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Matches 1 - 50 out of 4,876

Document Document Title
WO/2022/152146A1
The present disclosure relates to a cephalosporin antibacterial compound and a preparation method therefor. The cephalosporin antibacterial compound can exhibit antibacterial activity against Gram-negative bacteria and other bacteria.  
WO/2022/056401A1
Compositions that inhibit the HIV-1 viral infectivity factor (Vif) and methods of use thereof are provided. The disclosed compositions have inhibitory activity against Vif function and restore A3G enzymatic activity. The disclosed compos...  
WO/2021/232694A1
A method for nickel-based catalytic synthesis of 3-decarbamoyl cefuroxime acid. The method comprises the following steps: putting 2-furyl-2-methoxyiminoacetic acid and a nickel-based catalyst into a reaction device, adding a solvent, and...  
WO/2021/234094A1
A liquid pharmaceutical composition comprising ceftriaxone or a pharmaceutical acceptable salt or derivative thereof and at least one magnesium salt, magnesium oxide, and/or magnesium hydroxide is provided. Also provided are a method for...  
WO/2021/228007A1
The present invention relates to a cefoperazone magnesium compound, a preparation method therefor and an application thereof. A synergistic effect can be achieved by combining cefoperazone with magnesium; cefoperazone can inhibit the syn...  
WO/2021/228008A1
Disclosed in the present invention are a cefuroxime magnesium compound, a composition, a preparation method therefor and the use thereof. The preparation method comprises: providing a cefuroxime-containing compound, and providing a magne...  
WO/2021/228006A1
The present invention relates to a cefotaxime-magnesium compound, a preparation method therefor, and an application thereof. Cefotaxime is combined with magnesium so as to achieve a synergistic effect. Cefotaxime inhibits the cell wall s...  
WO/2021/159176A1
Provided herein are compounds of formula (I) which comprise a cephalosporin antibiotic (present moiety X), bonded to a piperidine diazeniumdiolate (NONOate) or a salt thereof. Also provided are compositions that include a compound descri...  
WO/2021/147986A1
Provided are a cephalosporin compound represented by formula I-1, I-2, or I-3, a pharmaceutical composition comprising same, and use thereof as an antibacterial agent.  
WO/2021/105512A1
This invention relates to probes for the detection of β-lactamase-type enzymatic activity. In particular, the invention relates to novel fluorogenic substrates for detecting the presence of a catalytically active β-lactamase and a dete...  
WO/2021/041583A1
Provided herein are β-lactamase probes that can be used to identify specific types and classes of β-lactamases in a sample, and methods of use thereof.  
WO/2020/263975A1
This disclosure provides multifunctional conjugate molecules in which at least one β-lactam antibiotic is covalently attached to a cannabinoid by means of a linker. The disclosed conjugate molecules are designed to deliver therapeutic b...  
WO/2020/204715A1
Provided herein are compounds useful as metallo-β-lactamase (MBL) inhibitors. The compounds have a formula A–B, where A is a β-lactam antibiotic moiety comprising a bridging methylene (-CH2-) covalently attached to -B; and B is a lat...  
WO/2020/206381A1
The present application provides novel cephem, penem, and monobactam compounds that exhibit antibiotic activity against both Gram-negative and Gram-positive bacteria, as well as compositions comprising these compounds and methods of usin...  
WO/2020/172206A1
A method of inhibiting, reducing growth of or destroying gram positive bacteria comprising contacting the gram positive bacteria with an effective amount of a 2-(substituted-amino)-imidazole compound and with an additional antibacterial ...  
WO/2020/099858A1
A compound of formula (Ia) and related aspects.  
WO/2019/070973A1
Cephem and penem compounds having a styrylmethylene moiety at the 3-position in the cephem or penem ring to which a positively charged leaving group is bonded and wherein the leaving group contains a vicinal diol or is bonded to a unsubs...  
WO/2019/049024A1
The invention relates to compounds of general formula (I), and their use for the treatment and diagnosis of degenerative disorders characterised by high cell proliferation and/or tissue degeneration.  
WO/2018/233477A1
The present invention discloses a method for removing a carboxyl and hydroxyl protecting group of a β-lactam compound. The method is removing a carboxyl and/or hydroxyl protecting group from a protected β-lactam compound under the acti...  
WO/2018/229580A1
The present invention relates to an improved process for the preparation of Cefovecin sodium of a Compound of Formula (1), by reacting THF Cephem Compound of Formula (6) with MAEM Compound of Formula (8).  
WO/2018/177048A1
The present invention relates to a crystal of cephalosporin intermediate 7α-methoxy cephalothin (I) and a method for preparing same. The crystal of 7α-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expre...  
WO/2018/123920A1
Provided are: a compound that exhibits a broad antibacterial spectrum against various bacteria, including gram-negative bacteria; and a pharmaceutical composition that has antibacterial activity against carbapenem-resistant bacteria.  
WO/2018/059213A1
Provided are compounds interfering with SAICAR synthesis, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain co...  
WO/2017/153892A1
A synthesis process of precursors of derivatives of beta-lactam compounds, said beta-lactam compounds being selected from 6-aminopenicillanic acid and 7-aminocephalosporanic acid, preferably 6-aminopenicillanic acid, comprising the follo...  
WO/2017/153824A1
A process for alkylating the hydroxymethyl group at position -3 of 7-Amino-3- hydroxymethyl-3-cephem-4-carboxylic acid (D-7-ACA) using an alkylating agent, strong acid and a suitable solvent(s).  
WO/2017/140072A1
Disclosed are a novel polymorphic cefuroxime sodium compound and a preparation method for crystals thereof, where the novel polymorphic cefuroxime sodium compound is prepared by employing a particle process crystal product molecular asse...  
WO/2017/140074A1
Disclosed are a cefmenoxime hydrochloride new crystalline compound and crystallization preparation method thereof; said cefmenoxime hydrochloride new crystalline compound is formed using particle processing for molecular assembly and mor...  
WO/2017/140073A1
Disclosed in the present invention are a cefathiamidine novel crystal compound and a crystallisation preparation method therefor, the cefathiamidine novel crystal compound being prepared using particle process crystal product molecular a...  
WO/2017/136642A1
The present disclosure relates to compounds having antimicrobial activity, compositions comprising said compounds in combination with β-lactam antibiotics, and methods of using the compounds and compositions.  
WO/2017/046756A1
The present invention relates to compound of formula (II) wherein R = -OCH(CH3)2, -CH3; or a pharmaceutically acceptable salt thereof. The present invention further relates to substantially pure cefixime proxetil; substantially pure cefi...  
WO/2017/042188A1
The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7- ACA).  
WO/2017/027062A1
The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam- antibiotic resistant. Specificity for mycobacteria is conferr...  
WO/2017/021390A1
The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the ...  
WO/2017/002903A1
The present invention provides a compound exhibiting a strong antimicrobial spectrum against various bacteria, including gram-negative bacteria, or a pharmaceutical composition having an antimicrobial activity against carbapenem-resistan...  
WO/2017/001364A1
The present invention relates to a process for the preparation of carbamoylamino pyrazole derivatives using diacetoxyiodobenzene (ΡhΙ(ΟΑc)2) in combination with a non-nucleophilic base.  
WO/2016/201905A1
Disclosed is a new industrial crystallisation technique for cefuroxime sodium, wherein a supercritical fluid extraction technique is combined with conventional crystallization techniques to realize the recrystallization of cefuroxime sod...  
WO/2016/175223A1
Provided are the following: compounds having a powerful anti-bacterial spectrum against a variety of bacteria, including gram-negative bacteria and gram-positive bacteria; and pharmaceutical compositions having antibacterial activity aga...  
WO/2016/142902A1
The present invention provides cefixime trihydrate (I) with surface area of less than 1.2 m2/gm containing impurity A1 less than 0.5% by area percentage of HPLC. The impurity A1 is one of the stereoisomers of impurity A as depicted below.  
WO/2016/128580A1
Provided is a synthesis of cephalosporin derivatives, characterized by the use of the new intermediates for the preparation of cephalosporin derivatives, a crystalline toluene hemi-solvate of benzhydryl (6R,7R)-7β-[(phenylacetyl)amino]-...  
WO/2016/123028A1
The present disclosure provides compounds that include a tetrazolone derivative of a carboxyl group of an active agent. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these comp...  
WO/2016/109259A2
Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.  
WO/2016/107331A1
A new crystal form of a Cefathiamidine compound and a preparation method therefor. The method comprises: dissolving a Cefathiamidine compound with the purity greater than or equal to 98% in a solvent selected from methanol and the like t...  
WO/2016/095660A1
A new crystal form of cefamandole sodium compound and preparation method thereof, the method comprising: adding cefamandole sodium solid to an organic solvent to prepare a 0.04-0.3 g/ml suspension, stirring and suspending for a period of...  
WO/2016/088041A1
The present invention relates to a stable extended-release composition of cefpodoxime proxetil and a process for its preparation. The composition comprises cefpodoxime proxetil, a stabilizer, and a release-controlling agent, wherein the ...  
WO/2016/065525A1
Disclosed is a use of oxopiperazinyl amide compounds as shown by formula I, and isomers, hydrates or salts thereof in the preparation of drugs for inhibiting PLK1 activity.  
WO/2016/046055A1
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...  
WO/2016/035845A1
The present invention provides an acid addition salt or sodium salt of a compound represented by formula (IA), a hydrate of the salt or a stable crystalline solid form of the salt. The salt or the crystalline solid form thereof is extrem...  
WO/2016/035847A1
The present intention provides compounds represented by formula (IV) (in the formula, R1 is a protecting group of an amino group, and R2 and R3 are each independently a protecting group of a carboxy group), pharmaceutically acceptable sa...  
WO/2016/027262A1
A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderop...  
WO/2016/025813A1
Described herein are crystalline forms of a compound of formula (ΙΙΓ), including toluene solvates ofT A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as cef...  

Matches 1 - 50 out of 4,876