Heterocyclic Compounds

Matches 651 - 700 out of 2,394	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >

Document	Document Title
WO/1999/021553A1	ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in bo...
WO/1999/021855A1	PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS Derivatives of pleuromutilin of formula (IA) or (IB) in which the glycolic ester moiety at position (14) is replaced by R?2¿(CH¿2?)¿m?X(CH¿2?)¿n?CH¿2?COO are of use in antimicrobial therapy. In which: each of n and m is independent...
WO/1999/020633A1	BENZOXAZINE DERIVATIVES, PREPARATION AND APPLICATION IN THERAPY The invention concerns compounds of formula (I) in which: R¿1? represents a hydrogen atom, a halogen, a C¿1?-C¿4? alkyl, methyl, hydroxy or amino group; R¿2? and R¿3?, identical or different, represent a hydrogen atom, a C¿1?-C¿4?...
WO/1999/012877A1	ENANTIOSELECTIVE REDUCTION OF KETONES WITH A SILANE AGENT/METAL COMPOUND/CHIRAL LIGAND SYSTEM The invention concerns a method for the enantioselective reduction of prochiral ketones into chiral alcohol's comprising the following steps: a) reacting a prochiral ketone with a silane agent, present in stoichimetric amount, in the pre...
WO/1999/010339A1	2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NOS INHIBITORS The present invention relates to 2-aminopyridine derivatives of formula (I) wherein G, R?1¿ and R?2¿ are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions c...
WO/1999/009987A1	METHOD FOR TREATING PREMENSTRUAL OR LATE LUTEAL PHASE SYNDROME This invention relates to methods of alleviating and managing symptoms associated with premenstrual syndrome and late luteal phase syndrome in a women by administering a tachykinin receptor antagonsit, preferably a neurokinin-1 receptor ...
WO/1999/003472A1	PERIPHERALLY ACTING ANTI-PRURITIC OPIATES Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising formula (I), wherein M is (a), (b) or (c), R, R?2¿, R?3¿, R?4¿, R?7¿, Ar?1¿ and Ar?2¿ are as defined in the spe...
WO/1999/000385A1	3-PYRIDYL-1-AZA-BICYCLO-ALKANE DERIVATIVES FOR PREVENTION AND TREATMENT OF CNS DISORDERS Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease...
WO/1998/057972A1	QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS The present invention provides a compound of formula (I) wherein R is phenyl, C�3?-C�7? cycloalkyl or heteroaryl, each of which being optionally benzo- or C�3?-C�7? cycloalkyl-fused and optionally substituted, including in the be...
WO/1998/057909A1	PROCESS FOR THE PRODUCTION OF RADIOIODINATED NEURORECEPTOR AGENTS The present invention is related to a process for producing radioiodinated neuroreceptor agents with improved yields. In said process the trialkyltin group of the precursor of the neuroreceptor agent is replaced by radioiodine in the pre...
WO/1998/057931A2	QUINOLINE-INDOLE ANTIMICROBIAL AGENTS, USES AND COMPOSITIONS RELATED THERETO Compounds of general formula (1), or a pharmaceutically acceptable salt and/or prodrug thereof, wherein each of A and B independently represent fused rings selected from a group consisting of monocyclic or polycyclic cycloalkyls, cycloal...
WO/1998/056383A1	PHARMACEUTICAL COMPOSITIONS CONTAINING CINCHONINE DICHLORHYDRATE The invention concerns pharmaceutical compositions containing cinchonine dichlorhydrate as active principle, with purity not less than 95 %. The invention also concerns a method for preparing cinchonine dichlorhydrate from cinchonine and...
WO/1998/054189A1	SPIRO-QUINUCLIDINE DERIVATIVES, THEIR PREPARATION AND USE The present invention discloses compounds of formula (I), or a pharmaceutically acceptable salt thereof; wherein n is 1 or 2 or 3, A is -O-, -S-, -CH�2?-, -O-CH�2?-, or -CH�2?-O-; B is -O-, -S-, -CH�2?-, -O-CH�2?-, or -CH�2?-...
WO/1998/054151A1	PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS The present invention provides a process for preparing thiadiazole azabicyclic compounds.
WO/1998/054158A1	QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p56?lck� TYROSINE KINASES This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56?lck� tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compoun...
WO/1998/054156A1	QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR P56?lck� TYROSINE KINASES This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these com...
WO/1998/054157A1	QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p56?1ck� TYROSINE KINASES This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56?lck� tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compoun...
WO/1998/052940A1	SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (I) wherein R?1�, R?2�, R?3� and R?4� are as described in the specification.
WO/1998/050383A1	5-PHENYL-1,3,4-OXADIAZOL-2(3H)-ONE DERIVATIVES AND THEIR USE AS 5-HT4 LIGANDS The invention concerns compounds of general formula (I) in which R�1? represents H, an alkyl or a cycloalkylmethyl, X�1? represents H or an alkoxy, or OR�1? and X�1? together represent a -OCH�2?O-, -O(CH�2?)�2?-, -O(CH�2?...
WO/1998/048801A1	2-AZABICYCLO COMPOUNDS 2-Azabicyclo compounds represented by general formula (1) or pharmaceutically acceptable salts thereof, which are nicotinic acetylcholine agonists and useful as remedies for diseases caused by central nerve degeneration such as Alzheimer...
WO/1998/047900A1	HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE The present invention relates to therapeutically active azabicyclic compounds of formula (I), a method of preparing the same and to pharmaceuticcal compositions comprising the compounds. The novel compounds are useful in treating a disea...
WO/1998/046226A1	METHOD FOR TREATING SCHIZOPHRENIA The present invention provides a method for treating a condition selected from the group consisting of schizophrenia, schizoaffective disorder, and schizophreniform disorder in a patient using a Compound (I).
WO/1998/046601A1	COMPOSITION FOR TREATING PAIN The present invention provides a composition useful for the treatment of pain, wherein the composition comprises Compound (I) and a Synergistic Analgesic.
WO/1998/046227A1	COMPOSITION FOR TREATING PAIN The present invention provides a composition useful for the treatment of pain, wherein the composition comprises Compound I and a Synergistic analgesic.
WO/1998/035663A1	PHARMACEUTICAL FORMULATIONS IN DRY FORM FOR THE ORAL ADMINISTRATION OF A CYCLIC QUATERNARY AMMONIUM COMPOUND The invention concerns pharmaceutical formulations containing 0.5 to 50 wt. % f a cyclic quaternary ammonium compound and suitable pharmaceutical excipients, and are formulated by wet granulation preferably with polysorbate 80.
WO/1998/033788A1	MATRIX METALLOPROTEINASE INHIBITORS A compound of formula (I), wherein W is -NHOH or -OH, R�1? is either free or protected hydroxymethyl or mercaptomethyl or derivatives thereof, R�2? is free or protected hydroxy, R�3? and R�4? is an organic group, R�5? is hydrog...
WO/1998/032758A1	SINGLE POT PROCESS FOR PRODUCING (Z)-AZABICYCLO OXIME ETHERS Biologically active O-substituted azabicyclo oximes having the Z configuration may be isolated simply, without chromatographic separation, and in high yield and Z/E purity through the coupling of a 1-azabicyclo-3-one with an O-substitute...
WO/1998/031661A1	BENZAMIDINE DERIVATIVES Benzamidine derivatives involving compounds represented by formulae (a) and (b) and analogs thereof or pharmaceutically acceptable salts thereof. These compounds show anticoagulant effects based on their excellent effects of inhibiting a...
WO/1998/022466A1	PROCESS FOR PREPARING MeO-Peg-PROTECTED DIHYDROQUININE OR DIHYDROQUINIDINE DERIVATIVES, NEW DIHYDROQUININE OR DIHYDROQUINIDINE DERIVATIVES AND THEIR USE It is known that dihydroquinine or dihydroquinidine derivatives can be successfully used as ligands in the enantioselective dihydroxylation. The new disclosed ligand systems based on dihydroquinine/quinidine, unlike the prior art ligands...
WO/1998/018326A1	COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC-RESISTANT INFECTIONS Compounds having antimicrobial activity are of the formula: A-B-N-Z(n) wherein N is a quinolyl, pyridyl or benzoquinolyl rings substituted at the carbon opposite the nitrogen on the nitrogen-containing ring by B-A wherein B is a carbon (...
WO/1998/018788A1	PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS The invention relates to compounds of formula (I) wherein Z, R�c?, y, m, u, Ar�2?, n, X, R�c'?, l and Ar�2? are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chron...
WO/1998/015551A1	QUINUCLIDINE DERIVATIVES AS ANTAGONISTS OF MUSCARINIC RECEPTORS The invention concerns compounds of formula (I) in which: R�1? represents one hydrogen atom, one halogen such as fluorine, chlorine, bromine or iodine, one C�1-6? alkyl group, linear or branched, one C�1-2? perfluoroalkyl group or ...
WO/1998/010761A1	CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH�2? group. The naphthosultam is further substituted with various ...
WO/1998/008826A1	PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS The invention relates to compounds of formula (I). These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.
WO/1998/008845A1	HERBICIDAL S-SUBSTITUTED 1,2,4,6-THIATRIAZINES Compounds of formula (I) in which Q�i? is an unsaturated five-membered optionally substituted or condensed heterocyclic ring and X is O, S, SO or SO2, and agronomically tolerated salts/N-oxides/isomers/enantiomers of these compounds ar...
WO/1998/007420A1	NEUROPEPTIDE-Y LIGANDS There are disclosed novel neuropeptide Y ligands having general formula (I) wherein the symbols W, A, D, R?1�, R?2�, R?3�, R?4� are further defined in the description. Compounds of formula (I) are agonists and antagonists of neur...
WO/1998/007722A1	QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONIST The present invention provides compounds of formula (I) as tachykinin receptor antagonists.
WO/1998/005644A1	NEW COMPOUNDS HAVING A SELECTIVE ANTITUMOUR, ANTIVIRAL, ANTIPARASITE AND ANTIFUNGIC ACTIVITY, WHICH BLOCK BIOSYNTHESIS OF PHOSPHORILCHOLINE BY SELECTIVE INHIBITION OF INTRACELLULAR CHOLINE KINASE OR ITS USE AS SECOND MESSENGER IN CELLULAR PROLIFERATION The invention relates to the design, synthesis and biological activity of new strategies for the development of compounds which have selective activities such as anticancer, antiviral, antiparasitic and antifungic activities. The inventi...
WO/1998/005659A1	AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R?1� is vinyl or ethyl; and R?2� is a group R?3�, R?4�CH�2?-, or R?5�R?6�C=CH-; wherein each of R?3� and R?4� is an azabi...
WO/1998/004517A1	ARYLCYCLOALKANE CARBOXYLIC ESTERS, THEIR USE, PHARMACEUTICAL COMPOSITIONS AND PREPARATION The invention relates to the use of compounds of general Formula (IA) wherein: A is an optionally substituted cycloalkane ring having 3 to 6 carbon atoms and attached at a single ring carbon atom thereof; Ar is phenyl or heteroaryl havin...
WO/1998/004258A1	FORMULATION FOR THE TREATMENT AND/OR PROPHYLAXIS OF DEMENTIA A pharmaceutical composition for administration to the skin, which comprises [R-(Z)]-$g(a)-(methoxyimino)-$g(a)-(1-azabicyclo [2.2.2]oct-3-yl)acetonitrile or a pharmaceutically acceptable salt thereof together with a suitable pharmaceuti...
WO/1998/000139A1	METHODS AND COMPOSITIONS FOR TREATING URINARY INCONTINENCE USING ENANTIOMERICALLY ENRICHED (S)-CLIDINIUM A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-clidinium. The method comprises administering a therapeutically effective amount of ...
WO/1998/000138A1	METHODS AND COMPOSITIONS FOR TREATING URINARY INCONTINENCE USING ENANTIOMERICALLY ENRICHED (R)-CLIDINIUM A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-clidinium. The method comprises administering a therapeutically effective amount of ...
WO/1997/049699A1	PIPERIDINE ACETIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOTIC DISORDERS The invention relates to compounds of formula (I) or a salt, solvate, or physiologically functional derivative thereof, in which X represents either CH2-CH2 or CH=CH; Y represents a group (a) or (b); R0 represents SO2Me or CONH2, and R1 ...
WO/1997/049692A1	1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE 1,2,4-Benzothiadiazine derivatives represented by formula (I) wherein D, R1, R2, R3, R4, R5, R12, R13, R14, R15 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are...
WO/1997/049698A1	PIPERIDINE ACETIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOTIC DISORDERS The invention relates to compounds of formula (I) or a salt, solvate, or physiologically functional derivative thereof, in which: X is CH2-CH2, CH=CH, or CC; Y is hydrogen, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C1-6 haloalkyl, C1-6 hyd...
WO/1997/046557A1	CINCHONAN BASED CHIRAL SELECTORS FOR SEPARATION OF STEREOISOMERS Enantioseparation methods using chemical compounds which contain the chiral 9,11-substituted-10,11-dihydro-cinchonan skeleton (9,11-Subst.-DHC) and the precursors thereof with the 9-substituted cinchonan skeleton (9-Subst.-C) are describ...
WO/1997/044339A1	ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and...
WO/1997/044321A1	ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and...
WO/1997/043246A1	PROCESS FOR THE PREPARATION OF 1-ALKOXYCARBONYL-3-PHENYLPROPYL DERIVATIVES A simple, efficient and high-productivity process for preparing high-quality 1-alkoxycarbonyl-3-phenylpropyl derivatives containing few impurities by catalytic reduction of 1-alkoxycarbonyl-3-oxo-3-phenylpropyl derivatives.

Matches 651 - 700 out of 2,394	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >