Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 501 - 550 out of 1,641

Document Document Title
WO/1998/002163A1
Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotrexate ('MTX') and are even superior to the newer...  
WO/1998/002162A1
The invention concerns compounds of formula (1) and their use in the preparation of medicines for treating thrombosis.  
WO/1998/000173A2
The present invention relates to Glutathione S-transferase (GST)/Reduced Glutathione (GSH) as a means for the $i(in-vivo) release of a drug that has been conjugated to specific electrophilic moieties via a sulfonamide bond. The drug may ...  
WO/1997/044038A1
Corticotropin releasing factor (CRF) antagonists of formula (I) and their use in treating anxiety, depression, and other psychiatric and neurological disorders.  
WO/1997/034606A1
A uveitis remedy comprising a least one member selected among compounds represented by general formula (I) and salts of the compounds as the active ingredient(s), wherein R1 represents one member selected from the group consisting of CH2...  
WO/1997/030971A1
The present application describes m-amidino phenyl analogs of formula (I), wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.  
WO/1997/021711A1
A new process is disclosed for preparing 4-aminopteridine derivatives having the general formula (I), in which R1 stands for a hydrogen atom, a C1-C4 alkyl group, a substituted or non-substituted aryl group, -NH2, -SR3, -OR3, -NHR3 or -N...  
WO/1997/020843A1
The invention provides compounds exhibiting the ability to deplete O6-alkylguanine-DNA alkyltransferase (ATase) activity in tumour cells. The compounds include certain pyrimidine derivatives of formula (II), wherein R is (i) a cyclic gro...  
WO1997001344A3
Method for inducing cell damage by administering a restraining agent (RA) to a target cell population at a concentration and under conditions sufficient to retard but not arrest the progress of the target cells through the cell cycle, an...  
WO/1997/010221A1
The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.  
WO/1997/003208A1
A microbial riboflavin-production process is disclosed. Riboflavin-producing micro-organisms are cultivated in a culture medium and the thus produced riboflavin is then isolated. The process is characterised in that the endogenous isocit...  
WO/1997/001344A2
Method for inducing cell damage by administering a restraining agent (RA) to a target cell population at a concentration and under conditions sufficient to retard but not arrest the progress of the target cells through the cell cycle, an...  
WO1996022990A3
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntingt...  
WO/1996/030019A1
Compounds represented by general formula (I) or salts thereof, (wherein R1 represents a member selected from the group consisting of CH2, CH2CH2, CH2O, CH2S and CH2SO; R2 represents hydrogen, lower (C1-4) alkyl or benzyl; R3 represents C...  
WO/1996/025935A1
A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective to treat ad...  
WO/1996/022991A1
The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are 'alpha'-1 adrenergic antagonists and are useful in the treat...  
WO/1996/022990A2
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntingt...  
WO/1996/022303A1
The present invention relates to a range of therapeutic compounds conjugated to one to three acyl groups derived from fatty acids. The therapeutic compounds are selected from the following group: 1) the corticosterone family of drugs; 2)...  
WO/1996/020710A1
Novel, heterocyclic compounds having at least one ring nitrogen, disclosed side chains and, in some embodiments, an oxygen ortho to the ring nitrogen inhibit inflammatory responses associated with TNF-'alpha' and fibroblast proliferation...  
WO/1996/017610A1
The use of a compound of formula (I), in which R1 and R2 which may be the same or different are N or CH, X1 and X2 which may be the same or different are hydrogen, hydroxy, or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl...  
WO/1996/015669A1
Methods and devices for preventing an adverse reaction of the skin to the presence of a skin-sensitizing agent by administering an effective amount of a potassium-sparing diuretic are disclosed.  
WO/1996/003989A1
A remedy for spinocerebellar degeneration containing a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, wherein R1 and R2 represent each hydrogen or they are combined tog...  
WO1995032203A3
The present invention relates to the use of pteridine derivatives of the formula Iin which X is O or NH and R<4>, for example, is hydrogen, phenyl or the radical R<4a>-CH2- and R<4a>, for example, is hydrogen, (C1-C4)-alkylmercapto, the ...  
WO1995018616A3
Disclosed is a method of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma or hypoglycemia. The method comprises administering to an animal a compound of the formula: hereof; wherein n is zero or 1; R4, R5...  
WO/1995/033749A1
A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofo...  
WO/1995/031987A1
The present invention relates to the use of pteridine derivatives of general formula (I) in which X is O, NH or N-(C1-C5)-alkanoyl, R3 is the radical -OR4, -NH5R6 or -S(O)mR7 and R, R1, R2, R4, R5, R6, R7 and m have the meanings given in...  
WO/1995/032203A2
The present invention relates to the use of pteridine derivatives of general formula (I) in which X is O or NH and R4 may, for instance, be hydrogen, phenyl or the radical R4a-CH2 and R4a is e.g. hydrogen, (C1-C4)-alkyl mercapto, the rad...  
WO/1995/031469A1
The invention provides novel pteridine nucleotide which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotides. The invention further provides for fluorescent...  
WO/1995/026963A1
The invention provides an aqueous folinate solution suitable for medical applications in the form of a sodium folinate solution which is stable when stored at refrigerator temperatures, i.e. does not crystallize.  
WO/1995/018616A2
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntingt...  
WO/1995/015147A1
Disclosed is the use of one or more compounds selected from the group of L-arginine, L-ornithine and L-citrulline or their salts, acid addition salts, esters or amides, as needed with the addition of folic acid or its salts and/or one or...  
WO/1995/011028A1
Various flavin derivatives are disclosed for administration to mammalian subjects as an anti-viral agent. Riboflavin and riboflavin derivatives are given as particular examples which may be preferred.  
WO/1994/027439A1
This invention relates to pteridine and 8-deazapteridine compounds and compositions containing the same which are useful for controlling insects in agricultural crops. These pteridines may be represented by structure (I) wherein R and R1...  
WO/1994/021636A1
Pterin derivatives having general formula (I) wherein R1 represents a group -(CHOH)2-CH3 or -(CHOH)2-CH2OH, R2 and R3 are not the same and represent either hydrogen or the group -(CH2)3CONH(CH2)4-NH-R4, wherein R4 represents hydrogen or ...  
WO/1994/021613A1
The invention concerns compounds of formula (I) in which two of the symbols A, B, D and E stand each for CR1 and each of the other two symbols stands for CH or nitrogen, or one of the other two symbols stands for CH while the other stand...  
WO/1994/017076A1
Novel compounds of formula (I) are found to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT). A novel method of preparing such compounds is also disclosed, as well as methods and compositions for employing the com...  
WO/1994/014810A1
A compound represented by general formula (A), a salt thereof, and an antirheumatic containing at least one of them as the active ingredient, wherein R1 and R2 may be the same or different from each other and each represents hydrogen or ...  
WO/1994/014780A1
The use of a compound which binds at the tetrahydrobiopterin site of NO synthase for the treatment of conditions where there is an advantage in inhibiting neuronal NO synthase with little or no inhibition of endothelial NO synthase is di...  
WO/1994/011001A1
Disclosed are therapeutic compounds having the formula: (R)j - (core moiety), including resolved enantiomers, diastereomers, hydrates, salts, solvates and mixtures thereof. j is an integer from one to three, the core moiety is either non...  
WO/1994/006431A1
Compounds comprise epoxide-substituted alkyl side chain (R) bonded to a core moiety, comprising Core moiety (I), wherein n is an integer from about 4 to about 16 and j is an integer from about 0 to about 12, including resolved enantiomer...  
WO/1994/002148A1
The invention relates to a pharmaceutical composition for treating and alleviating the symptoms of vulvitis and vulvovaginitis. The compositions according to the invention comprises 0.05-0.5 % by weight of folic acid, 0.25-2.5 % by weigh...  
WO/1993/022315A1
The invention relates to certain heteroaroyl-10-deazaaminopterin compounds, as well as a method and composition employing certain heteroaroyl-10-deazaaminopterin compounds for the treatment of inflammatory disease, such as rheumatoid art...  
WO/1993/022316A1
A process is provided for the preparation of 10-deazaaminopterins and 5,10- and 8,10-dideazaaminopterins starting from the corresponding homoterephthalic acid diester, by coupling the corresponding dicarboxylic acid diester having formul...  
WO1993020054A1
Fluorogenic chelators for Eu?3+ and Tb?3+ are provided, they form highly fluorescent complexes with Eu?3+ and Tb?3+. In all cases, the fluorescence observed was lanthanide-specific, long-lived and it was monitored by microsecond time-res...  
WO/1993/019069A1
Intermediates and a process for the synthesis of 6-monosubstituted tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolic acid. The intermediates are shown in their two enantiomeric forms as above, wherein R1 and R2 are the...  
WO/1993/017682A1
Compounds are disclosed having formula (I). The compounds of the invention are angiotensin II receptor antagonists.  
WO/1993/017022A1
The (6S_) stereoisomer of folinic acid is obtained in high optical purity by salification of (R, S) folinic acid with di- or polyamines and subsequent selective crystallization of the desired diastereomeric salt.  
WO/1993/015076A1
The treatment of racemic calcium folinate with a sodium salt of ethylendiaminotetraacetic acid and, preferably, calcium chloride determines the separation of a precipitate, whose mother liquors result enriched in a calcium salt of the le...  
WO/1993/015077A1
A compound represented by general formula (II) and an antirheumatic containing the same as the active ingredient, wherein W represents a group represented by any of the general formulae (III), (IV), (V), (VI).  
WO/1993/013102A1
5,10-Diakyl substituted 5,10-dideazaaminopterin and a cyclized derivative thereof are disclosed as potent antineoplastic agents. Also disclosed in an improved process for preparation of 10-ethyl-10-deazaaminopterin using the intermediate...  

Matches 501 - 550 out of 1,641