Heterocyclic Compounds

Matches 601 - 650 out of 5,407	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >

Document	Document Title
WO/2000/021955A1	QUINAZOLINE DERIVATIVES The invention relates to the use of compounds of formula (I), wherein: ring C is a 5-6-membered heterocyclic moiety; Z is -O-, -NH-, -S- or -CH¿2?-; R?1¿ is hydrogen, C¿1-4?alkyl, C¿1-4?alkoxymethyl, di(C¿1-4?alkoxy)methyl, C¿1-4?a...
WO/2000/020413A1	NOVEL 2-[3-PHENYL-2-PROPENYL]-1,2,3,4-TETRAHYDROXYISOQUINOLINE DERIVATIVES, PREPARATION METHOD AND USE AS FUNGICIDES The invention concerns compounds of formula (I) wherein: X represents a nitrogen atom or aH radical = R1, R2, R3, R4, R5, R6 identical or different in a particular position on the cycles bearing them, represent a hydrogen atom, a halogen...
WO/2000/018740A1	SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS This invention provides compounds of formula (1), wherein R¿1?, G¿1?, G¿2?, R¿4?, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof, which are useful as antineoplastic agents and in the treatment of polycys...
WO/2000/013683A2	NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS A range of aziridin-1-yl nitrobenzamides (A-C) are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2 N-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl) -N-[2...
WO/2000/014072A1	METHOD FOR PRODUCING CARBONYLDIIMIDAZOLE A method for producing carbonyldiimidazole from imidazole and phosgene in an inert solvent, wherein the coupled imidazole-hydrochloride product is separated from the obtained reaction mixture in the form of a melt by means of phase separ...
WO/2000/012498A1	QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS Compounds of formula (1) and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R?8¿ is H, -OR?12¿, -NR?12¿R?13¿, -NR?12¿C(O)R?13¿, cyano, -C(O)OR?13¿, -SR?12¿, -(CR?13¿R?14¿)¿t?(4-10 membered heterocycl...
WO/2000/011041A1	THERMAL- AND PHOTOINITIATED RADICAL POLYMERIZATION IN THE PRESENCE OF AN ADDITION FRAGMENTATION AGENT The invention relates to a composition comprising a) at least one ethylenically unsaturated monomer or oligomer, b) a radical initiator which forms a radical upon heating or upon irradiation with (UV) light from 305 nm to 450 nm and c) a...
WO/2000/009496A1	SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME The invention relates to compounds of formula (I) in which R?1¿, R?2¿, R?3¿ and R?4¿ have the meanings given in the claims. Said compounds are valuable active ingredients for the treatment and prophylaxis of diseases, for example car...
WO/2000/009490A1	BRASSIONOSTEROID BIOSYNTHESIS INHIBITORS Compounds represented by general formula (I) (for example, 4-(4-chlorophenyl)-2-phenyl-3-(1,2,4-triazoyl)butan-2-ol) or salts thereof, wherein R?1¿ represents lower alkyl; R?2¿ represents optionally substituted phenyl or lower alkyl; a...
WO/2000/009116A1	GRP RECEPTOR LIGANDS Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.
WO/2000/006550A1	PHENYLAZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND DRUGS FOR HYPERLIPEMIA Phenylazole compounds represented by general formula (1) or pharmaceutically acceptable salts thereof and drugs for hyperlipemia which contain these compounds as the active ingredient, wherein A represents imidazolyl, pyrazolyl, etc.; B ...
WO/2000/006564A1	DISUBSTITUTED MALEIMIDE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF Disubstituted maleimide compounds represented by general formula [I] or pharmaceutically acceptable salts thereof; and medicinal compositions and protein kinase (PKC) $g(b)-inhibitors containing these compounds. Because of selectively in...
WO/2000/006551A1	METHOD FOR THE PRODUCTION OF N,N'-CARBONYL DIAZOLES The invention concerns a method for the production of N,N'-carbonyl diazoles by reacting azoles with phosgene in a solvent, wherein the azole and the phosgene are introduced into an aromatic solvent dehydrated by distillation at a doses ...
WO/2000/005232A1	HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES Compounds of the formula (I) wherein A is unbranched C3-C5 alkylene optionally substituted by C1-C6 alkyl; X is O, S, NH or N(C1-C6 alkyl); Y is O, S, NH or N(C1-C6 alkyl); R is a C-linked, 4- to 6-membered ring, non-aromatic, heterocycl...
WO/2000/002863A1	METHOD FOR PRODUCING CARBONYL DIIMIDAZOLES The invention relates to a method for producing carbonyl diimidazoles of general formulas (Ia), (Ib), (Ic) or mixtures thereof, whereby R?1¿ represents hydrogen or a C¿1?-C¿4? alkyl radical and R?2¿ represents hydrogen or a methyl ra...
WO/2000/001704A2	BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS The invention relates to novel benzimidazoles of general formula (I), wherein R¿a? to R¿c?, A, Ar and B have the meanings given in Claim 1, to tautomers, stereoisomers, mixtures and pro-drugs thereof, derivatives thereof containing a g...
WO/2000/000465A1	HYDRAZINE DERIVATIVES The invention provides hydrazine derivatives of formula (I) wherein R?1¿ is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R?2¿ is an acyl group derived from an $g(a)-, $g(b)-, $g(...
WO/1999/067201A1	HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF THE PRODUCTION OF HUMAN CD23 AND OF THE TNF RELEASE Compounds of formula (I) wherein: R is methyl substituted by one to three groups selected from alkyl, aryl, alkenyl, and alkynyl; n is 0 or 1; R?1¿ is arylmethyl or heterocyclylmethyl; R?2¿ is alkyl, alkenyl, cycloalkyl or cycloalkenyl...
WO/1999/065882A1	2,4-DIAMINO-1,3,5-TRIAZINE, METHOD FOR THE PRODUCTION AND USE OF THE SAME AS HERBICIDES AND PLANT GROWTH REGULATORS The invention relates to compounds having formula (I), wherein R?1¿, R?2¿, R?3¿, R?4¿, A?1¿, A?2¿, X and n have the meanings defined in Claim 1. Said compounds and the salts thereof are suitable as herbicides and plant growth regul...
WO/1999/065899A1	NEW OXAZINYLAZOLE DERIVATIVES AS FUNGICIDES The present invention relates to oxazinylazole derivatives of formula (1), their preparation method and their use as a fungicide. Since the compounds of the present invention have a new structure which has not been ever developed, they h...
WO/1999/065884A1	CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES The compounds of formula (I) are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, and c...
WO/1999/064417A2	OXAZOLIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is -O- or -S-; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 hete...
WO/1999/062968A1	SUPPORTED GROUP 8-10 TRANSITION METAL OLEFIN POLYMERIZATION CATALYSTS Methods for preparing olefin polymers, and catalysts for preparing olefin polymers are disclosed. The polymers can be prepared by contacting the corresponding monomers with a Group 8-10 transition metal catalyst and a solid support. The ...
WO/1999/062890A1	ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X?1¿, R?1¿, R?2¿ and R?3¿ are as defined herein. The invention also relates to pharmaceutical ...
WO/1999/059959A1	BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES The invention concerns amide derivatives of Formula (I), wherein R?3¿ is (1-6C)alkyl or halogeno; m is 1-3 and R?1¿ is selected from substituents such as: (A) hydroxy, halogeno, (1-6C)alkyl, (1-6C)alkoxy, aryl, heteroaryl and heterocyc...
WO/1999/058495A1	NOVEL SUBSTITUTED CYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), wherein R'¿a? and R''¿a? are as defined in the description, or R forms with A a cyclic structure as defined ...
WO/1999/058530A1	WATER SOLUBLE AZOLES AS BROAD-SPECTRUM ANTIFUNGALS The present invention concerns novel compounds of formula (I); the $i(N)-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein L represents a radical of formula (a); (b); (c); (d...
WO/1999/058529A1	WATER SOLUBLE AZOLES AS BROAD-SPECTRUM ANTIFUNGALS The present invention concerns novel compounds of formula (I) the $i(N)-oxide forms, the pharmaceutically acceptable additon salts and stereochemically isomeric forms thereof, wherein L represents a radical of formulae (a), (b), (c), (d)...
WO/1999/058477A2	$i(N)-[3-[2-[(2,3-DIHYDRO-1$i(H)-INDEN-2-YL)ALKYLAMINO]-ETHYL]PHENYL CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATIONS The invention concerns a compound corresponding to general formula (I) wherein: R¿1? represents a 2,3-dihydro-1$i(H)-inden-2-yl group optionally substituted by one or two methoxy groups; R¿2? represents an alkyl group; and R¿3? repres...
WO/1999/058496A1	NOVEL SUBSTITUTED CYCLIC COMPOUNDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R?1¿, R?2¿, R?3¿, v and R?4¿ are as defined in the description; R' repr...
WO/1999/057114A1	HETEROCYCLIC CARBOXAMIDE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE PRODUCTION A compound of formula (I), wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong in...
WO/1999/057098A2	SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 A class of substituted $g(b)-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such a...
WO/1999/055665A1	AZINE USED AS FUNGICIDES The invention relates to novel azines, to a method for producing said azines and to their use as fungicides.
WO/1999/055670A2	IMIDAZOL-LIKE PRODUCTS AND DERIVATIVES Imidazol-like products, substituted imidazols, derivatives of imidazol-1-yl-esters and derivatives of imidazol-1-alkanoic acids. The imidazols and derivatives are used as extrinsic indicators in obtaining images and spectra of NMR.
WO/1999/054299A1	PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating disea...
WO/1999/054327A1	SOLUBLE AZOLE ANTIFUNGAL LACTATE SALT The lactic acid [CH¿3?CH(OH)CO¿2?H] addition salt of the compound of formula (I) wherein the molar ratio of lactic acid, preferably L-lactic acid, to the compound of formula (I) is preferably about 1:1, pharmaceutical compositions of t...
WO/1999/054284A1	ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE Compounds of formula (I) wherein R?1¿ is hydrogen or halogen; R?2¿ is electron withdrawing group; R?3¿ is hydrogen, hydroxy, lower alkoxy, cycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted, unsaturated hete...
WO/1999/054321A1	SUBSTITUTED DIAMINES AND THEIR USE AS CELL ADHESION INHIBITORS The invention is directed to physiologically active compounds of general formula (I): wherein R?1¿ represents R?5¿-L?3¿-, R?5¿-L?4¿-R?6¿-, R?5¿-L?4¿-R?7¿-L?5¿-, R?5¿-L?4¿-Ar?1¿-L?3¿-, R?5¿-L?4¿-Ar?1¿-L?6¿-R?6¿- or R?5�...
WO/1999/054312A1	THE USE OF DIHYDROPYRIMIDINES AS MEDICAMENTS, AND NOVEL SUBSTANCES The invention relates to dihydropyrimidines of general formula (I) and to the use of the same as medicaments for treating and preventing hepatitis B. The invention also relates to a method for producing medicaments containing the inventi...
WO/1999/052888A1	BUTENOLIDE DERIVATIVES AS ANTI-CANCER AGENTS A new butenolide (furandione) anti-cancer agent is 3,4dichloro-5(1'-methyl-1'formylamino)-2(5H)furanone, which is synthesized by the reaction of an alkylformamide (e.g., N-methylformamide) and a halogenated acylchloride (e.g., dichloroac...
WO/1999/052840A1	ASYMMETRIC SYNTHESIS OF 2-ARYL-1-SUBSTITUTED BUTAN-2,3-DIOLS The asymmetric production of pure diastereomeric (2R, 3R), (2R, 3S), (2S, 3R) and (2S, 3S)-2-aryl-1-substituted butan-2,3-diols from the derivatives of lactic acid.
WO/1999/051587A1	FUSED THIOPHENE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Fused thiophene derivatives represented by general formula (I) and interleukin-6 and/or interleukin-12 production inhibitors containing these derivatives as the active ingredient (in general formula (I), each symbol has the meaning as de...
WO/1999/048875A1	NOVEL CATIONIC COMPOUNDS, THEIR USE AS COUPLING AGENTS FOR OXIDATION DYEING OF KERATINOUS FIBRES, DYEING COMPOSITIONS AND DYEING METHODS The invention concerns novel di-benzene compounds comprising at least one cationic group Z, Z being selected among quaternized aliphatic chains, aliphatic chains comprising at least a quaternized saturated cycle, and aliphatic chains com...
WO/1999/048874A1	NOVEL CATIONIC COUPLING AGENTS, THEIR USE FOR OXIDATION DYEING OF KERATINOUS FIBRES, DYEING COMPOSITIONS AND DYEING METHODS The invention concerns novel monobenzene coupling agents comprising at least a cationic group Z, Z being selected among the aliphatic chains containing at least a quaternized unsaturated cycle, their use for oxidation dyeing of keratinou...
WO/1999/047508A1	BENZENESULFONAMIDE-DERIVATIVES AND THEIR USE AS MEDICAMENTS Compounds of formula (I), pharmaceutically acceptable salts or $i(in vivo) hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally ...
WO/1999/047497A2	CARBOXYLIC ACIDS AND ACYLSULFONAMIDES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT Compounds of formula (I), as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containi...
WO/1999/047507A2	1,3,4-THIADIAZOLES USEFUL FOR THE TREATMENT OF CMV INFECTIONS The present invention presents novel 1,3,4-thiadiazole derivatives of formula (I) which have useful antiviral activity against herpes virus, cytomegalovirus (CMV).
WO/1999/046246A1	HETARYL-SUBSTITUTED BENZYL PHENYL ETHERS, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE FOR COMBATING HARMFUL FUNGI AND ANIMAL PESTS The invention relates to hetaryl-substituted benzyl phenyl ethers of formula (I) in which the substituents have the following meanings: (Q): C(=CHOCH¿3?)-COOCH¿3?, C(=CHCH¿3?)-COOCH¿3?, C(=NOCH¿3?)-COOCH¿3?, C(=NOCH¿3?)-CONHCH¿3?...
WO/1999/044612A1	SUBSTITUTED QUINAZOLINES AND ANALOGS AND THE USE THEREOF The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and fo...
WO/1999/045008A1	3-[4-(4-CYANOPHENYL)THIAZOL-2-Y)]-1-(1H-1,2,4-TRIAZOL-1-YL)-BUTAN-2-OL DERIVATIVES HAVING ANTIFUNGAL ACTIVITY Azole derivatives of formula (I) wherein R?14¿, R?15¿ are each independently hydrogen or fluorine, T is a group of formula (T?1¿) or (T?2¿), wherein R?9¿ is pyrrolidinyl or a group A-NH-B-, A is hydrogen or straight-chain or branche...

Matches 601 - 650 out of 5,407	< 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 >