thereof; a medicinal composition comprising the compound and pharm...  
WO/1995/011680A1
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one o...  
WO/1995/005739A1
Use of 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides having formula (I), wherein n is 0, 1 or 2; R1 is hydrogen, C1-4alkyl or benzyl; and R represents (a) phenyl; phenyl substituted with 1 to 3 substituents independently selecte...  
WO/1995/006043A1
The present invention provides certain 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides, useful for the long-term preservation of wood and composite wood materials against wood damaging and wood destroying materials. The present in...  
WO/1995/005374A1
A cyclopentene derivative represented by general formula (I) and a pharmaceutically acceptable salt thereof: wherein Ar1 and Ar2 represent each independently phenyl, thienyl, pyridyl, indolyl, benzofuranyl or dihydrobenzofuranyl; A repre...  
WO/1995/000471A1
A compound represented by general formula (I) or a possible stereoisomer or optical isomer thereof, and a pharmaceutically acceptable salt thereof (wherein R1, R2, R3 and R4 represent each hydrogen, etc.; R6 and R7 represent each optiona...  
WO/1994/010156A1
Pyrimidinyl and triazinyl ethers and thioethers of formula (I) wehrein Q is (Q1), (Q2), (Q3); and the other definitions of the substituents are given in patent claim 1, and the salts of compounds of formula (I) have herbicidal activity a...  
WO/1994/005639A1
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specif...  
WO/1993/009102A1
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one o...  
WO/1992/020669A1
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.  
WO/1992/020660A1
Substituted 1-(2H)-isoquinolinones of structural formula (I) are angiotensin II antagonists which are useful in the treatment of hypertension and congestive heart failure.  
WO/1992/020696A1
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.  
WO/1992/020662A1
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of formula (I) are useful as angiotensin II antagonists.  
WO/1992/018490A1
Bicyclic derivatives of general formula (I), wherein X1 is -S- or -SO-; X2 is -CO- or -CS-; R1 is hydrogen, halogen or lower alkyl optionally substituted by halogen or lower alkoxy; R2 and R3 are each independently hydrogen, lower alkyl,...  
WO/1992/005164A1
Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.  
WO1991019475A1
This invention relates to certain quinolinyl-benzoheterobicyclic compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists and/or as mediator release inhibitors usef...  
WO/1991/017156A1
5-(1-Hydroxy-2-piperidinopropyl)-2(1H,3H)-indolone derivatives and analogs; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.  
WO/1990/003969A1
Selected indazoles have been found effective in the control of nonagronomic arthropods and are used for that purpose in compositions comprising appropriate carriers.  
WO/1984/004303A1
Compounds of the formula (I), wherein C1 and N4 are in trans configuration to each other, Y is OH, R1COO, R2R3NCOO- or R4O whereby R1 is an aliphatic hydrocarbon residue having 1-17 carbon atoms, a phenyl, 2,6-dimethylphenyl or 3- or 4-h...  
JP7073405B2
The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof,wherein the variables of compound of formula X are as defined in the claims and the description.  
JP2022513972A
Compounds of formula (I) as defined herein, which can regulate the KIF18A protein and thereby affect the cell cycle and cell proliferation processes to treat cancer and cancer-related diseases, and the compounds thereof. Synthetic interm...  
JP2021121626A
To provide mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration and prevention of cardiovascular diseases.There is provided a compound for use in a method of treating, amel...  
JP6893030B2
This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardi...  
JP2020502136A
The present invention relates to bisarylamide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisarylheterocycles of formula (I). [Chemical 1]  
JP2020502152A
The present invention relates to those use as an ether bond triazole compound, the method of manufacturing them, the medicine constituent containing them, and a NRF2 Acti beta. Especially the present invention relates to the compound of ...  
JP2020502123A
The present invention relates to those use as a Bisua reel heterocyclic compound, the method of manufacturing them, the medicine constituent containing them, and a NRF2 Acti beta. Especially the present invention relates to the Bisua ree...  
JP2020500918A
The present invention relates to those use as N-Aryl pyrazole compound, the method of manufacturing them, the medicine constituent containing them, and NRF2 regulator. Especially the compound of the present invention contains the compoun...  
JP6630671B2
The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.  
JP6615876B2
The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosur...  
JP6273250B2
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.  
JP6262228B2
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of makin...  
JP2017523213A
The present invention is in the field of medicinal chemistry, and relates to the compound which checks bacteria Gilase , and its medicine constituent. This compound is useful as inhibitor of bacteria Gilase activity and a bacterial infec...  
JP6182592B2
The invention relates to new amino-indole-substituted imidazolyl-pyrimidines of formula 1 wherein R1, R2, R3, R4 and R5 are defined as in claim 1 and pharmaceutically acceptable salts thereof and the use of these compounds for the prepar...  
JP6111276B2
The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I ar...  

Matches 201 - 250 out of 428