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Patent Searching and Data


Matches 301 - 350 out of 1,390

Document Document Title
WO/1998/004937A1
The invention relates to photochromic compounds of general formula (I), in which: R1-R8 represent various substituents, characterized in that at least two of the groups R3-R6 are C1-C6 alkoxy groups.  
WO/1998/001443A1
A compound of formula (I), or a salt thereof, or a solvate thereof, wherein Ra represents a group R�5? which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a), wherein X represents a hydroxy or...  
WO/1997/044034A1
A remedy for rosacea being efficacious even against intractable rosacea which cannot be completely cured by using remedies comprising antibiotics such as minocycline and having a low toxicity, little side effects and a long-lasting drug ...  
WO/1997/040046A1
Benzoquinolizine derivatives represented by general formula (1), pharmaceutically acceptable salts thereof and medicinal compositions containing the same as the active ingredients, wherein R1 represents hydroxy or alkoxy; R2 represents h...  
WO/1997/030999A1
A compound of formula (I), wherein R1 represents a bicyclic structure in which a cycloalkyl or heterocyclo ring is bound to NH and is fused to a second ring selected from aryl or heteroaryl, and in which either or each ring is optionally...  
WO/1997/031000A1
A compound of formula (I) wherein n is an integer of up to 3; R1 represents cycloalkyl, aryl, heteroaryl or heterocyclo, any of which rings may be fused to a second ring selected from aryl, heteroaryl, to give a bicyclic structure, and i...  
WO/1997/030971A1
The present application describes m-amidino phenyl analogs of formula (I), wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.  
WO/1997/029106A1
The present invention provides protoberberine alkaloid derivatives useful as anticancer agents, and methods of use thereof. The invention also provides protoberberine derivatives useful as topoisomerase inhibitors. The invention further ...  
WO/1997/029107A1
The present invention refers to benzo[c]quinolizine derivatives of general formula (I), their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.  
WO/1997/025309A1
Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful...  
WO/1997/017344A1
There are provided novel compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined in the specification and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for ...  
WO/1996/039407A1
Antibacterial compounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds wherein A is =CR6-; R1 is cycloalkyl of from three to eight car...  
WO/1996/025932A1
A preventive/remedy for interstitial pneumonia, inflammatory intestinal diseases or vascular thickening which contains as the active ingredient quinolizinone compounds represented by general formula (I), salts thereof or hydrates thereof...  
WO/1996/022089A1
The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having structure formula (I), wherein m is 0 to 3, n is 0 when Het is oxygen or sulfur, 0 to 4 when Het is nitrogen, Het is nitrogen, oxygen or ...  
WO/1996/013478A1
Novel retinoid-related compounds that can substitute for retinoic acid as preventives or remedies for various diseases and compounds that are antagonistic to retinoids, i.e., heterocyclic compounds represented by the general formula (1-I...  
WO/1995/026335A1
Novel n-arylaliphatic-n-alkyl-functionalised amides of formula (I), wherein Am is in particular a substituted piperidyl group. A method for preparing these compounds, and pharmaceutical compositions containing them are also disclosed. Th...  
WO/1995/010519A1
Antibacterical coumpounds having formula (I) and the pharmaceutically acceptable salts, esters and amides thereof, preferred examples of which include those coumpounds wherein R1 is cycloalkyl of from three to eight carbon atoms or subst...  
WO/1995/003302A1
Known and novel azabicyclic derivatives of formula (I) such as quinolizidines with calcium channel antagonist activity, in which: p, and q each independently represent an integer from 3 to 5; n is 0 to 6; m is 0 to 6; A is a bond, -CH=CH...  
WO/1994/024129A1
Compounds of formula (I), wherein R1 represents C1-4alkyl; and R2, R3, R4 and R5 each independently represent hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substit...  
WO/1994/019344A1
Compounds of formula X-NH-CO-Z and pharmaceutically acceptable salts thereof, and the use of a compound of said formula or a pharmaceutically salt thereof, wherein X is a monocyclic or polycyclic aromatic group, Z is of sub-formula (h), ...  
WO/1994/008994A1
Compounds of formula (I), wherein formula (I) consists of formulae (I-1) to (I-4), and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof, and their use as ph...  
WO/1994/007863A1
Stereoisomeric substituted and/or unsubstituted octahydronaphthoquinolizines (OHNQs), and derivatives and analogs thereof are provided, including pharmaceutical and diagnostic compositions, as well as methods of making and using these co...  
WO/1993/023357A1
The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such ...  
WO/1993/018027A1
Compounds of formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.  
WO/1993/016702A1
Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I) as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R1 is hydrogen or acarboxy-protecting grou...  
WO/1993/016730A1
Disclosed is a series of iodine derivatives of tetrabenazine, including compounds such as 2-hydroxy-2-iodovinyl-3-(2-methylpropyl)-9, 10-dimethoxy-1, 3, 4, 6, 7, 11b-hexahydro-2H-benzo[a]quinolizine. Tests indicate that these compounds a...  
WO/1993/011761A1
Aryltriflates and related compounds having general formula (1) wherein Ar is an aromatic or heteroaromatic system of a compound which has a therapeutic, biological activity when it, in the same position, carries a hydroxy, alkyloxy, halo...  
WO/1993/008187A1
Compounds of formula (I) wherein R1 is hydrogen, halogen, CF3, alkyl, alkoxy, alkylthio, alkylsulphonyl, alkylsulphinyl, acyl, cyano, alkoxycarbonyl, acylamino, hydroxy, nitro or amino, aminocarbonyl, or aminosulphonyl, phenyl or phenyl ...  
WO/1993/005040A1
Compounds of formula (I), wherein X is (a), (b), wherein L is N or CRc wherein Rc is hydrogen, alkoxy, halo, alkyl or cyano; Q is NR1, CH2, O or S; Ra is hydrogen, halo, alkyl, amino, nitro or alkoxy; Rb is hydrogen, halo, alkyl or alkox...  
WO/1993/005038A1
The use of a compound of formula (I) or pharmaceutically acceptable salt thereof, in which X1-(CH2)x-X2 forms a 5-7 membered ring wherein: X1 is O or S; X2 is O, S, NR or NRCO wherein R is hydrogen or C1-6alkyl; x is 1, 2 or 3; Y is O or...  
WO/1993/002677A1
The use of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables are as defined in the specification, in the manufacture of a medicament for use in the treatment of gastrointestinal disorders, car...  
WO1992018475A3
A compound of Formula I or a pharmaceutically acceptable salt thereof wherein n is 1 or 2; R1 and R2 are independently H (provided only one is H at the same time), -OH, CN, CH2CN, 2- or 4-CF3, CH2CF3, CH2CHF2, CH=CF2, (CH2)2CF3, ethenyl,...  
WO/1993/002383A1
Nonlinear optical (NLO) compositions are disclosed which contain polar disulfone-functionalized molecules (PDFMs), wherein the polar disulfone-functionalized molecules are of formula (I), where n is 0, 1 or 2; R1 and R2 each independentl...  
WO/1992/022550A1
Quinolone carboxylic acids of formula (I), wherein R1, R2, A and Y are as defined herein, and R3 is (alpha) have antibacterial properties.  
WO/1992/020749A1
A water-based recording ink comprising water, pigment, a water-soluble homopolymer, and a copolymer having both hydrophobic and hydrophilic parts. This ink can give printed characters excellent in density, lightfasteness and water resist...  
WO/1992/020678A1
The invention relates to new berbane derivatives, to the pharmaceutical compositions containing these compounds and to the preparation of same. In formula (I) R1 and R2 together form a methylene dioxy group and R3 represents an alkyl gro...  
WO/1992/018475A2
A compound of formula (I), or a pharmaceutically acceptable salt thereof wherein n is 0-3; R1 and R2 are independently H (provided only one is H at the same time), -OH (provided R4 is other than hydrogen), CN, CH2CN, 2- or 4-CF3, CH2CF3,...  
WO/1992/015579A1
This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body witho...  
WO/1992/012147A1
Substituted benzofuran derivatives of formula (I), wherein one of R1 and R2 is hydrogen or halogen and the other is, independently, an amino group or a C2-C4 alkanoyl amino group; R3 is hydrogen; a linear or branched C1-C4 alkyl, C1-C4 a...  
WO1992003417A3  
WO/1992/003417A2
Novel organic glass compositions are disclosed which are poled to achieve nonlinear optical properties. Novel compounds useful for making said poled compositions are also disclosed; as are a method and a device for transforming electroma...  
WO/1992/003136A1
Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I), as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R1 is hydrogen or a carboxy-protecting gr...  
WO/1992/003435A1
Compounds of formula (I) wherein R1 represents alpha in which p represents 2 or 3; R2 is a group OR4, where R4 is C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, a group OCOR5 where R5 is hydrogen or R4, or a group NHR6 or NR7R8 where R6, R7 and...  
WO/1991/016894A1
Novel compounds are disclosed having formula (I) as well as pharmaceutically acceptable salts, esters and amides thereof, wherein R1 is selected from (a) loweralkyl, (b) loweralkenyl, (c) halo(loweralkyl), (d) loweralkoxy, (e) cycloalkyl...  
WO/1991/016310A1
Antimicrobial quinolone thiourea compounds of general formula (I), wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...  
WO/1991/009842A1
Azo-type optically active compounds and polymers are provided based on compounds of the general structure [substituted aryl]-N=N-[substituted aryl] wherein aryl substituents are introduced which hinder or prohibit rotation around the sin...  
WO/1991/001128A1
The effects of photoaging or sun damage of skin including loss of collagen fibers and deterioration of small blood vessels in the dermis of the skin are repaired by applying topically to the epidermis effective amounts of a compound havi...  
WO/1991/001301A1
The effects of acne and psoriasis are relieved by applying either topically or by oral administration, a compound having structure(I), wherein R�1?, R�2?, R??3?, R�4?, and R�5? are independently selected from the group consisting...  
WO/1990/015058A1
Tricyclic nitrogen containing compounds, having central nervous system activity of structural formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 are independently hydrogen, C1-6 alkyl, alkenyl, or alkynyl, ...  
WO/1990/004591A1
Antimicrobial dithiocarbamoyl quinolone compounds of general formula (I), wherein A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobi...  

Matches 301 - 350 out of 1,390