Heterocyclic Compounds

Matches 301 - 350 out of 5,407	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2002/059074A1	BENZYLAMINE ANALOGUE A compound represented by the general formula (I) (wherein R?1¿ represents C¿1-6? alkyl, etc.; R?2¿ and R?3¿ are the same or different and each represents hydrogen, etc.; R?a¿ represents C¿1-6? alkyl, etc.; Arom represents aryl, et...
WO/2002/058632A2	PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR Primary intermediates for hair coloring compositions for oxidative of hair are compounds of the formula (1): where R¿1? and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿1? to C¿5? mono o...
WO/2002/058653A1	PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R¿1? and R¿2? are aech independently selected from hydrogen atoms, a C¿1? to C¿5? alkyl or hydroxyalkyl group...
WO/2002/059085A1	PROCESS FOR MAKING TRIAZOLE COMPOUNDS The present invention relates to the alkylation of N-methyl triazole to form 5-alkyl-1-methyl triazoles.
WO/2002/059080A2	TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invent...
WO/2002/058654A1	PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1), where R¿1? and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿1? to C¿5?...
WO/2002/059112A2	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compounds of formula III:wherein Z?1¿, Z?2¿, and Z?3¿ are described in the specification; Q is -S-, -O-, -N (R?4¿) -, or -CH (R?6¿) -; is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ...
WO/2002/059111A2	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compounds of formula (IIa): wherein R?1¿ is T-Ring D, wherein Ring D is 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?x...
WO/2002/056884A2	TREATMENT OF MALARIA WITH FARNESYL PROTEIN TRANSFERASE INHIBITORS Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing an...
WO/2002/057259A2	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compounds of formula (IIIa), wherein R?1¿ is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; ...
WO/2002/055012A2	THERAPEUTIC HETEROCYCLIC COMPOUNDS Provided herein is a compound having the formula (I) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, a...
WO/2002/055492A2	AN IMPROVED PROCESS FOR PREPARING PURE ONDANSETRON HYDROCHLORIDE DIHYDRATE An improved method for preparing dimethylamino-methyl-carbazolone and ondansetron base. A recrystallization process for preparing pure ondansetron hydrochloride dihydrate with a purity of at least 99.0% is also disclosed.
WO/2002/055013A2	THERAPEUTIC CHROMONE COMPOUNDS Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating, disorders, dementia, panic disorder, and sl...
WO/2002/055014A2	THERAPEUTIC CHROMAN COMPOUNDS Provided herein is a compound represented by the Formula (I) wherein said compounds are useful for the treatment of migraine. Also provided are processes for the preparation of compounds of Formula (I) and intermediates.
WO/2002/053543A1	PYRIDONE DERIVATIVE HAVING AFFINITY FOR CANNABINOID 2-TYPE RECEPTOR A compound having an affinity for a cannabinoid 2-type receptor. It is represented by the formula (I): (I) wherein R?1¿ represents a group represented by the formula -Y?1¿-Y?2¿-Y?3¿-Ra (wherein Y?1¿ is a single bond, etc.; Y?2¿ is ...
WO/2002/050066A2	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compounds of formula (II ):wherein Z?1¿ is nitrogen or CR?8¿; Q is -S-, -O-, -N(R?4¿)-, or -CH (R?6¿)-; R?1¿ is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicy...
WO/2002/049993A2	HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS The invention includes low molecular weight, non-peptidic, non-peptidommetic, organic molecules that can act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also suc...
WO/2002/050065A2	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compound of formula (IIc): wherein R?1¿ is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?...
WO/2002/050046A1	3-OX(ADI)AZOLYLPROPANOHYDROXAMIC ACIDS USEFUL AS PROCOLLAGEN C-PROTEINASE INHIBITORS Compound of formula (I), wherein X is C¿1-6? alkylene or C¿2-6? alkenylene, each of which is optionally substituted by one or more flluorine atoms; R is aryl or C¿3-8? cycloalkyl optionally substituted by one or more fluorine atoms; W...
WO/2002/048121A1	BENZAZOLONYLCARBONYL CYCLOHEXENONES AND USE THEREOF AS HERBICIDES The invention relates to cyclohexenone derivatives of benzazolons of general formula (I), wherein the variables R?1¿, R?2¿, R?3¿, A and Hex have the meaning as cited in claim 1, and the salts thereof, and the use thereof for controlli...
WO/2002/046151A1	DELTA 1-PYRROLINES USED AS PESTICIDES The invention relates to novel delta 1-pyrrolines of formula (I), in which R?1¿, R?2¿, R?3¿, m and Q have the meanings as cited in the description, to a number of methods for producing these substances, and to their use for controllin...
WO/2002/046170A2	ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO Compounds having activity as inhibitors of the JNK pathway are disclosed. The compounds of this invention are anilinopyrimidine derivatives having the following structure: (I) wherein R1 through R6 are as defined herein. Such compounds h...
WO/2002/044156A2	BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS Benzimidazole derivatives of Formula (I), which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the sam...
WO/2002/044120A1	COMPOUNDS ACTIVE AT THE GLUCOCORTICOID RECEPTOR III This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy and in the regulation of metabolism, espec...
WO/2002/044166A1	SUBSTITUTED QUINOLINES AS ANTITUMOR AGENTS The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt, pro-drug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions o...
WO/2002/042298A1	AMINOTHIAZOLES AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS Compounds of formula (I) in free or salt form, where A is a C¿6-?C¿15? monovalent aromatic group. R?1¿ is hydrogen, phenyl optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, C¿1?-C¿8?-alkyl, C�...
WO/2002/042248A2	NAPHTHALENE DERIVATIVES The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...
WO/2002/042254A1	PROCESS OF PRODUCING CARBONYL a-SUBSTITUTED NITROGEN-CONTAINING COMPOUNDS The present invention relates to a process of producing carbonyl a-substituted nitrogen-containing compounds, which comprises reacting a-halo-ketone or a-halo-aldehyde with primary amine, secondary amine or heterocycle compound containin...
WO/2002/040454A1	PROCESS FOR MANUFACTURE OF IMIDAZOLES Imidazoles may be manufactured by reacting a glyoxal, ammonia, an aldehyde, and optionally a primary amine, in the presence of a Bronsted acid whose pKa is approximately equal to the pKa of the ammonium cation of the primary amine, or if...
WO/2002/039970A1	NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): wherein X is selected from halogen; R?3¿ is selected from the group consisting of C?1¿ and C?2¿ alkyl and hydroxyethyl; and R and R?1¿...
WO/2002/040458A1	ISOXAZOLE DERIVATIVES Compounds of the general formula (I) or their salts or prodrugs have excellent insulin secretion promoting and blood sugar decreasing effects and are lowly toxic, thus being useful as drugs, particularly preventive and therapeutic agents...
WO/2002/040455A1	SUBSTITUTED AMIDOALKYL URACILS AND THEIR USE AS INHIBITORS OF THE POLY(ADP-RIBOSE) SYNTHETASE (PARS) The invention relates to novel amidoalkyl uracil derivatives of formula (I), to a method for the production thereof, and to their use as medicament active substances for the prophylaxis and/or treatment of medical disorders.
WO/2002/038550A1	PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME Pyrimidine derivatives of the general formula (I) exhibiting excellent selective herbicidal activity; and herbicides containing the same: (I) wherein R?1p¿ and R?1q¿ are each independently hydrogen, halogeno, optionally substituted C¿...
WO/2002/038561A1	INDOLYLMALEIMIDE DERIVATIVES AS PROTEIN KINASE C INHIBITORS Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or preven...
WO/2002/036555A1	SULFAMIDES AS GAMMA-SECRETASE INHIBITORS Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.
WO/2002/036734A2	AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatme...
WO/2002/036570A1	4-SUBSTITUTED QUINOLINES AS ANTITUMOR AGENTS The invention concerns compounds of formula (I), wherein each of R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?8¿, R?9¿, R?10¿ m, n, p, X, Y and Z have any meanings defined in the description, processes for their preparation, pharmaceut...
WO/2002/036584A1	CHOLESTEROL LOWERING BENZO`B! THIOPHENES AND BENZO`D! ISOTHIAZOLES The present invention relates to compounds of formula (I) wherein U, A?1¿, A?2¿, A?3¿, A?4¿, V, X, Y, Z, Q, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable...
WO/2002/036554A2	AMIDINO-UREA SEROTONIN RECEPTOR LIGANDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND METHODS FOR THEIR SNYTHESIS Novel amidino-urea 5-HT¿7? receptor ligands, methods of preparing such ligands, intermediate compounds useful in the preparation of the receptor ligands, pharmaceutical compositions comprising the receptor ligands, and methods of treati...
WO/2002/034745A1	CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.
WO/2002/034711A1	BIARYL COMPOUNDS AS SERINE PROTEASE INHIBITORS Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as...
WO/2002/034722A1	IMIDAZOLIUM SALTS AND THEIR USE OF THESE IONIC LIQUIDS AS A SOLVENT New 1,2,3- or 1,2,3,4- or 1,2,3,4,5- substituted imidazolium salts and their uses as solvent in catalysed organic reactions, as well as compositions containing them and a transition metal compound. They can be used in the following react...
WO/2002/032891A1	FLAVAN COMPOUNDS, THEIR PREPARATION AND THEIR USE IN THERAPY The present invention provides compounds, their preparation and their use in therapy, particularly the treatment of bacterial infection, of the formula (I) wherein p is selected from 4, 5 and 6; q is selected from 3, 4 and 5; each T is t...
WO/2002/032900A2	ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof, wherein Y?1¿, Y?2¿, Y?3¿, and Y?4¿ are independently selected from N, CH, etc.; R?1¿ is H, C¿1-8? alkyl, etc.; Q?1¿ is a 5-12...
WO/2002/032422A2	EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS The invention features a method of treating rheumatoid arthritis in a mammal comprising administering an agent that inhibits prostaglandin EP4 receptor (EP4) activity. Also featured is a method of identifying agents that selectively inhi...
WO/2002/032897A1	ALPHA-ARYL ETHANOLAMINES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS The instant invention provides beta¿3? adrenergic receptor agonists of structural Formula (I), wherein Ar is pyridyl, oxazolyl, thiazolyl or phenyl; Rs is a S- or 6- membered heterocycle; X is a direct bond or oxygen; and Y is a direct ...
WO/2002/030881A1	SULFONYLGUANIDINE The invention relates to sulfonylguanidine according to general tautomer formulae I and Ia, a method for the production thereof, medicaments containing said compounds and the use of sulfonylguanidines in the production of medicaments. Th...
WO/2002/030921A1	HERBICIDALLY ACTIVE PYRIDINE SULFONYL UREA DERIVATIVES The present invention relates to pyridine sulfonyl urea derivatives, salts or stereochemical isomers thereof showing an effective herbicidal activity in pre- and/or post-emergence treatment in rice farming, or to a method to use thereof,...
WO/2002/030908A1	INHIBITORS OF PROTEIN KINASES This invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein the variables are as defined in the description. The compounds of formula I are useful as kinase inhibitors.
WO/2002/028810A2	RETINOIDS FOR THE TREATMENT OF EMPHYSEMA The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for ...

Matches 301 - 350 out of 5,407	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >