Heterocyclic Compounds

Matches 351 - 400 out of 5,407	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2002/028839A1	BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS Benzimidazole and indole derivatives of the formula (I) that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxie...
WO/2002/026727A2	METHODS OF PROVIDING AND USING COMPOUNDS (RETINOIDS) HAVING ACTIVITY AS INHIBITORS OF CYTOCHROME P450RAI Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid...
WO/2002/024686A2	FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES This invention comprises the novel compounds of formula (I) wherein r, t, Y?1¿-Y?2¿, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and R?7¿ have defined meanings, having farnesyl transferase inhibiting activity; their preparation, composit...
WO/2002/024693A1	A PROCESS FOR PRODUCING 3,4-DIHYDRO NAPHTHYRIDINONE ANALOGS This invention is to provide a process for producing 3,4-dihydro naphthyridinone analogs and salts thereof containing the structure shown by the following structural formula (I).The naphthyridinone analogs with an electrowithdrawing grou...
WO/2002/024660A1	IMIDAZOLE DERIVATIVES OR THEIR SALTS Imidazole derivatives of the general formula (1) or salts thereof, medicines containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R?1¿ is lower alkyl; R?2¿ is alkyl or ar...
WO/2002/024682A1	FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS This invention comprises the novel compounds of formula (I)wherein r, s, t, Y?1¿-Y?2¿, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?7¿ have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions ...
WO/2002/024200A1	SUBSTITUTED AZOLE DERIVATIVES AS INHIBITORS OF CORTICOTROPIN RELEASING FACTOR The present invention relates to thiazoles, oxazoles, imidazoles and pharmaceutical compositions comprising said compounds antagonizing the corticotropin releasing factor receptor ('CRF receptor') and useful for the treatment of depressi...
WO/2002/024679A1	PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-$g(b)) INHIBITING ACTIVITY Pyridine compounds of general formula (I) wherein -R?1¿ represents, or in which R?11¿ is hydrogen, C¿1-6? alkyl, halogen, hydroxy, C¿1-12? alkoxy, nitro, amino, C¿1-6? alkylsulfonylamino, C¿1-6? alkoxycarbonyl, C¿1-6? alkylamino, ...
WO/2002/024651A1	A PROCESS FOR PRODUCING 2-AMINO-4,6-DISUBSTITUTED NICOTINIC ACID ESTER ANALOGS This invention is to provide a process for producing 2-amino-4,6-disubstituted nicotinic acid ester analogs and salts thereof, comprising the reaction shown by the following scheme. The ester analogs can be prepared in one pot, and in go...
WO/2002/024666A2	4-AMINO-QUINAZOLINES Quinazolines of the formula I, in which R, R?1¿, R?2¿, R?3¿, R?4¿ and Y have the meaning indicated in Patent Claim 1, and their salts or solvates as glycoprotein IbIX antagonists.
WO/2002/024685A1	INDOLE DERIVATIVES AND THEIR USE AS ANTIFUNGAL AND/OR ANTIPARASITIC AGENTS The invention concerns novel indole derivatives, their preparation method and their pharmacological activity as antimycotic and/or antiparasitic compounds.
WO/2002/024687A1	FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES This invention comprises the novel compounds of formula (I) wherein r, t, Y?1¿-Y?2¿, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and R?7¿ have defined meanings, having farnesyl transferase inhibiting activity; their preparation, composit...
WO/2002/022556A1	NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF UGS Amide derivatives represented by the following general formula (1) which have a C5$g(a) receptor antagonism, wherein each symbol has the meaning as defined in the description. These amide derivatives, optically active isomers thereof or ...
WO/2002/022605A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII, wherein Z?1¿ is N or C-R?9¿, Z?2¿ is N or CH, and Z?3¿ is N or C-R?x¿, provided that one of Z?1¿ ...
WO/2002/022603A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention provides novel pyrazole compounds that are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3. The compounds may be used to treat abnormal physiological function leading to diseases such as...
WO/2002/022604A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compounds of formula III:wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?x¿ and R?y¿ are taken toget...
WO/2002/022608A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel protein kinase inhibitors of formula (VII): wherein G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Rind C has ...
WO/2002/022601A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula (V) wherein Z?1¿ is N, CR?a¿, or CH, and Z?2¿ is N or CH, provided one of Z?1¿ and Z?2¿ is nitrogen; G i...
WO/2002/022607A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compounds of formula II:wherein Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1, 2, 4-triazinyl ring, and R?2¿, R?2¿, R?x¿, and R?y¿ are as described in t...
WO/2002/022584A1	THROMBIN INHIBITORS Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: where R?1¿ is hydrogen, or C¿1-4? alkyl, (CH¿2?)¿0-1?CN, C(O)R?14¿, (CH¿2?)�...
WO/2002/022606A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel pyrazole compounds of formula (IV) wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R?x¿ and R?y¿ are independen...
WO/2002/022550A2	CHIRAL AMINO ALCOHOLS AND PROCESS FOR PREPARATION OF SAME The disclosed invention comprises a compound having the formula (I), in which R?1¿ and R?2¿ independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the di...
WO/2002/022602A2	TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS This invention describes novel triazole compounds of formula (IX): wherein Z?1¿ is nitrogen or CR?9¿ and Z?2¿ is nitrogen or CH, provided that at least one of Z?1¿ and Z?2¿ is nitrogen; G is Ring C or Ring D; Ring C is selected from...
WO/2002/020472A1	SUBSTITUTED PHENYLCYCLOHEXANE CARBOXYLIC ACID AMIDES AND THE USE THEREOF The invention relates to substituted phenylcyclohexane carboxylic acid amides of formula (I), a method for the production thereof and the use thereof in medicaments, especially in the prevention and/or treatment of cardiovascular diseases.
WO/2002/020500A2	MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT Compounds of Formula (I) that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to po...
WO/2002/018349A2	PROCESS AND INTERMEDIATES FOR PREPARING RETROVIRAL PROTEASE INHIBITORS The instant invention provides processes and intermediates employed in the synthesis of ((2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)-amino-3-hydroxy-5- (2S-(1-tetrahydropyrimid-2-onyl)-3-methyl-butanoyl)amino-1,6 -diphenylhexane and analogs...
WO/2002/018368A1	TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS The present invention discloses novel tricyclic compounds represented by the formula (1.0), a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein tra...
WO/2002/016308A1	PHENYL- AND PHENYLALKYL-SUBSTITUTED ETHANOLAMINES AND ETHYLENEDIAMINES The invention relates to compounds of the general formula (1), wherein A, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ are defined as in the description and the claims. The invention further relates to a method for producing said compound...
WO/2002/016324A1	4-PHENYL-PYRIDINE DERIVATIVES AS NEUROKININ-1 RECEPTOR ANTAGONISTS The present invention relates to compounds of the general formula (I) wherein a.o. 5 R is hydrogen or halogen; R and R?2¿ or R?4¿ and R?4'¿ may be together -CH=CH-CH=CH-, optionally substituted by one or two substituents selected from...
WO/2002/013824A1	CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY The present invention is directed to compounds of the formula I (wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and X are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are...
WO/2002/014269A2	2,4-SUBSTITUTED PYRIDINE DERIVATIVES Disclosed are compounds of the formula (I) or pharmaceutically acceptable salts thereof wherein: (i) represents: (ii, iii, iv, v) and A, B, G, D, E, R¿a?, R¿b?, W, and Z are defined herein. These compounds are agonists, antagonists or ...
WO/2002/014311A2	UREA COMPOUNDS AND METHODS OF USES Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptabl...
WO/2002/014276A1	BENZOYLAMINOISOINDOLINE COMPOUNDS, PROCESSES FOR THE PREPARATION OF THE SAME AND INTERMEDIATES FOR THE SYNTHESIS THEREOF Benzoylaminoisoindoline compounds of the general formula [I] useful as drugs, or pharmacologically acceptable salts thereof; processes for the preparation of the compounds or the salts; and intermediates for the synthesis thereof; [I] wh...
WO/2002/012224A2	BICYCLIC COMPOUNDS AS H3 RECEPTOR LIGANDS Substituted N-substituted alkoxyphenyl compounds, compositions containing them, and methods of making and using them.
WO/2002/012190A2	NON-IMIDAZOLE ARYLOXYPIPERIDINES AS H3 RECEPTOR LIGANDS Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
WO/2002/012214A2	NON-IMIDAZOLE ARYLOXYALKYLAMINES AS H3 RECEPTOR LIGANDS Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
WO/2002/012197A1	1H-PYRAZOL DERIVATIVES, METHOD FOR PRODUCING THEM AND THEIR USE AS NITRIFICATION INHIBITORS The invention relates to 1H-pyrazol derivatives corresponding to general formula (I), wherein R?1¿ and R?3¿, independently of each other, represent H or a C¿1?-C¿4?-alkyl radical, R?2¿ represents H, halogen or a C¿1?-C¿4?-alkyl ra...
WO/2002/010140A2	IMIDAZOLYL DERIVATIVES The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
WO/2002/010161A1	PROCESS FOR PREPARING ARYLACETYLAMINOTHIAZOLES The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-arylacetylaminothiazole compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R?1¿, R?2¿, R?3¿, R?4¿...
WO/2002/010163A1	PROCESS FOR PREPARING AZACYCLOALKANOYLAMINOTHIAZOLES The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-azacycloalkanoylaminothiazole compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R?1¿, R?2¿, R?3...
WO/2002/008211A2	BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS Compounds, pharmaceutical compositions, and methods for the treatment of a hyperlipidemic condition in a subject. The compounds of the present invention are apical sodium co-dependent bile acid transport inhibitors and are 1,4-benzothiaz...
WO/2002/008213A1	COLCHINOL DERIVATIVES AS ANGIOGENESIS INHIBITORS The invention related to colchinol derivatives of the formula (I): Wherein: R?1¿, R?2¿ and R?3¿ are each independently hydroxy, phosphoryloxy (-OPO¿3?H¿2?), C¿1-4?alkoxy or an in vivo hydrolysable ester of hydroxy, with the proviso...
WO/2002/008232A1	4-PHENYL-PYRIDINE DERIVATIVES AS NEUROKININ-1 RECEPTOR ANTAGONISTS The invention relates to compounds of general formulas (IA) or (IB) wherein R?1¿ is (a), (b), (c), (d) or is -NH(CH¿2?)¿2?OH, -NR?3¿C(O)CH¿3? or -NR?3¿C(O)-cyclopropyl; R?2¿ is methyl or chloro; R?3¿ is hydrogen or methyl; R is h...
WO/2002/008199A2	EFFICIENT LIGAND-MEDIATED ULLMANN COUPLING OF ANILINES AND AZOLES The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa...
WO2001053268B1	INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating , e.g., kinases-dependent...
WO/2002/006255A2	HYDROXY-(PIPERIDIN-4-YL-METHYLAMINO)-ALKYL BETA-3 ADRENERGIC RECEPTOR ANTAGONISTS The invention provides compounds of Formula (I) having the structure wherein A, B, Z, R and R?1¿ are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders ...
WO/2002/006237A1	MEDICINE COMPRISING DICYANOPYRIDINE DERIVATIVE A 3,5-dicyanopyridine derivative or a salt thereof. The compound exhibits excellent activity of opening the maxi-K channel and bladder smooth muscle contracting activity based on the maxi-K opening activity, and thus can be used in the t...
WO/2002/003912A2	NOVEL C-4 SUBSTITUTED RETINOIDS Novel C-4 substituted all-trans retinoic acid analogs are synthesized and used to treat various cancers and dermatological diseases and conditions. These novel C-4 substituted all-trans retinoic acid analogs inhibit all-trans retinoic ac...
WO/2002/002538A1	AMINO ACID-N-CARBOXY ANHYDRIDES HVAING SUBSTITUENT AT NITROGEN Amino acid-N-carboxy anhydrides having an N-acyl substituent at nitrogen which are represented by the following general formula (1); and a process for producing the same. These compounds easily react with free amino acids, alcohols or nu...
WO/2002/002542A1	FIVE-MEMBERED-RING COMPOUND A five-membered-ring compound represented by the formula or a salt thereof: wherein X represents oxygen or sulfur; R?1¿ represents hydrogen, (un)substituted alkyl, etc.; R?2¿ represents hydrogen, (un)substituted alkyl, (un)substituted ...

Matches 351 - 400 out of 5,407	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >