Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 501 - 550 out of 1,390

Document Document Title
JP2010504919A
The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberbe...  
JP2010037223A
To provide a new oxime ester compound that can function as a highly sensitive radical polymerization initiator, and a curable composition using the same.The compound is represented by general formula (1) (wherein R1-R5 are each a hydroge...  
JP4417627B2  
JP2010024239A
To provide an inhibitor to enterokinesis aggravative action caused by nonsteroidal anti-inflammatory drugs, and to provide an antiinflammatory composition decreased in enterokinesis aggravating action.The inhibitor to enterokinesis aggra...  
JP4404473B2  
JP4391421B2  
JP4376971B2
CFTR channel activator compounds from the benzo[c]quinolizinium family or families of compounds derived therefrom, as well as pharmaceutical compositions containing said compounds, and the uses thereof, particularly for treating cystic f...  
JP4342797B2
This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceut...  
JPWO2007135970A1
The present invention shows a triazoryl machine etc. by which Ar1 may be replaced with a C1*6 Alkyl machine etc. among a formula (I)[type, and Ar2 is, A phenyl group etc. which may be replaced by a C1*6 alkoxy group etc. are shown, and X...  
JP4333036B2
The present invention concerns derivatives of general formula I (I' and I''), in which X represents a divalent radical of formula (a) or (b), R1, R2, R3, and R4 represent, independently of each other, a hydrogen atom, a hydroxy radical, ...  
JP4328049B2
A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 represents a hydrogen atom or a carboxyl-protecting group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, ...  
JPWO2007105751A1
[Subject] Offer of a compound which has the outstanding platelet aggregation inhibitory action. [Means for Solution] It is low-grade Alkyl to the 1st place, ;, such as cycloalkyl, -- the 3rd place -N(R0) C(O)-low-grade Al Killen CO2R0, l...  
JP2009526795A
The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least ...  
JP4272262B2
This invention concerns compounds of formulathe pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; -A- is a bivalen...  
JP2009507855A
This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain acyclic diamines, which are agonists of TRPV4 channel receptors.  
JP2009040789A
To provide new compounds, a method for producing them and a medicinal composition containing them.A pleuromutilin derivative or its pharmaceutically acceptable salt is represented by formula (IA): wherein, n and m are each independently ...  
JP2009035501A
To provide a molecule converting light energy into unidirectional rotational energy at a molecular level (light-driven rotating molecule).The light-driven rotating molecule has a pigment site and a block unit which bind to a rotating sha...  
JP4227729B2
Derivatives of pleuromutilin in which the glycolic ester moiety at position 14 is replaced by R<2>(CH2)mX(CH2)nCH2COO are of use in antimicrobial therapy.  
JP2009504658A
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondyli...  
JP2009504599A
The present invention refers to pharmaceutical composition comprising a DPP-IV inhibitor.  
JP4219975B2
This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are...  
JP2009501202A
The invention provides 3,11b- cis -dihydrotetrabenazine for use in halting or slowing the progress of one or more symptoms of Huntington's disease in a patient, and more particularly a symptom selected from involuntary movements such as ...  
JP4204069B2
PCT No. PCT/EP97/04166 Sec. 371 Date Jan. 29, 1999 Sec. 102(e) Date Jan. 29, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/05659 PCT Pub. Date Feb. 12, 1998Compounds of formula (3), and pharmaceutically acceptable salts and derivatives ...  
JP2008545673A
This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are...  
JP4197650B2
The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis o...  
JP2008297278A
To provide a low-molecular lysophosphatidic acid (LPA) receptor agonist and a prophylactic or therapeutic agent for various kinds of diseases caused by an LPA receptor, containing the agonist as an active ingredient.The LPA receptor agon...  
JP4195615B2  
JP4183918B2  
JP1999171893A5  
JP4163254B2
PCT No. PCT/EP96/05874 Sec. 371 Date Dec. 4, 1998 Sec. 102(e) Date Dec. 4, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/25309 PCT Pub. Date Jul. 17, 1997Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and ...  
JP2008214340A
To provide a pharmaceutical composition useful as a therapeutic agent for irritable bowel syndrome (IBS).As a result of intensive studies of a therapeutic agent for IBS, the inventors confirmed that N-(1H-tetrazol-5-yl)-1-phenoxy-4H-quin...  
JP2008199009A
To provide an organic electroluminescent device which is high in color purity and luminous efficiency, has a long lifetime and emits light in a red color system, and to provide a novel compound.The organic electroluminescent device inclu...  
JP4137636B2
It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R' is a group represented by the formula: -Y<1>-Y<2>-Y<3>R wherein Y<1> is single bond or the like; Y<2> ...  
JP4132155B2  
JP4132461B2  
JP2008169217A
To provide a compound having the affinity for a cannabinoid type 2 receptor.There is provided a compound represented by formula (I) [wherein R1 is a group of the formula: -Y1-Y2-Y3-Ra (Y1 is a single bond or the like, Y2 is -C(=O)-NH- or...  
JP2008524354A
W the present invention among a formula (I) [type A hydrogen atom, a halogen atom, -NRR, OR - NR-Ph-NRR - NR-Ph-OR - O-Ph-OR - O-Ph-NRR -- a basis -- expressing --; -- L -- cationic nature -- or -- un--- cationic nature -- connection -- ...  
JP2003535865A5  
JP4105358B2  
JP4101754B2
4-Oxoquinolizine derivatives (I) are new. 4-Oxoquinolizine derivatives of formula (I) and their salts are new. [Image] R1>H or carboxy protecting group; R2>H, halo, lower alkyl, lower alkoxy or OH; R3>phenyl or Het both optionally substi...  
JP4096127B2  
JP2004527451A5  
JP2007532580A5  
JP2008513382A
Methods and compositions containing a berberine compound or berberine related or derivative compound are provided for the prevention and treatment of hyperlipidemia, elevated cholesterol, and/or cardiovascular disease in mammalian subjec...  
JP4074509B2
The present invention relates to methods and intermediates for preparing compounds of the formula 1 and the pharmaceutically acceptable salts and solvates thereof, as well as structurally related compounds, wherein R<1>, R<2> and R<15> a...  
JP2008509957A
The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols...  
JP2002234892A5  
JP4050939B2  
JP4048780B2  
JP4031705B2
The present invention relates generally to a process for recovering copper and other metal values from metal-containing materials using controlled, super-fine grinding and medium temperature pressure leaching. Processes embodying aspects...  

Matches 501 - 550 out of 1,390