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JP2684573B2 |
The present invention relates to nonlinearly optically active organic compounds of following general formulae: in which: D is an electron-donor group, A, A1 which are identical or different are electron-acceptor groups. R1, R2, R3, R4 ar...
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JP2668259B2 |
Novel heterocyclic compounds of the formula : or pharmaceutically acceptable acid addition salts thereof having a more potent and longer lasting cytoprotective anti-ulcer action than known analogues, useful in the treatment or prophylaxi...
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JP2665342B2 |
Novel, racemic 1-(substd.-amino-methyl) -octa-hydro-indole-(2,3-a)-quinolizine derivs. (i) and their pharmaceutically useful acid adduct salts are prepd. from 1-(substd.-sulphonyl-oxy-methyl)-octa-hydro-indolo(2,3-a)-qu
inoli- zine deriv...
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JP2632858B2 |
Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufaccure of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigila...
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JP2621392B2 |
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JPH09503783A |
Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R<1> is cycloalkyl of from three to eight carbon atoms or sub...
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JPH0995452A |
To obtain a lipid-decomposing promoting agent which contains a specific alkaloid as an active ingredient and is useful for medicines, cosmetics and health food products. This alkaloid is included, as at least one active ingredient, in th...
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JP2593292B2 |
PURPOSE: To obtain a new synthetic intermediate useful in the synthesis of benzo[i,j]quinolizine for the 8-position of which methyl group is substituted, especially 6,7-dihydro -5,8-dimethyl-9-fluoro -1-oxo-1H,5H-benzo [i,j]quinolizine-2...
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JP2578576B2 |
Quinobenzothiazine derivatives of the formula as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R1 is hydrogen or acarboxy-protecting group, R2 and R3 are substitutents, A is oxy...
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JPH0930983A |
To obtain an apoptosis inhibitor having inhibitory action on apoptosis, useful for treating a hepatosis such as viral hepatitis, liver cirrhosis, etc., and a diseases, in which apoptosis participates, such as reduction in immunological f...
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JPH09500383A |
Known and novel azabicyclic derivatives of formula (I) such as quinolizidines with calcium channel antagonist activity, in which: p, and q each independently represent an integer from 3 to 5; n is 0 to 6; m is 0 to 6; A is a bond, -CH=CH...
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JP2566790B2 |
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JPH08511277A |
Novel n-arylaliphatic-n-alkyl-functionalised amides of formula (I), wherein Am is in particular a substituted piperidyl group. A method for preparing these compounds, and pharmaceutical compositions containing them are also disclosed. Th...
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JP2552436B2 |
PURPOSE: To advantageously obtain at a high yield the titled compound useful as a therapeutic agent for sleep disorder, by allowing a novel halogenated benzo[a]quinolizine derivative to react with CO under a specific condition and then a...
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JP2535062B2 |
NEW MATERIAL:A condensed heterocyclic compound of formula I [A is alkylene, alkenylene; R1 is halogen, cyano, nitro, alkyl which may be halogenated, alkoxy, alkenyloxy, alkinyloxy; R2 is H, alkyl which may be halogenated, alkenyl, phenyl...
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JPH08239383A |
To provide the subject novel derivative that is a specific 8-oxo-5,8- dihydro-6H-dibenzo[a,g]quinolizine-13-propanoic acid derivative and can treat the complaint as an anxiety accompanied by GABA transmission disorder of the GABAA recept...
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JPH08239384A |
To use a specific 1,2-crosslinked 1,4-dihydropyridine as an active ingredient that shows selective control action on the potassium channel relating to the modulation control of the central nervous system and is useful as a therapeutic ag...
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JPH08508509A |
PCT No. PCT/EP94/00992 Sec. 371 Date Sep. 28, 1995 Sec. 102(e) Date Sep. 28, 1995 PCT Filed Mar. 29, 1994 PCT Pub. No. WO94/24129 PCT Pub. Date Oct. 27, 1994This invention relates to compounds of formula (I): Formula (I) wherein R1 repre...
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JP2531487B2 |
PURPOSE: To obtain the subject extracted substance derived from a plant and useful for antiviral inhibition against a human immunodeficiency virus(HIV). CONSTITUTION: This extract is obtained from a mixture of (A) a non-fat starch derive...
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JPH08507758A |
Compounds of formula X-NH-CO-Z and pharmaceutically acceptable salts thereof, and the use of a compound of said formula or a pharmaceutically salt thereof, wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), ...
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JP2514136B2 |
Novel compounds are disclosed having formula (I) as well as pharmaceutically acceptable salts, esters and amides thereof, wherein R<1> is selected from (a) loweralkyl, (b) loweralkenyl, (c) halo(loweralkyl), (d) loweralkoxy, (e) cycloalk...
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JPH08504744A |
Aryltriflates and related compounds having general formula (1) wherein Ar is an aromatic or heteroaromatic system of a compound which has a therapeutic, biological activity when it, in the same position, carries a hydroxy, alkyloxy, halo...
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JPH0826017B2 |
The compound 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ij]quino
lizine-2-c arboxylic acid is disclosed as a potent antimicrobial agent with a broad spectrum of activity. Esters, acyl chlorides, alkylaminoalkyl ester salts and p...
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JPH08502273A |
PCT No. PCT/EP93/02775 Sec. 371 Date Apr. 11, 1995 Sec. 102(e) Date Apr. 11, 1995 PCT Filed Oct. 8, 1993 PCT Pub. No. WO94/08994 PCT Pub. Date Apr. 28, 1994Compounds of formula (I), wherein formula I consists of formulae (I-1) to (I-4), ...
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JPH0859469A |
PURPOSE: To obtain the ACAT inhibitor useful as a cholesterol absorption inhibitor and a preventive/therapeutic agent for arteriosclerosis, having excellent inhibitory action on cholesterol acyltransferase, comprising corydaline as an ac...
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JPH0813814B2 |
PURPOSE:To produce the title compound which is used as an intermediate of medicines, agricultural chemicals, or the like, industrially in high yield by reaction of a specific compound and another specific compound. CONSTITUTION:The react...
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JPH0813811B2 |
The invention relates to new heterocyclic compounds derived from 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acids, which corresponds to the formula (1) The invention also relates to their preparation and their use as medica...
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JPH0813815B2 |
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JPH085877B2 |
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JPH085878B2 |
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JPH08775B2 |
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JPH07330623A |
PURPOSE: To obtain a suppressant for neuron death useful as a medicine for preventing the selective deficiency in a neuron or a specific nervous population caused by the discontinuation of feed of neurotrophic factors in the cerebral ner...
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JPH07316051A |
PURPOSE: To obtain a new immunosuppressant, containing an immunosuppressively effective amount of berbeline (salt), capable of suppressing the production of an antibody without inhibiting proliferating reactions of lymphocytes and hardly...
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JPH0795175B2 |
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JPH0772177B2 |
1. Embonates of quinolonecarboxylic acids and of their derivatives of the formula (I) see diagramm : EP0209000,P10,F1 x Yn in which n represents 1 or 2, Y represents the radical of the formula see diagramm : EP0209000,P10,F2 in which R**...
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JPH0768460B2 |
A metal-containing indoaniline compound having the formula: wherein M is a metal atom of Group VIII, Ib, IIb, IIIb, IVa, Va, VIa or VIIa of the Periodic Table or its halide or oxide, rings A, B, C, D, E and F may have substituents, each ...
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JPH07179462A |
PURPOSE: To obtain a novel compound useful for the treatment and prevention of neurodegenerative disorders such as Alzheimer disease and neurotoxic injuries associated with ischemic, hypoxia toxicity or hypoglycemic symptoms, especially,...
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JPH07179461A |
PURPOSE: To obtain novel compounds useful for the treatment and prevention of neurodegenerative disorders such as Alzheimer disease and neurotoxic injuries associated with ischemic, hypoxia or hypoglycemic symptoms, especially, a fit of ...
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JPH0762111B2 |
NEW MATERIAL:A compound shown by formula I(X is heterocyclic group containing N atom; X<1> and X<2> are 1-8C alkyl, 1-8C alkoxy, F, Cl or Br; X<3> is Cl or Br; m and n are 0-3). EXAMPLE:3, 3-Bis[2-(p-pyrrolidinophenyl)-2-(p-methylphenyl)...
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JPH0759579B2 |
A process for preparing 6,7-dihydro-9-fluoro-5,8-dimethyl-1-oxo-1H,5H-benzo[i,j]quin
olizine-2- carboxylic acid, an antimicrobial, using 6-fluoro-2-methylquinoline as a starting material. A synthetic intermediate is also disclosed.
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JPH0747586B2 |
The invention relates to the use of a diarylimidazole of the formula I in which R<1> is a radical of the formula II where R<3> and R<6> are hydrogen and R<4> and R<5>, which may be identical or different, are lower alkyl or R<3>/R<4> and...
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JPH07504428A |
Compounds of formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
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JPH0739415B2 |
The compound (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quin
o-lizin-1-yl)carbonyl]-3-ethoxypyrrolidine of the formula I which has valuable pharmacological properties, is described. In particular, the compound of formula I h...
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JPH07109276A |
PURPOSE: To provide a novel compd. which can suppress arrhythmia and ventricular fibrillation, protect against myocardial ischemia, and can be orally administered. CONSTITUTION: A compd. of the formula [wherein R is 2,3-O-CH2-O or 2,3-(C...
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JPH0717506B2 |
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JPH0713194B2 |
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JPH075586B2 |
The invention relates to new azetidine derivatives of pyridonecarboxylic acids, substituted by an azetidine, of 1,4-dihydro-4-oxoquinoline-3-carboxylic, 4-oxo-1,8-naphthyridine- 3-carboxylic and 2,3-dihydro-7-oxo-7H-pyrido[1,2,3-de][1,4]...
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JPH07500588A |
Compounds of formula (I) wherein R1 is hydrogen, halogen, CF3, alkyl, alkoxy, alkylthio, alkylsulphonyl, alkylsulphinyl, acyl, cyano, alkoxycarbonyl, acylamino, hydroxy, nitro or amino, aminocarbonyl, or aminosulphonyl, phenyl or phenyl ...
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JPH06510764A |
PCT No. PCT/GB92/01612 Sec. 371 Date Nov. 14, 1994 Sec. 102(e) Date Nov. 14, 1994 PCT Filed Sep. 3, 1992 PCT Pub. No. WO93/05040 PCT Pub. Date Mar. 18, 1993Compounds of formula (I), (I) (a) (b) wherein L is N or CRc, wherein Rc is hydrog...
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JPH0692405B2 |
The novel compounds of the general formula in which Q<1>, together with the nitrogen atom, denotes a group of the formula <2bL>N-CH2CH2- (a) <2bL>N-CH2CH2CH2- (b), <2bL>N-CH=CH- (c), <2bL>N-CH2-CH=CH- (d), <2bL>N-CH2-S(O)p- (e), <2bL>N-C...
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